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1.
The spin probe method was employed to study in vitro the effect of regulatory peptide thyroliberin on structural state of surface (0.8 nm) and deep (2 nm) lipid layers of the
plasma membranes in mouse liver and brain. Thyroliberin in a concentration range of 10−3–10−18 M enhanced structural order of surface lipids, the maximum effect was observed at 10−9–10−10 M. The dose-effect dependencies for microviscosity of deep lipids were nonlinear and had 3 extrema at 10−4–10−7 M, 10−9 M, and 10−14–10−16 M. The greatest changes in lipid microviscosity produced by 10−9 M thyroliberin are explained by lipid-receptor interaction.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 8, pp. 151–154, August, 2007 相似文献
2.
V. V. Semenov M. Ya. Ibragimova B. I. Barabanshchikov 《Bulletin of experimental biology and medicine》1998,126(4):1023-1024
Experiments withCrepis capillaris dry seeds show that pretreatment with adrenaline hydrochloride and adrenaline hydrotartrate significantly reduces the number
of aberrations induced by the supermutagen ethylmethane sulfonate. The effective concentration ranges for adrenaline adrenaline
hydrotartrate and hydrochloride are 10−1–10−7 M and 10−3–10−7 M, respectively. Adrenaline hydrochloride is more effective than adrenaline hydrotartrate (79.1vs. 65%, respectively).
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 10, pp. 427–429, October, 1998 相似文献
3.
A study is performed of the effect of the phenol antioxidant katavidan on autooxidation of microsomes from rat liver exposed
to visible light. It is shown that katavidan in a concentration of 10−3 M inhibits but in concentrations of 10−5–10−7 M stimulates autooxidation of microsomes. No stimulation is observed under conditions of dark incubation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, № 10, pp. 393–394, October, 1994
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences 相似文献
4.
Yu. V. Burov L. V. Tat'yanenko N. V. Kharakhonycheva T. A. Kondrat'eva T. N. Robakidze 《Bulletin of experimental biology and medicine》1995,120(5):1125-1127
The effects of amiridine and of the comparable drugs tacrine and piracetam on synaptosomes and membranes of sarcoplasmic reticulum
were studied by electron paramagnetic resonance; in addition, the effects of these drugs on the activity of Ca2+, Mg2+-dependent ATPase regulating calcium transport in neurons were investigated. In concentrations of 10−7 to 10−5 M the drugs did not affect the structure of synaptosomal membranes of rat brain. Amiridine and tacrine in a concentration
of 0.1 mM reduced the rate of calcium ion transport across the sarcoplasmic reticulum membrane by inhibiting the function
of Ca2+, Mg2+-dependent ATPase and induced marked changes of the structural rigidity of the protein part of the membrane.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N№ 11, pp. 503–505, November, 1995
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences 相似文献
5.
E. I. Solntseva Yu. V. Bukanova R. U. Ostrovskaya T. A. Gudasheva T. A. Voronina V. G. Skrebitskii 《Bulletin of experimental biology and medicine》1996,121(2):138-142
The effect of two nootropics, piracetam and N-phenylacetyl-L-prolyglycine ethyl ester (GVS-111), is studied by measuring high-threshold
K+ and Ca2+ currents in isolated snail neurons using a two-microelectrode patch-clamp technique. Piracetam and GVS-111 are shown to reduce
the amplitude of both the K+ and the Ca2+ (to a lesser extent) current. The threshold concentrations for GVS-111 and piracetam are 10−9-10−8 M and 1–5×10−4 M, respectively. It is assumed that the antiamnestic effect of the nootropics is partially mediated by a blockade of ion
channels of the neuronal membrane.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 151–155, February, 1996
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
6.
A. A. Karelin R. N. Korotkina G. N. Matskevich V. V. Borisov A. A. Vishnevskii L. V. Polikarpova A. G. Kunitsyn 《Bulletin of experimental biology and medicine》2000,130(4):973-975
In vitro effects of folic acid (10−5, 10−4, and 10−3 M) on activities of γ-glutamyltransferase and glutathione reductase, the enzymes involved in glutathione metabolism, were
studied in tissue samples obtained after surgical treatment of the lungs and thymus. Folic acid did not change γ-glutamyltransferase
activity in lung cancer tissue, but in thymoma tissue this substance in a concentration of 10−3 M inhibited it by 16%. Folic acid had no effects on glutathione reductase activity in benign tumors and normal lung and thymus
tissues, but increased this activity in thymoma and lung cancer tissues. Activation of glutathione reductase was probably
related to binding of folic acid in the allosteric center of the enzyme, which probably induced conformational changes in
the catalytic center, acceleration of electron transport from NADPH2 to oxidized glutathione via flavin adenine nucleotide, and intense production of reduced glutathione.
Translated fromByulleten', Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 10, pp. 422–425, October, 2000 相似文献
7.
A. V. Semeikin V. M. Rzheznikov O. N. Minailova Ya. V. Dobrynin E. E. Mayatskaya 《Bulletin of experimental biology and medicine》1999,127(3):272-274
Antiproliferative effect of bis-β-chlorethylamine estrogen derivatives on human ovarian adenocarcinoma CaOV cells depends
on the dose of the drug. In concentrations of 10−5 and 5×10−6 M they inhibit, while in a dose of 5×10−7 M stimulate cell proliferation. It is assumed that CaOV cells express estradiol receptors. The interaction of these cytostatics
with estrogen-binding sites on CaOV cells is demonstrated.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 302–304, March, 1999 相似文献
8.
G. V. Cherepnev Yu. D. Slabnov A. P. Tsibul'kin F. G. Karimova R. S. Garaev 《Bulletin of experimental biology and medicine》1999,127(1):59-62
High radioprotective activity of xymedon was shown in mice. Radioprotective effects of this preparation were accompanied by
restoration of the delayed-type hypersensitivity response and Ca2+-ATPase activity in splenocytes which were inhibited by γ-irradiation (3 Gy). At concentrations of 10−3 and 10−6 M xymedon stimulated the activity of DNA topoisomerase-I of splenocyte nuclei. Here we discuss a mechanism of radioprotective
effects of pyrimidine derivatives associated with the inhibition of apoptosis of lymphoid cells and the stimulation of proliferation
and differentiation of lymphoid precursor cells.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 1, pp. 66–70, January, 1999 相似文献
9.
T. G. Pukhal’skaya O. A. Kolosova M. Y. Men’shikov A. M. Vein 《Bulletin of experimental biology and medicine》2000,130(1):633-635
Flunarizine and cinnarizine (IC50 6.8×10−6 and 2.8×10−5 M, respectively) inhibited3H-serotonin uptake by platelets. In higher doses, they blocked serotonin-induced platelet aggregation and stimulated3H-serotonin release from these cells. Imipramine did not affect serotonin-releasing effects of preparations. In all patients
cinnarizine was more potent in inhibiting serotonin uptake, and in half of the patients cinnarizine displayed higher activity
as an inductor of serotonin release.
Translated fromByulleten's Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 24–27, July, 2000 相似文献
10.
Antioxidant properties of thiamine 总被引:1,自引:0,他引:1
P. I. Lukienko N. G. Mel'nichenko I. V. Zverinskii S. V. Zabrodskaya 《Bulletin of experimental biology and medicine》2000,130(3):874-876
Thiamine (10−4–10−6 M) inhibits lipid peroxidation in rat liver microsome and free radical oxidation of oleic acidin vitro. Thiamine interacts with free radicals and hydroperoxides and is oxidized to thiochrome and thiamine disulfide. The antioxidant
effect of thiamine is probably related to sucessive transfer of 2H+ from the NH2 group of the pyrimidine ring and H+ from the thiazole ring (after its opening) to reactive substrates.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 9, pp. 303–305, September, 2000 相似文献
11.
I. G. Rebrov G. N. Kryzhanovskii N. P. Belykh T. F. Shukalova R. N. Glebov 《Bulletin of experimental biology and medicine》1996,122(2):778-781
Effects of picrotoxin and bicuculline on the muscimol-dependent36Cl− entry into synaptoneurosomes of the rat cerebral cortex are examined as well as desensitization of36Cl− entry at muscimol concentrations of 5 and 50 μM. At the 5 μM concentration (which is close to the muscimol IC50), picrotoxin and bicuculline inhibited Cl− entry into synaptoneurosomes and decreased the desensitization. At the 50 μM concentration, muscimol completely abolishes
the bicuculline effects both on Cl− entry and desensitization. Inhibition of Cl− entry by picrotoxin is also abolished by 50 μM muscimol, whereas the picrotoxin-induced decrease in the desensitization rate
is not. It is shown that both bicuculline effects result from inhibition of the GABA receptor, but the action of picrotoxin
on the desensitization of Cl− entry into synaptoneurosomes is not closely related to the functional activity of the GABA receptor/Cl− channel complex.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 8, pp. 144–147, August, 1996 相似文献
12.
Pukhal'skaya TG Kolosova OA Men'shikov MY Vein AM 《Bulletin of experimental biology and medicine》2000,130(7):633-635
Flunarizine and cinnarizine (IC50 6.8×10−6 and 2.8×10−5 M, respectively) inhibited3H-serotonin uptake by platelets. In higher doses, they blocked serotonin-induced platelet aggregation and stimulated3H-serotonin release from these cells. Imipramine did not affect serotonin-releasing effects of preparations. In all patients
cinnarizine was more potent in inhibiting serotonin uptake, and in half of the patients cinnarizine displayed higher activity
as an inductor of serotonin release.
Translated fromByulleten's Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 24–27, July, 2000 相似文献
13.
P. V. Sergeev S. A. Chukaev Yu. A. Korovkina 《Bulletin of experimental biology and medicine》1997,124(2):786-788
Effects of estradiol and testosterone and of the antiandrogens cyproterone acetate, niftolide, and antiestrogen tamoxifen
on the activities of human erythrocyte glutathione peroxidase and glutathione reductase were studiedin vitro. In contrast to hormone preperations, antihormones in high concentrations (10−4−5×10−4 M) modified the enzyme activities. Cyproterone acetate and tamoxifen increased the activity of glutathione reductase, while
tamoxifen stimulated glutathione reductase and inhibited glutathione peroxidase. Niftolide inhibited both enzymes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 185–187, August, 1997 相似文献
14.
O. I. Epshtein Kh. L. Gainutdinov M. B. Shtark 《Bulletin of experimental biology and medicine》1999,127(4):423-424
Various dilutions of antibodies to brain-specific protein S100, including those prepared by multiple consecutive dilutions
up to 10−12 and 10−400 of total weight, produced similar effects on the membranes ofHelix pomatia giant neurons, which varied only quantitatively. They induced membrane depolarization, reduced the amplitude or completely
blocked the action potential, accelerated the maximal rise of the action potential, reduced maximal conductance, and facilitated
the steady-state inactivation of ionic channels.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 4, pp. 466–467, April, 1999 相似文献
15.
Lukienko PI Mel'nichenko NG Zverinskii IV Zabrodskaya SV 《Bulletin of experimental biology and medicine》2000,130(9):874-876
Thiamine (10−4–10−6 M) inhibits lipid peroxidation in rat liver microsome and free radical oxidation of oleic acidin vitro. Thiamine interacts with free radicals and hydroperoxides and is oxidized to thiochrome and thiamine disulfide. The antioxidant
effect of thiamine is probably related to sucessive transfer of 2H+ from the NH2 group of the pyrimidine ring and H+ from the thiazole ring (after its opening) to reactive substrates.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 9, pp. 303–305, September, 2000 相似文献
16.
T. S. Golubeva O. Yu. Chertov M. V. Kiselevskii A. R. Tuguz 《Bulletin of experimental biology and medicine》1997,124(5):1104-1106
No nucleosomal fragmentation of DNA from lung adenocarcinoma cells was observed after 18 h of their incubation with normal
human platelets isolated from human peripheral blood. Platelet activation with 10−6, 10−7, and 10−8 M PAF did not lead to nucleosomal fragmentation of the target cell DNA.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 11, pp. 547–549, November, 1997 相似文献
17.
Semeikin AV Rzheznikov VM Mayatskaya EE Smirnova ZS 《Bulletin of experimental biology and medicine》2000,129(6):592-594
The effects of four new synthetic bis-β-chloroethylamine-containing estrogens and known cytostatic agents chlorophenacyl and
estradiol mustard were compared on monolayer cultures of transformed L-929 fibroblasts (from murine skin sarcoma). The drugs
within the concentration range of 10−5-5×10−7M inhibited proliferation of cultured cells by 67%. Chlorophenacyl displayed the least antiproliferative activity (15% inhibition
at 10−5M). Steroid nucleus introduced into the molecule enhanced antiproliferative activity of test drug in comparison with chlorophenacyl,
probably due to accumulation of the hormone-cytostatic molecules in cells. Estradiol had no effect on proliferative activity
of L-929 cells, and no specific estrogen-binding sites were found in cultured transformed fibroblasts. The antiproliferative
effect of hormone-cytostatics on this culture is not mediated via specific interactions with estrogen receptors.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 6, pp. 695–697, June, 2000 相似文献
18.
G. M. Molodavkin E. B. Burlakova L. I. Chernyavskaya T. A. Voronina N. I. Khorseva S. B. Seredenin 《Bulletin of experimental biology and medicine》1996,121(2):151-153
Benzodiazepine tranquilizers, phenazepam and flunitrazepam, administered to random-bred albino male rats in superlow doses
(10−9–10−15 mol/kg), are shown to exert an anxiolytic effect in the conflict test. In contrast to the case with the usual doses, the
above effect is not accompanied by marked myorelaxant or sedative effects.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, № 2, pp. 164–166, February, 1996 相似文献
19.
S. A. Gavrilova A. A. Guseva N. A. Medvedeva 《Bulletin of experimental biology and medicine》1997,124(5):1052-1055
The effects of bolus administration and short-term infusion of endothelin 1 in four doses (2×10−16, 2×10−14, 2×10−12, and 2×10−10 mol/kg) on arterial pressure and heart rate were compared in awake rats. Infusion and bolus administration of the two highest
doses increased arterial pressure and provoked bradycardia. Infusion of the two lowest doses increased heart rate without
concomitant changes in arterial pressure, while bolus injection of endothelin 1 in the same doses decreased both arterial
pressure and the heart rate.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 11, pp. 491–494, November, 1997 相似文献
20.
N. F. Avrova V. P. Ivanova V. A. Tyurin I. A. Gamalei I. V. Klyubin I. A. Shchepetkin E. V. Borunov Yu. Yu. Tyurina 《Bulletin of experimental biology and medicine》1994,117(1):45-47
It is shown that ganglioside GM1 in picomolar concentrations stimulates the phorbol-12-myristate-13-acetate (PMA)-induced
generation of active forms of oxygen by neutrophils and peritoneal macrophages. GM1 (10−11 M) is found to enhance the luminol-dependent chemiluminescence induced by 10−8 M PMA in mouse macrophages in comparison with the effect of PMA alone.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
1, pp. 44–46, January, 1994
Presented by A. N. Klimov, Member of the Russian Academy of Medical Sciences 相似文献