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1.
Hiroshi Shirozu Akira Hashizume Hiroshi Masuda Yosuke Ito Yoko Nakayama Takefumi Higashijima Masafumi Fukuda Shigeki Kameyama 《Clinical neurophysiology》2017,128(8):1504-1512
Objective
We aimed to validate the usefulness of gradient magnetic-field topography (GMFT) for analysis of ictal magnetoencephalography (MEG) in patients with neocortical epilepsy.Methods
We identified 13 patients presenting with an ictal event during preoperative MEG. We applied equivalent current dipole (ECD) estimation and GMFT to detect and localize the ictal MEG onset, and compared these methods with the ictal onset zone (IOZ) derived from chronic intracranial electroencephalography. The surgical resection areas and outcomes were also evaluated.Results
GMFT detected and localized the ictal MEG onset in all patients, whereas ECD estimation showed localized ECDs in only 2. The delineation of GMFT was concordant with the IOZ at the gyral-unit level in 10 of 12 patients (83.3%). The detectability and precision of delineation of ictal MEG activity by GMFT were significantly superior to those of ECD (p < 0.05 and p < 0.01, respectively). Complete resection of the IOZ in the concordant group provided seizure freedom in 3 patients, whereas seizures remained in 9 patients who had incomplete resections.Conclusions
Because of its higher spatial resolution, GMFT of ictal MEG is superior to conventional ECD estimation in patients with neocortical epilepsy.Significance
Ictal MEG study is a useful tool to estimate the seizure onset in patients with neocortical epilepsy. 相似文献2.
Michael B.H. Hall Ida A. Nissen Elisabeth C.W. van Straaten Paul L. Furlong Caroline Witton Elaine Foley Stefano Seri Arjan Hillebrand 《Clinical neurophysiology》2018,129(6):1221-1229
Objective
Kurtosis beamforming is a useful technique for analysing magnetoencephalograpy (MEG) data containing epileptic spikes. However, the implementation varies and few studies measure concordance with subsequently resected areas. We evaluated kurtosis beamforming as a means of localizing spikes in drug-resistant epilepsy patients.Methods
We retrospectively applied kurtosis beamforming to MEG recordings of 22 epilepsy patients that had previously been analysed using equivalent current dipole (ECD) fitting. Virtual electrodes were placed in the kurtosis volumetric peaks and visually inspected to select a candidate source. The candidate sources were compared to the ECD localizations and resection areas.Results
The kurtosis beamformer produced interpretable localizations in 18/22 patients, of which the candidate source coincided with the resection lobe in 9/13 seizure-free patients and in 3/5 patients with persistent seizures. The sublobar accuracy of the kurtosis beamformer with respect to the resection zone was higher than ECD (56% and 50%, respectively), however, ECD resulted in a higher lobar accuracy (75%, 67%).Conclusions
Kurtosis beamforming may provide additional value when spikes are not clearly discernible on the sensors and support ECD localizations when dipoles are scattered.Significance
Kurtosis beamforming should be integrated with existing clinical protocols to assist in localizing the epileptogenic zone. 相似文献3.
Sumiya Shibata Masao Matsuhashi Takeharu Kunieda Yukihiro Yamao Rika Inano Takayuki Kikuchi Hisaji Imamura Shigetoshi Takaya Riki Matsumoto Akio Ikeda Ryosuke Takahashi Tatsuya Mima Hidenao Fukuyama Nobuhiro Mikuni Susumu Miyamoto 《Clinical neurophysiology》2017,128(5):734-743
Objective
We describe temporal spread imaging (TSI) that can identify the spatiotemporal pattern of epileptic activity using Magnetoencephalography (MEG).Methods
A three-dimensional grid of voxels covering the brain is created. The array-gain minimum-variance spatial filter is applied to an interictal spike to estimate the magnitude of the source and the time (Ta) when the magnitude exceeds a predefined threshold at each voxel. This calculation is performed through all spikes. Each voxel has the mean Ta (<Ta>) and spike number (Nsp), which is the number of spikes whose source exceeds the threshold. Then, a random resampling method is used to determine the cutoff value of Nsp for the statistically reproducible pattern of the activity. Finally, all the voxels where the source exceeds the threshold reproducibly shown on the MRI with a color scale representing <Ta>.Results
Four patients with intractable mesial temporal lobe epilepsy (MTLE) were analyzed. In three patients, the common pattern of the overlap between the propagation and the hypometabolism shown by fluorodeoxyglucose-positron emission tomography (FDG-PET) was identified.Conclusions
TSI can visualize statistically reproducible patterns of the temporal and spatial spread of epileptic activity.Significance
TSI can assess the statistical significance of the spatiotemporal pattern based on its reproducibility. 相似文献4.
C. Cuello-Oderiz N. von Ellenrieder R. Sankhe A. Olivier J. Hall F. Dubeau J. Gotman 《Clinical neurophysiology》2018,129(6):1311-1319
Objectives
There are different neurophysiological markers of the Epileptogenic Zone (EZ), but their sensitivity and specificity for the EZ is not known in Focal Cortical Dysplasia (FCD) patients.Methods
We studied patients with FCD who underwent stereoelectroencephalography (SEEG) and surgery. We marked in the SEEG: (a) typical and atypical interictal epileptiform patterns, (b) ictal onset patterns, and (c) rates of ripples (80–250?Hz) and fast ripples (FRs) (>250?Hz). High frequency oscillations were marked automatically during one hour of deep sleep. Surgical outcome was defined as good (Engel I) or poor (Engel II–IV). We computed the sensitivity and, as a measure of specificity, the false positive rate to identify the EZ, and compared them across the different neurophysiological markers.Results
We studied 21 patients, 19 with FCD II. Ictal and typical interictal pattern were the markers with highest sensitivity, while the atypical interictal pattern had the lowest. We found no significant difference in specificity among markers. However, there is a tendency that FRs had the lowest false positive rate.Conclusion
The typical interictal pattern has the highest sensitivity. The clinical use of FRs is limited by their low sensitivity.Significance
We suggest to analyze the typical interictal pattern first. FRs should be analyzed in a second step. If, for instance, a focus with FRs and no typical interictal pattern is found, this area could be considered for resection. 相似文献5.
Davide Rossi Sebastiano Elisa Visani Dunja Duran Elena Freri Ferruccio Panzica Luisa Chiapparini Francesca Ragona Tiziana Granata Silvana Franceschetti 《Clinical neurophysiology》2017,128(10):1898-1905
Objective
We aimed this study at identifying cortical areas involved in the generation of interictal spikes in Rasmussen’s Encephalitis (RE) patients using magnetoencephalography (MEG), at comparing spike localization with the degree of cortical atrophy detected by MRI, and at identifying short-term changes during the follow-up.Methods
Five patients with RE underwent two MEG and magnetic resonance imaging (MRI) (six months interval). The sources of visually detected spikes were estimated using equivalent current dipoles technique; these were then superimposed on individual MRI and clustered; the locations of the clusters were related to the MRI stage of cortical atrophy.Results
All patients showed spikes and clusters located in different cortical areas in both recordings; the locations had a limited correspondence with cortical atrophy. The second recordings showed changes in the localisation of spikes and clusters, and confirmed the dissimilarities with neuroradiological abnormalities.Conclusions
The presence of clusters of spikes of variable localisation suggests that RE progresses in a multifocal and fluctuating manner. The cortical areas most involved in epileptogenesis did not completely coincide with the most atrophic areas.Significance
MEG can contribute to evaluating multifocal hemispheric spikes in RE and to better understand the time course of epileptogenic process. 相似文献6.
Vasileios Kokkinos Andreas M. Koupparis Michalis Koutroumanidis George K. Kostopoulos 《Clinical neurophysiology》2017,128(9):1553-1562
Objective
This work investigates the spatial distribution in time of generalized ictal spikes in the typical absences of childhood absence epilepsy (CAE).Methods
We studied twelve children with CAE, who had more than two typical absences during their routine video-EEG. Seizures were identified, and ictal spikes were marked over the maximum electronegative peak, clustered, waveform-averaged and spatiotemporaly analyzed in 2D electrode space.Results
Consistency of spatiotemporal patterns of ictal spikes was high between the absences of the same child, but low between children. Three main discharge patterns were identified: of anterio-posterior propagation, of posterio-anterior propagation and confined to the frontal/prefrontal regions. In 4 patients, the propagation patterns transformed during the seizure into either a lateralized diminished or a non-lateralized reverse direction form. Most spikes originated fronto-temporaly, all maximized over the frontal/prefrontal electrodes and mostly decayed prefrontaly. In 4 patients, lateralized propagation patterns were identified.Conclusions
Ictal spike propagation patterns suggest that epileptogenic CAE networks are personalized, interconnect distal areas in the brain – not the entire cortex – with a tendency to generate bilateral symmetrical discharges, sometimes unsuccessfully. The transformation of propagation patterns during the seizure indicates the existence of dynamic interplay within epileptogenic networks.Significance
Our results support the revised concept of ictogenesis of ILAE definition in genetic (also known as idiopathic) generalized epilepsies. Understanding the focal features in CAE avoids misdiagnosis as focal epilepsy and inappropriate treatment. 相似文献7.
Junpei Tanigawa Kuriko Kagitani-Shimono Junko Matsuzaki Rei Ogawa Ryuzo Hanaie Tomoka Yamamoto Koji Tominaga Shin Nabatame Ikuko Mohri Masako Taniike Keiichi Ozono 《Clinical neurophysiology》2018,129(9):2029-2037
Objective
Individuals with autism spectrum disorder (ASD) often show characteristic differences in auditory processing. To clarify the mechanisms underlying communication impairment in ASD, we examined auditory language processing with both anatomical and functional methods.Methods
We assessed the language abilities of adolescents with ASD and typically developing (TD) adolescents, and analyzed the surface-based morphometric structure between the groups using magnetic resonance imaging. Furthermore, we measured cortical responses to an auditory word comprehension task with magnetoencephalography and performed network-based statistics using the phase locking values.Results
We observed no structural differences between the groups. However, the volume of the left ventral central sulcus (vCS) showed a significant correlation with linguistic scores in ASD. Moreover, adolescents with ASD showed weaker cortical activation in the left vCS and superior temporal sulcus. Furthermore, these regions showed differential correlations with linguistic scores between the groups. Moreover, the ASD group had an atypical gamma band (25–40?Hz) network centered on the left vCS.Conclusions
Adolescents with ASD showed atypical responses on the auditory word comprehension task and functional brain differences.Significance
Our results suggest that phonological processing and gamma band cortical activity play a critical role in auditory language processing-related pathophysiology in adolescents with ASD. 相似文献8.
Eugen Gallasch Dietmar Rafolt Magdalena Postruznik Shane Fresnoza Monica Christova 《Clinical neurophysiology》2018,129(7):1397-1402
Objectives
Rotation of a static magnet over the motor cortex (MC) generates a transcranial alternating magnetic field (tAMF), and a linked alternating electrical field. The aim of this transcranial magnetic stimulation (TMS) study is to investigate whether such fields are able to influence MC excitability, and whether there are parallels to tACS induced effects.Methods
Fourteen healthy volunteers received 20?Hz tAMF stimulation over the MC, over the vertex, and 20?Hz tACS over the MC, each with a duration of 15?min. TMS assessments were performed before and after the interventions. Changes in motor evoked potentials (MEP), short interval intra-cortical inhibition (SICI) and intra-cortical facilitation (ICF) were evaluated.Results
The tACS and the tAMF stimulation over the MC affected cortical excitability in a different way. After tAMF stimulation MEP amplitudes and ICF decreased and the effect of SICI increased. After tACS MEP amplitudes increased and there were no effects on SICI and ICF.Conclusions
The recorded single and paired pulse MEPs indicate a general decrease of MC excitability following 15 min of tAMF stimulation.Significance
The effects demonstrate that devices based on rotating magnets are potentially suited to become a novel brain stimulation tool in clinical neurophysiology. 相似文献9.
Gopal Krishna Dash Chaturbhuj Rathore Malcolm K. Jeyaraj Pandurang Wattamwar Sankara P. Sarma Kurupath Radhakrishnan 《Clinical neurophysiology》2018,129(5):946-951
Objective
Interictal regional paroxysmal fast activity (RPFA) on scalp EEG is common in patients with focal cortical dysplasia (FCD). Little data exists regarding the presence of RPFA in other etiologies.Methods
We studied the association between RPFA and etiology on MRI in patients with drug resistant focal epilepsy undergoing presurgical evaluation in 2011. RPFA was defined as ≥3 consecutive spikes with a frequency of ≥10?Hz lasting ≥300?ms but <4?s.Results
626 patients fulfilled the inclusion criteria. Of these, 138 (22%) patients had RPFA while rest had other interictal epileptiform discharges (IEDs). RPFA was located at posterior head region in 52.2% patients, frontal regions in 24.6% patients and over temporal regions in 17.4% patients. Focal gliosis (61, 44%) and FCD (27, 19%) were common etiologies in patients with RPFA. Compared to patients with other IEDs, patients with RPFA were more likely to have focal gliosis (61/138 vs. 39/488; p?<?0.0001) or FCD (27/138 vs 37/488; p?<?0.001) as the etiology of epilepsy.Conclusion
In developing countries, focal gliosis is more common than FCD as the underlying etiology in patients with RPFA on scalp EEG.Significance
Focal gliosis should be considered as one of the common substrate for RPFA on scalp EEG. 相似文献10.
Puneet Jain Robyn Whitney Samuel Strantzas Blathnaid McCoy Ayako Ochi Hiroshi Otsubo O. Carter Snead Shelly Weiss Elizabeth Donner Elizabeth Pang Rohit Sharma Amrita Viljoen Anne Keller James M. Drake James T. Rutka Cristina Go 《Clinical neurophysiology》2018,129(12):2642-2649
Objectives
The objective of this study was to review our experience with intra-operative “train of five” stimulation using subdural grid for motor mapping in children undergoing epilepsy surgery evaluation.Methods
Twenty consecutive children below 18-years of age with drug-refractory epilepsy who underwent invasive-EEG monitoring using subdural-grid placement and intra-operative motor mapping using direct cortical stimulation by sub-dural grid electrodes (IODCS-SDG) at our institution between January-2016 and June-2017 were reviewed. Stimulation was delivered through the subdural-grid electrodes using a train-of-five pulses and muscle responses were recorded by motor-evoked-potentials (MEPs). Intra-operative direct cortical stimulation delivered through a ball-tipped probe (IODCS-probe) and extra-operative motor-mapping (EODCS-SDG) were also performed.Results
IODCS-SDG was completed in 20 patients and subsequent EODCS-SDG was done in 17/20 patients. MEP responses were more commonly obtained in the deltoid (19/20), extensor-digitorum-communis (20/20) and first-dorsal-interosseus (19/20). The median thresholds varied between 40?V and 60?V for the six muscle groups. The respective IODCS-probe thresholds tended to be similar. No stimulation-provoked seizures or anaesthesia-related complications were noted during IODCS-SDG. EODCS-SDG could not be completed in 4/17 children and mapping data obtained was frequently inadequate. Nine patients demonstrated 100% concordance between IODCS-SDG and EODCS-SDG for the common mapped body regions. Stimulation-provoked seizures during EODCS-SDG were seen in 6/17 (35.3%) and after-discharges in 7/17 (41.2%) children.Conclusions
IODCS-SDG could be performed safely in children with drug refractory epilepsy undergoing invasive EEG monitoring.Significance
IODCS-SDG may be a useful adjunct to EODCS-SDG in motor mapping for children. 相似文献11.
Felice T. Sun Sharanya Arcot Desai Thomas K. Tcheng Martha J. Morrell 《Clinical neurophysiology》2018,129(3):676-686
Objective
Subacute and long-term electrocorticographic (ECoG) changes in ambulatory patients with depth and cortical strip electrodes were evaluated in order to determine the length of the implant effect.Methods
ECoG records were assessed in patients with medically intractable epilepsy who had depth and/or strip leads implanted in order to be treated with brain-responsive stimulation. Changes in total spectral power, band-limited spectral power, and spike rate were assessed.Results
121 patients participating in trials of the RNS® System had a total of 93994 ECoG records analyzed. Significant changes in total spectral power occurred from the first to second months after implantation, involving 55% of all ECoG channels (68% of strip and 47% of depth lead channels). Significant, but less pronounced, changes continued over the 2nd to 5th post-implant months, after which total power became more stable. Similar patterns of changes were observed within frequency bands and spike rate.Conclusions
ECoG spectral power and spike rates are not stable in the first 5?months after implantation, presumably due to neurophysiological and electrode-tissue interface changes.Significance
ECoG data collected in the first 5?months after implantation of intracranial electrodes may not be fully representative of chronic cortical electrophysiology. 相似文献12.
Riёm El Tahry Z. Irene Wang Aung Thandar Irina Podkorytova Balu Krishnan Simon Tousseyn Wu Guiyun Richard C. Burgess Andreas V. Alexopoulos 《Clinical neurophysiology》2018,129(8):1651-1657
Objective
Selected patients with intractable focal epilepsy who have failed a previous epilepsy surgery can become seizure-free with reoperation. Preoperative evaluation is exceedingly challenging in this cohort. We aim to investigate the diagnostic value of two noninvasive approaches, magnetoencephalography (MEG) and ictal single-photon emission computed tomography (SPECT), in patients with failed epilepsy surgery.Methods
We retrospectively included a consecutive cohort of patients who failed prior resective epilepsy surgery, underwent re-evaluation including MEG and ictal SPECT, and had another surgery after the re-evaluation. The relationship between resection and localization from each test was determined, and their association with seizure outcomes was analyzed.Results
A total of 46 patients were included; 21 (46%) were seizure-free at 1-year followup after reoperation. Twenty-seven (58%) had a positive MEG and 31 (67%) had a positive ictal SPECT. The resection of MEG foci was significantly associated with seizure-free outcome (p?=?0.002). Overlap of ictal SPECT hyperperfusion zones with resection was significantly associated with seizure-free outcome in the subgroup of patients with injection time ≤20?seconds(p?=?0.03), but did not show significant association in the overall cohort (p?=?0.46) although all injections were ictal. Patients whose MEG and ictal SPECT were concordant on a sublobar level had a significantly higher chance of seizure freedom (p?=?0.05).Conclusions
MEG alone achieved successful localization in patients with failed epilepsy surgery with a statistical significance. Only ictal SPECT with early injection (≤20?seconds) had good localization value. Sublobar concordance between both tests was significantly associated with seizure freedom. SPECT can provide essential information in MEG-negative cases and vice versa.Significance
Our results emphasize the importance of considering a multimodal presurgical evaluation including MEG and SPECT in all patients with a previous failed epilepsy surgery. 相似文献13.
Alonso Zea Vera Gewalin Aungaroon Paul S. Horn Anna W. Byars Hansel M. Greiner Jeffrey R. Tenney Todd M. Arthur Nathan E. Crone Katherine D. Holland Francesco T. Mangano Ravindra Arya 《Clinical neurophysiology》2017,128(10):2087-2093
Objective
To examine current thresholds and their determinants for language and motor mapping with extra-operative electrical cortical stimulation (ECS).Methods
ECS electrocorticograph recordings were reviewed to determine functional thresholds. Predictors of functional thresholds were found with multivariable analyses.Results
In 122 patients (age 11.9 ± 5.4 years), average minimum, frontal, and temporal language thresholds were 7.4 (± 3.0), 7.8 (± 3.0), and 7.4 (± 3.1) mA respectively. Average minimum, face, upper and lower extremity motor thresholds were 5.4 (± 2.8), 6.1 (± 2.8), 4.9 (± 2.3), and 5.3 (± 3.3) mA respectively.Functional and after-discharge (AD)/seizure thresholds were significantly related. Minimum, frontal, and temporal language thresholds were higher than AD thresholds at all ages. Minimum motor threshold was higher than minimum AD threshold up to 8.0 years of age, face motor threshold was higher than frontal AD threshold up to 11.8 years age, and lower subsequently. UE motor thresholds remained below frontal AD thresholds throughout the age range.Conclusions
Functional thresholds are frequently above AD thresholds in younger children.Significance
These findings raise concerns about safety and neurophysiologic validity of ECS mapping. Functional and AD/seizure thresholds relationships suggest individual differences in cortical excitability which cannot be explained by clinical variables. 相似文献14.
Golnoush Alamian Ana-Sofía Hincapié Annalisa Pascarella Thomas Thiery Etienne Combrisson Anne-Lise Saive Véronique Martel Dmitrii Althukov Frédéric Haesebaert Karim Jerbi 《Clinical neurophysiology》2017,128(9):1719-1736
Objective
Neuroimaging studies provide evidence of disturbed resting-state brain networks in Schizophrenia (SZ). However, untangling the neuronal mechanisms that subserve these baseline alterations requires measurement of their electrophysiological underpinnings. This systematic review specifically investigates the contributions of resting-state Magnetoencephalography (MEG) in elucidating abnormal neural organization in SZ patients.Method
A systematic literature review of resting-state MEG studies in SZ was conducted. This literature is discussed in relation to findings from resting-state fMRI and EEG, as well as to task-based MEG research in SZ population. Importantly, methodological limitations are considered and recommendations to overcome current limitations are proposed.Results
Resting-state MEG literature in SZ points towards altered local and long-range oscillatory network dynamics in various frequency bands. Critical methodological challenges with respect to experiment design, and data collection and analysis need to be taken into consideration.Conclusion
Spontaneous MEG data show that local and global neural organization is altered in SZ patients. MEG is a highly promising tool to fill in knowledge gaps about the neurophysiology of SZ. However, to reach its fullest potential, basic methodological challenges need to be overcome.Significance
MEG-based resting-state power and connectivity findings could be great assets to clinical and translational research in psychiatry, and SZ in particular. 相似文献15.
Seung Suk Kang Angus W. MacDonald Matthew V. Chafee Chang-Hwan Im Edward M. Bernat Nicholas D. Davenport Scott R. Sponheim 《Clinical neurophysiology》2018,129(1):210-221
Objective
To better understand the origins of working memory (WM) impairment in schizophrenia we investigated cortical oscillatory activity in people with schizophrenia (PSZ) while they performed a WM task requiring encoding, maintenance, and retrieval/manipulation processes of spatial information.Methods
We examined time–frequency synchronous energy of cortical source signals that were derived from magnetoencephalography (MEG) localized to cortical regions using WM?related hemodynamic responses and individualized structural head-models.Results
Compared to thirteen healthy controls (HC), twelve PSZ showed performance deficits regardless of WM?load or duration. During encoding, PSZ had early theta and delta event-related synchrony (ERS) deficits in prefrontal and visual cortices which worsened with greater memory load and predicted WM performance. During prolonged maintenance of material, PSZ showed deficient beta event-related desynchrony (ERD) in dorsolateral prefrontal, posterior parietal, and visual cortices. In retrieval, PSZ showed reduced delta/theta ERS in the anterior prefrontal and ventral visual cortices and diminished gamma ERS in the premotor and posterior parietal cortices.Conclusions
Although beta/gamma cortical neural oscillatory deficits for maintenance/retrieval are evident during WM, the abnormal prefrontal theta-frequency ERS for encoding is most predictive of poor WM in schizophrenia.Significance
Time-frequency-spatial analysis identified process- and frequency-specific neural synchrony abnormalities underlying WM deficits in schizophrenia. 相似文献16.
Gewalin Aungaroon Andrew Trout Rupa Radhakrishnan Paul S. Horn Ravindra Arya Jeffrey R. Tenney Todd M. Arthur Katherine D. Holland Francesco T. Mangano James L. Leach Leonid Rozhkov Hansel M. Greiner 《Clinical neurophysiology》2018,129(9):1842-1848
Objective
We evaluated the impact of radiotracer injection latency and post-injection seizure duration on subtraction ictal SPECT co-registered to MRI (SISCOM) test performance in identifying the epileptogenic zone (EZ) in children with drug-resistant epilepsy who had undergone a resective epilepsy surgery.Methods
SISCOM concordance with the EZ was retrospectively reviewed to evaluate its performance in 113 children. The impact of radiotracer injection latency and post-injection seizure duration was evaluated for their predictive value of SISCOM localization accuracy.Results
The overall sensitivity and specificity of SISCOM in identifying an EZ was 64.8% (95%CI?=?50.6–77.3) and 40.7% (95%CI?=?28.1–54.3). The positive likelihood ratio and diagnostic odd ratio was 1.09 (95%CI?=?0.80–1.48) and 1.26 (95%CI?=?0.59–2.71), respectively. Logistic regression showed that injection latency and post-injection seizure duration did not significantly predict the probability of true positive SISCOM (p-value?=?0.45 and 0.29, respectively).Conclusion
Radiotracer injection latency and post-injection seizure duration were not shown to have a statistical significant impact on SISCOM performance in identifying the EZ.Significance
This study demonstrates that further study of factors contributing to the performance of SISCOM in EZ identification in children is needed. 相似文献17.
Shuichiro Neshige Masao Matsuhashi Katsuya Kobayashi Takeyo Sakurai Akihiro Shimotake Takefumi Hitomi Takayuki Kikuchi Kazumichi Yoshida Takeharu Kunieda Riki Matsumoto Ryosuke Takahashi Susumu Miyamoto Hirofumi Maruyama Masayasu Matsumoto Akio Ikeda 《Clinical neurophysiology》2018,129(9):2038-2048
Objective
To assess the feasibility of multi-component electrocorticography (ECoG)-based mapping using “wide-spectrum, intrinsic-brain activities” for identifying the primary sensori-motor area (S1-M1).Methods
We evaluated 14 epilepsy patients with 1514 subdural electrodes implantation covering the perirolandic cortices at Kyoto University Hospital between 2011 and 2016. We performed multi-component, ECoG-based mapping (band-pass filter, 0.016–300/600?Hz) involving combined analyses of the single components: movement-related cortical potential (<0.5–1?Hz), event-related synchronization (76–200?Hz), and event-related de-synchronization (8–24?Hz) to identify the S1-M1. The feasibility of multi-component mapping was assessed through comparisons with single-component mapping and electrical cortical stimulation (ECS).Results
Among 54 functional areas evaluation, ECoG-based maps showed significantly higher rate of localization concordances with ECS maps when the three single-component maps were consistent than when those were inconsistent with each other (p?<?0.001 in motor, and p?=?0.02 in sensory mappings). Multi-component mapping revealed high sensitivity (89–90%) and specificity (94–97%) as compared with ECS.Conclusions
Wide-spectrum, multi-component ECoG-based mapping is feasible, having high sensitivity/specificity relative to ECS.Significance
This safe (non-stimulus) mapping strategy, alternative to ECS, would allow clinicians to rule in/out the possibility of brain function prior to resection surgery. 相似文献18.
Timothy J. Gawne Jeffrey F. Killen John M. Tracy Adrienne C. Lahti 《Clinical neurophysiology》2017,128(3):397-407
Objective
We used a combination of simulation and recordings from human subjects to characterize how saccadic eye movements affect the magnetoencephalogram (MEG).Methods
We used simulated saccadic eye movements to generate simulated MEG signals. We also recorded the MEG signals from three healthy adults to 5° magnitude saccades that were vertical up and down, and horizontal left and right.Results
The signal elicited by the rotating eye dipoles is highly dependent on saccade direction, can cover a large area, can sometimes have a non-intuitive trajectory, but does not significantly extend above approximately 30 Hz in the frequency domain. In contrast, the saccadic spikes (which are primarily monophasic pulses, but can be biphasic) are highly localized to the lateral frontal regions for all saccade directions, and in the frequency domain extend up past 60 Hz.Conclusions
Gamma band saccadic artifact is spatially localized to small regions regardless of saccade direction, but beta band and lower frequency saccadic artifact have broader spatial extents that vary strongly as a function of saccade direction.Significance
We have here characterized the MEG saccadic artifact in both the spatial and the frequency domains for saccades of different directions. This could be important in ruling in or ruling out artifact in MEG recordings. 相似文献19.
Yuto Suzuki Rei Enatsu Aya Kanno Satoko Ochi Nobuhiro Mikuni 《Clinical neurophysiology》2018,129(10):2132-2136
Objective
This study investigated the function and networks of the auditory cortices in the posterior lateral superior temporal area (PLST) using a combination of electrical cortical stimulation and diffusion tensor imaging (DTI).Methods
Seven patients with intractable focal epilepsy in which the PLST auditory cortices were identified during the electrical cortical stimulation were enrolled in this study (left side: four patients, right side: three patients). Electrical stimulation at 50?Hz was applied to the chronically implanted subdural electrodes to identify the PLST auditory cortices. DTI was used to identify the subcortical fibers originating from the PLST auditory cortices found by electrical stimulation.Results
Electrical stimulation of the right PLST auditory cortices induced hearing impairment in three patients and left side stimulation elicited hearing illusory sounds in four patients. DTI detected the middle longitudinal fasciculus (MLF) in all patients, the superior longitudinal fasciculus (SLF) in six patients and the inferior fronto-occipital fasciculus (IFOF) in three patients, originating from the PLST auditory cortices.Conclusion
This study suggests different functional roles between the right and left PLST auditory cortices, and the networks originating from these areas.Significance
MLF, SLF and IFOF might be associated with the auditory processing. 相似文献20.
Shennan Aibel Weiss Brent Berry Inna Chervoneva Zachary Waldman Jonathan Guba Mark Bower Michal Kucewicz Benjamin Brinkmann Vaclav Kremen Fatemeh Khadjevand Yogatheesan Varatharajah Hari Guragain Ashwini Sharan Chengyuan Wu Richard Staba Jerome Engel Michael Sperling Gregory Worrell 《Clinical neurophysiology》2018,129(10):2089-2098