急性脑血管意外后高压氧治疗对血糖的影响

目的分析高压氧治疗对急性脑血管意外患者血糖的影响。方法将180例急性脑血管意外患者随机分为高压氧(HBO)治疗组(A组)和对照组(B组)，分别测量两组患者治疗前后血糖浓度。结果高压氧治疗后急性脑血管意外患者血糖浓度较对照组明显降低。结论高压氧治疗能使急性脑血管意外后升高的血糖降低，促进病损的脑组织修复。     

应用高压氧治疗脑外伤失语症的临床效果观察

目的探讨高压氧对于脑外伤失语症患者的临床治疗效果。方法将98例脑外伤失语症患者随机分为观察组(联合高压氧治疗)与对照组(常规治疗),每组各49例。对比分析两组患者的临床治疗效果。结果 49例观察组患者中,总有效45例,总有效率约为91.84%;49例对照组患者中,总有效22例,总有效率约为44.90%;观察组与对照组临床总有效率比较差异性显著(P0.05),具有统计学意义。结论与临床常规治疗方法相比,高压氧治疗方法对于脑外伤失语症患者有着更加显著的临床治疗效果,值得临床借鉴应用。     

高压氧治疗脑外伤135例分析

目的　探讨高压氧治疗脑外伤的疗效。方法　 135例脑外伤病人在常规治疗基础上行高压氧治疗 ,与对照组 135例病人进行对比分析。结果　高压氧组疗效显著优于对照组 (P <0 0 5 )。结论　高压氧是脑外伤重要的治疗手段之一。     

头针联合高压氧及神经节苷脂注射液对脑外伤后偏瘫患者的康复治疗效果分析

目的:探讨头针联合高压氧及神经节苷脂注射液对脑外伤后偏瘫患者的临床疗效.方法:选取某院2019年1月～2020年12月期间收治的脑外伤后偏瘫患者118例,随机数字法分为对照组和研究组各59例,对照组采用高压氧与神经节苷脂注射液治疗,观察组在此基础上给予头针治疗,比较两组治疗前后患肢功能、认知能力、日常生活能力及肌力改善...     

高压氧治疗脑外伤临床观察

目的探讨高压氧对脑外伤的临床治疗效果。方法选择200例患者,随机分为观察组和对照组,对照组采用药物和物理治疗,观察组在此基础上加用高压氧治疗,比较两组疗效。结果观察组总有效率为89％,对照组总有效率为74％,差异有统计学意义（P〈0.05）;治疗前两组GCS和DRS评分差异无统计学意义,治疗后GCS评分增加,DRS评分降低,与治疗前差异显著,但观察组变化幅度更大,与对照组比较,差异有统计学意义。结论高压氧是一种治疗脑外伤非常有效的手段。     

针灸配合高压氧治疗脑外伤的疗效研究

目的探讨针灸配合高压氧治疗脑外伤的临床研究。方法选择2014年1月至2015年1月在我院进行治疗的78例脑外伤患者,随机将78例患者分成两组,治疗组与对照组,每组39例。对照组单独采取高压氧治疗,治疗组采取针灸配合高压氧进行治疗,两组患者都以3个月为1个疗程。治疗前后对两组患者进行GCS(格拉斯昏迷量表)评分及ADL(日常生活能力量表)比较,比较两组患者治疗前后的意识情况及日常生活能力。结果治疗组患者治疗前ADL评分为(25.6±12.3),对照组患者治疗前ADL评分为(25.7±12.4),两组患者治疗前后ADL评分无明显差异(P>0.05),无统计学意义。治疗后,治疗组的ADL评分为(72.4±14.3),对照组的ADL评分为(58.5±14.3),治疗组患者治疗后ADL评分明显高于对照组(P<0.01),有统计学意义。治疗组患者治疗前GCS评分为(6.3±1.36),对照组患者治疗前GCS评分为(6.4±1.24),两组患者治疗前后GCS评分无明显差异(P>0.05),无统计学意义。治疗后,治疗组的GCS评分为(8.6±1.4),对照组的GCS评分为(11.7±2.9),治疗组患者治疗后ADL评分明显高于对照组(P<0.01),有统计学意义。结论针灸配合高压氧治疗脑外伤具有良好的临床疗效,可明显改善患者的意识状态,提高患者的生存质量,可在临床中推广应用。     

早期高压氧治疗脑损伤后失语症80例疗效分析

目的 探讨高压氧治疗脑外伤、脑卒中后失语症的治疗效果.方法 对80例失语症患者(其中脑外伤24例,脑卒中56例)高压氧辅助治疗(HB0组)的临床资料进行分析,并与住院常规药物、语言训练治疗(对照组)相比较.结果 HB0组总有效率为81.25%,明显高于对照组(57.50%)(P＜0.01);脑外伤患者1个疗程的HB0治疗,总有效率达83.33%;脑卒中患者从1个疗程增加到2个疗程,总有效率从70.73%增至93.33%.结论 脑外伤、脑卒中后失语症患者康复期越早做HB0治疗效果越好;脑卒中患者适当延长HB0的疗程,有利于语言功能的恢复.     

高压氧对颅脑损伤患者C-反应蛋白和血糖的影响

目的探讨高压氧治疗对中重型颅脑损伤后血糖和C-反应蛋白的影响。方法根据入院时首次GCS计分,符合人选标准的84例颅脑损伤患者中中型颅脑损伤（G1）44例、重型颅脑损伤（G2）40例,再分别随机将G1、G2组中的患者分为治疗组和对照组,治疗组给予常规治疗及高压氧治疗,对照组仅常规治疗。分别测定全部患者入院24小时内、高压氧治疗第一个疗程和高压氧治疗第二个疗程后的清晨血糖和C-反应蛋白值,并进行对比分析。结果颅脑损伤后空腹血糖和C-反应蛋白的增高与颅脑损伤程度均成正相关关系,且空腹血糖和C-反应蛋白两者之间也成正相关性。结论测定空腹血糖和C-反应蛋白有助于了解颅脑损伤的病情。高压氧治疗可以降低空腹血糖和C-反应蛋白。     

高压氧护理干预在脑外伤失语症中的应用效果

目的探讨应用高压氧治疗脑外伤失语症的护理方法,并观察其临床效果。方法选取2012年6月~2014年4月本院120例脑外伤失语症患者,在尊重患者或其家属治疗意见的基础上将其分为观察组与对照组,每组60例,对照组实施常规护理,观察组实施高压氧护理干预方法,比较两组护理干预前后中国康复研究中心汉语标准失语症检查（CRRCAE）评分及干预后各种失语症状的发生率。结果干预后两组CRRCAE评分均高于干预前（P〈0.05）,观察组CRRCAE评分高于对照组（P〈0.05）,观察组完全性失语、运动性失语、感觉性失语及命名性失语的发生率均显著低于对照组（P〈0.05）。结论高压氧护理干预能有效提高高压氧治疗失语症的临床效果,改善患者的失语症状,值得临床重视。     

高压氧治疗对颅脑损伤患者血浆D－二聚体和血糖的影响及疗效观察

目的探讨高压氧治疗对颅脑损伤患者血浆D-二聚体和血糖的影响及疗效观察。方法抽取280例颅脑损伤患者随机分成高血氧治疗组和对照组2组,检测并比较2组高压氧治疗前后患者血浆D-二聚体及血糖水平。结果高压氧治疗后患者血浆D-二聚体及血糖水平显著低于治疗前,差异具有统计学意义（P〈0．05）。结论高压氧治疗可以显著降低颅脑损伤患者血浆D-二聚体及血糖水平,对改善预后降低致残率有显著疗效。     

上海市社区卫生服务中心医务人员伦理学知识调查及建议

目的:调查上海社区卫生服务中心医务人员的伦理学知识认知情况.方法:采取分层抽样方式,于2016年6—8月对上海市245家社区卫生服务中心的7552名医务人员进行问卷调查.结果:医务人员对伦理学知识非常了解、基本了解、了解很少和完全不了解的人数分别为536人(7.1%)、5411人(71.7%)、1536人(20.3%)和69人(0.9%).不同岗位、职称、学历的医务人员之间存在着明显的伦理学知识认知差距.结论:上海社区卫生服务中心医务人员的伦理学知识了解程度仍有待提高,需加强伦理学知识的学习和应用.     

Studies on the receptors involved in the action of the various agents in the phenylbenzoquinone analgesic assay in mice

1. Tolerance to the activity of several narcotic analgesics (morphine, levorphanol, and methadone) and several narcotic-antagonist analgesics (pentazocine, cyclazocine, and nalorphine) was studied in the mouse phenylbenzoquinone stretching test. Virtually complete tolerance was induced by chronic treatment with each of the narcotic agents, while no apparent tolerance was induced by the narcotic antagonists.2. In morphine-tolerant mice there was a high degree of cross-tolerance to the effects of not only the other narcotic drugs but also to those of the narcotic antagonists, acetylsalicylic acid, and physostigmine.3. The effects of morphine and pentazocine were antagonized by naloxone but not by atropine, while the effects of physostigmine were antagonized by atropine but not by naloxone. Neither atropine nor naloxone antagonized the effect of acetylsalicylic acid.4. The results of the tolerance study suggest that there is a fundamental difference in the consequences of receptor interaction for the narcotic and the narcotic-antagonist analgesics. Morphine-tolerant mice exhibit cross-tolerance non-specifically. The selectivity of naloxone and atropine differentiates the narcotic and narcotic-analgesics from the other two agents used in this analgesic test.     

Nifedipine in the treatment of hypertension in the elderly

The effect of nifedipine monotherapy, retard tablets, 20 mg bid, was evaluated in 23 hypertensive patients, mean age, 79 +/- 2 years. Twenty-one patients completed an eight-week study. Blood pressure (BP) decreased to 160/90 mm Hg in 15 patients; in four additional patients diastolic BP dropped by 15% to 28%. In a subset of five patients with isolated systolic hypertension, a significant reduction in systolic BP was noted. Side effects were relatively mild and only two patients discontinued the study. The results suggest that nifedipine monotherapy offers an alternative, logic, therapeutic approach to hypertension in the elderly.     

Interactions among the cannabinoids in the antagonism of the abdominal constriction response in the mouse

The ability of ⁹-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8,11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E₁ (PGE₁) and bradykinin was tested. THC was an effective antagonist against all nociceptive agents with an ED₅₀ in all cases between 1.0 and 2.6 mg/kg. CBN, while also effective against all nociceptive agents, was less potent than THC, with an ED₅₀ range between 46.2 and 112.5 mg/kg. CBD in doses as high as 200 mg/kg was without effect. Using PGE₁ as the nociceptive agent, 11-OH THC was equipotent to THC while 8,11-diOH THC was inactive. Naloxone, while able to antagonise the antinociceptive effect of morphine against formic acid-induced writhing, did not reverse the antinociceptive effects of THC. There were no pharmacological interactions between THC, CBD and CBN.     

Neurotensin causes a greater increase in the metabolism of dopamine in the accumbens than in the striatum in vivo

Differential pulse voltammetry with carbon fibre electrodes was used to study the effect of central administration of neurotensin on the extracellular level of 3,4-dihydroxyphenylacetic acid (DOPAC) in the nucleus accumbens and the striatum in anaesthetised rats. Intracerebroventricular injection of neurotensin (10 micrograms) increased the peak height for DOPAC 20 min after administration in the nucleus accumbens but only after 40 min in the striatum. The maximum increase was similar in both regions, with 30% and 27% above the pre-injection basal level, respectively. Neurotensin (1 micrograms) however increased the extracellular level of DOPAC in the nucleus accumbens alone. Neurotensin (0.1, 1.0 and 3.0 micrograms/0.5 microliter), injected into the ventral tegmental area, induced a potent and long-lasting elevation of the peak height for DOPAC in the nucleus accumbens, while the same doses in the substantia nigra produced effects on the metabolism of dopamine in the striatum of smaller amplitude and shorter duration. The maximum effect of each dose was about 2.5 times greater in the mesolimbic, compared to the nigrostriatal system. Amphetamine (2 mg/kg, s.c.) decreased the extracellular level of DOPAC with a similar magnitude, both in the nucleus accumbens (52%) and the striatum (47%). Intracerebroventricular administration of neurotensin (1 micrograms), 5 min after amphetamine, did not alter the effect of amphetamine on the extracellular level of DOPAC either in the nucleus accumbens or the striatum. However, neurotensin (10 micrograms) partially reversed the effect of amphetamine in the nucleus accumbens and had a similar but smaller and delayed effect in the striatum. The results from the present study, together with previous neurobehavioural studies, suggest that neurotensin has a relatively selective action on the mesolimbic dopaminergic system in the rat.     

Role of the liver in the disposition of intravenous nitroglycerin in the rat

Previous studies have indicated that the liver is the main site of nitroglycerin (NTG) elimination when the drug is systematically infused. To examine this hypothesis, we measured the apparent systemic clearance (Cls) of nitroglycerin in anesthesized rats receiving a constant intravenous infusion at a dose of 100 micrograms per kg per min. Animals were divided into shunt and sham groups; the former had undergone a portal vein ligation 10 days prior to the study, while the latter was subjected to a sham operation. On the study day, half of the animals of each group also received probenecid at 200 mg/kg, i.v., a drug previously reported to inhibit organic nitrate ester reductase (ONER) activity in rat liver. Arterial NTG samples were obtained at 41, 43 and 45 min of infusion in all four experimental groups; Cls was 439 +/- 32 ml per kg per min (mean +/- S.E.) in sham, 460 +/- 44 in sham and probenecid, 477 +/- 39 in shunt, and 461 +/- 34 in shunt and probenecid animals. During NTG infusion, hepatic blood flow (measured with a constant infusion of indocyanine green) was decreased markedly in shunted rats as was liver/body weight, indicating hepatic atrophy. The specific activity of hepatic ONER was similar in all four groups. In spite of marked differences in hepatic blood flow and hepatic mass, the Cls was similar in all four groups. The liver does not appear to be a major site for the elimination of systemic nitroglycerin as hitherto assumed.     

抗生素在预防普外科手术切口感染中的价值分析及其预防

目的:分析抗生素在预防普外手术切口感染中的临床价值.方法:选择我院收治的100例普外科手术患者作为观察对象(2015年2～11月),采用随机分组的方式将100例普外科手术患者分成对照组与实验组,分别在术后使用抗生素及术前1h使用抗生素,观察两组手术切口感染率及患者的疼痛评分.结果:对照组切口感染率(16.00％)明显高于实验组(4.00％),两组之间对比疼痛评分存在显著差异(P＜0.05),有统计学意义.结论:针对普外科手术患者根据患者的切口类型科学、合理选择抗生素及选择适当的使用时间能有效减少术后手术切口感染,有效改善患者预后.     

女性医务人员健康状况的研究

目的探讨女性医务人员健康状况的特点。方法对2877例医院工作人员健康查体资料进行统计学分析。结果①女性医务人员中,41.0%的人员患有不同类型的疾病,略高于男性患病率（36.8%）,二者差异有统计学意义（P=0.029）;②女性医务人员高脂血症为31.9%（212/665）,低于男性（65.9%,274/416）;③脂肪肝患病率女性（32.6%,181/556）,亦低于男性（45.9%,151/329）;④女性相关疾病中,乳腺疾病和子宫肌瘤的患病率分别为4.8%和3.4%;而宫颈糜烂为20.2%;⑤女性医务人员高血糖为11.0%（77/702）,高血压为4.6%（56/1229）。结论女性医务人员中妇科与乳腺疾病是健康体检的重点,代谢性疾病也应加以关注。