绿芦苇,丹顶鹤

正一芦苇的爱情,都已献给了湿地。芦苇穗子乳白,毛茸茸的,柔情似水,是写给湿地的情诗。一片片的芦苇,就是一片片情诗的世界。这种爱情浩大,洁白,不计代价,不可阻挡。湿地最终接纳了这种真诚的追逐。芦苇荡,原本没有不可告人的秘密。这位母亲,她是在自己的地域招摇呐喊,其实,是为了从容地深居。在翠绿葱郁里,在野阔星稀中,芦苇营造飞禽爱的蜗居。白云绿水蓝天,是给飞禽儿子的房产。她和儿子就住在一起,从     

不经意中相逢

很多很多年前的那个下午。古朴的江南小镇,他们萍水相逢。那时她一个人,第一次来到这个陌生的小镇旅行。不料,在途中钱包丢失。一个女孩子,身处异乡,连往远方的家中打个求援电话的钱都没有。那种窘境,是不言而喻的。她已经顾不上少女的矜持了,向路人求救。可是,路人无不躲闪而过。茫茫人海,有谁会相信一个素不相识的路人?这时候,他出现了。她清楚地记得,那天他穿着一身     

相濡以沫

她嫁他,是奉父母之命,媒妁之言。也不是没有心爱之人,5年的相知相惜,之间却横亘着千山万壑。是门不当户不对的,父母死活不同意。她爱的那人家里,也是千阻万挡的。于是分了手,灰了心。不再做梦。父母让她嫁他,她点头。那年,她已年过三十。青春的心,早已成为一只昨日枝头的小鸟,啁啾在往昔里。往昔是什么?     

牌九人生

天牌满身的疮痍,绚丽的色彩。叱咤风云,无上崇高,权倾江山,令人威慑。可最后的命运总不尽人意。也许风雨太急,太狂大,方消耗了它的光环。无声无息地埋于弱小者的脚下,有些许叹息,又很荣耀。这便是一国之君的自苦自怜,无论夹杂多少埋怨与痛责,只能委曲求全,只有自我埋葬。地牌很     

轮回

惶然地,将日历上的纸翻到了最后一页。漫长的等待,终又等到生命的下一个轮回。千年的轮回,辛苦劳作,收获了,也失去了。下一次生命的开始,不知又要面对怎样的酸甜苦辣,喜怒哀乐。生命。从一个开始,到一个结束。一点一点地,在时间的流逝中体味着生命本身。生之快乐,生之痛苦,生之     

半生缘

正说不清,这是怎样的缘,让我遇见你。在这萧萧秋日,原本一泓湖水一样的心地,又沸腾起喧闹的情感,尽管外表依然端肃沉静。昏昏的天空,雾气四下蒸腾,空旷的马路,我与你并行。记不住说了什么,更多的是沉默,沉默是最好的语言。没有什么情意的表白,那美丽的明眸,胜过万语千言。人到中年,自认为是波澜无     

绿丝巾飘呀飘

正去另一个城市办事。空气里处处飘荡着生动的气息,一缕一缕,仿若春天萌动的绿,心也被浸濡得润酥酥的。犹豫了一整天,到底想不出要不要拨通那个号码。晚饭后,出去散步。不知不觉,来到那条鹅卵石铺就的小路。路很长,很窄。两个人在上面走,会有点儿拥挤。如果是恋人,恰恰好。路两旁栽满树木,远远看着,一棵挨一棵,密密匝匝。走近了才知,树上的叶子已开始凋落,地上疏疏落落的,墨青,浅黄,红棕,铺     

学着平衡

有一次,儿子摔倒了,磕破了嘴唇,顿时血肉模糊,他大哭。我立刻跑过去,手忙脚乱,不知道从哪下手,只是紧紧地抱着他。但儿子挣扎着,喊着"姥爷,姥爷"。那一刻,心中有些失落。在孩子的心目中,姥爷是最能保护他的人,所以,在他陷入"危难"的时刻,他只要姥爷。有时工作比较忙碌,心情不是很好,面对孩子,会把自己的不良情绪发泄到他的身上。过后又非常自责。孩子,正是顽皮的时候,作为妈妈,我不但没有包容他,还要     

莫让男孩变女孩

男女本属世间矛盾二物。一属阳,一属阴。刚柔并进,相互平衡。男女各有各的风貌,各有各的秉性。为男,应刚毅坚强,为女,则是温柔妩媚有加。 来来往往便熟识了同事的儿子——帆帆。察看其嬉笑怒骂,言行举止,帆帆根本不是那回事儿。十三四岁的男孩,说话娘娘腔,嗲声嗲气,走路扭着臀部,一步三摇。高兴时,喜欢勾着小手指,时不时还喜欢抱着妈妈,甚至来几下亲吻的动作。可     

平淡

荡气回肠的乐章,始于无闻,终于无闻;激湍飞泻的瀑布,始于宁静,终于宁静;声势显赫的权势,始于落寞,终于落寞。形形色色的人生,始于平淡,终于平淡。平淡,才是人生的真正况味。 生命的过程,本来就很平淡,如一片落叶。那挂在梢头的树叶,当初不过是一星鹅黄,继而碧绿,甚或泛红,最后不知不觉地暗淡成褐色,化为泥土。这是自然规律,也是尘世间所有生物的轨迹。     

Development in in vitro toxicology

There are three principal pressures driving the development of in vitro toxicology: (1) the need for more efficient testing systems to cope with the large number of xenobiotics currently being developed; (2) public pressure to reduce animal experimentation; and (3) a need for a better understanding of the mechanisms of toxicity. Within this, in vitro toxicology is focused on local, systemic, and target-organ toxicity. It is becoming increasingly apparent that a step or decision-tree approach using input of a variety of experimental data (physicochemical properties, biokinetics, cytotoxicity) provides the most efficient system for predicting toxicity. Examples of the use of in vitro toxicity systems for prediction of systemic toxicity and target-organ (liver) toxicity are presented.Originally presented at ECCP 93.     

Age-related changes in polyamines in memory-associated brain structures in rats

Polyamines putrescine, spermidine and spermine are positively charged aliphatic amines and have important roles in maintaining normal cellular function, regulating neurotransmitter receptors and modulating learning and memory. Recent evidence suggests a role of putrescine in hippocampal neurogenesis, that is significantly impaired during aging. The present study measured the polyamine levels in memory-related brain structures in 24- (aged), 12- (middle-aged) and 4- (young) month-old rats using liquid chromatography/mass spectrometry and high performance liquid chromatography. In the hippocampus, the putrescine levels were significantly decreased in the CA1 and dentate gyrus, and increased in the CA2/3 with age. Significant age-related increases in the spermidine levels were found in the CA1 and CA2/3. There was no difference between groups in spermine in any sub-regions examined. In the parahippocampal region, increased putrescine level with age was observed in the entorhinal cortex, and age did not alter the spermidine levels. The spermine level was significantly decreased in the perirhinal cortex and increased in the postrhinal cortex with age. In the prefrontal cortex, there was age-related decrease in putrescine, and the spermidine and spermine levels were significantly increased with age. This study, for the first time, demonstrates age-related region-specific changes in polyamines in memory-associated structures, suggesting that polyamine system dysfunction may potentially contribute to aged-related impairments in hippocampal neurogenesis and learning and memory.     

休克过程中肾上腺髓质素变化的研究进展

Adrenomedullin (AM) is a new peptidergic regulator of vascular function. AM serves as a hormone, which has many biological properties, plays an important role in the many pathophysiological processes, especially shock. This review will highlight the structure, biological properties of AM and the relationship between AM and shock.     

Seasonal variations in acute toxoplasmosis in pregnant women in Slovenia

Between December 1999 and December 2004, 40 081 pregnant women were examined for toxoplasmosis with Toxo-IgG, Toxo-IgM enzyme immunoassay. Women with positive results were then retested with the Toxo-IgG avidity assay for recent toxoplasmosis. Recent acute toxoplasmosis in pregnant women was found to be significantly more frequent (p < 0.01) during winter than summer. The incidence of acute toxoplasmosis during winter-spring was also significantly more frequent (p < 0.025) than summer-autumn. This phenomenon should be taken into account when formulating preventive measures for toxoplasmosis, especially for pregnant women.     

Secular change in menarche in women in Madrid

The age at menarche was estimated by recollection in 1617 women between the ages of 18 and 60 in Madrid and a nearby suburb, Pinto. The population of Pinto is working-class and the Madrid group, taken from residential neighbourhoods , belongs to the upper middle class. In both groups we found a diminution in average age at menarche, from 14.04 to 13.02 years in Madrid and from 14.55 to 13.16 years from about 1935 to about 1965 in Pinto. These changes have been more intense in the group which is less well-off economically, where living conditions have varied much more drastically.     

Uteroglobin in the developing rabbit conceptus in vivo and in vitro

Summary Uteroglobin (UGL) was measured in day- 4 to day-10 rabbit conceptuses by a competitive ELISA. Levels in blastocyst fluid, tissues, coverings and in the early fetus were determined separately. The total amount of UGL increased from 18.4 ng to 6.8 g per conceptus. The UGL content of individual day-6 blastocysts was studied in vitro. Culturing was carried out up to 60 h in Ham's F10 medium with polyvinylpyrrolidone as macromolecular component, with and without progesterone, and with progesterone plus estradiol. UGL was determined in the blastocyst fluids, tissues with coverings and in the culture media. After labelling with [³⁵S]-methionine, protein patterns of total blastocysts and of culture media were analysed by two-dimensional gel electrophoresis and fluorography. The morphology of cultured blastocysts was examined by electron microscopy. During 60 h of culture, the blastocysts expanded in diameter by 84%, and released 19% of their initial UGL content into the medium, independent of the hormonal substitution. Neither de novo synthesis, nor degradation of UGL was found: the protein remained unlabelled in fluorography, and its total quantity was not significantly different from that of non-cultured controls. Trophoblast, endoderm and embryoblast cells showed well preserved cell organelles and intercellular junctions, while the morphological differentiation of the germ layer was inhibited.