共查询到20条相似文献，搜索用时 625 毫秒
1.
Evelien E. Geertsema Maryse A. van ’t Klooster Nicole E.C. van Klink Frans S.S. Leijten Peter C. van Rijen Gerhard H. Visser Stiliyan N. Kalitzin Maeike Zijlmans 《Clinical neurophysiology》2017,128(1):153-164
Objective
We aimed to test the potential of auto-regressive model residual modulation (ARRm), an artefact-insensitive method based on non-harmonicity of the high-frequency signal, to identify epileptogenic tissue during surgery.Methods
Intra-operative electrocorticography (ECoG) of 54 patients with refractory focal epilepsy were recorded pre- and post-resection at 2048 Hz. The ARRm was calculated in one-minute epochs in which high-frequency oscillations (HFOs; fast ripples, 250–500 Hz; ripples, 80–250 Hz) and spikes were marked. We investigated the pre-resection fraction of HFOs and spikes explained by the ARRm (h2-index). A general ARRm threshold was set and used to compare the ARRm to surgical outcome in post-resection ECoG (Pearson X2).Results
ARRm was associated strongest with the number of fast ripples in pre-resection ECoG (h2 = 0.80, P < 0.01), but also with ripples and spikes. An ARRm threshold of 0.47 yielded high specificity (95%) with 52% sensitivity for channels with fast ripples. ARRm values >0.47 were associated with poor outcome at channel and patient level (both P < 0.01) in post-resection ECoG.Conclusions
The ARRm algorithm might enable intra-operative delineation of epileptogenic tissue.Significance
ARRm is the first unsupervised real-time analysis that could provide an intra-operative, ‘on demand’ interpretation per electrode about the need to remove underlying tissue to optimize the chance of seizure freedom. 相似文献2.
Katsuya Kobayashi Riki Matsumoto Masao Matsuhashi Kiyohide Usami Akihiro Shimotake Takeharu Kunieda Takayuki Kikuchi Kazumichi Yoshida Nobuhiro Mikuni Susumu Miyamoto Hidenao Fukuyama Ryosuke Takahashi Akio Ikeda 《Clinical neurophysiology》2017,128(9):1673-1681
Objective
We aimed to clarify that high frequency activity (HFA) of cortico-cortical evoked potentials (CCEPs), elicited by single pulse electrical stimulation (SPES), reflects cortical excitability.Methods
We recruited 16 patients with refractory partial epilepsy who had chronic subdural electrode implantation for presurgical evaluation. A repetitive SPES was given to (1) the seizure onset zone (SOZ) and (2) the control cortices (non-seizure onset zone: nSOZ). CCEPs were recorded from the neighboring cortices within SOZ and nSOZ. We applied short-time Fourier transform to obtain the induced responses for the timing of early (<50 ms after SPES) and late CCEP components and analyzed the logarithmic power change for ripple (<200 Hz) and fast ripple (>200 Hz) bands.Results
Twenty-one clear CCEPs were recorded for both the SOZ and nSOZ. The HFA power of early CCEPs in SOZ significantly increased compared to that in nSOZ in both frequency bands, particularly in mesial temporal lobe epilepsy (MTLE).Conclusion
Similar to the features of spontaneous pathological HFOs, the power of stimulus-induced HFAs in SOZ were greater than that outside SOZ, particularly in MTLE.Significance
HFA overriding CCEPs can be a surrogate marker of cortical excitability in epileptic focus. 相似文献3.
Hiroshi Shirozu Akira Hashizume Hiroshi Masuda Yosuke Ito Yoko Nakayama Takefumi Higashijima Masafumi Fukuda Shigeki Kameyama 《Clinical neurophysiology》2017,128(8):1504-1512
Objective
We aimed to validate the usefulness of gradient magnetic-field topography (GMFT) for analysis of ictal magnetoencephalography (MEG) in patients with neocortical epilepsy.Methods
We identified 13 patients presenting with an ictal event during preoperative MEG. We applied equivalent current dipole (ECD) estimation and GMFT to detect and localize the ictal MEG onset, and compared these methods with the ictal onset zone (IOZ) derived from chronic intracranial electroencephalography. The surgical resection areas and outcomes were also evaluated.Results
GMFT detected and localized the ictal MEG onset in all patients, whereas ECD estimation showed localized ECDs in only 2. The delineation of GMFT was concordant with the IOZ at the gyral-unit level in 10 of 12 patients (83.3%). The detectability and precision of delineation of ictal MEG activity by GMFT were significantly superior to those of ECD (p < 0.05 and p < 0.01, respectively). Complete resection of the IOZ in the concordant group provided seizure freedom in 3 patients, whereas seizures remained in 9 patients who had incomplete resections.Conclusions
Because of its higher spatial resolution, GMFT of ictal MEG is superior to conventional ECD estimation in patients with neocortical epilepsy.Significance
Ictal MEG study is a useful tool to estimate the seizure onset in patients with neocortical epilepsy. 相似文献4.
Karin Trimmel Jens Sachsenweger Gerald Lindinger Eduard Auff Fritz Zimprich Ekaterina Pataraia 《Clinical neurophysiology》2017,128(3):472-479
Objectives
Language functional magnetic resonance imaging (fMRI) represents the clinical standard for language lateralization assessment in presurgical epilepsy evaluation, but still many patients experience postoperative language deficits. Event-related potentials (ERPs), especially the negative component around and after 400 ms, are related to language processing and could therefore represent a complementary method of language lateralization assessment.Methods
Scalp EEG was recorded from 64 locations in 36 epilepsy patients and 37 controls during three visually presented language tasks: A short-term language memory task (differentiation memorized vs. unknown words), a phonological task (detection of rhymes in word pairs), and a semantic decision task (differentiation words vs. pseudowords). ERPs were analyzed in the 300 ms–800 ms epoch. Language fMRI was routinely obtained in patients.Results
ERPs were significantly more negative over the left compared to the right hemisphere in all three tasks in patients and controls. Laterality indices showed highest concordance with fMRI for the Word/Pseudoword Task.Conclusions
ERPs of language processing were lateralized to the left hemisphere in the majority of epilepsy patients and controls. In patients, single-subject laterality indices showed high concordance with fMRI results.Significance
Results indicate that scalp-derived ERPs are a promising tool to investigate lateralization of language function in epilepsy patients. 相似文献5.
Tommaso Fedele Georgia Ramantani Sergey Burnos Peter Hilfiker Gabriel Curio Thomas Grunwald Niklaus Krayenbühl Johannes Sarnthein 《Clinical neurophysiology》2017,128(7):1220-1226
Objective
Fast ripples (FR, 250–500 Hz) in the intraoperative corticogram have recently been proposed as specific predictors of surgical outcome in epilepsy patients. However, online FR detection is restricted by their low signal-to-noise ratio. Here we propose the integration of low-noise EEG with unsupervised FR detection.Methods
Pre- and post-resection ECoG (N = 9 patients) was simultaneously recorded by a commercial device (CD) and by a custom-made low-noise amplifier (LNA). FR were analyzed by an automated detector previously validated on visual markings in a different dataset.Results
Across all recordings, in the FR band the background noise was lower in LNA than in CD (p < 0.001). FR rates were higher in LNA than CD recordings (0.9 ± 1.4 vs 0.4 ± 0.9, p < 0.001). Comparison between FR rates in post-resection ECoG and surgery outcome resulted in positive predictive value PPV = 100% in CD and LNA, and negative predictive value NPV = 38% in CD and NPV = 50% for LNA. Prediction accuracy was 44% for CD and 67% for LNA.Conclusions
Prediction of seizure outcome was improved by the optimal integration of low-noise EEG and unsupervised FR detection.Significance
Accurate, automated and fast FR rating is essential for consideration of FR in the intraoperative setting. 相似文献6.
Objective
We evaluated the performance of our previously developed seizure prediction approach on thirty eight seizures from ten patients with focal hippocampal epilepsy.Methods
The seizure prediction system was developed based on the extraction of correlation dimension, correlation entropy, noise level, Lempel-Ziv complexity, largest Lyapunov exponent, and nonlinear interdependence from segments of intracranial EEG.Results
Our results showed an average sensitivity of 86.7% and 92.9%, an average false prediction rate of 0.126 and 0.096/h, and an average minimum prediction time of 14.3 and 33.3 min, respectively, using seizure occurrence periods of 30 and 50 min and a seizure prediction horizon of 10 s. Two-third of the analyzed seizures showed significantly increased complexity in periods prior to the seizures in comparison with baseline.In four patients, strong bidirectional connectivities between epileptic contacts and the surrounding areas were observed. However, in five patients, unidirectional functional connectivities in preictal periods were observed from remote areas to epileptogenic zones.Conclusions
Overall, preictal periods in patients with focal hippocampal epilepsy were characterized with patient-specific changes in univariate and bivariate nonlinear measures.Significance
The spatio-temporal characterization of preictal periods may help to better understand the mechanism underlying seizure generation in patients with focal hippocampal epilepsy. 相似文献7.
J.P. Neverdahl P.M. Omland M. Uglem M. Engstrøm T. Sand 《Clinical neurophysiology》2017,128(12):2411-2418
Objective
To investigate motor cortical excitability, inhibition, and facilitation with navigated transcranial magnetic stimulation (TMS) in migraine in a blinded cross-sectional study.Methods
Resting motor threshold (RMT), cortical silent period (CSP), short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF) were compared in 27 interictal migraineurs and 33 controls. 24 female interictal migraineurs and 27 female controls were compared in subgroup analyses. Seven preictal migraineurs were also compared to the interictal group in a hypothesis-generating analysis. Investigators were blinded for diagnosis during recording and analysis of data.Results
SICI was decreased in interictal migraineurs when compared to healthy controls (p = 0.013), CSP was shortened in female interictal migraineurs (p = 0.041). ICF was decreased in preictal compared to interictal migraineurs (p = 0.023). RMT and ICF were not different between interictal migraineurs and controls.Conclusion
Cortical inhibition was decreased in migraineurs between attacks, primarily in a female subgroup, indicating an importance of altered cortical inhibition in migraine.Significance
Previous studies on motor cortical excitability in migraineurs have yielded varying results. This relatively large and blinded study provides support for altered cortical inhibition in migraine. Measuring intracortical facilitation in the period preceding migraine attacks may be of interest for future studies. 相似文献8.
Alice D. Lam Douglas Maus Sahar F. Zafar Andrew J. Cole Sydney S. Cash 《Clinical neurophysiology》2017,128(9):1647-1655
Objective
In mesial temporal lobe (mTL) epilepsy, seizure onset can precede the appearance of a scalp EEG ictal pattern by many seconds. The ability to identify this early, occult mTL seizure activity could improve lateralization and localization of mTL seizures on scalp EEG.Methods
Using scalp EEG spectral features and machine learning approaches on a dataset of combined scalp EEG and foramen ovale electrode recordings in patients with mTL epilepsy, we developed an algorithm, SCOPE-mTL, to detect and lateralize early, occult mTL seizure activity, prior to the appearance of a scalp EEG ictal pattern.Results
Using SCOPE-mTL, 73% of seizures with occult mTL onset were identified as such, and no seizures that lacked an occult mTL onset were identified as having one. Predicted mTL seizure onset times were highly correlated with actual mTL seizure onset times (r = 0.69). 50% of seizures with early mTL onset were lateralizable prior to scalp ictal onset, with 94% accuracy.Conclusions
SCOPE-mTL can identify and lateralize mTL seizures prior to scalp EEG ictal onset, with high sensitivity, specificity, and accuracy.Significance
Quantitative analysis of scalp EEG can provide important information about mTL seizures, even in the absence of a visible scalp EEG ictal correlate. 相似文献9.
Tommaso Fedele Claudio Schönenberger Gabriel Curio Carlo Serra Niklaus Krayenbühl Johannes Sarnthein 《Clinical neurophysiology》2017,128(10):1851-1857
Objective
The detectability of high frequency oscillations (HFO, >200 Hz) in the intraoperative ECoG is restricted by their low signal-to-noise ratio (SNR). Using the somatosensory evoked HFO, we quantify how HFO detectability can benefit from a custom-made low-noise amplifier (LNA).Methods
In 9 patients undergoing tumor surgery in the central region, subdural strip electrodes were placed for intraoperative neurophysiological monitoring. We recorded the somatosensory evoked potential (SEP) simultaneously by custom-made LNA and by a commercial device (CD). We varied the stimulation rate between 1.3 and 12.7 Hz to tune the SNR of the N20 component and the evoked HFO and quantified HFO detectability at the single trial level. In three patients we compared Propofol® and Sevoflurane® anesthesia.Results
In the average, amplitude decreased in both in N20 and evoked HFO amplitude with increasing stimulation rate (p < 0.05). We detected a higher percentage of single trial evoked HFO with the LNA (p < 0.001) for recordings with low impedance (<5 kΩ). Average amplitudes were indistinguishable between anesthesia compounds.Conclusion
Low-noise amplification improves the detection of the evoked HFO in recordings with subdural electrodes with low impedance.Significance
Low-noise EEG might critically improve the detectability of interictal spontaneous HFO in subdural and possibly in scalp recordings. 相似文献10.
Objective
Phase synchronization is suggested to be among the mechanisms that can explain the effects of transcranial alternating current stimulation (tACS). However, little is known about the effects of tACS on event-related oscillatory activity. Therefore the objective was to investigate frequency-related effects of frontal tACS on event-related oscillatory power.Methods
In a double blind randomized controlled cross-over design, twenty-four participants received 12 min of delta (2.5 Hz), theta tACS (5 Hz) and sham tACS at an intensity of 1 mA peak-to-peak. Event-related delta- and theta-related oscillatory activity was recorded to reward- and punishment-related feedback signals.Results
Delta tACS decreased feedback-related oscillatory power in the 1.5 and 3.5 Hz frequency range. This effect was driven by power changes below the tACS frequency stimulation.Conclusion
Exogenous field potentials can attenuate event-related oscillatory activity in a rhythm slightly below the stimulation frequency. Our findings suggest an interaction between tACS and event-related rhythmic activity that extends beyond phase synchronization.Significance
These findings add novel insights into the mechanisms of tACS after-effects. 相似文献11.
Nicolas Carpentier Thierry Cecchin Laurent Koessler Valérie Louis-Dorr Jacques Jonas Jean-Pierre Vignal Marc Carpentier William Szurhaj Patrice Bourgin Louis Maillard 《Clinical neurophysiology》2017,128(9):1696-1706
Objectives
To describe the hippocampal stereo-electroencephalogram during sleep according to sleep stages (including N2 sleep) and cycles, together with the hippocampal spindles.Methods
All patients with drug-resistant focal epilepsy undergoing intra-hippocampal implantation between August 2012 and June 2013 at Nancy University Hospital were screened. Six patients with explored hippocampus devoid of pathological features were analyzed. During one night, we identified continuous periods of successive N2, N3 and REM sleep for two full cycles. We performed a spectral analysis of the hippocampal signal for each labeled sleep period.Results
N2, N3 and REM sleeps were individualized according to their spectral powers, for each frequency band and sleep cycle. Hippocampal spindles showed dynamic intrinsic properties, the 11.5–16 Hz frequency band being mainly dominant, whereas the 9–11.5 Hz frequency band heightening during the beginning and the end of the transient. For N3 and REM sleep stages, the power of the hippocampal signal was significantly decreased between the first and the second sleep cycle.Conclusion
Distinct N2 sleep, fast spindles and homeostatic profile are all common properties shared by hippocampus and cortex during sleep.Significance
The close functional link between hippocampus and cortex may have various sleep-related substrates. 相似文献12.
Tamara Gedankien Peter J. Fried Alvaro Pascual-Leone Mouhsin M. Shafi 《Clinical neurophysiology》2017,128(12):2419-2427
Objective
We studied the correlation between motor evoked potentials (MEPs) and early TMS-evoked EEG potentials (TEPs) from single-pulse TMS before and after intermittent Theta Burst Stimulation (iTBS) to the left primary motor cortex (M1) in 17 healthy older participants.Methods
TMS was targeted to the hand region of M1 using a MRI-guided navigated brain stimulation system and a figure-of-eight biphasic coil. MEPs were recorded from the right first dorsal interosseous muscle using surface EMG. TEPs were extracted from a 61-channel EEG recording. Participants received 90 single TMS pulses at 120% of resting motor threshold before and after iTBS.Results
Across all participants, the change in N15-P30 TEP and MEP amplitudes were significantly correlated (r = 0.69; p < 0.01). Average TEP responses did not change significantly after iTBS, whereas MEP amplitudes showed a significant increase.Conclusions
Changes in corticospinal reactivity and cortical reactivity induced by iTBS are related. However, the effect of iTBS on TEPs, unlike MEPs, is not straightforward.Significance
Our findings help elucidate the relationship between changes in cortical and corticospinal excitability in healthy older individuals. Going forward, TEPs may be used to evaluate the effects of theta-burst stimulation in non-motor brain regions. 相似文献13.
Sung Wook Chung Benjamin P. Lewis Nigel C. Rogasch Takashi Saeki Richard H. Thomson Kate E. Hoy Neil W. Bailey Paul B. Fitzgerald 《Clinical neurophysiology》2017,128(7):1117-1126
Objectives
To examine the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) on cortical reactivity in the dorsolateral prefrontal cortex.Methods
10 healthy participants were stimulated with either iTBS, cTBS or sham at F3 electrode. Single- and paired-pulse TMS and concurrent electroencephalography (EEG) were used to assess change in cortical reactivity and long-interval intracortical inhibition (LICI) via TMS-evoked potentials (TEPs) and TMS-evoked oscillations.Results
Significant increases in N120 amplitudes (p < 0.01) were observed following iTBS over prefrontal cortex. Changes in TMS-evoked theta oscillations and LICI of theta oscillations were also observed following iTBS (increase) and cTBS (decrease). Change in LICI of theta oscillations correlated with change in N120 amplitude following TBS (r = ?0.670, p = 0.001).Conclusions
This study provides preliminary evidence that TBS produces direct changes in cortical reactivity in the prefrontal cortex. Combining TBS with TMS-EEG may be a useful approach to optimise stimulation paradigms prior to the conduct of clinical trials.Significance
TBS is able to modulate cortical reactivity and cortical inhibition in the prefrontal cortex. 相似文献14.
Mamede de Carvalho Artiom Poliakov Cristiano Tavares Michael Swash 《Clinical neurophysiology》2017,128(11):2200-2204
Objective
We studied motor unit recruitment to test a new method to identify motor unit firing rate (FR) variability.Methods
We studied 68 ALS patients, with and without upper neuron signs (UMN) in lower limbs, 24 patients with primary lateral sclerosis (PLS), 13 patients with spinal cord lesion and 39 normal subjects. All recordings were made from tibialis anterior muscles of normal strength. Subjects performed a very slight contraction in order to activate 2 motor units in each recording. 5–7 motor unit pairs were recorded in each subject. Mean consecutive differences (MCD) were calculated for each pair of potentials. The mean MCD for each muscle was estimated as the mean from the total number of pairs recorded. A p value < 0.01 was accepted as significant.Results
MCD of FR frequency was less in the subjects with spinal cord lesion and PLS. In addition, the FR frequency of the 1st motor unit in a pair of units was markedly reduced in PLS, and in subjects with spinal cord lesions.Conclusion
These results support a lower threshold and reduced FR fluctuation in spinal motor neurons of spastic patients.Significance
This method can be developed for detection of UMN lesions. 相似文献15.
Valerie Van Cauwenberge Rachida El Kaddouri Karel Hoppenbrouwers Jan R. Wiersema 《Clinical neurophysiology》2017,128(4):529-537
Objective
We investigated cognitive reappraisal in children with ADHD by means of the late positive potential (LPP) and self-report ratings. We expected diminished LPP modulation following reappraisal and lower self-report scores in children with ADHD.Methods
Eighteen children with ADHD and 24 typically developing (TD) children (8–12 years) performed a cognitive reappraisal task, while EEG was recorded, and filled out a questionnaire on cognitive reappraisal.Results
Despite the lack of main reappraisal effects on LPP, the LPP was less positively modulated during reappraisal in ADHD compared to TD children.Conclusions
Children with ADHD reported less use of reappraisal and could be distinguished from TD children based on LPP modulation. However the lack of main effects of reappraisal on LPP in both groups hinders clear interpretation of this finding and questions the suitability of LPP modulation within the current paradigm as a neural index of reappraisal in children 8–12 years old, and warrants further research on the inter-individual variability and sensitivity of LPP modulation as a neural index of emotion regulation in children.Significance
This is the first study investigating the LPP during cognitive reappraisal in children with ADHD. 相似文献16.
Gert Pfurtscheller Andreas R. Schwerdtfeger Annemarie Seither-Preisler Clemens Brunner Christoph Stefan Aigner Joana Brito Marciano P. Carmo Alexandre Andrade 《Clinical neurophysiology》2017,128(1):183-193
Objectives
In the brain and heart, oscillations at about 0.1 Hz are conspicuous. It is therefore worthwhile to study the interaction between intrinsic BOLD oscillations (0.1 Hz) and slow oscillations in heart rate interval (RRI) signals and differentiate between their neural and vascular origin.Methods
We studied the phase-coupling with a 3T scanner with high scanning rate between BOLD signals in 22 regions and simultaneously recorded RRI oscillations in 23 individuals in two resting states.Results
By applying a hierarchical cluster analysis, it was possible to separate two clusters of phase-coupling between slow BOLD and RRI oscillations in the midcingulum, one representative for neural and the other for vascular BOLD oscillations. About half of the participants revealed positive time delays characteristic for neural BOLD oscillations and neurally-driven RRI oscillations.Conclusions
The results suggest that slow vascular and neural BOLD oscillations can be differentiated and that intrinsic oscillations (0.1 Hz) originate in the cingulum or its close vicinity and contribute to heart rate variability (HRV).Significance
The study provides new insights into the dynamics of resting state activities, helps to explain HRV, and offers the possibility to investigate slow rhythmic neural activity changes in different brain regions without EEG recording. 相似文献17.
Objective
In healthy individuals, the perception of an intense bitter taste decreased the reward value of visual food cues, as reflected by the reduction of a specific event-related brain potential (ERP), frontal late positivity. The current cross-modal ERP study investigated responses of female patients with binge-eating symptoms (BES) to this type of visual-gustatory stimulation.Methods
Women with BES (n = 36) and female control participants (n = 38) viewed food images after they rinsed their mouth with either bitter wormwood tea or water.Results
Relative to controls, the patients showed elevated late positivity (LPP: 400–700 ms) to the food images in the bitter condition. The LPP source was located in the medial prefrontal cortex. Both groups did not differ in the ratings for the fluids (intensity, bitterness, disgust).Conclusions
This ERP study showed that a bitter taste did not decrease late positivity to visual food cues (reflecting food reward) in women with BES.Significance
The atypical bitter responding might be a biological marker of this condition and possibly contributes to overeating. Future studies should additionally record food intake behavior to further investigate this mechanism. 相似文献18.
E. De Bruijn S.W.R. Nijmeijer P.A. Forbes J.H.T.M. Koelman F.C.T. Van Der Helm M.A.J. Tijssen R. Happee 《Clinical neurophysiology》2017,128(10):1937-1945
Objective
To identify effects of a deviant motor drive in the autospectral power of dystonic muscles during voluntary contraction in cervical dystonia patients.Methods
Submaximal (20%) isometric head-neck tasks were performed with the head fixed, measuring surface EMG of the sternocleidomastoid, splenius capitis and semispinalis capitis in CD patients and controls. Autospectral power of muscle activity, and head forces was analyzed using cumulative distribution functions (CDF). A downward shift between the theta/low alpha-band (3–10 Hz) and the high alpha/beta-band (10–30 Hz) was detected using the CDF10, defined as the cumulative power from 3 to 10 Hz relative to power from 3 to 30 Hz.Results
CDF10 was increased in dystonic muscles compared to controls and patient muscles unaffected by dystonia, due to a 3–10 Hz power increase and a 10–30 Hz decrease. CDF10 also increased in patient head forces.Conclusions
Submaximal isometric contractions with the head fixed provided a well-defined test condition minimizing effects of reflexive feedback and tremor. We associate shifts in autospectral power with prokinetic sensorimotor control.Significance
Analysis of autospectral power in isometric tasks with the head fixed is a promising approach in research and diagnostics of cervical dystonia. 相似文献19.
Lisbeth Hoejkjaer Larsen Ivan Chrilles Zibrandtsen Troels Wienecke Troels Wesenberg Kjaer Mark Schram Christensen Jens Bo Nielsen Henning Langberg 《Clinical neurophysiology》2017,128(11):2217-2226
Objective
Stroke is one of the leading causes of physical disability due to damage of the motor cortex or the corticospinal tract. In the present study we set out to investigate the role of adaptations in the corticospinal pathway for motor recovery during the subacute phase after stroke.Methods
We examined 19 patients with clinically diagnosed stroke and 18 controls. The patients had unilateral mild to moderate weakness of the hand. Each patient attended two sessions at approximately 3 days (acute) and 38 days post stroke (subacute). Task-related changes in the communication between motor cortex and muscles were evaluated from coupling in the frequency domain between EEG and EMG during movement of the paretic hand.Results
Corticomuscular coherence (CMC) and intermuscular coherence (IMC) were reduced in patients as compared to controls. Paretic hand motor performance improved within 4–6 weeks after stroke, but no change was observed in CMC or IMC.Conclusions
CMC and IMC were reduced in patients in the early phase after stroke. However, changes in coherence do not appear to be an efficient marker for early recovery of hand function following stroke.Significance
This is the first study to demonstrate sustained reduced coherence in acute and subacute stroke. 相似文献20.
Yukiko Tsuji Yu-ichi Noto Kensuke Shiga Satoshi Teramukai Masanori Nakagawa Toshiki Mizuno 《Clinical neurophysiology》2017,128(6):1069-1074