Muscular co-contraction is related to varus thrust in patients with knee osteoarthritis

BackgroundPatients with knee osteoarthritis often present with varus thrust and muscular co-contraction during gait. It is unclear if these adaptations are related. The objective was to examine the relationship between muscle co-contraction and varus thrust during gait in patients with knee osteoarthritis and to determine if these relationships are modulated by disease severity or history of knee ligament rupture.MethodsParticipants (n = 42, 23 women, mean age 58 years) with knee osteoarthritis completed gait trials at self-selected speeds. Varus thrust was measured with an eight camera motion capture system sampled at 100 Hz. Co-contraction ratios were measured with surface electromyography sampled at 2000 Hz over the quadriceps, hamstrings, and gastrocnemius. Disease severity was measured on radiographs and history of anterior cruciate ligament rupture was confirmed on magnetic resonance imaging. Linear regression analyses examined the relationship between varus thrust and co-contraction ratios after controlling for radiographic disease severity and history of anterior cruciate ligament rupture.FindingsHigher vastus lateralis–lateral hamstring (b = 0.081, P < 0.001; R² = 0.353) and vastus medialis–medial hamstring (b = 0.063, P = 0.028; R² = 0.168) co-contraction ratios were associated with greater varus thrust. Quadriceps-gastrocnemius co-contractions ratios were not related to varus thrust (P > 0.05). Radiographic disease severity or history of anterior cruciate ligament injury did not significantly contribute to regression models.InterpretationGreater quadriceps-hamstring co-contraction is associated with greater varus thrust in patients with knee osteoarthritis. Potential explanations include increased co-contraction may provide stability or there is a proprioceptive reflex that is independent of any stabilizing role. Research is needed to test these hypotheses.     

Alterations in patellofemoral kinematics following vastus medialis transection in the anterior cruciate ligament deficient rabbit knee

Background

Anterior cruciate ligament deficiency and quadriceps muscle weakness are considered to be important risk factors for aberrant patellar tracking and subsequent patellofemoral osteoarthritis. However, data from in vivo experiments looking at dynamic patellar joint kinematics and muscle force are scarce. Therefore, the purpose of this study was to evaluate the effects of anterior cruciate ligament transection and loss of vastus medialis force on patellar tracking in the rabbit knee in vivo.

Methods

Eight skeletally mature New Zealand White Rabbits, weighing 6.0 kg (0.6 kg standard deviation) were used. The experimental trials consisted of active, concentric and eccentric movements of the knee joint. Measurements were performed with the intact, the anterior cruciate ligament deficient, and the vastus medialis transected knee. Patellofemoral kinematics (shift, rotation) were quantified from high speed video.

Findings

Following anterior cruciate ligament transection, patellar tracking occurred more laterally, and caused a significant lateral rotation of the patella. The addition of vastus medialis transection did not alter patellar tracking or rotation significantly for any of the force-matched experimental conditions.

Interpretation

The loss of the anterior cruciate ligament results in lateral patellar shift and rotation while the loss of vastus medialis muscle force does not affect patellar tracking or rotation in the anterior cruciate ligament deficient knee. We suggest that the current results should be considered carefully in future interpretations of knee extensor imbalance. More research is needed to describe the contribution of vastus medialis muscle strength to medial patellofemoral stability and confirm these results in the human knee.     

Decreased quadriceps force steadiness following anterior cruciate ligament reconstruction is associated with altered running kinematics

BackgroundAnterior cruciate ligament reconstruction is associated with quadriceps dysfunction and altered knee mechanics, but the relationship between these outcomes is not clear. Inclusion of metrics such as the stability of torque output could provide additional insights into the relationship between quadriceps dysfunction and knee mechanics. The purposes of this study were to: (1) measure the difference in quadriceps force steadiness between anterior cruciate ligament reconstructed and contralateral limbs; and (2) assess the relationship of quadriceps force steadiness and peak torque with knee flexion excursion during running.MethodsTwenty-eight participants (14 female, age 20 (5) years) underwent quadriceps strength testing and gait analysis. Force steadiness was measured with the standard deviation and coefficient of variation of the participants' detrended torque. Knee flexion excursion was calculated during the stance phase of running trials. Differences between limbs for force steadiness and peak torque were assessed with paired sample t-tests, and a Pearson's product-moment correlation coefficient determined the relationship between pairs of variables.FindingsAnterior cruciate ligament reconstructed limbs presented with a significant deficit in relative force steadiness compared to the contralateral limb (4.03 (1.04) % and 3.58 (1.41) % (P < .05), respectively). In addition, the relationship of quadriceps strength and force steadiness with knee flexion excursion was altered in anterior cruciate ligament reconstructed limbs due to the inability of the quadriceps to sustain a controlled force output.InterpretationThese results suggest that considering both the magnitude and quality of force production can provide important insight into comprehensive quadriceps function.     

Effect of suspension training on neuromuscular function,postural control,and knee kinematics in anterior cruciate ligament reconstruction patients

BACKGROUNDSuspension training (SET) is a method of neuromuscular training that enables the body to carry out active training under unstable support through a suspension therapy system. However, there have been few reports in the literature on the application of SET to anterior cruciate ligament reconstruction (ACLR) patients. It is not clear what aspects of the patient''s function are improved after SET.AIMTo investigate the effect of SET on the neuromuscular function, postural control, and knee kinematics of patients after ACLR surgery. METHODSForty participants were randomized to an SET group or a control group. The SET group subjects participated in a SET protocol over 6 wk. The control group subjects participated in a traditional training protocol over 6 wk. Isokinetic muscle strength of the quadriceps and hamstrings, static and dynamic posture stability test, and relative translation of the injured knee were assessed before and after training. RESULTSThe relative peak torque of the quadriceps and hamstrings in both groups increased significantly (P < 0.001), and the SET group increased by a higher percentage than those in the control group (quadriceps: P = 0.004; hamstrings: P = 0.011). After training, both groups showed significant improvements in static and dynamic posture stability (P < 0.01), and the SET group had a greater change than the control group (P < 0.05). No significant improvement on the relative translation of the injured knee was observed after training in either group (P > 0.05). CONCLUSIONOur findings show that SET promotes great responses in quadriceps and hamstring muscle strength and balance function in ACLR patients.     

Intra-articular anesthesia and knee muscle response

BACKGROUND: Many receptors located within the intra-articular knee structures contribute to the neuromuscular responses of the knee. The purpose was to compare the automatic postural response induced by a perturbation at the foot before and after an intra-articular injection of a local anesthetic (bupivicaine), after a saline (sham) injection, and after no intra-articular injection (control) in the knee. METHODS: Muscle onset latencies and automatic response magnitudes for the vastus medialis, vastus lateralis, biceps femoris, medial hamstrings, tibialis anterior, and gastrocnemius were measured using electromyography (EMG) when anteriorly directed perturbations were applied to the feet of 30 subjects. All subjects then received a lidocaine skin injection followed by: an intra-articular bupivicaine injection (treatment group); an intra-articular saline injection (sham group); or no injection (control group), depending on their randomized group assignment. The perturbation tests were then repeated. FINDINGS: Muscle onset latencies and automatic response magnitudes did not change as a result of the intra-articular injections. Latencies were significantly greater for the vastus medialis and vastus lateralis when compared to the medial hamstrings, biceps femoris and tibialis anterior (P<0.001). Automatic response magnitudes for the tibialis anterior were significantly greater than those of the hamstrings, which were greater than those of the quadriceps (P<0.001). INTERPRETATION: There were no differences in muscle response when anteriorly directed perturbations were applied to the foot with or without an injection of local anesthetic in the knee. Intra-articular receptors were either unaffected by the anesthetic or the extra-articular receptors or receptors of the other joints were able to compensate for their loss.     

Changes in knee motion pattern after anterior cruciate ligament injury - case report

BACKGROUND: After an anterior cruciate ligament injury, the contra-lateral non-injured leg has been found to adapt towards the injured leg. Accordingly, in order to study changes in knee motion pattern after an anterior cruciate ligament injury, the ideal is to compare the same leg prior to and after the injury. However, this is very seldom possible. The purpose of the present study was to describe changes in static and dynamic sagittal tibial translation, electromyographic activity and muscle torque relevant to an anterior cruciate ligament tear in one patient evaluated both before and after the injury. METHODS: A male soccer player was examined 11 weeks before and eight weeks after an anterior cruciate ligament injury. Sagittal tibial translation was measured with the CA-4000 electrogoniometer; statically during Lachman's test, and dynamically during isokinetic muscle testing, one-legged squat and level walking. The electromyographic activity of mm. quadriceps and hamstrings, was registered simultaneously during the one-legged squat test. FINDINGS: Static tibial translation was increased by approximately 2 mm, while dynamic tibial translation was decreased by 0.4 mm at isokinetic testing, 0.9 mm at one-legged squat and 2.4 mm during level walking compared to before the injury. Muscle torque decreased 30% and 35% for the quadriceps and the hamstrings muscle, respectively. The electromyographic activity revealed similar activation levels in quadriceps and a doubled level of activation in hamstring compared to before the injury. INTERPRETATION: In spite of an increase in static tibial translation eight weeks after an anterior cruciate ligament injury, the tibial translation decreased during activity, thus indicating that the patient could stiffen the knee in order to protect it against increased shear forces.     

Local neuromuscular characteristics associated with patellofemoral pain: A systematic review and meta-analysis

BackgroundLocal neuromuscular deficits have been reported in people with patellofemoral pain. We synthesised the neuromuscular characteristics associated with patellofemoral pain to help identify interventional targets and potential mechanisms.MethodsFive databases were searched for local neuromuscular characteristics in case-control studies. Electromyography, flexibility, muscle performance and cross-sectional area data were derived from functional or isolated task investigations and synthesised accordingly. An evidence gap map was constructed.FindingsSixty-seven studies were included. In functional tasks, electromyographic investigations showed moderate evidence of small effect for vastus medialis onset-delays relative to vastus lateralis (0.44 [0.03, 0.85]) during stepping/stair negotiation tasks, and higher biceps femoris mean excitation amplitudes (0.55 [0.06, 1.04]) in single-leg triple-hop test. In isolated tasks, we found moderate evidence of medium effect for lower Hoffman-reflex amplitude of vastus medialis (−1.12 [−1.56, −0.67]). Muscle performance investigations showed; strong evidence with medium and small effects for lower extensors concentric (−0.61 [−0.81, −0.40]) and eccentric (−0.56 [−0.79, −0.33]) strength, and moderate evidence of medium effect of lower isometric (−0.64 [−0.87, −0.41]) strength, moderate evidence with small effect for rate of force development to 30% (−0.55[−0.89, −0.21]), 60% (−0.57[−0.90, −0.25]) and medium effect to 90% (−0.76[−1.43, −0.10]) of maximum voluntary contraction, and small effect for lower flexors concentric strength (−0.46 [−0.74, −0.19]) and extensors total work (−0.48 [−0.90, −0.07]). Flexibility investigations showed tighter hamstrings (−0.57 [−0.99, −0.14]).InterpretationDifferences within quadriceps and hamstrings motor-control, hamstrings tightness, and quadriceps and hamstrings weakness are associated with patellofemoral pain, and can be used to guide investigations of treatment effects.     

Comparison of muscle activation levels and knee valgus between individuals with medial patellofemoral ligament reconstruction and healthy individuals during fatiguing step down task

BackgroundMedial patellofemoral ligament reconstruction becomes first-choice surgical procedure for patients with a history of lateral patellar dislocations but there is limited knowledge about neuromuscular activation patterns of individuals with a history of patellar dislocation who underwent medial patellofemoral ligament reconstruction.ObjectiveThe aim of this study was to compare muscle activation levels and knee valgus during step down performance test between individuals with a history of medial patellofemoral ligament reconstruction and healthy individuals.MethodsFifteen individuals with medial patellofemoral ligament reconstruction and 15 healthy individuals were included. Vastus medialis obliquus, vastus lateralis and gluteus medius muscle activation levels and knee valgus were measured during 60-s- step down performance test. Two-way repeated-measures of analysis of covariance was used for statistical analysis.FindingsCompared to the healthy individuals, individuals with medial patellofemoral ligament reconstruction showed lower vastus medialis obliquus (p = .04) and gluteus medius (p = .005) activation levels, and higher knee valgus (p = .002) in last period of the step down performance test.InterpretationSince the significant results were only observed in the fatiguing section of the test, endurance tests may provide more information about neuromuscular control of the individuals with history of medial patellofemoral ligament reconstruction. Future studies should investigate whether endurance exercises that target to improve vastus medialis obliquus and gluteus medius activity result in better clinical outcomes than conventional programs for individuals with medial patellofemoral ligament reconstruction.     

Adjustable-length loop cortical button versus interference screw fixation in quadriceps tendon anterior cruciate ligament reconstruction – A biomechanical in vitro study

BackgroundThis biomechanical cadaveric in vitro study aimed to evaluate and compare the dynamic elongation behavior and ultimate failure strength of tibial adjustable-length loop cortical button versus interference screw fixation in quadriceps tendon-based anterior cruciate ligament reconstruction.MethodsSixteen human quadriceps tendons were harvested and fixed into porcine tibiae using either biodegradable interference screw (n = 8) or adjustable loop device (n = 8) fixation. An acrylic block was utilized for femoral adjustable loop device fixation for both groups. All constructs were precycled for 10 times at 0.5 Hz and manually retensioned before tested in position and force control mode each for 1000 cycles at 0.75 Hz according to in vitro loading conditions replicating the in vivo ACL environment. Subsequently, an ultimate failure test at 50 mm/min was performed with mode of failure noted.FindingsTibial IS fixation showed no statistically significant differences in the initial (−0.46 vs. −0.47 mm; P = 0.9780), dynamic (2.18 mm vs. 2.89 mm; P = 0,0661), and total elongation (1.72 mm vs. 2.42 mm; P = 0,0997) compared to adjustable loop device fixation. The tibial button fixation revealed an increased ultimate failure load (743.3 N vs. 606.3 N; P = 0.0027), while stiffness was decreased in comparison to screw fixation (133.2 N/mm vs. 153.5 N/mm; P = 0,0045).InterpretationAnterior cruciate ligament reconstruction for quadriceps tendon graft using a tibial adjustable-length loop cortical button provides for comparable dynamic stabilization of the knee with increased ultimate failure load at decreased stiffness compared to screw fixation.     

Knee joint mechanics under quadriceps--hamstrings muscle forces are influenced by tibial restraint

BACKGROUND: To investigate the role of quadriceps and hamstrings muscle recruitments on knee joint mechanics, measurement studies constrain the tibial anterior-posterior translation at a point away from the joint. This generates a restraining force perpendicular to the tibia thus introducing an artefact shear force that likely alters joint mechanics and forces in cruciate ligaments. METHODS: A 3D nonlinear finite element model of the entire knee joint, including tibiofemoral and patellofemoral joints, was used to investigate joint mechanics in flexion (0 degrees -90 degrees ) under isolated and combined hamstrings and quadriceps activation. The effect of tibial restraint at two locations on results was studied and compared with the reference boundary condition of tibia constrained by pure moments. FINDINGS: Tibial restraint by a force rather than a pure moment substantially influences the joint response. For identical forces, hamstrings have much greater moment generating capacity at larger flexion angles while quadriceps are more effective at smaller angles. INTERPRETATION: Tibial constraint by a restraining force rather than a pure moment causes an artefact force on the joint that vary with muscle forces and restraining location. These artefact shear forces, especially when placed closer to the joint, considerably reduce forces in cruciate ligaments; in anterior cruciate ligament at near full extension and in posterior cruciate ligament at larger flexion angles. The beneficial effects of muscle co-contraction in reducing anterior cruciate ligament forces at near full extension and in posterior cruciate ligament forces at near 90 degrees , however, disappear as the restraint on the tibia approaches the joint. The artefact forces could distort results and their interpretations.     

Isokinetic evaluation of quadriceps and hamstrings symmetry following anterior cruciate ligament reconstruction

After anterior cruciate ligament (ACL) reconstruction, isokinetic muscle parameters are commonly measured to assess the dynamic status of the knee and to monitor progress in rehabilitation. This study evaluated the symmetry of the quadriceps and hamstrings musculature in postsurgical and contralateral normal limbs of subjects who had undergone one of two types of ACL reconstruction. Subjects were also evaluated for differences on selected isokinetic parameters between types of surgery and lengths of postoperative periods. Postsurgical and normal contralateral limbs of 46 subjects aged 18 to 49 years (mean, 23.7 years) were divided into groups according to type of autogenous intraarticular ACL substitute and length of postoperative period. Results of paired t-tests and analyses of variance indicated significant asymmetries between limbs for all measures of quadriceps and hamstrings musculature strength and endurance (p less than .001) irrespective of the type of reconstruction technique. Average surgical knee deficits in hamstrings endurance were significantly less for the long-term (41 to 101 months) follow-up group (1.9%) than for the intermediate (24 to 40 months) group (12.1%). The results suggest that extended periods of time are required to approximate hamstrings endurance symmetry after ACL reconstruction. Asymmetries between postsurgical and contralateral normal limbs in these subjects may reflect either incomplete rehabilitation or an inability to regain full isokinetic strength and endurance after ACL reconstruction.     

Co-activation during gait following anterior cruciate ligament reconstruction

BackgroundHeightened co-activation of the quadriceps and hamstrings has been reported following anterior cruciate ligament reconstruction during various tasks, and may contribute to post-traumatic osteoarthritis risk. However, it is unclear if this phenomenon occurs during walking or how co-activation influences gait biomechanics linked to changes in joint health.MethodsCo-activation and gait biomechanics were assessed in 50 individuals with ACLR and 25 healthy controls. Biomechanical outcomes included knee flexion displacement, peak vertical ground reaction force magnitude and rate, peak internal knee extension and valgus moments and rates, sagittal knee stiffness, and the heelstrike transient. Co-activation was calculated for the flexors and extensors collectively (i.e. composite), the medial musculature, and the lateral musculature.FindingsComposite co-activation was greater in the ACLR limb compared to the contralateral limb and the control cohort during the preparatory and heelstrike phases of gait, and co-activation of the medial musculature was greater in the ACLR limb compared to the control cohort during the heelstrike phase. Greater co-activation in multiple gait phases was associated with less knee flexion displacement (r = −0.293 to −0.377), smaller peak vertical ground reaction force magnitude (r = −0.291), smaller peak internal knee extension moment (r = −0.291 to −0.328), and greater peak internal knee valgus moment (r = 0.317).InterpretationIndividuals with ACLR displayed heightened co-activation during walking which was associated with biomechanical outcomes that have been linked to negative changes in joint health following ACLR. These data suggest that excessive co-activation may contribute to the mechanical pathogenesis of post-traumatic osteoarthritis.ClinicalTrials.gov Identifier: NCT02605876.     

Effects of neuromuscular training on knee joint stability after anterior cruciate ligament reconstruction

[Purpose] This study examined the effects of neuromuscular training on knee joint stability after anterior cruciate ligament reconstruction. [Subjects and Methods] The subjects were 16 adults who underwent arthroscopic anterior cruciate reconstruction and neuromuscular training. The Lysholm scale was used to assess functional disorders on the affected knee joint. A KT-2000 arthrometer was used to measure anterior displacement of the tibia against the femur. Surface electromyography was used to detect the muscle activation of the vastus medialis oblique, vastus lateralis, biceps femoris, and semitendinosus before and after neuromuscular training. [Results] There was significant relaxation in tibial anterior displacement of the affected and sound sides in the supine position before neuromuscular training. Furthermore, the difference in the tibial anterior displacement of the affected knee joints in the standing position was reduced after neuromuscular training. Moreover, the variation of the muscle activation evoked higher muscle activation of the vastus medialis oblique, vastus lateralis, biceps femoris, and semitendinosus. [Conclusion] Neuromuscular training may improve functional joint stability in patients with orthopedic musculoskeletal injuries in the postoperative period.Key words: Arthrometer, Anterior cruciate ligament reconstruction, Neuromuscular training     

Reduced step length reduces knee joint contact forces during running following anterior cruciate ligament reconstruction but does not alter inter-limb asymmetry

BackgroundAnterior cruciate ligament reconstruction is associated with early onset knee osteoarthritis. Running is a typical activity following this surgery, but elevated knee joint contact forces are thought to contribute to osteoarthritis degenerative processes. It is therefore clinically relevant to identify interventions to reduce contact forces during running among individuals after anterior cruciate ligament reconstruction. The primary purpose of this study was to evaluate the effect of reducing step length during running on patellofemoral and tibiofemoral joint contact forces among people with a history of anterior cruciate ligament reconstruction. Inter limb knee joint contact force differences during running were also examined.Methods18 individuals at an average of 54.8 months after unilateral anterior cruciate ligament reconstruction ran in 3 step length conditions (preferred, − 5%, − 10%). Bilateral patellofemoral, tibiofemoral, and medial tibiofemoral compartment peak force, loading rate, impulse, and impulse per kilometer were evaluated between step length conditions and limbs using separate 2 factor analyses of variance.FindingsReducing step length 5% decreased patellofemoral, tibiofemoral, and medial tibiofemoral compartment peak force, impulse, and impulse per kilometer bilaterally. A 10% step length reduction further decreased peak forces and force impulses, but did not further reduce force impulses per kilometer. Tibiofemoral joint impulse, impulse per kilometer, and patellofemoral joint loading rate were lower in the previously injured limb compared to the contralateral limb.InterpretationRunning with a shorter step length is a feasible clinical intervention to reduce knee joint contact forces during running among people with a history of anterior cruciate ligament reconstruction.     

Peak knee biomechanics and limb symmetry following unilateral anterior cruciate ligament reconstruction: Associations of walking gait and jump-landing outcomes

BackgroundAberrant walking-gait and jump-landing biomechanics may influence the development of post-traumatic osteoarthritis and increase the risk of a second anterior cruciate ligament injury, respectively. It remains unknown if individuals who demonstrate altered walking-gait biomechanics demonstrate similar altered biomechanics during jump-landing. Our aim was to determine associations in peak knee biomechanics and limb-symmetry indices between walking-gait and jump-landing tasks in individuals with a unilateral anterior cruciate ligament reconstruction.MethodsThirty-five individuals (74% women, 22.1 [3.4] years old, 25 [3.89] kg/m²) with an anterior cruciate ligament reconstruction performed 5-trials of self-selected walking-gait and jump-landing. Peak kinetics and kinematics were extracted from the first 50% of stance phase during walking-gait and first 100 ms following ground contact for jump-landing. Pearson product-moment (r) and Spearman's Rho (ρ) analyses were used to evaluate relationships between outcome measures. Significance was set a priori (P ≤ 0.05).FindingsAll associations between walking-gait and jump-landing for the involved limb, along with the majority of associations for limb-symmetry indices and the uninvolved limb, were negligible and non-statistically significant. There were weak significant associations for instantaneous loading rate (ρ = 0.39, P = 0.02) and peak knee abduction angle (ρ = 0.36, p = 0.03) uninvolved limb, as well as peak abduction displacement limb-symmetry indices (ρ= − 0.39, p = 0.02) between walking-gait and jump-landing.InterpretationNo systematic associations were found between walking-gait and jump-landing biomechanics for either limb or limb-symmetry indices in people with unilateral anterior cruciate ligament reconstruction. Individuals with an anterior cruciate ligament reconstruction who demonstrate high-involved limb loading or asymmetries during jump-landing may not demonstrate similar biomechanics during walking-gait.     

Association Between Knee Joint Muscle Activation and Knee Joint Moment Patterns During Walking in Moderate Medial Compartment Knee Osteoarthritis: Implications for Secondary Prevention

ObjectiveTo determine associations between knee moment features linked to osteoarthritis (OA) progression, gait muscle activation patterns, and strength.DesignCross-sectional secondary analysis.SettingGait laboratory.ParticipantsConvenience sample of 54 patients with moderate, medial knee OA (N=54).InterventionsNone.Main Outcome MeasuresKnee moments and quadriceps and hamstrings activation were examined during walking. Knee extensor and flexor strength were measured. Waveform patterns were extracted using principal component analysis. Each measured waveform was scored against principal components (PCs) that captured overall magnitude (PC1) and early to midstance difference (PC2) features, with higher PC2 scores interpreted as greater moment differential and more prolonged muscle activity. Correlations were calculated between moment PC scores and muscle PC and strength scores. Regression analyses determined moment PC score variance explained by muscle PC scores and strength.ResultsAll correlations for knee adduction moment difference feature (KAMPC2) and prolonged muscle activity (PC2) were significant (r=−0.40 to −0.54). Knee flexion moment difference feature (KFMPC2) was significantly correlated with all quadriceps and medial hamstrings PC2 scores (r=−0.47 to −0.61) and medial hamstrings magnitude feature (PC1) (r=−0.52). KAMPC2 was significantly correlated with knee flexor strength (r=0.43), and KFMPC2 was significantly correlated with knee extensor (r=0.60) and flexor (r=0.55) strength. Regression models including muscle PC2 scores and knee flexor strength explained 46% of KAMPC2 variance, whereas muscle PC2 scores and knee extensor strength explained 59% of KFMPC2 variance.ConclusionsMuscle activation patterns and strength explained significant variance in moment difference features, highest for the knee flexion moment. This supports that exercises such as neuromuscular training, focused on appropriate muscle activation patterns, and strengthening have the potential to alter dynamic loading gait patterns associated with knee OA clinical progression.     

Neuromuscular training improves knee proprioception in athletes with a history of anterior cruciate ligament reconstruction: A randomized controlled trial

BackgroundAthletes exhibit deficits in knee proprioception following anterior cruciate ligament reconstruction. Neuromuscular training programs improve knee proprioception in uninjured athletes; however, the effects on knee proprioception in athletes who have undergone anterior cruciate ligament reconstruction is not well understood. The purpose of this study was to examine the effects of a neuromuscular training program on knee proprioception in athletes who have returned to sport following anterior cruciate ligament reconstruction.MethodsTwenty-four male athletes, who had undergone anterior cruciate ligament reconstruction within the previous 6–12 months and returned to sport, participated in this randomized controlled trial. Athletes were randomly allocated to an experimental group (n = 12) that took part in an 8-week neuromuscular training program or a control group (n = 12) that simply continued their typical training routine. Knee position sense was assessed at baseline and after the 8-week period (post-testing). One-way analysis of covariance, with baseline performance included as a covariate, was used to compare knee position sense errors for the reconstructed limbs of the experimental and control groups at the post-testing time point.FindingsKnee position sense errors decreased by 51.7% for the experimental group and only 4.4% for the control group over the 8-week period. As a result, the experimental group demonstrated lower knee position sense errors, compared to the control group, at the post-testing time point (P < .001).InterpretationAthletes with a history of anterior cruciate ligament reconstruction may benefit from participation in a neuromuscular training program, even after completing post-operative rehabilitation.     

Effect of muscle loads and torque applied to the tibia on the strain behavior of the anterior cruciate ligament: an in vitro investigation

Background

Very little is known about the effects of applied torque about the long axis of the tibia in combination with muscle loads on anterior cruciate ligament biomechanics. The purpose of this study was to determine the effect of muscle contraction and tibial torques applied about the long axis of the tibia on anterior cruciate ligament strain behavior.

Methods

Six cadaver knee specimens were used to measure the strain behavior of the anterior cruciate ligament. Internal and external axial torques were applied to the tibia when the knee was between 30° and 120° of flexion in combination with the conditions of no muscle load, isolated quadriceps load, and simultaneous quadriceps and hamstring loading.

Findings

The highest anterior cruciate ligament strain values were measured when the muscles were not loaded, when the knee was at 120° of flexion, and when internal tibial torques were applied to the knee. During muscle loading the highest anterior cruciate ligament strain values were measured at 30° of flexion and then the strain values gradually decreased with increase in knee flexion. During co-contraction of the quadriceps and hamstring muscles the anterior cruciate ligament was unstrained or minimally strained at 60°, 90° and 120° of knee flexion.

Interpretation

This study suggests that quadriceps and hamstring muscle co-contraction has a potential role in reducing the anterior cruciate ligament strain values when the knee is in deep flexion. These results can be used to gain insight into anterior cruciate ligament injury mechanisms and to design rehabilitation regimens.     

A hierarchy in functional muscle roles at the knee is influenced by sex and anterior cruciate ligament deficiency

BackgroundSex-related neuromuscular differences have been linked to greater risk of anterior cruciate ligament injuries in females. Despite this, it remains unclear if sex-related differences are present after injury. This study sought to determine if sex differences are present in the functional roles of knee joint muscles in an anterior cruciate ligament deficient population.MethodsAn isometric, weight-bearing, force-generation protocol required injured and healthy males and females to modulate ground reaction forces. Electromyography was used to classify the functional role of 10 lower limb muscles in their contribution to knee joint stability during various loading directions. These roles were compared between the four groups at 12 loading directions using a directional analysis.FindingsFunctional muscle roles were different between groups, except for injured males and healthy females. Healthy males had either joint actuators or specific joint stabilisers, but no general stabilisers; the vastus medialis and lateralis of injured males and healthy females were classified as general stabilisers while injured females added the gluteus medialis and medial gastrocnemius as general stabilisers.InterpretationA population-based hierarchy in functional muscle roles was discovered. Healthy males demonstrated the most specific muscle roles, which can be viewed as more adaptive to variable loading conditions. The more generalised stabilisation strategies seen in injured males and females would alter joint loading which may be detrimental to the knee joint health over time. In summary, (1) these injuries alter muscle roles; (2) these alterations are sex-specific; (3) rehabilitation might be optimised if sex-differences are considered.     

Associations between isometric quadriceps strength characteristics,knee flexion angles,and knee extension moments during single leg step down and landing tasks after anterior cruciate ligament reconstruction

BackgroundIt is unclear of how peak knee extension torque and early rate of torque development outcomes are related to lower extremity loading and sagittal plane movement in activities of daily living and landing tasks despite consistent deficits after anterior cruciate ligament reconstruction. The purpose of this cross-section study is to assess the ability of quadriceps strength characteristics to predict movement patterns during a step down and single leg drop crossover hopping tasks.MethodsFifty-two individuals with a unilateral history of anterior cruciate ligament reconstruction completed three trials of the step down and crossover hopping tasks on their involved limb. Participants completed three isometric knee extension contractions at 90° knee flexion with visual feedback to assess peak knee extension torque and rate of torque development during the first 0–100 ms and 100–200 ms of the contraction.FindingsPeak knee extension torque explained the greatest variance in peak knee extension moment (R² = 40.4%, p < 0.001) and knee flexion angle (R² = 46.7%, p < 0.001) during the crossover hop landing. Rate of torque development (0–100 ms) was the only predictor of knee flexion angle (R² = 19.8%, p = 0.01) at initial contact during the crossover hopping landing. Rate of torque development (100–200 ms) explained 17.6% of the variance in peak knee extension moment during the step down (p = .03).InterpretationPeak knee extension torque and early rate of torque development outcomes demonstrate limited relationships between movement of activities of daily living and sport-specific tasks. These limitations should be considered when interpreting the results of isometric strength testing in a clinical setting.