胶样粟丘疹1例

报告1例胶样粟丘疹。患者女,60岁,务农。双眼周粟粒大小、淡黄色半透明扁平丘疹,逐渐增多,无自觉症状2年。组织病理显示真皮上部可见均质化并有裂隙的团块,类似淀粉样物质。弹力纤维染色显示弹力纤维断裂。诊断为胶样粟丘疹。     

皮肤镜及反射式共聚焦显微镜辅助诊断儿童结缔组织增生性毛发上皮瘤1例

患儿女，11岁，下颌肿物5年。皮肤科情况：下颌黄豆大小丘疹，色黄、质硬，边界清楚，中央略凹陷，其上可见针尖大小粟丘疹样突起。皮损组织病理检查示：真皮浅层可见上皮样条索及角囊肿，间质胶原纤维致密、增生。反射式共聚焦显微镜(RCM)检查示：真皮浅层可见多个低折光圆形、长形瘤细胞团块，瘤团内可见大小、形态相似的低折光鱼子样细胞，中央可见中高折光均质团块，周围包绕明亮的胶原纤维束呈平行排列，部分瘤团内可见高折光多边形小团块结构。皮肤镜检查示：皮损区边界清楚，呈象牙白色背景，边缘见线状血管及黄白色圆形结构灶性分布，中央少量薄层鳞屑。诊断：结缔组织增生性毛发上皮瘤(desmoplastic trichoepithelioma, DTE)。RCM和皮肤镜对疑似DTE患者，能在无创诊断、鉴别诊断及病理取材定位方面提供较可靠的辅助诊断价值，尤其对儿童患者及面部皮损具有较高临床应用价值。     

Nodular colloid degeneration

报告1例结节性胶样变性.患者女,53 岁.因面部起半透明的丘疹、结节和斑块伴轻微瘙痒8 年就诊.组织病理检查显示真皮全层可见团块状淡红色无定形的物质,内有许多裂隙和散在分布的成纤维细胞.PAS染色阳性,刚果红染色阴性.弹性纤维染色示胶样物质团块内和周围有团块状变性的弹性纤维.符合结节性胶样变性的诊断.组织病理上该病需与成人胶样粟丘疹、结节性皮肤淀粉样变性及进行性获得性淋巴管瘤等鉴别.     

婴幼儿血管瘤皮肤镜下特征

目的观察婴幼儿血管瘤在皮肤镜下的特征,以探讨皮肤镜用于无创性诊断婴幼儿血管瘤的可行性。方法回顾性分析2016年7月-2017年1月本科确诊的67例婴幼儿血管瘤皮损的皮肤镜下特征和临床资料。结果婴幼儿血管瘤皮肤镜下结构特征为:红色腔隙样结构、膨大扩张的血管结构、皮损周边血管结构、蓝紫色腔隙样结构、弥漫性红色结构。单因素回归分析显示,患者年龄和婴幼儿血管瘤皮肤镜下各结构特性无显著相关性。婴幼儿血管瘤依据皮肤镜下主要形态结构模式,可分为四型:以"鹅卵石"样红色腔隙样结构为主的血管瘤、以膨大扩张血管结构为主的血管瘤、以稀疏排列的红色腔隙样结构为主的血管瘤和以弥漫性红色结构为主的血管瘤。结论婴幼儿血管瘤皮肤镜下具有特征性结构,皮肤镜可作为婴幼儿血管瘤无创性诊断手段。     

皮肤假腺样鳞状细胞癌

报告1例皮肤假腺样鳞状细胞癌。患者男,71岁。右侧面部半球形暗红色肿物3个月,迅速增大,无自觉症状。皮肤镜示皮损中央黄白色角化斑片,上覆鳞屑,边缘为白色无结构区,可见毛囊角栓及周围白晕,线状及螺旋状血管。皮损组织病理检查:表皮萎缩,部分缺失,真皮内可见大量上皮样细胞成巢浸润性生长,呈团块及条索状,形成假腺样结构,可见棘层松解细胞以及不典型核分裂象,瘤体间及周围存在混合炎性细胞浸润。诊断:假腺样鳞状细胞癌。     

儿童血管角化瘤皮肤镜下表现分析

目的探讨儿童血管角化瘤皮肤镜下表现。方法回顾性分析8例确诊为儿童血管角化瘤的皮肤镜下图像特点。结果8例患儿皮损在皮肤镜下均可见大量腔隙样结构及其周围白色面纱样结构。结论血管角化瘤在皮肤镜下具有一定的特异性模式,应用皮肤镜有利于提高该病诊断准确率。     

胶样粟丘疹1例并文献复习

目的分析胶样粟丘疹的临床特点。方法报告本院诊治的1例胶样粟丘疹,并回顾复习国内报道的35例类似病例。结果本例为51岁女性患者,农民,双侧手背淡黄色丘疹5年,累及面部3年,无自觉症状。皮损组织病理示:真皮上部可见大片均质性有裂隙、无定形的淡嗜酸性胶样物质沉积。诊断:胶样粟丘疹。36例胶样粟丘疹患者的平均发病年龄(44.09±9.72)岁,其中男14例,女22例,男女比例为7∶11。仅有2例(5.56%)有皮损发生在非曝光部位,余均发生于曝光部位,且有25例(69.44%)与过度日晒有关。结论胶样粟丘疹患者女性多于男性,本病与过度日光曝晒有密切关系。     

有多种皮损表现的胶样粟丘疹

报告1例胶样粟丘疹.患者女,52岁.眼周、舌部丘疹2年,手部角化斑1年.体格检查:双眼周可见多个直径3～5 mm的肤色和棕色丘疹,舌及下唇黏膜下散在直径2～3 mm的黄白色小结节,部分为紫红色.组织病理学检查:真皮上层许多无结构均质的嗜酸性物质,结晶紫和刚果红染色阴性.诊断:胶样粟丘疹.该病需要和原发性系统性淀粉样变性病及类脂蛋白沉积症鉴别.     

家族性儿童型胶样粟丘疹

儿童型胶样粟丘疹(juvenile colloid milium,JCM)是一种较为罕见的疾病,其特征是儿童日光暴露部位皮肤丘疹样损害,该病病因不明,但一些学者推测可能是遗传易感性及日光诱导导致角质形成细胞损害所致,我们报道一例家族性胶样粟丘疹。     

皮肤镜在面部激素依赖性皮炎和脂溢性皮炎诊断中的应用评价

目的总结面部激素依赖性皮炎和脂溢性皮炎的皮肤镜特征,评估皮肤镜在二者鉴别诊断中的意义。方法选择2015年9月-2016年1月本院收治的面部激素依赖性皮炎(FCAD,47例)和脂溢性皮炎(SD,39例),分析该两组疾病皮肤镜下特点(背景颜色、血管形态、血管排列方式、毛囊异常、鳞屑表现及其他相关指征)。结果该两组疾病患者均见玫瑰花团结构。FCAD患者皮肤镜下见红色或深红色背景下的多形性或分支状血管呈网状或不规则性分布,点状或线状血管比例较低。SD患者为黄红色或红色背景下的多形性或点状血管呈不规则性或簇状排列,多见黄色鳞屑,部分可见毛囊周围黄红色油滴状晕样结构,毛囊角栓。结论 FCAD患者和SD患者皮肤镜下特征截然不同,皮肤镜检查有助于诊断和鉴别诊断该两组疾病。     

Unusual Manifestations of Familial Juvenile Colloid Milium in Two Siblings

Juvenile colloid milium is an extremely rare degenerative dermatosis of the dermal connective tissue manifesting before puberty. This chronic skin condition, detected primarily in sun‐exposed areas, is clinically characterized by the development of translucent, yellowish papules and plaques containing gelatinous material and by the presence of eosinophilic, fissured material in the papillary dermis. We present two cases of juvenile colloid milium, in a 13‐year‐old girl and her 10‐year‐old brother; the condition emerged in both at approximately 6 years of age and progressively worsened. They both presented with multiple yellowish, translucent, firm, flat papules and plaques mainly over the face on the cheeks and on the perioral and periocular areas in a unique linear pattern.     

UV-induced colloid milium

A 39-year-old woman is reported who developed numerous confluent yellowish semitranslucent papules of the face over 8 months. The patient habitually exposed herself to UVA-radiation twice a week for 7 years for aesthetic reasons. Histological, histochemical and immunohisto-chemical examinations were consistent with the diagnosis of adult colloid milium. A review of the literature is discussed. This case emphasizes the close relationship between long-term sun exposure, solar elastosis and adult colloid milium.     

Infrared‐induced adult colloid milium treated with fractionated CO2 laser

Adult colloid milium is a rare cutaneous deposition disorder that frequently involves areas of chronic sun exposure. The most common clinical presentation exhibits multiple, firm, and amber‐colored papules that cluster to form large plaques. Histologically, there are masses of amorphous, eosinophilic material expanding the papillary dermis, and at times extending into the mid‐dermis, with adjacent solar elastosis. When this disorder affects the face, disfiguring is of great concern and treatment is often sought. Attempts to safely remove colloid milium are generally unsuccessful. Dermabrasion has been reported to be effective. The present authors present a case with extensive facial colloid milium successfully ablated by the fractionated CO₂ laser.     

Colloid milium arising on a non-sun-exposed area in an adult

A 59-year-old woman presented with multiple translucent papules on the inner surface of the tragus of the right ear. Initially they were treated with cryotherapy, with a later biopsy revealing the diagnosis of colloid milium. The histology was unusual for adult colloid milium as the lesion lacked a Grenz zone and evidence of solar elastosis. This together with a lack of aetiological factors made it difficult to classify the subtype of colloid milium.     

Juvenile colloid milium

INTRODUCTION: Colloid Milium is a rare disease. It is characterized by the development, on sun-exposed areas, of clusters of yellow and translucid, hard papules, that seeps a gelatinous substance when opened. This dermatitis predominantly affects elderly patients and, exceptionally, children. We report a case of juvenile colloid milium. OBSERVATION: A 14 year-old boy consulted for papular, translucid or amber-brown lesions, occasionally hemorrhagic on the cheeks, nose upper lip and the upper edge of the helix of both ears. He was born to consanguineous parents. Living in a rural area, he was exposed to sun during agricultural activities. The lesions had progressed since he was 6 years old and were exacerbated in the summertime. There was no similar case in the family. Histological exploration of a papular lesion showed areas of atrophic epidermis and the presence of a few vacuolized keratinocytes. The epidermis was lifted by nodular lumps of amorphous eosinophilic material deposited in the superficial dermis. Staining with Congo red was negative. DISCUSSION: Juvenile colloid milium is a benign but unesthetic dermatitis. The inducing role of sun exposure is obvious, as in colloid milium of adults, but other pathogenic hypotheses also exist.     

Colloid milium

The differential diagnosis and classification of colloid milium, a relatively rare disorder, may be difficult. In this paper, a case report of a 52-year-old male patient with characteristic clinical and histological signs of colloid milium is therefore presented. Recently gained insights into the aetiopathogenesis of colloid milium are discussed.     

Nodular colloid degeneration: distinctive histochemical and ultrastructural features

We recently evaluated a patient with a unique form of nodular colloid degeneration. Lesions consisted of pruritic, purpuric plaques involving the upper and lower extremities and the neck. Examination of a biopsy specimen revealed large, fissured masses of amorphous material in addition to solar elastosis. The amorphous material showed negative reactions to stains for amyloid, and other histochemical studies showed results similar to those for colloid milium. The amorphous masses demonstrated a marked positive reaction to the Verhoeff-van Gieson stain for elastin. Electron microscopic examination revealed masses of degenerated elastic tissue bordered by fibrillar material that resembled amyloid morphologically. We believe this case represents a nodular form of solar degeneration with clinical and histologic resemblances to both colloid milium and cutaneous amyloidosis.     

胶样粟丘疹1例

患者女,47岁,农民。双颧部可见对称分布的淡黄色半透明扁平丘疹4年。皮损组织病理示:真皮乳头内可见无结构的嗜伊红均质性物质,内有裂隙,甲紫蓝染色、PAS染色均(+)。诊断:胶样粟丘疹。     

Juvenile colloid milium associated with conjunctival and gingival involvement

Juvenile colloid milium is an uncommon cutaneous disease characterized by translucent papules distributed on sun-exposed areas with early onset. Association of juvenile colloid milium with conjunctival and gingival deposits is uncommon and interesting. We report a case of juvenile colloid milium associated with conjunctival and gingivai deposits of an amyloid-like homogeneous eosinophilic material. It seems that all 3 of these in our patient may be different expressions of the same pathologic disease.     

Paracolloid of the Skin

A 51-year-old Caucasian man presented with a yellowish lesion containing multiple protuberances over his right cheek. Light and electron microscopic examination revealed an anhistic substance lacking definite characteristics of either amyloid or collid milium. The term paracolloid degeneration of the skin is introduced to designate this substance which is believed to derive from collagen. A review of the literature showed similar cases previously published under the names of nodular amyloidosis or disseminated colloid.