依达拉奉联合奥扎格雷钠治疗急性脑梗死的临床分析

目的观察依达拉奉联合奥扎格雷钠治疗急性脑梗死的疗效和安全性。方法36例急性脑梗死患者给予依达拉奉和奥扎格雷钠,并与应用奥扎格雷钠和三七总甙注射液治疗的34例患者进行比较。结果治疗后依达拉奉组和三七总甙组ESS评分均有改善(P<0.05),但依达拉奉组改善更明显,且与三七总甙组有显著性差异(P<0.05)。结论依达拉奉联合奥扎格雷钠治疗急性脑梗死能有效改善神经功能,安全性高。     

依达拉奉联合奥扎格雷钠治疗急性脑梗死疗效观察

目的：观察依达拉奉联合奥扎格雷钠治疗急性脑梗死患者的疗效。方法选择2010‐02—201‐07邯郸市第二医院收治的55例急性脑梗死患者,随机分为观察组（30例）和对照组（25例）。对照组在常规治疗的同时加用奥扎格雷钠治疗,观察组在对照组治疗基础上加用依达拉奉治疗,评价2组临床疗效、神经功能缺损（NIHSS）评分及日常生活能力（ADL）评分。结果观察组总有效率96.67％,高于对照组的76.00％,2组比较差异有统计学意（P＜0.05）。治疗后2组NIHSS及ADL评分均明显改善,观察组改善幅度优于对照组,差异有统计学意义（ P＜0.05）。结论依达拉奉联合奥扎格雷钠治疗急性脑梗死临床疗效肯定,可改善患者的神经功能缺损评分及日常生活能力,提高患者的生活质量。     

奥扎格雷钠联合依达拉奉治疗急性脑梗死疗效观察

目的观察奥扎格雷钠联合依达拉奉治疗急性脑梗死的临床疗效。方法 150例急性脑梗死患者随机分为依达拉奉(治疗组)75例和常规治疗组(对照组)75例。对照组给予常规治疗并静滴奥扎格雷钠80mg,2次/d,连用14d;治疗组在常规治疗的基础上加用依达拉奉注射液30mg静滴,2次/d,连用14d。2组均禁用溶栓、降纤、抗凝药物及其他神经保护剂。分别在治疗前、后对患者进行欧洲卒中评分(ESS)、日常生活能力(ADL)评定和常规检查,ESS增分率判定临床疗效。结果 2组治疗前后ESS及ADL评分比较差异有统计学意义(P<0.05)。2周后治疗组显效率及有效率明显高于对照组(P<0.05),且无明显不良反应。结论奥扎格雷钠联合依达拉奉能改善脑梗死患者预后,疗效确定。     

奥扎格雷钠联合依达拉奉治疗急性脑梗死的疗效观察

目的：观察奥扎格雷钠联合依达拉奉治疗急性脑梗死的临床疗效。方法126例急性脑梗死患者随机分为治疗组63例和对照组63例,治疗组应用奥扎格雷钠与依达拉奉联合治疗,对照组应用奥扎格雷钠治疗,比较2组疗效。结果治疗组总有效率与基本痊愈率均高于对照组,差异有统计学意义（ P＜0.05）。结论奥扎格雷钠联合依达拉奉治疗急性脑梗死效果显著,疗效安全,值得临床推广应用。     

依达拉奉联合奥扎格雷钠治疗急性脑梗死疗效观察

目的研究依达拉奉联合奥扎格雷治疗急性脑梗死的效果。方法将我院2009年住院的90例急性脑梗死患者随机分为3组,分别采用依达拉奉、奥扎格雷及依达拉奉联合奥扎格雷治疗。结果单用依达拉奉组有效率73.3%,单用奥扎格雷钠组有效率70.0%,联合治疗组有效率86.7%。联合治疗组总有效率分别高于奥扎格雷组和依达拉奉组,差异均有统计学意义（P〈0.05）,依达拉奉组与奥扎格雷钠组比较差异无统计学意义（P〉0.05）。结论依达拉奉联合奥扎格雷治疗急性脑梗死效果好,值得临床推广应用。     

依达拉奉联合奥扎格雷钠治疗2型糖尿病并发急性脑梗死疗效

目的探讨依达拉奉联合奥扎格雷钠治疗2型糖尿病并发急性脑梗死的有效性及安全性。方法选取我院收治的52例2型糖尿病并发急性脑梗死患者,分为单一组(n=26)和联合组(n=26),单一组单纯使用奥扎格雷钠治疗,联合组应用依达拉奉和奥扎格雷钠治疗,比较2组治疗效果及不良反应发生情况。结果联合组神经功能缺损评分、日常生活活动能力评分明显优于单一组(P0.05);联合组有效率为88.46%,明显高于单一组的73.08%,差异有统计学意义(P0.05);2组不良反应率比较,差异无统计学意义(P0.05)。结论依达拉奉联合奥扎格雷钠治疗2型糖尿病并发急性脑梗死具有一定的有效性和安全性,可促进患者神经功能康复和提高生活质量,值得推广应用。     

奥扎格雷钠联合依达拉奉治疗对急性脑梗死患者神经系统功能恢复的影响

目的：探讨奥扎格雷钠联合依达拉奉治疗对急性脑梗死患者神经系统功能恢复的影响。方法选取2011‐01—2014‐01于我院治疗的130例急性脑梗死患者为研究对象,随机分为观察组65例和对照组65例,对照组在常规治疗的基础上,静滴奥扎格雷钠;治疗组在对照组治疗基础上静滴依达拉奉,14 d为一疗程,比较2组患者治疗前后的神经功能缺损评分并评价临床疗效。结果治疗后观察组和对照组患者NIHSS评分及NDS评分均较治疗前有明显改善,差异有统计学意义（P＜0.01）;且观察组治疗后NIHSS评分及NDS评分均优于对照组,差异有统计学意义（P＜0.01）。结论奥扎格雷钠联合依达拉奉治疗有利于急性脑梗死患者神经系统功能恢复,可明显提高临床疗效。     

依达拉奉联合奥扎格雷钠治疗脑梗死临床研究

目的 观察依达拉奉联合奥扎格雷钠治疗脑梗死的疗效及安全性.方法 120例脑梗死患者随机分为2组,分别采用奥扎格雷钠及依达拉奉联合奥扎格雷钠治疗.以疗程14d神经功能缺损程度评分及2个月时日常生活能力指数评分(Barthel)为标准观察疗效.结果 治疗组显效率、总有效率、神经功能缺损程度评分和日常生活能力指数评分改变与对照组比较,差异均有统计学意义(均P<0.05),2组均无明显不良反应.结论 依达拉奉联合奥扎格雷钠治疗脑梗死安全有效,能显著改善患者的预后.     

依达拉奉联合奥扎格雷钠治疗进展性脑梗死临床观察

目的 观察依达拉奉联合奥扎格雷钠治疗进展性脑梗死的疗效和安全性.方法 符合进展性脑梗死标准的82例患者随机分为观察组42例和对照组40例.对照组患者给予常规治疗+奥扎格雷钠;观察组给予常规治疗+奥扎格雷钠+依达拉奉.2组疗程均为21 d.2组患者于治疗前后进行NIHSS神经功能缺损评分、日常生活能力(ADL)评分和hs-CRP、D-二聚体的测定.结果 治疗21 d后,观察组痊愈率和总有效率均显著高于对照组(χ2=4.0397,4.8308,P均＜0.05).在hs-CRP、D-二聚体、NIHSS评分、ADL评分四项指标方面,治疗后观察组均显著优于对照组(t=2.4486,2.5964,2.1936,7.0401,P＜0.05).结论 依达拉奉与奥扎格雷钠联合治疗进展性脑梗死有协同效果,优于奥扎格雷钠单药治疗,无明显不良反应.     

依达拉奉联合奥扎格雷钠治疗急性脑梗死的疗效观察

目的 探讨依达拉奉联合奥扎格雷钠治疗急性脑梗死的有效性和安全性.方法 将90例急性脑梗死患者随机分为2组,治疗组45例,常规治疗基础上应用依达拉奉30mg加生理盐水100ml,静滴,2次/d,奥扎格雷钠80mg加生理盐水100ml,静滴,2次/d.对照组45例,常规治疗基础上只应用奥扎格雷钠80mg加生理盐水100ml,静滴,2次/d.2周后行疗效评定.结果 治疗组有效率91%,对照组有效率80%.结论 依达拉奉联合奥扎格雷钠治疗急性脑梗死疗效肯定,有效改善急性脑梗死的神经功能缺失.     

Treatment with rituximab in patients with polyneuropathy with anti-MAG antibodies

Journal of Neurology -     

Factors associated with satisfaction with care among patients with epilepsy

OBJECTIVE: The purpose of the work described here was to determine those variables associated with satisfaction with care among patients with epilepsy. METHODS: We interviewed patients followed at a tertiary epilepsy center. Predictor variables included age, gender, race, education, income, insurance, seizure frequency, and Quality of Life in Epilepsy-10 inventory (QOLIE-10) results. Target variables were the subscales of the Short Form Patient Satisfaction Questionnaire (PSQ-18). We used univariate analysis to identify those variables significantly associated with the subscales and multiple linear regression to determine those independently significant. RESULTS: The study population comprised 193 patients. Lower education and better QOLIE-10 scores were independently associated with general satisfaction with care. The mental health scale was associated with general satisfaction with care. Lower educational level was the only variable independently associated with patient satisfaction with communication, the financial aspect of care, and time spent with physician. CONCLUSION: Lower educational level and better quality of life are the main variables associated with higher general satisfaction with care among patients with epilepsy.     

Children with ADHD and motor dysfunction compared with children with ADHD only

The purpose of this study was to identify group differences in children with attention-deficit-hyperactivity disorder and motor dysfunction (ADHD-MD) and ADHD only, and to evaluate the medication responsiveness of ADHD-MD. Sixty-three children (49 males and 14 females; mean age 9 years 10 months, SD 2 years 10 months) underwent a triple blind, placebo-controlled crossover study evaluating two dose levels of methylphenidate (0.3 mg/kg and 0.5 mg/kg [corrected], twice daily) and placebo. Forty-nine trials were completed. Nineteen were children with ADHD-MD, 44 had ADHD only. Behavior and functioning were assessed at home and at school. Treatment effects were assessed using the Abbreviated Symptom Questionnaire for Parents and Teachers. Children with ADHD-MD were more likely to have severe ADHD-combined type and other neurodevelopmental and behavioral problems. Both groups of children had a linear dose response to medication (placebo, low, high) and there was no evidence of a group by dose interaction or an overall group effect at home or school. The lack of group effect suggests that these children responded to medication like the other subgroups.