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1.
Aim of the work
This work aimed to measure serum ferritin and transferrin levels and to study the presence of metabolic syndrome (MetS) in Egyptian systemic lupus erythematosus (SLE) females and to correlate them with disease activity, damage, clinical status and subclinical atherosclerosis.Patients and methods
The study included 50 SLE female patients and 25 matched control. SLE disease activity index (SLEDAI) and damage index (DI) were assessed and the presence of MetS determined. Serum ferritin was measured by enhanced chemi-luminescence and the carotid intima-media thickness (cIMT) was assessed by B-mode ultrasound.Results
The mean cIMT (0.71?±?0.14?mm) and ferritin (2098?±?132.99?ng/ml) were significantly higher in patients compared to controls (0.62?±?0.05?mm and 71.7?±?18.7?ng/ml; p?=?0.003 and p?<?0.001, respectively). 28% of patients and 12% controls had MetS. 6(12%) had a thickened cIMT (≥0.9?mm), 3 of them had atherosclerotic plaques (≥1.3?mm). The cIMT significantly correlated (p?<?0.05) with age (r?=?0.54), disease duration (r?=?0.55), SLEDAI (r?=?0.37), DI (r?=?0.52), ferritin (r?=?0.31), cholesterol (r?=?0.32), triglycerides (r?=?0.7), fasting blood sugar (r?=?0.72), systolic (r?=?0.68) and diastolic (r?=?0.7) blood pressure and negatively with transferrin (r?=??0.31), low (r?=??0.32) and high-density lipoprotein (r?=??0.53) and C3 (r?=??0.66). Patients with MetS had significantly higher cIMT (0.9?±?0.3?mm) versus those without (0.64?±?0.1?mm)(p?<?0.0001).Conclusion
MetS in SLE is a associated with accelerated atherosclerosis while serum ferritin and transferrin are strong indicators of SLE activity and damage. Considering the association with MetS and measuring the cIMT in SLE patients is recommended and provides a useful marker for detecting subclinical cases and predicting future cardiovascular events. 相似文献2.
Background
Coronary artery disease is one of the main causes of death in diabetes mellitus (DM). Egypt was listed among the world top 10 countries regarding the number of diabetic patients by the International Diabetes Federation (IDF).Aim of work
Assessment of the extent of coronary atherosclerotic disease and lesion tissue characterization among diabetic compared to non-diabetic Egyptian patients.Methodology
IVUS studies of 272 coronary lesions in 116 patients presented with unstable angina were examined. The patients were divided into two groups: diabetic group (50 patients with 117 lesions) and non-diabetic group (66 patients with 155 lesions).Results
As compared to the non-diabetic group, the diabetic patients were more dyslipidemic (84% vs 39.4%, p?=?0.001) with higher total cholesterol level (194.6?±?35.3 vs 174.4?±?28.5?mg/dl, p?=?0.001) and higher LDL-C (145.3?±?27.1 vs 123.2?±?31.4, p?=?0.001). Regarding lesions characteristics, the diabetic group had longer lesions (19.4?±?7.4 vs 16.3?±?7.9?mm, p?=?0.002) with higher plaque burden (60.8?±?15.3 vs 54.8?±?14.0, p 0.002) and more area stenosis percentage (60.8?±?15.6 vs 55.6?±?14.1, p?=?0.008). Structurally, the diabetic group lesions had more lipid content (19.8?±?8.8 vs 16.8?±?8.7, p?=?0.008) and more necrotic core (17.6?±?7.4 vs 14.7?±?4.8, p?=?0.008) but less calcification (6.9?±?3.6 vs 11.8?±?6.3, p?=?0.001). The RI was negative in both groups, 0.95?±?0.13 in the diabetic group vs 0.98?±?0.19 in non-diabetic group (p?=?0.5). Within the diabetic group lesions, the dyslipidaemic subgroup had more lipid content (23.?±?5.2 vs 14.6?±?8.6, p?=?0.01) but less fibrotic component (48.6?±?4.7 vs 59.1?±?13.6%, p?=?0.01) and less calcification (10.9?±?6.8% vs 14.07?±?3.8%, p?=?0.02) as compared to the nondyslipidaemic subgroup.Conclusions
Diabetic patients with coronary atherosclerosis in Egypt have longer lesions with higher plaque burden and more percent area stenosis with negative remodeling index. The diabetic lesions had more lipid content and more necrotic core but less calcification. 相似文献3.
Marwa A. Hammad Shaimaa M. Abdel-Latif Omaima Z. Shehata Amany M. Mohiey El-Din 《The Egyptian Rheumatologist》2019,41(1)
Background
Endothelial cell dysfunction has been described in Behçet disease (BD) not only as a cause of major vascular events but also related to chronic inflammation in different organ systems.Aim of the work
To study the relation of serum endocan, a marker of endothelial dysfunction, with clinical manifestations and disease activity in BD patients.Patients and methods
This study included 23 BD patients and 23 matched controls. Disease activity was assessed by the Behcet Disease Current Activity Form (BDCAF). Serum endocan was measured in all subjects.Results
The mean age of the patients was 32.5?±?6.8?years and they were 16 males and 7 females (M:F 2.3:1) with mean disease duration of 7?±?5.2?years. Their mean BDCAF was 2.26?±?1.32. A significant difference was found between serum endocan level among active patients 328.24?±?195.3?ng/L, inactive patients (169.8?±?35.7?ng/L) and controls (160.6?±?39.7?ng/L)(p?=?0.001). Patients with genital ulcers, papulopastular lesions and arthritis at the time of the study had higher serum endocan level than those without (p?=?0.002, p?=?0.006 and p?=?0.0001 respectively). Serum endocan levels correlated significantly with the BDCAF, neutrophil/lymphocyte ratio, platelet lymphocyte ratio and C-reactive protein (r?=?0.94, p?=?0.0001; r?=?0.82, p?=?0.0001, r?=?0.44, p?=?0.04 and r?=?0.48, p?=?0.02 respectively). The optimum serum endocan cut-off point for active BD was 191.5?ng/L with a sensitivity and specificity of 100% and 86% respectively (area under curve 0.99, 95% confidence interval 0.96-1).Conclusion
Serum endocan may serve as a potential marker of disease activity in BD. Patients with genital ulcers, papulopastular lesions and arthritis showed higher serum endocan levels. 相似文献4.
Fatma Yilmaz Coşkun Gülçin Elboğa Gökhan Altunbaş Ertan Vuruşkan Berna Kaya Uğur Murat Sucu 《Journal of electrocardiology》2018,51(3):440-442
Objective
The purpose of this study was to investigate the influence of electrical stimulation transmitted through the body during electroconvulsive therapy on traditional and relatively new ventricular repolarization parameters (Rate corrected QT interval (QTc), QT dispersion (QTd), rate corrected JT interval (JTc), JT dispersion (JTd), T-peak to T-end interval (Tp-e) and Tp-e/QTc ratio) under propofol anaesthesia.Methods
Twenty-two patients (aged 18–50?years) who were each scheduled for ECT for major depression, bipolar disorder or schizophrenia enrolled to the study. Electrocardiography (ECG) recordings were obtained before anaesthesia and within 3–5?min after electrical stimulus of ECT for measurements. QTc, QTd, JTc, JTd, Tp-e and Tp-e/QTc were measured as repolarization indices.Results
The study included twenty-two patients, 9(40.9%) females and 13(59.1%) males, and the mean age accounted for 33.57?±?9.95?years. The comparison of the measured parameters before and after ECT, which were not statistically different, were as follows: QTc (416.52?±?46.64 vs 430.00?±?34.00msn; p?=?0.18), JTc (308.09?± 25.09 vs 315.47?±?26.89msn; p?=?0.30), QTd (22.27?±?11.51 vs 20.45?±?9.9msn; p?=?0.52) and JTd (22.72?±?11.2 vs 17.72?±?10.20msn; p?=?0.06). Also, no significant difference was detected at the following parameters Tp-e (80.0?±?13.45 vs 78.63?±?15.21msn; p?=?0.65) and Tp-e/QTc ratio (0.19?±?0.03 vs 0.18?±?0.07; p?=?0.08). On the other hand, HR showed a significant increase after ECT at 88.13?±?13.74 vs 93.0?±?15.2?bpm; p?=?0.03.Conclusion
QTc, QTd, JTc, JTd, Tp-e interval and Tp-e/QTc ratio, which are thought to be potential repolarisation markers for ventricular arrhythmias, did not demonstrate significant change within 3–5?min of electrical stimulation during ECT. 相似文献5.
Ghada Youssef Nashwa Taher Allam Wafaa Gaber Angie Afifi Dina Hesham 《The Egyptian Heart Journal》2018,70(1):35-40
Background
Rheumatoid arthritis (RA) is associated with elevated plasma level of inflammatory markers. Chronic inflammation is known to predispose to endothelial dysfunction and increased arterial stiffness, which is an important marker of subclinical atherosclerosis and increased cardiovascular risk.Objective
The aim is to test for the relationship between disease activity and arterial stiffness in RA patients.Methods
The study included 90 RA patients, at different grades of disease activity and 45 healthy subjects, as a control group. Patients were subjected to full history taking and clinical examination, laboratory investigations including serum lipid profile and high sensitivity CRP (hs-CRP) measurements and plain x-rays of hands and feet. Modified Larsen method was used as radiographic scoring method. Disease activity score (DAS 28) was used for assessment of disease activity. Transthoracic echocardiography was performed to detect aortic stiffness parameters. Duplex ultrasound imaging of both common carotid arteries was performed to measure carotid stiffness parameters.Results
The mean age of RA patients was 39.86?±?9.39?years and most of them (83.3%) were females. RA patients had higher carotid stiffness index compared to control group patients (8.57?±?4.83 vs 4.08?±?1.13, p?<?.001). Very poor correlation was found between DAS-28 and aortic (r?=?0.1, p?=?.28) as well as carotid (r?=?0.05, p?=?.7) stiffness indices. No statistically significant correlation was found between hs-CRP and aortic stiffness index (r?=?0.64, p?=?.55). Disease duration was significantly correlated to intima-media thickness (p?<?.01) as well as with other carotid stiffness parameters. Age also show a statistically significant positive correlation with carotid stiffness parameters.Conclusion
RA is associated with increased arterial stiffness, a well-recognized marker of cardiovascular risk. This is attributed to the inflammatory nature of the disease. It seems that the most important factors determining stiffness are patients' age and duration of illness. 相似文献6.
Background
Left ventricular (LV) global longitudinal strain (GLS) reliably assesses LV systolic function. The precise relation between LV wall stress and serum Brain natriuretic peptide (BNP) concentrations in hemodialysis (HD) patients needs to be clarified. BNP levels are raised in patients with end-stage renal disease (ESRD) and could reflect LV impairment among HD patients.Aim of this work
This study sought to evaluate the clinical utility of LV-GLS, wall stress and serum BNP levels in chronic HD patients. The correlations between BNP levels with both LV wall stress and LV-GLS were assessed.Patients and methods
30 ESRD patients on regular HD {categorized into 15 patients with LV ejection fraction (EF)?≤?50% and 15 patients with LV EF?>?50%} and 15-age matched healthy subjects were included. LV function and structure were assessed by conventional echocardiography including LV meridional wall stress (LVMWS), LV mass index (LVMI) and 2-dimensional speckle tracking echocardiography for determination of LV-GLS. Serum BNP levels were evaluated after HD session.Results
There were significant increase of LVMSW (189.2?±?81 vs. 72.2?±?20.6?dynes/cm2?×?1000, P?<?0.0001), higher levels of BNP (1238?±?1085.5 vs. 71?±?23.4?pg/ml, P?<?0.0001) while LV-GLS was significantly reduced (15.1?±?3.1 vs. 20.8?±?1.7%, P?<?0.0001) in HD patients compared to controls. Higher values of LVMWS (246.9?±?67.5 vs. 131.5?±?43.6?dynes/cm2?×?1000, P?<?0.0001) and BNP (1925.4?±?1087 vs. 550.5?±?496.5?pg/ml, P?<?0.0005) with further impairment of LV-GLS (13.8?±?2.5 vs. 16.4?±?5.4%, P?<?0.05) were found in patients with LV EF?≤?50% than those with LV EF?>?50%. Serum levels of BNP were positively correlated with LVMI (r?=?0.896, P?<?0.0001) and LVMWS (r?=?0.697, P?<?0.0001) but negatively correlated with LV-GLS (r?=??0.587, P?<?0.0001).Conclusion
LV-GLS and LVMWS are useful imaging markers for detection of LV dysfunction in HD patients. Serum BNP level is influenced by LV structural abnormalities and suggested to be a crucial hemodynamic biomarker in those patients. 相似文献7.
Letícia Dinis da C. Braga Amelio F. Godoy-Matos Priscila de Oliveira Siciliano José Otávio do Amaral Corrêa Denise Pires Carvalho 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(5):673-675
Aims
Dipeptidyl peptidase-4 (DPP4) is an adipokine with greater expression in visceral fat and related with insulin resistance (IR). Polycystic ovary syndrome (PCOS) is also associated with IR. Our study aims to evaluate DPP4 activity in PCOS.Materials and Methods
Thirty PCOS patients were compared to 28 healthy women. Body composition by dual X-ray absorptiometry (DXA), plasma activity of DPP4 and biochemical variables were performed. All participants underwent an oral glucose tolerance test for insulin and glucose analysis.Results
DPP4 activity was similar in both groups (PCOS 5823?±?926 vs Control 5501.8?±?975; p?=?0.20). PCOS patients were more IR with lower levels of SHBG (32 vs 47, p?=?0.02) and Matsuda index (15.6 vs 20.4, p?=?0.03) and higher HOMA-IR (2.8 vs 1.7, p?<?0.01), in addition to increased levels of testosterone (55 vs 25, p?<?0.01). DPP4 was correlated to HbA1c (r?=?0.279, p?=?0.03), HDL-c (r?=??0.28, p?=?0.03) and SHBG (r?=??0.256, p?=?0.05).Conclusions
Although PCOS was well characterized as IR and hyperandrogenic, DPP4 was not different in this group. However, a relationship between DPP4 and markers of IR were found. More studies are warranted. 相似文献8.
Kamna Singh Ritu Singh Sudhir Chandra Sanjay Tyagi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):275-278
Objectives
The present study aims to evaluate the levels of HDL and Paraoxonase-1 (PON1) and their correlation in atherosclerotic patients with and without diabetic mellitus (DM) as well as in control subjects in Northern Indian population.Materials and methods
We analyzed lipid profiles and Serum PON1 levels by automated analyzer and ELISA, respectively. Study subjects (N?=?150) were divided in three groups; Group I: Atherosclerotic patients without DM (N?=?50), Group II: Atherosclerotic patients with DM (N?=?50); Group III: Controls (N?=?50).Results
We found a significantly (p?<?0.0001) low levels of HDL-C in Group I (32.2?±?7.3) and Group II (36.9?±?11.5) as compared to Group III (41.0?±?7.1). PON-1 levels were also significantly lower in Group I (60.1?±?10.5) and Group II (50.0?±?13.9) when compared to Group III (95.0?±?12.0). We observed a significant correlation (r?=?0.59, p?<?0.001) between the levels of PON1 and HDL-C in study subjects.Conclusions
The reduced levels of HDL and PON-1 and their significant correlation in CAD patients may be associated with the pathogenesis of this disease. Considering HDL as a dependent variable, Paraoxonase-1 is the most important parameter contributing to the total variation in HDL in CAD. 相似文献9.
Aim of the work
To measure serum peptidyl arginine deiminase (PADI4) enzyme level in rheumatoid arthritis (RA) patients and to assess its role in diagnosis and monitoring patient improvement.Patients and methods
The study included 31 RA patients and 10 age and sex matched healthy controls. Serum PADI4 and anti-cyclic citrullinated peptide (anti-CCP) were measured. Disease activity score (DAS28) was calculated. Patients were followed-up at 3 months with measurement of serum PADI4, anti-CCP and DAS28.Results
Mean age of the patients was 42.4?±?7.8 years, female:male?=?5.2:1 and disease duration 8.1?±?5.4 years. The DAS28 was 5?±?1.2 and modified health assessment questionnaire (MHAQ) was 0.8?±?0.6. Mean anti-CCP (129.3?±?74.8?ng/ml) and PADI-4 levels (532.9?±?240.9?pg/ml) in patients were significantly higher than in controls (8.4?±?4.4?ng/ml and 156?±?31?pg/ml respectively; p?<?0.001 both). At a cut-off value?≥?250?pg/ml, PADI4 was highly diagnostic for RA (sensitivity 90.3%, specificity 100%; area under curve?=?0.97 with no significant difference from anti-CCP at a cut-off of 15 ng/ml (sensitivity 93.5%, specificity 100%; AUC ?=?0.99). Serum PADI4 level showed a significant correlation with DAS28 (r?=?0.49, p?=?0.047). At follow up (n?=?20), no significant difference in PADI4, anti-CCP level or DAS28 scores was found but changes in serum PADI4 level significantly correlated with changes in DAS28 (r?=?0.82, p?<?0.001). Mean serum PADI4 level was significantly lower in improved patients (184.4?±?10.2?pg/ml) compared to unimproved (563.3?±?251.9?pg/ml, p?<?0.001).Conclusion
Serum PADI4 was diagnostic for RA and comparable with anti-CCP. It correlated with disease activity and could be a promising follow up marker of remission. 相似文献10.
Alin O. Stirban Cosmina I. Bondor Bogdan Florea Ioan A. Veresiu Norina A. Gavan 《Journal of diabetes and its complications》2018,32(9):851-856
Objective
Advanced glycation end products (AGE) contribute to the development of diabetes complications. Their accumulation in skin can be non-invasively assessed by measurement of skin autofluorescence (SAF). Our study investigated whether SAF correlates with measures of diabetic peripheral neuropathy (DPN).Methods
In a multi-center study (8 centers), 497 consecutive individuals with diabetes mellitus were investigated.Forearm SAF was measured using the AGE Reader (Groningen, The Netherlands). DPN was assessed using the Toronto Clinical Neuropathy Score (TCNS), the Neuropathy Symptoms Score (NSS) and the Neuropathy Disability Score (NDS).Results (mean?±?SD)
According to the TCNS, SAF (arbitrary units - AU) was increased in individuals with DPN (TCNS?>?5): 2.59?±?0.56?AU compared with those without DPN (TCNS?≤?5): 2.45?±?0.53?AU, (p?=?0.04) and significantly increased with the severity of DPN (p?=?0.028).Higher SAF was detected in individuals with neuropathic deficits (NDS?>?2): 2.58?±?0.56?AU vs. those without deficits (NDS?≤?2): 2.45?±?0.53?AU, (p?=?0.009) as well as in individuals with symptoms (NSS?>?2): 2.54?±?0.56?AU vs. those without symptoms (NSS?≤?2): 2.40?±?0.47?AU, (p?=?0.022).Conclusions
Accumulation of AGE in skin is increased in individuals with DPN and progresses with the severity of DPN. Therefore, SAF measurement, an easy-to-use, quick and non-invasive method, might help in identifying subjects at high risk for having DPN. 相似文献11.
Mazen M. Alsheikh Abeer M. El-Shafey Heba H. Gawish Enas T. El-Desoky 《The Egyptian Rheumatologist》2019,41(2)
Aim of the work
The aim of this study was to evaluate interleukin-23 (IL-23) level in the sera of rheumatoid arthritis (RA) patients and to determine its relation with disease activity and severity.Patients and methods
This study was carried out on 40 RA patients and 40 healthy control subjects. All patients were subjected to full history taking, thorough clinical examination, radiological and laboratory investigations including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anti-cyclic-citrullinated peptide (anti-CCP) antibodies. Serum IL-23 was measured by enzyme-linked immunosorbent assay. Disease activity score (DAS-28) and rheumatoid arthritis severity scale (RASS) were assessed.Results
Patient's mean age was 43.3?±?10.4?years and they were 37 females and 3 males. The mean disease duration of the patients was 4.98?±?4.1?years (1–15?years) with a mean DAS-28 of 4.8?±?1.2 (2.4–7.6) and RASS of 41.1?±?16.9 (16.7–85). The mean IL-23 serum level was significantly higher in RA patients (67.6?±?39.2?pg/ml) compared to the control (37.7?±?15.6?pg/ml) (p?<?0.001). There were significant correlations between IL-23 levels with the DAS-28 (r?=?0.35,?p?=?0.02), RASS (r?=?0.31, p?=?0.04), CRP (r?=?0.39, p?=?0.02), ESR (r?=?0.45, p?=?0.004), RF (r?=?0.48, p?=?0.002) and anti-CCP antibodies (r?=?0.35, p?=?0.04). At a cut-off value of 45?(pg/ml), IL-23 had a sensitivity of 77.8% and a specificity of 75% for detection of active disease and at 43.5?pg/ml the sensitivity was 88.2% and specificity 83.3% for occurrence of physical damage.Conclusion
IL-23 could be a useful marker for disease activity in RA. Its correlation with RASS suggested that IL-23 might be a therapeutic target for prevention of disability. 相似文献12.
Background
The beneficial effects of atrial septal defect (ASD) device closure on electrical cardiac remodeling are well established. The timing at which these effects starts to take place has yet to be determined.Objectives
To determine the immediate and short term effects of ASD device closure on cardiac electric remodeling in children.Methods
30 pediatric patients were subjected to 12 lead Electrocardiogram immediately before ASD device closure, 24 h post procedure, 1 and 6?months after. The maximum and minimum P wave and QT durations in any of the 12 leads were recorded and P wave and QT dispersions were calculated and compared using paired T test.Results
The immediate 24?h follow up electrocardiogram showed significant decrease in P maximum (140.2?±?6 versus 130.67?±?5.4?ms), P dispersion (49.73?±?9.01 versus 41.43?±?7.65?ms), PR interval (188.7?±?6.06?ms versus 182.73?±?5.8?ms), QRS duration (134.4?±?4.97?ms versus 127.87?±?4.44), QT maximum (619.07?±?15.73?ms versus 613.43?±?11.87), and QT dispersion (67.6?±?5.31 versus 62.6?±?4.68?ms) (P?=?0.001). After 1?month all the parameters measured showed further significant decrease with P dispersion reaching 32.13?±?6 (P?=?0.001) and QT dispersion reaching 55.0?±?4.76 (P?=?0.001). These effects were maintained 6?months post device closure.Conclusion
Percutaneous ASD device closure can reverse electrical changes in atrial and ventricular myocardium as early as the first 24 h post device closure. 相似文献13.
Khaled Mohamed Said Ahmed Ibrahim Nassar Ahmed Fouad Ali A. Ramzy Mustafa Fayed Fadle Abd Allah 《The Egyptian Heart Journal》2018,70(4):353-359
Background
Two-dimensional (2D) speckle-tracking strain imaging is a novel method for assessment of regional myocardial deformation that uses tracking of acoustic speckles or kernels rather than Doppler myocardial velocities. It has been suggested that Left atrial (LA) strain as measured by 2D speckle tracking can be used to evaluate dynamic LA function.Objective
To study the relation between left atrial deformation and the severity of coronary artery stenosis in patients with stable coronary artery disease (CAD).Study design
30 patients with stable coronary artery disease (SCAD) with coronary artery stenosis (>50%) who were admitted for elective coronary angiography at Ain Shams University hospitals and AlAzhar University hospitals were included in the study. Measurements of conventional echocardiographic parameters as well as LA strain and strain rate parameters were obtained, Syntax (SX) score was calculated for all patients.Results
Patients were categorized into 3 groups: low Syntax score of <23 (Group I), moderate syntax score 23–32 (Group II) and high syntax score of ≥33 (Group III). Peak atrial longitudinal strain (PALS) (Group I: 29.80?±?4.48, Group II: 22.44?±?1.42, Group III: 19.53?±?4.46; p?<?0.001) and Peak atrial contraction strain (PACS) (Group I: 13.43?±?4.05, Group II: 10.84?±?2.47, Group III: 7.19?±?0.71; p?<?0.022) were significantly lower in high syntax group. Significant negative correlation was found between SX score level and LA strain parameters (PALS and PACS) (r?=?0.861; p?<?0.001).Conclusion
Left atrial deformation analysis by 2D Speckle tracking Doppler Echocardiography can predict the severity of coronary affection in patients with stable CAD. 相似文献14.
Nermeen A. Fouad Maha H. Nassr Hanan M. Fathi Othman M. Zaki Ahmed A. Negm Soha H. Senara 《The Egyptian Rheumatologist》2019,41(2):93-97
Aim of the work
To determine the serum progranulin levels in rheumatoid arthritis (RA) patients and to study its relation with disease activity assessed clinically and by ultrasound (US).Patients and methods
The study included 52 RA patients and 19 age and sex matched controls. Disease activity score (DAS-28) and modified health assessment questionaire were assessed. Progranulin was measured by ELISA. Ultrasound examination was performed and the German US7 score (USS) recorded.Results
The patients mean age was 42.8?±?10.5?years; disease duration was 4.9?±?5.02?years; 47 females and 5 males with a mean DAS28 of 4.4?±?0.9 (3 in remission; 5 low activity; 31 moderate and 13 high). The mean serum progranulin level in patients (9.5?±?45.5?ng/ml) was significantly elevated compared to control (32.74?±?9.2?ng/ml) (p?<?0.0001). There was a significant difference in the progranulin levels and USS according to the grades of disease activity (p?<?0.0001 and p?=?0.037 respectively). The progranulin and USS significantly correlated with the DAS28 (r?=?0.64, r?=?0.58; p?<?0.0001 respectively) and erythrocyte sedimentation rate (p?<?0.0001). The progranulin and USS significantly correlated with each other (r?=?0.32, p?=?0.02). At a cut-off value 51.5?ng/ml, progranulin would discriminate between patients and control at sensitivity 96.2%, specificity 100% and accuracy 99%.Conclusion
Serum progranulin levels were higher in RA patients than age and sex matched controls. It significantly correlated with disease activity measured by DAS28, ESR and ultrasound activity measured by German US7 score. Serum progranulin levels may be a useful biomarker in RA disease. Ultrasound correlated with ESR and DAS28 in RA patients. 相似文献15.
Viral N. Shah Mengdi Wu Sarit Polsky Janet K. Snell-Bergeon Jennifer L. Sherr Eda Cengiz Linda A. DiMeglio Rodica Pop-Busui Kara Mizokami-Stout Nicole C. Foster Roy W. Beck 《Journal of diabetes and its complications》2018,32(10):961-965
Aims
To evaluate gender differences in diabetes self-care components including glycemic, blood pressure and lipid control, utilization of diabetes technologies and acute diabetes complications in adults with type 1 diabetes.Methods
A total of 9,481 participants >18 years were included in the analysis, 53% were female. Variables of interest included glycemic control measured by HbA1c, systolic/diastolic blood pressures, presence of dyslipidemia, insulin delivery modality, and rates of acute complications.Results
Glycemic control was similar in women and men (mean HbA1c in both groups: 8.1%?±?1.6% (64?±?16 mmol/mol), (p?=?0.54). More women used insulin pump therapy (66% vs. 59%, p?<?0.001) but use of sensor technology was similar (p?<?=?0.42). Women had higher rates of diabetic ketoacidosis (DKA) (5% vs. 3%, p?<?0.001) and eating disorders (1.7% vs. 0.1%, p?<?0.001). Severe hypoglycemia rates were not different between men and women (p?=?0.42). Smoking (6% vs 4%, p?<?0.001), systolic (125?±?14.2 vs. 121?±?14.4, p?<?0.001) and diastolic blood pressure (73.3?±?9.5 vs. 72.2?±?9.3, p?<?0.001) and rate of dyslipidemia (28% vs. 23%, p?<?0.001) were higher in men.Conclusion
While glycemic control in type 1 diabetes was similar regardless of gender, rates of DKA and eating disorders were higher in women while rates of smoking, hypertension and dyslipidemia were higher in men. 相似文献16.
Asmaa A. Shaaban Nadia A. Elkadery Hebatallah A. El-Shamy Rana A. El-Hilaly Nadia G. El-Hefnawy Nesrine A. Mohamed 《The Egyptian Rheumatologist》2019,41(1)
Aim of the work
To investigate the role of endothelial protein C receptor (EPCR) (membrane and soluble forms) as a biomarker of lupus nephritis (LN) in systemic lupus erythematosus (SLE) patients and to study its relation to the prognosis and response to treatment.Patients and methods
The study included 30 SLE patients and 30 matched healthy volunteers as well as 10 renal biopsies from surgical nephrectomy as a control for membranous (mEPCR) examination. SLE disease activity index-2000 and damage index were assessed. Serum sEPCR was measured. Renal expression of mEPCR was analyzed. All patients were reassessed after 3?months.Results
Patients were 26 females and 4 males with a mean age of 29.6?±?10.04?years and disease duration of 4.4?±?3.5?years. Their mean SLEDAI was 13.9?±?9.9 and damage index 1?±?1.5. Serum levels of sEPCR were significantly higher in patients with LN (19.9?±?5.7?ng/ml) than those without (8.95?±?4.2?ng/ml) and controls (5.3?±?2.6?ng/ml)(p?<?0.001). SLE patients with cutaneous vasculitis (n?=?9) had significantly higher sEPCR levels than those without (18.1?±?7.8 vs 10.2?±?5.2?ng/ml)(p?=?0.02). There was a significant correlation between sEPCR percentage of change and of SLEDAI-2k with and without LN (p?<?0.01 and p?<?0.05). A significant difference was observed in sEPCR according to the prognosis and treatment response after 3?months. mEPCR stained positively in glomeruli and tubules of LN patients with no relation to histopathological grading.Conclusion
sEPCR plays a role in the pathogenesis, is related to a bad prognosis and poor response to treatment in LN. mEPCR was not related to LN grading. 相似文献17.
Hania S. Zayed Amr Amin Samy Alsirafy Nahla D. Elsayed Soheir Abo Elfadl Mohamed Nasreldin Dalia Enaba Zeinab Nawito 《Arab Journal Of Gastroenterology》2018,19(2):71-75
Background and study aims
Central nervous system (CNS) involvement in hepatitis C virus (HCV) infection has different facets such as anxiety, depression, cognitive impairment and vasculitis. We were interested in detecting subclinical CNS involvement in chronic HCV infected subjects with and without systemic vasculitis.Patients and methods
Nineteen patients (15 females and 4 males) with chronic HCV infection (mean age 46.5?±?7 and mean duration since diagnosis of HCV infection 4.7?±?4?years, including 6 (32%) Child-Pugh class A cirrhotic patients) and 30 age, sex and education matched healthy control subjects were studied. Thirteen patients had associated vasculitis. Patients and control subjects were assessed using the block design and comprehension subtests of Wechsler Bellevue Adult Intelligence Scale, Wechsler Memory scale (WMS), Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI). Brain HMPAO Single Photon Emission Computed Tomography (SPECT) was performed for HCV patients.Results
Patients with HCV had lower scores on the block design test compared to control subjects (8.37?±?1.89 versus 10.37?±?1.47, p?<?0.001), lower total WMS scores (43.15?±?10.49 versus 60.27?±?8.08, p?<?0.001) and higher anxiety and depression scores (16.94?±?10.46 and 37.17?±?10.38 versus 10.3?±?4.67 and 28.9?±?5.99, p?=?0.004 and 0.001, respectively). Total WMS were lower in HCV patients with vasculitis compared to those without vasculitis (39.14?±?9.3 versus 51.17?±?8.3, p?=?0.019) while the block design and comprehension tests, BAI and BDI were not significantly different between both groups. The block design and comprehension tests, WMS, BAI and BDI were not significantly different between cirrhotic and non-cirrhotic patients. Seven patients had different patterns of cerebral hypoperfusion on SPECT, and all of them had associated vasculitis. Abnormal SPECT was associated with lower total WMS scores (35.87?±?10.8 versus 46.79?±?8.6 in those with normal SPECT, p?=?0.049).Conclusions
Vasculitis may contribute to the development of neuropsychiatric involvement in HCV patients. 相似文献18.
Mohamed A. Mekky Ahmad R. Riad Marwa A. Gaber Mohamed O. Abdel-Malek Yosef M. Swifee 《Arab Journal Of Gastroenterology》2018,19(2):76-79
Background and study aims
Many regimens are tried in managing overt hepatic encephalopathy (HE). We investigated the efficacy of rifaximin versus metronidazole in management of an acute episode of HE on top of cirrhosis.Patients and methods
An open label prospective controlled trial was conducted on patients with an acute episode of HE on top of cirrhosis who were randomly divided into metronidazole-group (M-group) and rifaximin-group (R-group) with 60 patients in each.The main outcome measure was the clinical improvement of HE, duration of hospital stay and the changes in the level of serum ammonia after 3?days of starting therapy.Results
Both M-group and R-group were comparable as regards age and sex (mean age 51?±?11?years and 49?±?12; male/female ratio 45:15 and 50:10, respectively). Forty-six patients (76.7%) in M-group compared with forty-five (75%) in R-group showed clinical improvement (p?=?0.412). Hospital stays were comparable between both group; 4.2?±?2.1 and 3.9?±?1.7 for M-group and R-group; respectively (p?=?0.435). There was no significant difference of venous ammonia levels (Mean of delta 160.77?±?185.34?µg/dL and 207.95?±?218.43?µg/dL with p 0.664 and 0.974 in M-group and R-group, respectively). No adverse events were reported throughout the whole study.Conclusion
Rifaximin and metronidazole are equally effective in management of acute episode of overt HE, therefore, re-auditing of treatment protocols of HE are warranted especially in limited resource settings. 相似文献19.
Kunihiro?Maeda Shogo?Kikuchi Naoto?Miura Keisuke?Suzuki Wataru?Kitagawa Hiroyuki?Morita Shogo?Banno Hirokazu?Imai
Background
Focal segmental glomerulosclerosis-like lesions have been proposed to be predictive factors for IgA nephropathy. This single center, retrospective cohort study was designed to clarify which clinical and pathological factors are predictive of decreased estimated glomerular filtration rate (eGFR) at 5 and 10 years in IgA nephropathy patients.Methods
Of the 229 patients with IgA nephropathy who were admitted to Aichi Medical University Hospital between 1986 and 2010, 57 were included in this study during the 5 to 10 years after renal biopsy. Clinical, laboratory, and pathological parameters were analyzed by multiple linear regression analysis with backward elimination to determine independent risk factors. After identifying such factors, we compared patients with and without each factor using the Student’s t test, Wilcoxon test, or Mann–Whitney U test.Results
Four variables were identified as predictive factors for progression of IgA nephropathy: initial eGFR (p?=?0.0002), glomerular tip adhesion (p?=?0.004), global sclerosis (p?=?0.019), and diastolic blood pressure (p?=?0.024). The annual decrease in eGFR of patients with (n?=?9) or without glomerular tip adhesions (n?=?48) was 4.13?±?3.58 and 1.49?±?2.89 ml/min/1.73 m2, respectively (p?=?0.015). Serum total cholesterol levels were 231?±?45 mg/dl and 196?±?42 mg/dl, respectively (two-sided p?=?0.064; one-sided p?=?0.032).Conclusions
The presence of glomerular tip adhesions predicts the progression of IgA nephropathy. High levels of serum total cholesterol may affect glomerular tip adhesions.20.
Tomoyuki Kabutoya Yasushi Imai Yasuhiro Yokoyama Ayako Yokota Tomonori Watanabe Takahiro Komori Kazuomi Kario 《Journal of electrocardiology》2018,51(6):1099-1102