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1.
Xu Ren Chun-Lan Zhu Xu-Fu Qin Hong Jiang Tian Xia Yong-Ping Qu 《World Journal of Clinical Cases》2019,7(1):102-108
BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB) is pathologically similar to intraductal papillary mucinous neoplasm(IPMN). However, there are several significant differences between them. The rate of IPMN associated with extrapancreatic malignancies has been reported to range from 10%-40%, and it may occasionally be complicated with the presence of fistulas. IPMN associated with malignant IPNB is extremely rare and only nine cases have been reported in the literature.CASE SUMMARY We report a 52-year-old man who presented with recurrent cholangitis for nine months. Computed tomography and magnetic resonance cholangiopancreatography showed the common bile duct stricture with dilated pancreatobiliary duct without other abnormal findings. The underlying pathogenesis could not be identified based on the radiologic images. Endoscopic retrograde cholangiopancreatography revealed a pancreatobiliary fistula with dilated main pancreatic duct, biliary stricture with dilated biliary tree, and mucus discharge from the enlarged orifice of the major papilla. The patient underwent SpyGlass cholangiopancreatoscopy due to a suspected mucin-producing biliary neoplasm and indeterminate main pancreatic duct dilatation. Multiple papillary growing neoplasms with vascular images, with the extent of lesions spreading in the biliopancreatic ductal lumens, were identified by SpyGlass. In addition, the presence of a pancreatobiliary fistula was also identified. The patient was diagnosed as having benign IPMN and malignant IPNB with focal invasion by postoperative pathology. Furthermore, varying histological subtypes were present in both IPMN and IPNB. Pylorus-preserving pancreaticoduodenectomy was performed on the patient with excellent results during the 52 month followup period.CONCLUSION We deemed that pancreatography and SpyGlass allowed for an efficient diagnosis of IPMN with pancreatobiliary fistula, whereas the etiology could not be identified by radiologic imaging. 相似文献
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脐尿管瘘是一种膀胱畸形疾病,男性多见.临床表现为脐部漏尿,漏尿程度视瘘管的大小而定,脐部漏口为皮肤或黏膜所覆盖.静脉注射靛胭脂或从尿道导管将亚甲蓝注入膀胱,可见染色尿液自脐部漏出,故可诊断[1]. 相似文献
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对自由基和抗氧化剂的基本知识,自由基在ICU常见疾病发生发展中的作用以及抗氧剂的临床应用四方面内容进行综述,提示了ICU护士了解这四方面内容是临床实践的组成部分. 相似文献
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1病例介绍患者女,67岁。因"发热半个月,黑便1d"于2006年6月9日入院。患者半个月前起发热,多次测得体温≥39.0℃,无寒战,无咳嗽、咳痰,无腹痛、腹泻,无尿急、尿痛,无腰痛、咽痛,当地医院予抗生素、激素治疗体温反复,昨日起解黑便,共2次,伴头晕,晕厥1次,无呕血,为进一步诊治转入本院。既往类风湿关节炎 相似文献
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代谢综合征又称代谢异常心血管综合征,它是一组心血管疾病危险因素的聚集和组合,包括高血压、高血脂(血脂异常)、高血糖(糖尿病、血糖调节受损、糖耐量异常)、肥胖、吸烟、炎症、血凝增强、纤溶降低等。心血管疾病是人类头号杀手,给社会和家庭带来了沉重的经济负担。对于心血管疾病这种新的流行病学表现, 相似文献
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Jun-Hui Guo Yuan-Yuan Wang Jiang-Wei Zhang Pei-Min Liu Yan-Jun Hao Hai-Rui Duan 《World Journal of Clinical Cases》2020,8(7):1326-1336
BACKGROUND Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor.Apatinib has demonstrated encouraging antitumor activities.This study aimed to observe the efficacy and safety of apatinib for the treatment of multiple brain micrometastases.CASE SUMMARY We report two patients with multiple brain micrometastases after failure of second-line treatment.Both patients had extracerebral metastases.When the patients took 250 mg/d apatinib orally,the intracerebral lesions disappeared.The extracerebral lesions were partially alleviated.Both patients had a progressionfree survival of more than 12 mo and were still stable.The safety was good.The main adverse events(AEs)were mild hypertension and proteinuria,which could be controlled.CONCLUSION Apatinib has clear efficacy and good tolerance in patients with multiple brain micrometastases after failure of second-line treatment. 相似文献
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Michael Kindermann Oliver Adam Nikos Werner Prof. Dr. Michael Böhm 《Clinical research in cardiology》2007,96(11):767-786
This article provides information and commentaries on trials which were presented at the Hotline and Clinical Trial Update
Sessions at the European Society of Cardiology Congress 2007 in Vienna. The key presentations were performed by leading experts
in the field with relevant positions in the trials or registries. It is important to note that unpublished reports should
be considered as preliminary data, as the analysis may change in the final publications. The comprehensive summaries have
been generated from the oral presentation and the webcasts of the European Society of Cardiology and should provide the readers
with the most comprehensive information of relevant publications. 相似文献
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Berry GP Bamber JC Armstrong CG Miller NR Barbone PE 《Ultrasound in medicine & biology》2006,32(4):547-567
The ultrasonic measurement and imaging of tissue elasticity is currently under wide investigation and development as a clinical tool for the assessment of a broad range of diseases, but little account in this field has yet been taken of the fact that soft tissue is porous and contains mobile fluid. The ability to squeeze fluid out of tissue may have implications for conventional elasticity imaging, and may present opportunities for new investigative tools. When a homogeneous, isotropic, fluid-saturated poroelastic material with a linearly elastic solid phase and incompressible solid and fluid constituents is subjected to stress, the behaviour of the induced internal strain field is influenced by three material constants: the Young's modulus (E(s)) and Poisson's ratio (nu(s)) of the solid matrix and the permeability (k) of the solid matrix to the pore fluid. New analytical expressions were derived and used to model the time-dependent behaviour of the strain field inside simulated homogeneous cylindrical samples of such a poroelastic material undergoing sustained unconfined compression. A model-based reconstruction technique was developed to produce images of parameters related to the poroelastic material constants (E(s), nu(s), k) from a comparison of the measured and predicted time-dependent spatially varying radial strain. Tests of the method using simulated noisy strain data showed that it is capable of producing three unique parametric images: an image of the Poisson's ratio of the solid matrix, an image of the axial strain (which was not time-dependent subsequent to the application of the compression) and an image representing the product of the aggregate modulus E(s)(1-nu(s))/(1+nu(s))(1-2nu(s)) of the solid matrix and the permeability of the solid matrix to the pore fluid. The analytical expressions were further used to numerically validate a finite element model and to clarify previous work on poroelastography. 相似文献
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Molski M 《Homeopathy : the journal of the Faculty of Homeopathy》2011,100(4):259-263
Analytical time-dependent functions describing the change of the concentration of the solvent S(t) and the homeopathic active substance A(t) during decimal and centesimal dilution are derived. The function S(t) is a special case of the West-Brown-Enquist curve describing ontogenic growth, the increase in concentration of the solvent during potentization resembles the growth of biological systems. It is demonstrated that the macroscopic S(t) function is the ground state solution of the microscopic non-local Horodecki-Feinberg equation for the time-dependent Hulthèn potential at the critical screening. In consequence potentization belongs to the class of quasi-quantum phenomena playing an important role both in biological systems and homeopathy. A comparison of the results predicted by the model proposed with the results of experiments on delayed luminescence of a homeopathic medicine is made. 相似文献
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K. Zehi F. Ben HamidaA. Belkadhi T. NaanaaM. Ben Zid M. DouikM. Zouari 《Journal de Traumatologie du Sport》2007
The objective of our work is to clarify the contribution of knee arthrometer in the diagnosis of the anterior laxity of the knee, to look for the factors of escalation of this pathology, to estimate the objective results and outcomes following of the anterior cruciate ligament surgery. It is about a retrospective study which concerned 78 patients presenting the anterior chronic laxity of the knee, investigated, treated and followed in the M.-T.-Kassab Institute of Orthopaedics over a period of 10 years. The average age of our patients was of 27.6 years with a male ascendancy. The anterior cruciate ligament surgery was realized according to the technique of Kenneth-Jones under arthroscopy. The arthrometer has been used to determine the outcome 6 months after the surgery. Before the surgery, the average anterior translation of the tibia was 15.3 mm, 95% of the patients had 8 mm previous absolute laxity, while the differential was about 4 mm in 87% of the cases in which comparative study could be made. There was a statistically significant correlation between the Lachman's test, the internal meniscus injuries and the delay accident — surgery with the anterior knee laxity in the arthrometer. The postoperative average laxity was bout 8.2 mm and earning was proportional to the importance of the initial tibial translation. The present study demonstrates that arthrometer tests may be an objective complement for the clinical exam, with a diagnostic, previous and therapeutic purpose. 相似文献
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Ankle sprains are the most common injury of the musculoskeletal system and are associated with significant societal and economic impacts. It has been proven that classical therapeutic strategies may not be effective in preventing recurrent injuries: the recurrence rates reported in the literature can reach 73%. In order to provide an effective rehabilitation solution, a destabilizing orthosis was developed. This device is equipped with a mechanical articulator reproducing the subtalar mechanics and placed under the heel. In this paper, we present the main results of a preliminary clinical study conducted between 2004 and 2007. All subjects included in this study were treated with the abovementioned orthosis during 10 rehabilitation sessions of 30 minutes each. Data show a relatively low recurrence rate of 12% for the overall population. Moreover, it's of primary importance to note that this satisfactory ratio is largely reduced (3% of recurrence rate) for the 29 patients who performed one training session per month after the 10th initial rehabilitation sessions. Hence, the destabilizing orthosis appears to be an effective solution to prevent recurrent ankle sprains. However, joint protection requires long-term and regular training sessions. This result has motivated the development of a similar device allowing patients to perform training sessions at home. Finally, data obtained in this study are promising awaiting the final results of the comparative, multicentric and independent clinical trials currently managed by the Hospices Civils de Lyon. 相似文献
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R.C. Chivers 《Ultrasound in medicine & biology》1978,4(4):353-361
Discussions of the phase and amplitude fluctuations of waves travelling through inhomogeneous media have previously considered only fluctuations caused by the variation of sound velocity in the medium, density variations being ignored since in water and air they can be shown to be small. In biological tissues this assumption cannot be made, and this paper derives the fluctuation dependence on velocity and density variations of characteristic dimension large compared to the wavelength.Previous discussions have shown a more appropriate formulation to be that of the fluctuation dependence on bulk modulus and density variations and this analysis is presented for the first time. The form of the solutions is shown to be simplified for extreme values of the wave parameter, but formulae for comparison with experiment require the specification of the analytical form of the correlation coefficients of the parameter variations.The fluctuations for correlation coefficients of the form exp (−r2/a2) are evaluated both for the general case, and for extreme values of the wave parameter.It is found that the density variations contribute to the fluctuations only insofar as they are cross-correlated with the velocity fluctuations (for velocity and density variations); while the amplitude fluctuations, for small values of the wave parameter and the specific form of correlation coefficients used, are independent of frequency. 相似文献
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张深山 《临床心身疾病杂志》2010,16(3):204-206
目的探讨喹硫平对精神分裂症患者阴、阳性症状和社会功能康复的影响。方法将100例精神分裂症患者随机分为两组,每组50例,研究组口服喹硫平治疗,对照组口服舒必利治疗,观察8周。于治疗前及治疗第1周、4周、8周末、出院1月末采用简明精神病量表、阴性症状量表、阳性症状量表评定精神症状,于治疗前和出院1月末采用社会功能缺陷筛选量表评定社会功能缺陷状况。结果治疗后两组简明精神病量表、阴性症状量表、阳性症状量表评分均较治疗前有显著下降(P〈0.01);治疗第1周末,研究组各量表评分均较对照组下降显著(P〈0.05或0.01),其他时段评分两组均无显著性差异(P均〉0.05)。两组出院1月末社会功能缺陷筛选量表总分及各因子分均较治疗前有显著下降;研究组总分及职业功能、社会活动、家庭活动、生活能力因子分均较对照组下降更显著(P〈0.05或0.01)。结论喹硫平治疗精神分裂症疗效显著且与舒必利相当,但喹硫平起效更快,对社会功能缺陷的改善显著优于舒必利。 相似文献
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Markus K.H. Malo Janne P. Karjalainen Hanna Isaksson Ossi Riekkinen Jukka S. Jurvelin Juha Töyräs 《Ultrasound in medicine & biology》2010
Quantitative ultrasound (QUS) measurements are used in the diagnostics of osteoporosis. However, the variation in the thickness and composition of the overlying soft tissue causes significant errors to the bone QUS parameters and diminishes the reliability of the technique in vivo. Recently, the dual frequency ultrasound (DFUS) technique was introduced to minimize the errors related to soft tissue effects. In this study, the significance of soft tissue induced errors and their elimination with the DFUS technique were simulated using the finite difference time domain technique. Furthermore, we investigated the potential of the DFUS corrected integrated reflection coefficient (IRC) of bone to detect changes in the cortical bone density. The effects of alterations in the thickness of fat and lean tissue layers and the inclination between the soft-tissues and between the soft tissue-bone layers were simulated. When the angle of the soft tissue interface was zero, i.e., perpendicular to the incident ultrasound beam, the DFUS-calculated soft tissue composition correlated highly linearly with the true soft tissue composition. The inclination between the soft tissue-bone layers was found to be critical. Even a 2-degree inclination between the soft tissue and the bone surface induced an almost 18% relative error in the corrected IRC. Increasing the inclination between the soft tissue layers increased the error in the DFUS-calculated lean and fat tissue thickness. This error was especially significant at inclination angles greater than 20 degrees. The significant soft tissue induced errors in IRC values (>300 %) could be effectively minimized (<10 %) by means of the DFUS correction. Importantly, after the DFUS correction, physiologically relevant variation in the cortical bone density could be detected (p < 0.05). (E-mail: Markus.Malo@uef.fi) 相似文献
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Robert Taylor Jr. PhD Joseph V. Pergolizzi MD Alexander Sinclair MD Robert B. Raffa PhD Dominic Aldington FRCA Stanford Plavin MD Christian C. Apfel MD PhD 《Pain practice》2013,13(4):332-344
Poorly controlled acute pain during the postoperative setting after abdominal surgery can be detrimental to the patient. Current pain management practices for the postoperative abdominal surgery patient rely heavily on opioids, which are associated with many unwanted side effects. Recently, interest surrounding regional anesthesia has been growing owing to its demonstrated efficacy and safety outcomes. More specifically, the transversus abdominis plane (TAP) block procedure has attracted attention owing to its ability to successfully block peripheral pain signaling in the abdomen, its ease of use, few complications, and its greater acceptability. A majority of the studies published has demonstrated the successful reduction in pain in many abdominal surgical procedures using local anesthetics during the TAP block. However, the short duration of the pain block causes the patient to still rely on other analgesics throughout the additional postoperative days. Preliminary studies using continuous infusion catheters placed in the TAP has been one of the ways to prolong the nerve block in the abdomen; however, technical and operational issues currently limit the widespread adoption of this method. In this review, current studies will be presented and summarized to update the field on the potential benefits of the TAP block procedure, in addition to providing insight into the future direction of the drugs that could be used for TAP block. 相似文献
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孕产妇分娩前后心身健康状况调查 总被引:1,自引:0,他引:1
目的 探讨孕产妇分娩前后心身健康状况,为临床干预提供依据.方法 对100名孕产妇产前、产后1周、4周、12周末采用焦虑自评量表、抑郁自评量表和爱丁堡产后抑郁量表评定焦虑抑郁状况,于产前、产后1周末检测血清雌二醇和孕酮水平.结果 入组被试产后焦虑自评量表、抑郁自评量表和爱丁堡产后抑郁量表评分随着时间的延续均呈持续性下降(... 相似文献