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Background

Medical student reflection is integral for professional development. Preliminary findings suggest that short-format writing promotes reflection and identifies impactful experiences. We sought to determine whether reflective writing could be used as a clerkship needs assessment.

Methods

During their surgical clerkship, medical students submitted “tweet”-format reflections and completed a standardized evaluation. “Tweet” content was analyzed using modified grounded theory methods and coded by valence, content, and reflection. Sub-coding was conducted to compare feedback between “tweets” and evaluations.

Results

We analyzed 286 reflections and 214 evaluation comments; 176 “tweets” were reflective (62%). “Tweets” commented on “patient interaction” (53%), “educational experience” (38%), “physician interaction” (26%), and “career decisions” (10%). A significant difference was observed between “tweets” and evaluations with regard to the number that provided feedback on experiences with “critically ill or dying patients.”

Conclusions

Reflections provided real-time reactions to impactful clerkship events, notably those involving critically ill or dying patients. This focus on illness may represent an unmet need for discussions related to end of life care. Overall, reflections provided more actionable feedback compared to evaluations.  相似文献   

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长期以来,在凸轮机构中用压力角α;在连杆机构中用传动角γ(因为丨90°-γ丨=α,实质上仍是压力角)作为衡量机构传动质量的指标和设计依据。本文通过分析,指出了压力角作为这种指标的缺陷和提出了新的机构传动质量指标Ψ'=tga'tgφ',其中α'为实际压力角,φ'为从动件与机架间的当量摩擦角。文章还阐述了新指标在机构分析和综合上的应用。  相似文献   

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Background

Red blood cell-derived microparticles are biologically active, submicron vesicles shed by erythrocytes during storage. Recent clinical studies have linked the duration of red blood cell storage with thromboembolic events in critically ill transfusion recipients. In the present study, we hypothesized that microparticles from aged packed red blood cell units promote a hypercoagulable state in a murine model of transfusion.

Methods

Microparticles were isolated from aged, murine packed red blood cell units via serial centrifugation. Healthy male C57BL/6 mice were transfused with microparticles or an equivalent volume of vehicle, and whole blood was harvested for analysis via rotational thromboelastometry. Serum was harvested from a separate set of mice after microparticles or saline injection, and analyzed for fibrinogen levels. Red blood cell-derived microparticles were analyzed for their ability to convert prothrombin to thrombin. Finally, mice were transfused with either red blood cell microparticles or saline vehicle, and a tail bleeding time assay was performed after an equilibration period of 2, 6, 12, or 24 hours.

Results

Mice injected with red blood cell-derived microparticles demonstrated an accelerated clot formation time (109.3?±?26.9 vs 141.6?±?28.2?sec) and increased α angle (68.8?±?5.0 degrees vs 62.8?±?4.7 degrees) compared with control (each P?<?.05). Clotting time and maximum clot firmness were not significantly different between the 2 groups. Red blood cell-derived microparticles exhibited a hundredfold greater conversion of prothrombin substrate to its active thrombin form (66.60?±?0.03 vs 0.70?±?0.01 peak OD; P?<?.0001). Additionally, serum fibrinogen levels were lower in microparticles-injected mice compared with saline vehicle, suggesting thrombin-mediated conversion to insoluble fibrin (14.0 vs 16.5?µg/mL, P?<?.05). In the tail bleeding time model, there was a more rapid cessation of bleeding at 2 hours posttransfusion (90.6 vs 123.7?sec) and 6 hours posttransfusion (87.1 vs 141.4?sec) in microparticles-injected mice as compared with saline vehicle (each P?<?.05). There was no difference in tail bleeding time at 12 or 24 hours.

Conclusion

Red blood cell-derived microparticles induce a transient hypercoagulable state through accelerated activation of clotting factors.  相似文献   

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Ischemia induced by cross-clamping the aorta during open-heart operations initiates progressive metabolic derangement. If the duration of ischemia is short, these derangements are easily reversed by restoring the flow of blood containing oxygen and substrate. If ischemia is prolonged, treatment designed to ameliorate ischemic damage may be necessary. Three problems are discussed: (1) loss of adenine nucleotides, particularly adenosine triphosphate, (2) impairment of calcium sequestration, and (3) formation of microemboli in coronary vessels. The rationale for postbypass treatment is presented.  相似文献   

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An approach to intraoperative protection of the myocardium is described that attempts to increase glucose utilization by infusion of high-energy solutions during aortic cross-clamping. Infusion of hypertonic glucose or glucose plus insulin prior to aortic cross-clamping has enhanced contractility and increased high-energy phosphate moieties in animals with induced ischemia. Recent pilot experiments in our laboratory suggest that infusions of creatine may result in increased production of creatine phosphate, which in turn induces phosphorylation of adenosine diphosphate to adenosine triphosphate, possibly enhancing myocardial contractility. The intraoperative clinical benefits of these infusions remain to be proved, however.  相似文献   

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Normothermic ischemic arrest by aortic cross-clamping, a widely used clinical technique, is associated with metabolic changes in the myocardium that are incompletely understood. The effects of aortic cross-clamping on glycolytic pathways as well as associated morphological changes are discussed. Emphasis is placed on the conservation of high-energy phosphate moieties during the period of cross-clamping as well as during reperfusion. A marked reduction in total high-energy phosphates (62%) and glycogen (63%) and an increase in lactate production (243%) denote a shift to anaerobic metabolism during the period of arrest. Despite reperfusion, total high-energy nucleotides remained depressed. The data suggest that persistent abnormal myocardial carbohydrate metabolism and low levels of high-energy nucleotides prevent recovery of contractility following normothermic ischemic arrest and reperfusion.  相似文献   

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An in vitro technique for isolating prostatic cells from blood has been applied to the study of circulating prostatic cells during a transurethral resection of the prostate. Our findings indicate that prostatic cells that are added to the blood in vitro can be isolated by the technique described and that cells resembling prostatic cells can be isolated from the blood of the patient undergoing transurethral resection of the prostate. Furthermore, the results of our study suggest that (i) in selected patients, needle biopsy of the prostate should be carried out prior to transurethral resection of the prostate and that (ii) patients who have multifocal adenocarcinoma diagnosed at the time of transurethral resection of the prostate may not be suitable candidates for future prostatectomy.  相似文献   

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Seven cases of delayed operation for renal trauma are presented. The only kidney lost would have been lost with early operation. No undue friability of the renal tissue was found. The flank approach in delayed procedures for renal trauma has certain advantages over the transabdominal approach.  相似文献   

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Fifty patients scheduled for surgery under lumbar epidural anaesthesia were included in a study to evaluate the possibility of localising the epidural space solely by means of an acoustic signal. With an experimental set-up, the pressure generated during the epidural puncture procedure was translated into a corresponding acoustic signal. One anaesthetist held the epidural needle with both hands and detected the epidural space by means of this acoustic signal. At the same time, a second anaesthetist applied the loss of resistance technique and functioned as control. In all patients the epidural space was located with the acoustic signal. This was confirmed by conventional loss of resistance in 49 (98%) of the patients; in one patient (2%) it was not. We conclude that it is possible to locate the epidural space using an acoustic signal alone.  相似文献   

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TP—801控制集成运放参数的自动测试系统具有自动测试、自动分档、计数、显示、打印等功能。速度快、结构简单、测试简便、可靠与成本低是系统的主要特点。本文介绍了硬件框图、软件结构和主程序流程图。通过介绍一个测试过程、调试与整定方法,简述计算方法、测试范围与测试精度等问题。  相似文献   

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Multiple level injuries of the cervical spine   总被引:2,自引:0,他引:2  
W.A. Hadden  W.J. Gillespie 《Injury》1985,16(9):628-633
In a group of 105 patients admitted to hospital with injuries of the cervical spine, the incidence of injuries at multiple levels was 24 per cent. Multi-level injuries occurred in 17 out of 54 patients (31 per cent) sustaining a noteworthy neurological injury and in 8 out of 51 when such an injury was absent. This incidence is higher than previously reported, probably due to increasingly elaborate investigations. In the majority of cases, treatment of the dominant injury was unchanged by the demonstration of injuries at other levels, but in a small number, serious errors in treatment arose or could have arisen. Careful multi-level assessment, including assessment of the cervicothoracic junction, is indicated before selecting management. While conventional or computerized axial tomography may occasionally be necessary to achieve this, good conventional radiography remains the most important investigation. Computerized axial tomography is particularly useful in establishing the anatomy of complex injuries in the upper cervical spine.  相似文献   

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