Book Reviews

Book reviewed in this article: Radiology of Skeletal Trauma. By Lee F. Rogers, M.D., Professor and Chairman, Department of Radiology, Northwestern University Medical School Renal Sonography. Practical Radiologic Diagnosis. By D. R. Germann and J. K. Fisher Computed Tomography of the Heart. Experimental Studies. Thesis by Claes G. Skiolde-brand. Spontaneous Intracerebral Haematomas: Advances in Diagnosis & Therapy. An Introduction to Diagnostic Ultrasound. Michael B. Love M.D., Charles C. Thomas X-Ray Diagnosis in Neonates. Koteles Gy. Manual of Cardiac Surgery. Volume I. By Bradley J. Harlan, M.D. Pathologies Malformatives et Neo-Natales. By Denis Gardeur and A. Palmieri. Atlas of Computerised Emission Tomography. P. J. Ell, J. M. Deacon, P. H. Jarritt. Clinical Radiology of the Liver – Part A and Part B. Edited by Hans Herlinger Radiodiagnosis of the Vertebrae in Adults. By A. Wackenheim. 1983. The Pediatric Chest. Radiological, Clinical and Pathological Observations. Alvin H. Felman. Charles C. Thomas     

Book Reviews

Book reviewed in this article: Physics for Radiologists by P.P. Dendy and B. Heaton. A Radiographic Index. By M. Goldman Publishers: Williams & Wilkins & Associates, Operative Ultrasound of the Liver and Biliary Ducts. By H. Bismuth and D. Castaing Magnetic Resonance Imaging in Diseases of the Nervous System. An Introduction by Ivan Moseley Prenatal Diagnosis of Congenital Anomalies Edited by Romero, Pilu, Jeanty, Ghidini, Hobbins Small Bowel Radiology. By J. Lissner, G. Antes and F. Eggemann Congenital Dysplasia ana Dislocation of the Hip. By Dietrich Tonnis with eollaboraataon of H. Legal and R. Graf Law for the Medical Profession , by Dix Errington, Nicholson & Powe. Published by Butterworth Physical Aspects of Brachytherapy by T.J. Godden. Publishers: Adam Hilger Review of Computed Radiography By Tateno, Iinuma and Takano Sectional Fetal Anatomy in Ultrasound by A. Staudach Time Dose & Fractionation in the Radiation Therapy of Cancer. By J.M. Vaeth and J. Meyer “Ultrasound Teaching Cases Volumes 1 and 2” second edition. By Hylton B. Meire, Keith C. Dewbury and David O. Cosgrove Dosimetry in Radiotherapy Volumes 1 & 2. By International Atomic Energy Agency. Ultrasound of the Abdomen. By C. Roy translated from the French by Wackenheim, MT Tuberculosis of the Bones and Joints. By M. Martini. The Radiologists First Reader. By Harry W. Fischer Perspectives in Radiology. By Clyde A. Helms A Textbook of Radiological Diagnosis Volume 4. The Alimentary Tract. The Hollow Organs & Salivary Glands. By K.C. Simpkins Lung Tumours. By B. Hoogstraten, B.J. Addis, H.H. Hansen, N. Martini and S.G. Spiro Magnetic Resonance Imaging: Atlas of the Head, Neck and Spine. By Catherine M. Mills; Jack de Groot; and Jonathan P. Posin Atlas of Nuclear Medicine. Edited by Douglas Van Nostrand and Sheldon Baum. The Ultrasound Handbook. By Rebecca Hall. Tumours of the Larynx. By E. Meyer-Breiting and A. Burkhardt. Recent Results in Cancer Research: Combined Modality Therapy of Gastrointestinal Tract Cancer. By P. Schlag, P. Hohenberger and U. Metzger. Ultrasonography of the Spleen. By Jean-Noel Bruneton; M. Benozio; M. Blery; H.A. Gharbi; B. Senecail and V. Tran-Minh. Dynamic Radiology of the Abdomen: Normal and Pathologic Anatomy. By Morton A. Meyers. Operative Ultrasonography—During Hepatobiliary and Pancreatic Surgery. By B. Deixonne and F.M. Lopez.     

Prognostic factors for high-grade malignant glioma: Development of a prognostic index

Summary Although the prognosis of high grade malignant glioma patients is generally poor, it is possible to identify groups of patients with varying prognoses. Basing our results on the first MRC glioma study, multivariate methods were used to identify prognostic factors independently associated with the length of survival. Young age, the presence of fits, especially of long duration, extensive surgical removal of tumour and good clinical performance status were found to be the most important predictors of longer survival. The effect of tumour grade (3 or 4) was not significant, being considerably diluted by an association with extent of neurosurgery. A prognostic index was derived which split the patients into 6 groups of varying prognoses, with 2-year survival rates of between 1 and 32%. The results were verified in patients entered into a subsequent MRC trial. The successful identification of different prognostic groups suggests the use of this index as an aid in making treatment decisions for individual patients, and in interpreting the results of uncontrolled phase II studies.This report was prepared on behalf of the participating members by S.P. Stenning, L.S. Freedman (statisticians) and N.M. Bleehen (Chairman). The following clinicians and their colleagues participated in the Misonidazole or BR2 studies and/or are members of the Brain Tumour Working Party: G.E. Adams, A.M.A. Ayoub Bey, R.O. Barnard, J. Bozzino, J.D. Bradshaw, T.B. Brewin, J. Bullimore, D.P. Dearnaley, P. Gortvai, N.F.C. Gowing, A. Gregor, J.M. Henk, H.F. Hope-Stone, A. Hovenden, N. Howard, H. Hughes, A. Jones, R.M. Kalbag, I. Kerby, V. Levin, A.R. Lyons, D.S. Murrell, M.J. Ostrowski, C.E. Polkey, R. Rampling, R.I. Rothwell, P.F. Salaman, C. Scholtz, J.S. Scott, R. Sealy, L.F.N. Senanayake, B. Southcott, J. Stone, H.M. Sultana, B.E. Tomlinson, C.S. Treip, S. Vaidya, P. Wale, P.J. Winter, P. Xavier. Data management was carried out by Mrs. Bethan Smith.     

Book Reviews

Book reviewed in this article: Endourologj: Principles and practice. Editor A.D. Smith, W.R. Casteneda-Suniga M.D. & J.G. Bronson. 1986. Plain X-ray Diagnosis of the Acute Abdomen, Second Edition. By M.H. Gough, M.W.L. Gear and A.S. Daar. A Practical Approach To Modern Imaging Equipment. Second Edition. By Thomas T. Thompson, M.D. DNA Content and Prognosis in Breast Cancer By Anders Fallenius Angiocardiography. Current Status and Future Developments. Edited by H. Just and P.H. Heintzen. Computed Tomography of the HEAD and Neck. Edited by Barbara L. Carter, M.D. The Tethered Spinal Cord. Edited by Robert N.N. Holtzman M.D. and Bennett M. Stein M.D. Ultrasound-Guided Biopsy and Drainage By G. Pedio, H.R. Burger, H.J. Einighammer and R. Hanke Multiple Choice Questions in Radiodiagnosis. By A. Crozier, D. Finlay and P. Paciorek. Paediatric Oncology an Illustrated Introduction W. R. McWhirter and J. P. Masel Williams & Wilkins. Guide to the Ultrasound Examination of the Abdomen. By Leon Skolnick.     

Book Reviews

Book reviewed in this article: Management of Persons Accidentally Contaminated with Radionuclides — NCRP Report No. 65. Influence of Dose and its Distribution in Time on Dose-Response Relationships for Low-Let Radiations. (N.C.R.P. Publication 64) April 1980. Sclerosing Bone Dysplasias. By P. Beighton and B. J. Cremin. Progress in Nuclear Medicine Volume 6 Cardiovascular Nuclear Medicine. Series Editors A Donath, A. N. Serafini. Radionuclide Imaging Artifacts. L. David Wells and Donald R. Bernier. Abdominal Ultrasound. Static & Dynamic Scanning 2nd Edition. By Hans Holm et al Two Dimensional Echocardiography. Joseph A. Kisslo. 1980. Pearls in Diagnostic Radiology. Harold D. Rosenbaum. Correlative Sectional Anatomy of the Head and Neck. Editors Joseph R. Thompson and Anton N. Hasso. Radiation Quantities and Units - ICRU Report 33.     

Book Reviews

Book reviewed in this article: BJR Supplement 17: Central Axis Depth Dose Data for Use in Radiotherapy. Exercises in Diagnostic Ultrasonography of the Abdomen. By F.S. Weill and A. de Mouel. Atlas of Radiologic Anatomy, 2nd Edition. By Lothar Wicke. Notes on Radiological Diagnosis. The Trainee's Survival Kit. By Lawrence S.W. Lau and John F. de Campo. Introduction to Organ Imaging. A Guide to Use and Interpretation. By John A. Bloom-field. M.C.Q.'s in Radiology. By A.H. Chapman and P.J. Robinson. Nuclear Magnetic Resonance and its Clinical Applications. Edited by R.E. Steiner and G.K. Radda. NMR Tomography of the Normal Brain. By Guenther Gademann. Report of Proceedings of a Study on the Protection of the Australian Public from Ionising Radiation     

Book Reviews

Book reviewed in this article: RPL Dosimetry: Radiophotoluminescence in Health Physics. By J.A. Perry Clinical Applications of Doppler Ultrasound Edited By Taylor KJW, Burns PN and Wells PNT Innovations in Radiation Oncology. By H. Rodney Withers and L. J. Peters Investigational Techniques in Oncology Edited by N.M. Bleehen. Renal and Adrenal Tumors. by E. Lohr and L. Leder. Case Studies in Diagnostic Imaging by P. Nisbet, W. Gedroyc and S. Rankin. Bioeffects Literature Reviews 1980–1987 By H.D. Rott. Computed Tomography of the Temporal Bone and Orbit. Author Frans W. Zonneveld. Guide to Sonography of the Infant Hip. By Reinhard Graf. Radiological Case Book. By Perry Duplex Sonography by E.G. Grant and E.M. White.     

Book Reviews

Book reviewed in this article: The Control of Exposure of the Public to Ionizing Radiation in the Event of Accident or Attack. Review of Biological Effects of Ultrasound: Mechanical and Clinical Implications. N.C.R.P. Report No. 74 – December 1983. Recent Results in Cancer Research No. 85 – Urological Cancer: Chemotherapeutic Principles and Management. Positron Emission Tomography of the Brain – Technology and Application. By Jan-Eric Litton. Colo-Proctology. Edited by J.-Cl. Givel and F. Saegesser. Intraocular Tumours. Edited by P.K. Lom-matzsch and F.C. Blodi. Soft Tissue Ossification. By J.M. Connor. The Human Environment Past, Present & Future. By Merril Eisenbud.     

Book Reviews

Book reviewed in this article: Radiology of Musculoskeletal Stress Injury. By Theodore E. Keats. Hysterosalpingography: Techniques and Interpretation By Robert B. Hunt and Alvin M. Siegler. Basic Principles of Radiographic Expasure By Dianne C. DeVos. Chesney's Radiographic Imaging. By John Ball and Tony Price. Mammograph - 83 Radiological Exercises for Students and Practitioners. By P. Haehnel Hodgkin's Disease. Edited by P. Selby and T. J. McElwain. Common Problems in Gastrointestinal Radiology. By William M. Thompson. Biomedical Magnetic Resonance Technology. By C-N. Chen and D. I. Hoult. Pros and Cons in PTA and Auxiliary Methods. By E. Zeitler and W. Seyferth.     

Book Reviews

Book reviewed in this article: Critical Issues in Setting Radiation Dose Limits. Proceedings of the Seventeenth Annual Meeting of the National Council on Radiation Protection and Measurements, 1981. Radiology and Imaging for Medical Students. By David Sutton Radiation Protection in Paediatric Radiology. Cardiac Roentgenology Shadows of the Heart. By Marvin L. Daves. Malignancy Grading of Chondrosarcoma. A Cytochemical, Morphological and Clinical Study. Dr. A. Kreicbergs. Quality Assurance in Diagnostic Radiology. By Joy M. McLemore R.T. Chest Imaging: An Integrated Approach. Edited by Richard A. Mintzer Ultrasonic Sectional Anatomy. By Patricia Morley, Gabriel Donald and Roger Sanders. Intestinal Radiation Injury. A Morphological and Pathophysiological Study in the Cat. Scientific Basis of Medical Imaging. Ed. P. N. T., Wells. Nuclear Medicine. Clinical and Technological Bases. By J. T. Andrews and M. Jean Milne. Quantitative Risk in Standards Setting. Proceedings of the Sixteenth Annual Meeting of the National Council on Radiation Protection and Measurements. Nuclear Particles in Cancer Treatment. Professor Fowler.     

Book Reviews

Soft tissue sarcoma. Edited by Laurence H. Baker. 160 pages. Martinus Nijhoff Publishers, Boston 1983. Price: NLG 90/USD 36.

Gynecologic cancer. Edited by Arlene A. Forastiere. Contemporary issues in clinical oncology. Vol. 2. Series editor Peter H. Wiernik. 307 pages with 49 figures and 88 tables. Churchill Livingstone, Edinburgh 1984. Price: GBP 36.

Computers in radiotherapy and oncology. Edited by R. F. Mould. 248 pages. Adam Hilger, Bristol 1984. Price: GBP 24/USD 39.     

Book Reviews

Book reviewed in this article: X-ray Microscopy in Clinical and Experimental Medicine–by T. A. Hall, H. O. E. Rockert and R. L. deC. H. Saunders. Cisternography and Hydrocephalus–A Symposium. 559 pages. Edited by John C. Har-bert, David C. McFullough, Alfred J. Luessenhop & Giovanni Di Chiro. Modern Trends in Radiotherapy–2. Edited by-Thomas J. Deeley–Butterworths, 1972. “Computers in Radiotherapy.” British Institute of Radiology, 1971–Special Report Number 5. 187 pages. Radiographic Examination of the Urinary Tract. Howard M. Pollack, M.D. Roentgenography and Roentgenology of the Temporal Bone, Middle Ear and Mastoid Process. Fundamental Physics of Radiology. W. J. Meredith and J. B. Massey. Published by John Wright and Sons Ltd., Bristol, England. Practical Procedures in Diagnostic Radiology. By H. M. Saxton and Basil Strickland. Second Edition. Mammography. By Robert L. Egan. A Monograph in the Bannerstone Division of American Lectures in Roentgen Diagnosis. Acute Ureteric Obstruction. By P. M. Bret-land. Roentgenologic Diagnosis. Vol. 1 and 2. Radiological Diagnosis of Digestive Tract Disorders in the Newborn. Frontiers of Radiation Therapy and Oncology Vol. 7. The Interrelationship of the Immune Response and Cancer. Angiography of Trauma. Author: Whei-Rung Fu. Charles C. Thomas     

Book Reviews

Book reviewed in this article: Orthopaedic Radiology Edited by William M. Park and Sean P. Hughes An Introduction to Clinical Imaging. By D. Lloyd Dixon and Leslie M. Dugdale Orthopedic Radiology — A Practical Approach. By Adam Greenspan. Foreword by Michael W. Chapman Clinical Radiobiology by A.H.W. Nias. Self Assessment in Radiology and Imaging 4: Orthopaedics. By Dennis J. Stoker and Elisabeth A. Tilley. Magnetic Resonance Imaging of the Spine. By Michael T. Modic; Thomas J. Masaryk; and Jeffrey S. Ross. Self Assessment in Radiology & Imaging: Gastrointestinal Radiology. By M. Berger. “Emergency Radiology”. By Theodore E. Keats. Cross-Sectional Anatomy for Computed Tomography. By Michael L. Farkas. Contrast Media. By Ed. D.H. Carr. Manual of Oncologic Therapeutics 1989/90. By Robert E. Wittes. Clinical Radiation Oncology: Indications, Techniques and Results. By C.C. Wang MD. Biomedical Magnetic Resonance Imaging: Principles, Methodology and Applications. By Felix W. Wehrli; Derek Shaw; and J. Bruce Kneeland. The Physics of Medical Imaging. By Steve Webb. E.N.T. Radiology Textbooks Diagnostic Imaging of the Nose and Paranasal Sinuses. By Glyn A.S. Lloyd. Self Assessment in Radiology and Imaging — Ear, Nose and Throat. By Maurice Hawthorn & Richard Num. Self Assessment in Radiology & Imaging 5 Nuclear Medicine. By Shabu Karimjee, Adrian Thomas and Wendy Taylor.     

Local control of oropharyngeal carcinoma after two accelerated hyperfractionation radiation therapy schemes

In October 1979 we started an accelerated hyperfractionation program consisting of 1.6 Gy/fraction, 2 fractions/day for 12 days or 38.4 Gy. Due to acute toxicity, the patients were then given a 2-week break and resumed once daily radiation therapy with 1.8 Gy/fraction up to 65 Gy, designated as the b.i.d.-q.d. program. In August 1982, the program was changed and the latter part of the treatment was continued on the twice daily program with 1.6 Gy/fraction for a total of 64 Gy, designated as the b.i.d.-b.i.d. program. We evaluated the local control rates of 140 patients with squamous cell carcinomas arising from the oropharynx, that is faucial tonsil and base of tongue. After these treatment regimens, the 36 month actuarial local rates for the T1-4 lesions were 56% for b.i.d.-q.d. (52 patients) and 85% for b.i.d.-b.i.d. (88 patients) with a p value of 0.0013. For the T1-2 lesions the corresponding rates were 81% (13 patients) and 97% (44 patients) with a p value of 0.53. The difference was marked for the T3-4 lesions, that is 47% vs 77% respectively with a p value of 0.017, and those patients without nodal metastases, that is 46% vs 93% with a p value of 0.00043. The improvement was probably due to marked shortening of the overall treatment course following b.i.d.-b.i.d. accelerated program--in this case 1 1/2 weeks. Our preliminary data suggests that the b.i.d.-b.i.d. program is superior to the b.i.d.-q.d. program. The seemingly improved local control rates for the treatment of oropharyngeal carcinomas requires a clinical prospectively randomized trial for confirmation, that is b.i.d.-b.i.d. versus b.i.d.-q.d. versus standard fractionation (q.d.) program.     

Book Reviews

Book reviewed in this article: Testicular Tumours. Editors: Douglas and Johnson. Haemotopoietic and Gastronomical Investigations with Radionuclides. Pulmonary Radiation Reactions. By G. J. Weir and S. M. Michaelson. Charles C. Thomas Progress in Nuclear Medicine–Neuro-Nnclear Medicine. Simplified Physics for Radiology Students. By Barbara Howl. Atlas of Arteriography in Occlusive Cerebrovascular Disease. By Jorge Weibel and William S. Fields. Recent Advances in the Study of Cerebral Circulation. Edited by Juan M. Taveras, Herman Fischgold and Domenico Dilenge. “CENTRAL AXIS DEPTH DOSE FOR USE IN RADIOTHERAPY” (British Journal of Radiology Supplement No. 11). Atlas of Roentgen Anatomy of the Skull by Lewis E. Etter. Revised Third Printing. Charles C. Thomas.     

Localization of the monoclonal antibody HMFG2 after intravenous and intraperitoneal injection into nude mice bearing subcutaneous and intraperitoneal human ovarian cancer xenografts

Xenografts (s.c. and i.p.) of human ovarian cancer, shown to express the tumor associated antigen defined by the monoclonal antibody HMFG2, were used to investigate in vivo localization of the radioiodinated antibody after i.p. and i.v. injection. Following i.v. injection, maximum uptake (31.4 +/- 3.5%/g s.c. tumor) was seen in s.c. tumors at 48 h after injection. Tumor:normal tissue ratios increased with time to 240 h. Uptake by ascites and i.p. tumors was less, with a maximum of 10.0 +/- 8%/g ascites reached at 16 h and 11.4 +/- 3.2%/g i.p. tumor at 96 h. After i.p. injection uptake in s.c. xenografts was maximal (14.8 +/- 2.0%/g) at 20 h. For ascites, the i.p. route of administration resulted in high uptake (27.7 +/- 5.8%/g) early (2 h) with an ascites:normal tissue ratio of 69.3 and a specific antibody:nonspecific antibody ratio of 30.8. Except for data at one time point, uptake by i.p. solid tumor was similar to that seen for s.c. tumor. These data strongly suggest that large concentration advantages can be achieved in ascites cells by regional i.p. injection, but that i.p. solid tumor may rely on i.v. delivery of antibody before uptake.     

Peripheral primitive neuroectodermal tumors:a rare case report

We-aimed-to-explore-the-diagnosis-and-treatment-of-peripheral-primitive-neuroectodermal-tumors-(pPNETs).-We-retrospectively-analyzed-the-diagnosis-and-treatment-process-of-a-patient-who-was-diagnosed-with-pPNETs-by-pathology.-This-case-was-a-man-with-soft-masses-arising-from-the-left-chest-wal-near-the-armpit-and-left-supraclavicular-of-a-47-year-old-man.-The-patient-mainly-presented-with-the-masses-which-increasing-gradual-y-with-obvious-pain.-Needle-biopsy-showed-that-they-were-both-metastatic-adenocarcinoma.-Ultrasonography-B-revealed-blood-flow-of-these-two-low-density-placeholders-can-be-seen-in-the-signal,-not-oppression-axil-ary-and-vein.-Radical-resection-of-the-masses-were-performed.-Histopathologic-study-and-immunohistochemistry-(IHC)-confirmed-the-masses-to-be-peripheral-primitive-neuroectodermal-tumors.-pPNETs-is-a-rare-malignant-smal-round-cel-tumor.-CT-and-MRI-examination-can-estimate-the-resectability-of-the-tumor;Ultrasound-B-can-make-sure-its-inside-blood-supply-and-the-positional-relationship-between-the-mass-and-the-surrounding-vasculature.-The-diagnosis-of-pPNETs-is-based-primarily-on-histopathologic-study-and-IHC,-especial-y-those-with-the-characteristics-of-the-Homer-Wright-and-neuroendocrine-markers.-Radical-resection-of-the-tumor-is-the-most-ef-ective-therapeutic-method.-The-ef-ect-of-adjuvant-chemo-radiation-is-worth-af-irmation.-Autologous-stem-cel-rescue-besides-adjuvant-chemotherapy-has-been-associated-with-prolonged-survival.     

Amifostine before chemotherapy: improved tolerance profile of the subcutaneous over the intravenous route.

INTRODUCTION: The i.v. administration of the cytoprotective agent amifostine is associated with reversible clinical hypotension, protracted emesis, and malaise in a various percentage of patients. We evaluated, prospectively, whether the s.c. route is a better tolerated alternative to the i.v. route in patients receiving chemotherapy. PATIENTS AND METHODS: Fifty-nine patients treated with "once every 2 weeks" regimens received 1000 mg of amifostine i.v. before chemotherapy. Patients who developed protracted vomiting and malaise and/or clinical hypotension for two consecutive i.v. administrations received the same dose of amifostine s.c. for the subsequent cycles (i.v./s.c. study). In an additional cohort of 12 patients (s.c. study), 1000 mg of amifostine were given s.c. since the first chemotherapy cycle. RESULTS: In the i.v./s.c. study, 8 (13.5%) patients showed protracted emesis/malaise and/or clinical hypotension during the first two cycles. An additional 4 (6.6%) patients developed similar side effects during the subsequent cycles. Switching to the s.c. route, an improved tolerance was noted. In the s.c. study, a total of 76 injections was administered. Protracted vomiting or clinical hypotension was absent, and this tolerance profile was significantly better than the i.v. one (P = 0.001). There were no other systemic side effects related to the s.c. administration. CONCLUSIONS: Amifostine, at a dose of 1000 mg, is better tolerated when administered s.c. Switching to the s.c. route in patients with poor tolerance using the i.v. administration allows the continuation of cytoprotection with minor side effects. Although preliminary, 1000 mg of amifostine effectively protected against the lower, still more frequently administered doses of chemotherapy given once every 2 weeks.     

Book Reviews

Book reviewed in this article: The Visible Human Body - An Atlas of Sectional Anatomy. By Gunther Von Hagens, Lynn J. Romrell, Michael H. Ross and Klaus Tiedemann Liver Imaging: Current Trends and New Techniques. By Joseph T. Ferrucci and David D. Stark Which Tests For My Unborn Baby? A Guide to Prenatal Diagnosis. By Lachlan de Crespigny and Rhonda Dredge Ultrasound of Appendicitis and its Differential Diagnosis. By Julien B.C.M. Puylaert Normal and Abnormal Swallowing Imaging in Diagnosis and Therapy. By Bronwyn Jones and Martin W. Donner MCQ's - FRCR Part I. By Paul Butler, Charles Blakeney MRI of the Brain III: Neoplastic Disease. By Anton N. Hasso, Miyuki Shakudo and Edla Chidrychi Atlas of Anal Endosonography. By Clive I. Bartram and Sarah J.D. Burnett Urological Oncology - Dilemmas and Developments. By A.R. Alderson, R.T.D. Oliver, I.W.F. Hanham and H.J.G. Bloom Radioactive Heaven and Earth. A Report of the IPPNW International Commission to Investigate the Health and Environmental Effects of Nuclear Weapons Production and the Institute for Energy and Environmental Research Head and Neck Radiology. By Arnold Noyek Abdominal Sonography. By Mordecai Koenigsberg and Janet Hoffman-Tretin Radiology of the Extremities. By N. Baker Gastrointestinal Radiology. By Jack Farman Imaging of Orthopedic Trauma (Second Edition). By Thomas H. Berquist High-Resolution CT of the Lung. By W. Richard Webb, N.L. Muller and D.P. Naidich MRI of the Central Nervous System: A Pathology Atlas. By K. Mori (Ed.) Practical Radiotherapy Planning. Second Edition. By Jane Dobbs, Ann Barrett and Dan Ash Early Detection and Treatment of Liver Cancer. By K. Okuda, T. Tobe and T. Kitagawa Radiological, Clinical & Bio-mechanical Aspects of Chest Trauma. By S.A. Groskin Concomitant Continuous Infusion Chemotherapy and Radia tion. By Marvin Rotman and C. Julian Rosenthal Radiopathology of Organs and Tissues. By E. Schere, C. Streffer and K.R. Trott     

Comparison of the pharmacokinetics and efficacy of irinotecan after administration by the intravenous versus intraperitoneal route in mice

Irinotecan (CPT-11) is a new drug active in colorectal cancer. A comparison was made of the efficacy and pharmacokinetics of CPT-11 after i.p. versus i.v. administration to mice. We found that i.p. administration of CPT-11 to mice bearing C26 colon cancer was more efficient and less toxic than i.v. administration; a 100-mg i.p. dose induced an increase in life span equivalent to that produced by a 300-mg i.v. dose, and toxic deaths appeared after doses of 400 mg/kg given i.v. and 800 mg/kg given i.p. Pharmacokinetic parameters of CPT-11 and SN-38 were compared after i.v. or i.p. administration in mice bearing P388 leukemia ascites. Peritoneal CPT-11 and SN-38 AUC values were higher after i.p. administration than after i.v. injection. Plasmatic AUC values remained equivalent. Moreover, peritoneal CPT-11 clearance was 10-fold lower after i.p. versus i.v. administration. If the survival and pharmacologic advantage of i.p. CPT-11 in the murine model considered can be translated to a safe and practical mode of therapy in patients and if local toxicity does not prove to be a major adverse effect, then a potentially useful agent could be added to the drugs known to be active when given by the i.p. route for adjuvant therapy in colon cancer. Received: 21 October 1997 / Accepted: 12 December 1997