糖周灵胶囊对STZ诱导糖尿病大鼠下肢神经机械痛阈的影响

目的:糖周灵胶囊对STZ诱导糖尿病大鼠下肢神经机械痛阈的影响。方法:将60只雄性SD大鼠适应性饲养1周后,随机分为正常对照组和造模组,其中正常组(10只),造模组分为糖尿病组、糖周灵小剂量组、中剂量组、高剂量组、维生素c组各10只;造模成功后,糖周灵小剂量组以糖尿病0.44 g/(kg·d)给药;中剂量组按0.88 g/(kg·d)给药;大剂量组按1.75 g/(kg·d)给药,维生素C组按0.05 g/(kg·d)给药,糖尿病组及对照组给予等量蒸馏水,给药时间为16周,16周后用Von Frey测量仪测定机械痛阈值,观察糖周灵胶囊对糖尿病大鼠下肢神经机械痛阈的影响。结果:正常对照组与维生素C组存在明显差异(P0.05);正常对照组、模型组与小剂量组存在明显差异(P0.01);模型组与小剂量组、中剂量组、大剂量组存在显著差异(P0.01),与维C组相比,糖周灵小、中、大剂量组存在明显差异(P0.05),与糖周灵大剂量相比,糖周灵小、中剂量无明显差异(P0.05)。结论:糖尿病模型组机械痛阈值最低,糖周灵糖周灵胶囊一定程度上可以提高糖尿病大鼠机械痛阈值,改善糖尿病神经病变神经功能,对糖尿病周围神经病变具有一定保护作用。     

大叶团花中一种醛糖还原酶和山梨醇积聚抑制剂的分离和鉴定

醛糖还原酶是多元醇途径的一种关键酶。该酶在糖尿病并发症如神经稿变、视网膜病变和白内障病理过程中具有重要意义。山梨醇经醛糖还原酶催化产生较山梨醇脱氢酶转化产生更迅速,从而导致山梨醇积聚。极性糖乙醇的细胞内积聚可产生高渗作用,     

糖末通丸治疗糖尿病周围神经病变148例观察

目的：观察糖末通丸治疗糖尿病周围神经病变的疗效。方法：288例分为两组，治疗组148例在用西药控制血糖的基础上加糖末通丸治疗，对照组140例用西药控制血糖及加维生素B、维生素B12治疗，1个月为一疗程。结果：治疗组总有效率96．6％，对照组总有效率85．7％，两组比较有非常显著性差异（P〈0．01）。结论：糖末通丸能明显改善糖尿病周围神经病变的临床症状。     

中西医结合治疗外伤性前房出血40例

中西医结合治疗外伤性前房出血４０例解放军２０８医院（１３００００）王秋，薛兰长春市宽城区中医院时岩【关键词】外伤性前房出血，高渗糖，三七注射液外伤性前房出血是眼外伤常见的并发症，处置不当常可引起继发性青光眼及角膜血染等并发症。笔者应用高渗糖静脉注射、...     

入夏杨梅食疗佳

杨梅为夏季水果之一，其富含丰富的蛋白质、糖、果酸、钙、磷及多种维生素，其中维生素C、B12对防癌治癌有积极作用。果中的纤维素可刺激肠管蠕动，有利于体内有害物质的排泄。夏季选用杨梅可用于辅助治疗各类疾病，大家不妨一试。     

高渗糖局部治疗腹部切口脂肪液化的临床研究

目的:探讨高渗糖局部治疗腹部切口脂肪液化的疗效。方法:48例患者随机分为治疗组(28例)和对照组(20例)。对照组应用生理盐水冲洗伤口并置入干纱条引流;治疗组在此基础上,局部应用高渗糖溶液冲洗后,置入高渗糖湿纱条引流,观察切口愈合情况。结果:治疗组切口愈合时间显著低于对照组。结论:腹部切口脂肪液化局部高渗糖溶液治疗能显著缩短愈合时间。     

糖末安治疗糖尿病周围神经病变32例临床观察

目的：对糖末安胶囊的临床效果进行观察，并与临床使用维生素B1、B12的患者进行对照。方法：治疗组口服糖末安胶囊，每次5粒，每日3次；对照组肌注维生素B1、B12隔日1次，均30天为1个疗程。结果：治疗组显效率为53．66％，总有效率为87．5％，对照组显效率为20％，总有效率为50％。结论：糖末安胶囊能明显缓解糖尿病周围神经病变(DPN)临床症状，改善血液流变学特征，提高神经传导速度，治疗DPN临床疗效显著。     

桃金娘果多糖的抗氧化性研究

目的：探研桃金娘果多糖的抗氧化能力。方法：采用SephadexG-100凝胶层析法对桃金娘果多糖进行分离、纯化,获得纯化多糖I（CPI多糖）和纯化多糖Ⅱ（CPⅡ多糖）2个组分的多糖。分别测定桃金娘果粗多糖、CPⅠ多糖和CPⅡ多糖对Fe3＋的还原能力,并采用羟基自由基（·oH）体系、1,1-二苯基苦基苯肼基自由基（DPPH·）体系,对粗多糖、CPI多糖和CPⅡ多糖进行抗氧化性能研究,以维生素C作为对照。结果：CPⅡ多糖对·OH和DPPH·均表现出较强的清除能力,与维生素C的抗氧化能力相接近。结论：桃金娘果CPⅡ多糖具有较强的抗氧化作用,还原能力接近维生素C;粗多糖有一定的抗氧化能力,CPI多糖几乎没有抗氧化能力。     

糖神散治疗2型糖尿病周围神经病变临床研究

目的 :观察糖神散对 2型糖尿病周围神经病变的作用并探讨其作用机制。方法 :随机将 80例病人分成治疗组、中药对照组、西药对照组 ,分别口服糖神散、济生肾气丸、维生素 B1 及维生素 B6 ,治疗 14周。结果 :糖神散可明显改善临床症状 ;对血糖、果糖胺有降低作用 ,但无统计学意义 ;对血脂、肝功能、肾功能无影响 ;可明显降低红细胞中山梨醇的含量 ,改善血液流变学指标 ,加快运动神经传导速度。结论 :糖神散主要通过抑制多元醇代谢亢进和改善血液流变学来实现对 2型糖尿病周围神经病变的治疗     

糖痹康对DPN大鼠山梨醇通路的影响

目的探讨糖痹康对糖尿病周围神经病变(DPN)大鼠山梨醇通路的影响。方法按空腹血糖水平,从80只Wister大鼠中随机抽取20只作为空白对照组,其余60只大鼠采用一次性腹腔注射60 mg/kg STZ建立糖尿病模型,1周后测空腹血糖,血糖≥16.7 mmol/L者入选高血糖模型。高血糖造模8周后,以空腹血糖升高,坐骨神经神经传导速度降低,鼠尾热痛阈值升高,坐骨神经轴突萎缩和脱髓鞘作为DPN造模成功。将40只DPN大鼠随机分为模型对照组,弥可保组,糖痹康低、中、高剂量组,给予药物治疗4周后测定醛糖还原酶活力,Na+-K+ATP酶活力及山梨醇含量。结果与空白对照组比较,模型对照组、弥可保组及糖痹康低、中、高剂量组大鼠醛糖还原酶活力升高(P0.01),坐骨神经中山梨醇含量增加(P0.01),Na+-K+ATP酶活力降低(P0.01);与模型对照组比较,弥可保组及糖痹康低、中、高剂量组大鼠醛糖还原酶活力降低(P0.01),坐骨神经中山梨醇含量降低(P0.01),Na+-K+ATP酶活力升高(P0.01)。结论糖痹康能够降低醛糖还原酶活力,降低山梨醇含量及提高ATP酶活力,通过调节山梨醇代谢通路改善DPN,可能是糖痹康治疗DPN的作用机制之一。     

鱼腥草注射液与15种药物和3种输液的配伍稳定性研究

目的:探讨鱼腥草注射液与临床上常用的15种药物和3种输液配伍稳定性,为临床鱼腥草注射液的合理配伍用药提供参考。方法:按照临床配伍方式,将鱼腥草注射液与所选取的15种常用药物和3种输液进行配伍,测定配伍后10 min和2 h的外观、pH、不溶性微粒和鱼腥草素含量的变化。结果:鱼腥草注射液与更昔洛韦和维生素B1配伍后pH均超过了注射剂允许的范围,除了庆大霉素注射液、5%和10%葡萄糖注射液外,鱼腥草注射液与其他注射液配伍含10μm微粒数均超过药典规定,与左氧氟沙星、环丙沙星、庆大霉素、地塞米松和维生素C配伍后,鱼腥草素的含量下降均接近甚至超过10%。结论:鱼腥草注射液与5%和10%葡萄糖注射液无明显配伍禁忌,但应避免与5%葡萄糖盐水和上述15种药物配伍使用。     

金粟兰酊湿敷配合TDP照射治疗带状疱疹临床观察

目的 观察金粟兰酊在带状疱疹患者治疗中的作用.方法 将患者92例随机平分为两组,均同时使用复方甘草酸苷注射液、维生素C、维生素B12静脉治疗的基础上,治疗组患者皮损处用金粟兰酊湿敷加TDP照射20 min,对照组采用3％的硼酸溶液湿敷20 min.结果 观察组患者在治疗有效率、止疱时间、止痛时间、结痂时间、皮损痊愈时间、是否留有后遗神经痛等方面明显优于对照组（P＜0.05）.结论 金粟兰酊湿敷配合TDP照射可显著缩短带状疱疹患者病程、减少或减轻后遗神经痛的发生.     

清眩汤治疗椎基底动脉供血不足眩晕临床疗效观察

目的：观察清眩汤治疗椎基底动脉供血不足眩晕的临床疗效和相关实验室检查改变。方法：72例椎基底动脉供血不足眩晕患者确诊后随机分成治疗纽和对照组,2纽综合治疗均给予西比灵、维生素E口服和维生素B6200rag、胞二磷胆碱500rag加于5％葡萄糖生理盐水500ml中静脉滴注,qd,治疗组除上述用药外,每日口服1剂清眩汤,水煎服,分早、晚两次口服,疗程为14天。观察项目包括起效时间、临床疗效、治疗前后经头颅多普勒（TCD）及血流变学变化和3个月内复发率。结果：治疗组在起效时间、临床疗效、治疗前后TCD和血流变学变化及防止复发等方面均优于对照组（P〈0．05）。结论：在椎基底动脉供血不足眩晕的综合治疗中,加用清眩汤可显著提高临床疗效。     

甲亢性肝功能损害270例临床分析

目的：探讨甲亢性肝损害的临床特点和治疗措施。方法：回顾性地分析270例甲亢性肝损害的临床资料。结果：①甲亢性肝损害的发生率为31％,肝损害发生率与年龄大小,甲亢病程,病情轻重呈正相关（P〈0．05）;②肝功能损害以ALT升高为主（占85．1％）;③治疗以控制甲亢为主,保肝为辅。结论：甲亢容易合并肝功能损害,肝功能损害的轻重程度与患者年龄大小、病程长短及病情轻重有关。甲亢性肝损害如诊断及时,积极治疗,预后良好。     

硫普罗宁治疗酒精性肝炎36例临床观察

目的：探讨硫普罗宁（化学名称：N-（2-巯基丙酰基）-甘氨酸）对酒精性肝炎的临床疗效。方法：酒精性肝炎患者56例,随机分成2组,观察组36例,对照组20例。两组患者均严格戒酒,注意休息,给予高蛋白、高热量、低脂饮食,并补充维生素B、维生素C、维生素K及叶酸,给予强力宁、肝泰乐、能量合剂等保肝药物。观察组加用硫普罗宁200mg,加入5％葡萄糖注射液250ml静滴,1次／d。4周为一疗程,观察临床症状、体征变化和不良反应,疗程结束后复查肝功及肝脏B超。结果：观察组总有效率为94．4％,对照组总有效率为70％,两组治疗前后血清天门冬酸氨基转移酶、丙氨酸氨基转移酶、谷氨酰转肽酶下降非常明显,差异具有显著性（P〈0．05）。结论：硫普罗宁治疗酒精性肝炎疗效显著。     

Quercetin allievates oxidative stress in streptozotocin-induced diabetic rats

Diabetes mellitus is found in almost all populations and is emerging as a growing problem in developing countries. A large number of studies are in progress to fi nd natural sources, which are effective in reducing the intensity of diabetes. Quercetin, a constituent present in fruits and vegetables, was studied in two different doses (50 and 80 mg/kg body weight) for 45 days to assess its effect on streptozotocin induced diabetes. The blood glucose level was elevated in diabetic rats. Circulatory lipid peroxidation, vitamin C, vitamin E and enzymic antioxidants such as superoxide dismutase and catalase were analyzed. Alterations in the antioxidant defense were observed in diabetic animals compared to normal. Oral administration of quercetin to diabetic rats resulted in a decrease in the levels of blood glucose, plasma thiobarbituric acid reactive substances and hydroperoxides. Quercetin also resulted in the activities of superoxide dismutase, catalase coming to near normal, along with the levels of vitamin C and vitamin E. Quercetin at lower doses was found to be more effective. These result indicate that quercetin ameliorated the diabetes-induced changes in oxidative stress.     

The wound healing properties of Channa striatus-cetrimide cream-- tensile strength measurement

Channa striatus, a fresh water snakehead fish, is reported to enhance dermal wound healing. Biochemical components such as amino acids and fatty acids are important for the synthesis of collagen fibers during wound healing. Arachidonic acid, a precursor of prostaglandin plays a vital role in healing the wounds. Haruan (C. striatus) contains all the essential amino acids for wound healing particularly glycine as well as high contents of arachidonic acid and polyunsaturated fatty acids that can promote prostaglandin synthesis. In the present work we have studied the wound healing effect of C. striatus in Sprague-Dawley rats. Cream formulations having different haruan fish extract concentrations as the active ingredient were prepared and stabilized, and they were applied to the wounds. The healing of wounds was characterized by an increase in the tensile strength of the skin, determined on the 7th post-operative day in each case. Haruan treatment of wounds promotes remodeling of collagen, by the synthesis of inter- and intra-molecular protein crosslinking and thus produces a marked increase (P<0.05) in tensile strength as compared to the cetrimide treated group. On the basis of our experiment we conclude that C. striatus helps in wound healing as indicated by the increase in tensile strength. We hypothesise that this effect may be due to its high content of arachidonic acid, glycine and polyunsaturated fatty acids. The mechanism of wound healing will be investigated in future studies.     

复方木尼孜其颗粒治疗黄褐斑临床疗效观察及安全性评价

目的:探讨复方木尼孜其颗粒治疗黄褐斑临床疗效及安全性评价,为临床诊断治疗提供参考。方法:将本组120例黄褐斑患者根据随机数字表法随机分为对照组(n=60)和观察组(n=60)。观察组给予复方木尼孜其颗粒治疗,对照组口服维生素C、维生素E治疗。两组均以1个月为1个治疗疗程,两个疗程后观察疗效。结果:观察组治疗后总有效率(78.33%)显著高于对照组(55.00%),且具有显著性差异(P<0.05);两组患者治疗前FSH、LH、E2比较无显著性差异(P>0.05);观察组患者治疗后FSH、LH、E2均明显低于治疗前,且具有显著性差异(P<0.05);观察组治疗后LH、E2显著低于对照组治疗后,且有显著性差异(P<0.05);而FSH比较两组变化无显著性差异(P>0.05);观察组治疗后MCI值显著低于对照组,且有显著性差异(P<0.05);两组患者均未出现明显的不良反应。结论:复方木尼孜其颗粒治疗黄褐斑临床疗效显著,可明显改善患者皮损区皮肤,具有重要临床研究价值,值得推广应用。     

Treatment of melasma with Pycnogenol

Melasma (or chloasma) is a common disorder of cutaneous hyperpigmentation predominantly affecting sun-exposed areas in women. The pathogenesis of melasma is not fully understood and treatments are frequently disappointing and often associated with side effects.Pycnogenol is a standardized extract of the bark of the French maritime pine (Pinus pinaster), a well-known, potent antioxidant. Studies in vitro show that Pycnogenol is several times more powerful than vitamin E and vitamin C. In addition, it recycles vitamin C, regenerates vitamin E and increases the endogenous antioxidant enzyme system. Pycnogenol protects against ultraviolet (UV) radiation. Therefore its efficacy in the treatment of melasma was investigated.Thirty women with melasma completed a 30-day clinical trial in which they took one 25 mg tablet of Pycnogenol with meals three times daily, i.e. 75 mg Pycnogenol per day. These patients were evaluated clinically by parameters such as the melasma area index, pigmentary intensity index and by routine blood and urine tests.After a 30-day treatment, the average melasma area of the patients decreased by 25.86 +/- 20.39 mm(2) (p < 0.001) and the average pigmentary intensity decreased by 0.47 +/- 0.51 unit (p < 0.001). The general effective rate was 80%. No side effect was observed. The results of the blood and urine test parameters at baseline and at day 30 were within the normal range. Moreover, several other associated symptoms such as fatigue, constipation, pains in the body and anxiety were also improved.To conclude, Pycnogenol was shown to be therapeutically effective and safe in patients suffering from melasma.     

Evaluation of wound healing properties of Arrabidaea chica Verlot extract

ETHNOPHARMACOLOGICAL RELEVANCE: Arrabidaea chica Verlot. (Bignoniaceae), popularly known as Crajiru, has been traditionally used as wound healing agent. AIM OF THE STUDY: Investigate in vitro and in vivo healing properties of Arrabidaea chica leaves extract (AC). MATERIALS AND METHODS: AC was evaluated in vitro in fibroblast growth stimulation (0.25-250 microg/mL) and collagen production stimulation (250 microg/mL) assays. Allantoin (0.25-250 microg/mL) and vitamin C (25 microg/mL) were used as controls respectively. DPPH and Folin-Ciocalteau assays were used for antioxidant evaluation, using trolox (0.25-250 microg/mL) as reference antioxidant. To study wound healing properties in rats, AC (100mg/mL, 200 microL/wound/day) was topically administered during 10 days and wound area was evaluated every day. Allantoin (100mg/mL, 200 microL/wound/day) was used as standard drug. After treatment, wound sites were removed for histopathological analysis and total collagen determination. RESULTS: AC stimulated fibroblast growth in a concentration dependent way (EC50=30 microg/mL), increased in vitro collagen production and demonstrated moderate antioxidant capacity. In vivo, AC reduced wound size in 96%, whereas saline group showed only 36% wound healing. CONCLUSION: AC efficiency seems to involve fibroblast growing stimulus and collagen synthesis both in vitro and in vivo, beyond moderate scavenging activity, corroborating Crajiru folk use.