Electrohydraulic lithotripsy (EHL) for the treatment of large retained common duct stones

Retained biliary stones may be too large for extraction through the existing T-tube tract. It may be necessary to dilate the tract, crush the stones or use endoscopic papillotomy. There are reports of stones and the extracting basket becoming stuck in the T-tube tract and tract ruptures caused by extracting large stones. In this study electrohydraulic lithotripsy (EHL) is used in combination with T-tube tract choledochoscopy for the fragmentation of large stones prior to basket extraction. T-tube choledochoscopy was performed under IV sedation and sterile conditions no sooner than one month following common bile duct exploration. The Olympus 4.9-mm choledochoscope was passed through the T-tube tract to visualize the stone. A #5 Fr EHL probe was passed through the endoscope and advanced to within 1 mm of the surface of the stone. EHL discharge was started at a low energy level being increased until the spark discharges caused stone fragmentation. The resultant stone fragments were basket extracted under direct vision. The procedure was used in twelve patients with removal of all stones in eleven patients. Eight patients were treated with one endoscopic session. Because of multiple stones, two patients required two sessions and one patient four sessions. In one patient stone position prevented adequate fragmentation and endoscopic papillotomy also failed. Repeat choledochoscopy and EHL were successful. There were no complications of EHL or choledochoscopy in any of the patients. EHL was both effective and safe for fragmentation of large common duct stones when performed under direct vision using a choledochoscope.     

Retained common bile duct stones. Endoscopic papillotomy is the preferred approach

In six patients who had undergone cholecystectomy and common bile duct exploration, the postoperative T-tube cholangiogram demonstrated stones. Endoscopic cholangiography demonstrated a normal common bile duct in 2 patients and stones in 4 patients. In the latter group, endoscopic papillotomy and stone extraction were successful.     

Laparoscopic transduodenal papillosphincteroplasty

In the past 20 years, the approach to biliary lithiasis has changed tremendously as a result of advances in endoscopic and laparoscopic techniques. The two most important open surgical techniques involve extraction of the stones from the common bile duct combined with choledochoenterostomy and papillotomy followed by transduodenal papillosphinteroplasty. Ideally, the choledochotomy is followed by the insertion of a T-tube in the common bile duct. The transcystic approach has never been considered. The first endoscopic papillotomy was performed in 1973. Subsequently, it became the most widely used method for removal of common bile duct stones. In this report we explore the possibility of performing a laparoscopic transduodenal papillosphincteroplasty, following the strict rules commonly used in surgery. After cholecystectomy, a Fogarty catheter, is introduced through the cystic duct. This is followed by a minimal duodenotomy, then incision of the papillar sphincter. In this surgical proposal, we do not intend to substitute technique, but this method should be considered the ultimate solution in the laparoscopic approach to cholecystic choledocholithiasis.     

Retained and recurrent bile duct stones: operative management

Retained and recurrent bile duct stones can now be treated by a variety of nonoperative means. These include retrieval through instrumentation of the T-tube tract, chemical dissolution, endoscopic papillotomy, or lithotripsy. Operative management, however, is an alternative means of therapy that carries negligible mortality, minimal morbidity, and a high success rate. If operative management is used, for most patients common duct exploration, stone retrieval, and T-tube insertion will suffice. However, if the patient has risk factors that suggest the possibility of further stone disease, a drainage procedure such as a sphincteroplasty or choledochoduodenostomy should be added. Nonoperative management is now the first choice for managing retained or recurrent bile duct stones. If these methods fail or cannot be utilized, operative management can be used with a similar low mortality, low morbidity, and high success rate.     

Choledochoscopy. A cost-minimization analysis.

Although choledochoscopy for the prevention of retained bile duct stones has been postulated as cost effective, no economic evaluation exists to substantiate this claim. We performed a cost-minimization analysis on 287 patients who underwent choledochoscopy during operations for biliary tract calculi between 1981 and 1987 to assess the economic impact of choledochoscopy versus noncholedochoscopic alternatives in obtaining a stone-free duct. Common duct exploration was positive for calculi in 75% of patients. Choledochoscopy-detected residual stones after duct exploration in 10% of patients. Residual stones were more frequent after positive (12.5%) than negative (2.7%) duct explorations. retained stones occurred in 4.5% of patients after operation. Sensitivity, specificity, and negative predictive values of choledochoscopy were 67%, 100%, and 95%, respectively. Cost-minimization analysis showed that total cost of either selective ($75,250) or routine ($110,450) choledochoscopy significantly exceeded the total cost of obtaining a stone-free duct for patients with retained stones via either extraction through a T-tube tract ($17,545) or by endoscopic papillotomy ($45,675). Because choledochoscopy was not economically competitive with noncholedochoscopic, nonoperative alternatives, reduction of choledochoscopy fees was implemented to economically justify continued use of choledochoscopy. We conclude that choledochoscopy is clinically efficacious in obtaining a stone-free duct, but endorsement of either routine or selective choledochoscopy by cost-minimization analysis requires careful assessment of fee structure to make choledochoscopy competitive economically.     

Experience with percutaneous transhepatic fiberoptic choledochoscopy for retained stones in the biliary tract

Summary Residual choledochal stones in 11 patients and stones in the intrahepatic bile ducts in 5 patients were successfully removed by the use of the fiberoptic choledochoscope (FCH-6T), introduced percutaneously into the intrahepatic biliary tract. The reasons for the use of percutaneous transhepatic extraction were: (1) unsuccessful endoscopic papillotomy; (2) unsuccessful choledochoscopic removal via the T-tube tract; (3) high surgical risk; (4) the presence of percutaneous transhepatic biliary drainage for acute cholangitis and acute pancreatitis. All stones were extracted through the liver or the papilla of Vater after crushing them. All minor complications such as pain, vomiting, or fever resolved without further therapy. Percutaneous transhepatic choledochoscopy proved safe and effective for the removal of retained choledochal stones and was essential for the treatment of stones in the intrahepatic bile ducts.     

Endoscopic sphincterotomy for retained common bile duct stones in patients with T-tube in situ in the early postoperative period

We report on thirty-nine patients who underwent endoscopic sphincterotomy (ES) and stone extraction for retained common bile duct calculi with a T-tube in situ. Sixteen of the patients had undergone unsuccessful attempts at removal by flushing or dissolution by cholesterol solvents. A total of 76 stones were present: 53 distal to the T-tube and 23 proximal to the T-tube. ES and clearance of the common bile duct was achieved in 37 patients (95 per cent) and complications occurred in three patients (7.7 per cent). This method is an effective and relatively safe method in the early postoperative period allowing rapid treatment during the same admission as for the original operation and early hospital discharge.     

Endoscopic sphincterotomy for common bile duct calculi

A series of 74 patients having endoscopic sphincterotomy for common bile duct calculi is reported. Complete stone extraction was achieved in 53 cases (72%). Seventeen of 21 patients with retained calculi following recent biliary surgery had successful extractions (80%). Of 30 patients having had a cholecystectomy, 21 (70%) were successful, but only 15 of 23 patients with obstructive jaundice and no previous biliary surgery had the ducts cleared of calculi. Failure was due to multiple stones in the duct, or calculi too large to pass through the sphincterotomy. Endoscopic sphincterotomy is advocated in patients with obstructive jaundice due to stones, moving to early surgery should it prove unsuccessful. The results in patients with a T-tube in situ are comparable to extraction of the calculi along the T-tube tract.     

Choledochoscopy in common bile duct surgery for choledocholithiasis: A must: Eight years experience in 441 consecutive patients

Between 1975 and 1983, 441 choledochoscopy were performed in a series of 451 consecutive patients undergoing surgical common biliary duct exploration for choledocholithiasis. In 127 patients (27.8%), no stones were found. Forty-five cases (10%) of choledocholithiasis missed by surgical and radiologic exploration methods were found by choledochoscopy. Therefore the retained stone rate decreased from 10 per cent to 2 per cent. Fourteen patients (3%) died at surgery, ten of whom (2%) were over 70. Postoperative biliary tract was drained in 98 patients (8%) using external drainage. Biliary tract patency was checked on the tenth postoperative day by the tube cholangiography. When retained stones were not found, T-tube was removed on the 20th day after surgery. When retained stones were found (11 patients, 2%) an endoscopic papillotomy was performed. Choledochoscopy is a significant addition in biliary surgery. It reduces operative mortality and morbidity, decreases retained stone rate, diminishes indications for biliary anastomosis and sphincterotomy, and is easy to perform without specific training. Its extensive and systematic use is advocated when- ever common bile duct patency has to be surgically demonstrated in choledocholithiasis.     

Delayed cholangitis resulting from a retained T-tube fragment encased within a stone: a rare complication

Inserting a T-tube after choledochotomy for the removal of bile duct stones remains a time-honored practice. Biliary drainage after bile duct exploration has some advantages. It minimizes bile leakage, provides access for cholangiography, and removes occasional retained stones. The use of T-tubes also has been associated with significant complications. Biliary sepsis, bile duct trauma during removal, bile leakage leading to peritonitis, retention of a fragment, stricture formation after removal have been reported. We report an unusual case of cholangitis caused by a T-tube fragment within a large stone, occurring 11 years after bile duct exploration. A 39-year-old woman underwent common bile duct exploration with insertion of a T-tube. Cholangiography was normal, but as the T-tube was removed, its horizontal limb was missing. The patient failed to present for endoscopic removal a few weeks after surgery Five years later, she presented with recurrent biliary pains and a mild episode of cholangitis. This last episode was associated with severe pain and jaundice. After initial conservative treatment, endoscopic retrograde cholangiopancreatography was performed, and endoscopic removal of the fragment and stone material was successful. Despite the declining numbers of bile duct explorations in the laparoscopic era and the tendency to use transcystic drainage or primary closure of a choledochotomy, the T-tube will continue to be a useful tool in biliary surgery, subject to consideration of the indications and the available alternatives. The reported case highlights the importance of careful tube preparation to prevent partial separation at removal, and early removal of a missing fragment to avoid potential serious complications.     

Is surgical bile duct revision in choledocholithiasis still indicated?]

Endoscopic papillotomy with stone extraction is increasingly performed for the management of common bile duct stones either before cholecystectomy or as a sole procedure leaving the gallbladder in situ. We have therefore evaluated the method of operative common duct exploration. 94 cases with bile duct stones treated by cholecystectomy and common bile duct exploration were reviewed. The 30-day mortality was 2.1% with an overall morbidity of 19%. A retained stone was found on postoperative T-tube cholangiography in 6 patients and in all cases was removed percutaneously via the T-tube track. Patients were divided into three age groups (less than or equal to 60, 61-75, greater than 75 years). In each patient various risk factors were recorded. Correlation was made between age, risk factors and patient's morbidity. No correlation was found between age and morbidity. Patients with up to two risk factors had a morbidity of 10%. With three to four risk factors the morbidity increased to 19%, reaching 47% in patients with five and more risk factors. Cholecystectomy with common bile duct exploration is a safe procedure even in the elderly patient. Careful evaluation of risk factors is necessary. Endoscopic papillotomy with or without cholecystectomy should be considered in high risk patients.     

Agents for gallstone dissolution

Numerous methods are presently available for gallstone dissolution, including oral bile salts; cholesterol solvents such as mono-octanoin and methyl tert-butyl ether; calcium or pigment solvents such as EDTA and polysorbate; mechanical extraction techniques through a T-tube tract or after endoscopic sphincterotomy; or fragmentation methods such as ultrasonography or electrohydraulic lithotripsy, lasers, and extracorporeal shock waves. Which, if any, of these methods will be appropriate for an individual patient depends on the type of stones, whether they are in the gallbladder or bile ducts, whether access to the biliary tree is available, the patient's age and general medical condition, and the availability of expert radiologists, endoscopists, and newer equipment. In the United States, the only available oral bile salt for cholesterol gallstone dissolution is chenodeoxycholate. Ursodeoxycholate, which is more rapid and less toxic, has not been approved by the Federal Drug Administration. These agents are most effective in thin women with small, floating, radiolucent cholesterol gallstones in a functioning gallbladder. Only about half of this small subset of patients, however, will experience partial or complete dissolution of stones in 6 to 12 months. Moreover, recurrence is very likely, and the potential toxicity of long-term therapy is unknown. Thus, for most patients, cholecystectomy remains the most cost-effective and, perhaps, safest option. Intragallbladder instillation of methyl tert-butyl ether and extracorporeal shock wave therapy are also likely to be applicable to only small subsets of patients and to be associated with high recurrence rates. In patients with retained ductal cholesterol stones and access to the biliary tree, mono-octanoin therapy is advantageous in that it can be begun as soon as cholangiography demonstrates no extravasation. In properly selected patients, a 90 percent success rate with mono-octanoin infusion can be expected within a week. Radiologic or endoscopic extraction techniques require maturation of a relatively straight T-tube tract but are not dependent on the type of stone. In the hands of experts, these techniques are highly successful. In postcholecystectomy patients without access to the biliary tree, endoscopic sphincterotomy has become the preferred method of management and can be expected to succeed in more than 90 percent of patients. At this point, the exact role for ultrasonic or electrohydraulic lithotripsy and lasers is unknown. However, these techniques may be applicable in the future in patients with retained bile duct stones in whom extraction and infusion techniques have failed.     

Endoscopic diagnosis and management of biliary and pancreatic disease

The diagnosis and management of pancreatic and biliary tract disease require the closely coordinated efforts of the surgeon, radiologist, gastroenterologist, endoscopist and pathologist. Modern surgery needs a precise data base to meet the demands for speed, accuracy and a successful outcome. The sequential approach to the differential diagnosis of jaundice, with its emphasis on “noninvasive” diagnostic tests⁶² and lengthy evaluation⁶³ has been preempted by precise positive diagnostic studies. Our approach to the patient suspected of pancreatic or biliary tract disease has been revolutionized by developments in fiberoptic endoscopy and radiology, culminating in the techniques of ERCP, endoscopic biliary surgery, PTC and the removal of common duct stones through the T-tube tract. The therapeutic value of endoscopic biliary surgery and T-tube tract extraction of retained common duct stones as alternatives to secondary biliary tract surgery is clearly established. We are aware of the potential for dissolving cholesterol gallstones with oral medication or direct injection of solvents into the biliary tree. These advances will be clinically available shortly.Preoperative diagnosis of periampullary cancer permits the patient's referral to a specialized center that promises a lower operative mortality and the best chance for cure.⁶⁴ The frustrations and disappointments of operations for pancreatic cancer can be reduced by accurate preoperative diagnosis and palliative bypass surgery.^{[65.] and [66.]}The influence on surgical options of endoscopic biliary surgery and extraction or dissolution of stones through the T-tube tract is not yet clear. The pressure on the surgeon to clear the biliary tree at operation is lessened, since the mortality increase caused by adding common duct exploration (2.4%)⁶⁷ to elective cholecystectomy (0.6%) in the difficult case is greater than the hazard of endoscopic biliary surgery for choledocholithiasis (1.1%).⁶⁶ In patients with acute cholecystitis, preoperative definition of cystic duct patency and anatomy may reduce the hazard of cholecystectomy alone (2.4%) and allow the surgeon to exercise options that reduce the risk of the added common duct exploration (8%).⁶⁷ Cholangiographic studies performed by PTC or ERCP techniques may obviate the need for some common duct explorations. Initial endoscopic surgery can be used to control cholangitis by removing common duct stones and establishing biliary drainage or to facilitate clearing the biliary tree at operation. Alternatively, in the difficult operation, biliary drainage may be established by placing a T-tube in the common bile duct and extraction or dissolution techniques may be used postoperatively, when the patient is stable.^{[68.] and [69.]}These new concepts, therapies and techniques force us to reevaluate the indications for “exploratory laparotomy”, particularly in the elderly.^{[68.] and [72.]} More important, they herald a new era in surgery of the biliary tract and pancreas, when preoperative appreciation of pathologic anatomy and normal variants, with use of endoscopic and radiologic techniques, will produce the consistent yield of excellence desired by all.     

腹腔镜下胆道再手术治疗肝内外胆管结石122例

目的探讨腹腔镜下胆道再手术治疗肝内外胆管结石的策略。方法回顾性分析2006年2月至2011年5月期间122例腹腔镜下胆道再手术治疗肝内外胆管结石患者的临床资料。患者均经腹腔镜下再手术治疗。结果88例术后放置T管,6～8周后,通过纤维胆道镜拔管或取石成功;34例胆管一期缝合;出现并发症8例,均经非手术治疗治愈;无围手术期死亡,全部康复出院。结论腹腔镜下再手术治疗肝内外胆管结石提高了安全性,降低了再手术率。     

Lithotripsy in the laparoscopic era.

OBJECTIVES: The overall prevalence of gallstones in the United States is between 10% and 15%. Eighty-five percent of common bile duct (CBD) stones can be removed by endoscopic sphincterotomy with basket or balloon extraction, or both. The introduction of mechanical lithotripsy improved the results up to 90%. We present one case of retained CBD stone after 2 failed endoscopic sphincterotomies and balloon/basket extraction treated by electrohydraulic lithotripsy (EHL). METHODS: A fifty-year-old man underwent ERCP for suppurative cholangitis. Because of the failure of stone extraction, he was taken to the operating room for an open cholecystectomy and CBD exploration. The intraoperative cholangiogram showed contrast flowing into the duodenum. Seven weeks later, the patient presented with mild pancreatitis, and a T-tube cholangiogram revealed a stone impacted in the distal CBD. Percutaneous balloon extraction was again unsuccessful. RESULTS: The patient underwent a single 2.5-hour session of EHL via the T-tube tract. Mild pulmonary edema occurred intraoperatively. Complete clearance of the CBD was obtained without the need for additional ERCP. CONCLUSIONS: EHL is a valid and effective option for difficult retained common bile duct stones after failed ERCP.     

Endoscopic management of retained bile stones with an indwelling T-tube

Background Endoscopic sphincterotomy (ES) is widely used for the treatment of residual bile duct stones in patients who had common bile duct (CBD) exploration and T-tube insertions. Methods In a 4-year period 45 patients were referred for endoscopic removal of residual bile duct stones. All patients had been operated 7–15 days earlier for choledocholithiasis and had a T-tube in the common bile duct (CBD). Results Four patients were excluded. Three patients had a periampullary carcinoma and the fourth patient had no residual stone seen at cholangiography. All patients had a successful ES, conventional in 34, precut-knife in 3, and with the rendezvous technique in 4 patients. In 24 patients, all having stones distal to the T-tube, complete clearance of the CBD was achieved during one session and the T-tube was removed after 48 h. In the remaining 17 patients (15 having stones proximal to the T-tube), the T-tube had to be removed first and following stone extraction, a plastic stent was inserted in the CBD. Complete bile duct clearance and stent removal was achieved in a second session 3–4 weeks later. There were no serious complications or biliary related symptoms after the procedures and after a mean follow-up period of 18 months. Conclusion The endoscopic technique is safe and efficient for the treatment of residual stones after CBD exploration with a T-tube insertion, offering immediate cure compared to the percutaneous techniques. It is also an ideal method for the diagnosis of periampullary carcinomas. Online publication: 24 August 2004     

Early postoperative endoscopic sphincterotomy for retained common duct stones

The results of endoscopic sphincterotomy in 30 patients with retained common bile duct stones and a T-tube in situ following surgical exploration of the common bile duct are presented. Successful stone extraction was achieved in 27 cases (90%). There was one death, which was not procedure related. Early postoperative T-tube cholangiography is advocated and if necessary sphincterotomy can be safely performed 1 week following surgery. This approach has advantages in shortening hospital stay and minimising patient discomfort.     

Laparoscopic antegrade biliary stenting for postoperative endoscopic clearance of biliary stones.

Unsuspected ductal stones discovered during laparoscopic cholecystectomy may necessitate conversion to an open procedure, laparoscopic extraction, or postoperative endoscopic papillotomy. In order not to lose the advantages of a minimally invasive treatment and to decrease the likelihood of postoperative endoscopic failure, laparoscopic antegrade biliary stenting was attempted in 10 unselected patients (8 women, 2 men; mean age 52 +/- 11.4 years) with intraoperatively detected common bile duct stones. The mean diameter of these stones was 7 mm (range 5-11 mm). One stenting failed because of stone impaction, but the procedure was successful with effective biliary drainage in nine patients. The mean operative time was 70 (range 50-165) minutes. Subsequent ERCP was performed a mean of 8 (range 6-20) days after surgery. Deep cannulation, stent-guided papillotomy, and duct clearance was achieved in all stented patients, without any complication. Laparoscopic antegrade biliary stenting provides a guide for subsequent endoscopic stone removal, minimizing the risks of either stent migration or endoscopic failure. This combined technique is safe and cost effective and may be considered when ductal stones are discovered unexpectedly during laparoscopic cholecystectomy.     

Laparoscopic choledochotomy for bile duct stones

In the era of laparoscopic surgery, treatment strategies for common bile duct stones remain controversial. Laparoscopic choledochotomy is usually indicated only when transcystic duct exploration is not feasible. However, laparoscopic choledochotomy provides complete access to the ductal system and has a higher clearance rate than the transcystic approach. In addition, primary closure of the choledochotomy with a running suture and absorbable clips facilitates the procedure. Therefore, to avoid postoperative biliary stenosis, all patients with bile duct stones can be indicated for choledochotomy, except for those with nondilated common bile duct. Placement of a C-tube also provides access for the clearance of possible retained stones by endoscopic sphincterotomy as a backup procedure. C-tube placement, in contrast to T-tube insertion, is advantageous in terms of a relatively short hospital stay. In conclusion, laparoscopic choledochotomy with C-tube drainage is recommended as the treatment of choice for patients with common bile duct stones. Received: February 27, 2001 / Accepted: March 19, 2001     

Endoscopic papillotomy while the gallbladder is in situ.

The authors report on their experience with 25 patients who underwent an endoscopic papillotomy with gallbladder in situ and review the current literature on this topic. Twenty-four out of 25 patients in this study had their common bile duct cleared of stones. Five patients (24%) required cholecystectomy on follow-up at an average of 14.4 months. There was no mortality associated with the procedure. The authors' experience and review of the literature suggest that endoscopic papillotomy plays an important role in the removal of common bile duct stones in persons who have their gallbladder in situ, especially in those patients who are at high risk for surgery, either because of advanced age or other medical problems. However, the use of endoscopic papillotomy alone in young, healthy persons is more problematic because of the relatively high rate of cholecystitis or recurrent biliary colic necessitating a cholecystectomy at a later date. The authors suggest that, in the future, the ideal treatment regimen for common bile duct stones in patients with their gallbladder in situ may be urgent endoscopic papillotomy with a scheduled elective laparoscopic cholecystectomy.