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1.
Development and preliminary validation of the multiattribute Rhinitis Symptom Utility Index 总被引:3,自引:0,他引:3
Revicki D. A. Leidy N. K. Brennan-Diemer F. Thompson C. Togias A. 《Quality of life research》1998,7(8):693-702
The Rhinitis Symptom Utility Index (RSUI) was developed as a preference-based measure of rhinitis symptoms. The RSUI consist of ten questions on the severity and frequency of stuffy or blocked nose, runny nose, sneezing, itching, watery eyes and itching nose or throat over a 14 day period. A cross-sectional survey of 100 adults with allergic rhinitis was completed, with data collected on rhinitis history and severity, physician-rated rhinitis severity, the Rhinitis Quality of Life Questionnaire (RQLQ) and the Health Utilities Index Mark 2 (HUI2). The mean age of the patients was 37±11 years and 60% were female and 38% had a diagnosis of asthma. A multiplicative multiattribute utility function was developed from patient-derived preferences for different rhinitis-related symptom states. The mean RSUI score for this sample was 0.72±0.23, with a range of 0.15–1.0. Two week reproducibility of the RSUI was weak (ICC=0.40). The index differentiated patients by physician-rated severity (p<0.05) and was correlated 0.35 (p<0.001) with the HUI2 and –0.67 (p<0.001) with the RQLQ total score. The RSUI is brief and easy to administer and the results of this study support its reliability and validity. The modest reproducibility reflects the day to day variability of rhinitis. The RSUI may be a useful patient outcome for clinical trials and for cost-effectiveness studies comparing medical treatments for rhinitis. 相似文献
2.
Negative Mood and Quality of Life in Patients with Asthma 总被引:3,自引:0,他引:3
Aydanur Ekici Mehmet Ekici Turkan Kara Hatice Keles Pınar Kocyigit 《Quality of life research》2006,15(1):49-56
The aim of this study was to evaluate the effect of negative mood states at the moment of questionnaire, and other patient
and disease characteristics on quality of life (QoL) in patients with asthma. The study groups were composed of 116 stable
adult asthmatic patients and 116 age and sex matched healthy subjects. We used Short-Form Health Survey-36 (SF-36) for the
assessment of general QoL in all participants, and the Asthma Quality of Life Questionnaire (AQLQ) for the assessment of disease
specific QoL in patients with asthma. We evaluated negative mood in all subjects with a questionnaire including six mood subscales
in three categories (nervous-anxious, hostile-angry and fearful-panicky). Negative mood scores were not different between
asthmatic and comparison groups (p=0.4), but both SF-36 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores were significantly lower
in asthmatic group (p=0.003 and p=0.001, respectively). Multiple linear regression analysis in all study population indicated that both reduced PCS and MCS
scores of SF-36 were associated with negative mood score (β=−0.28, p<0.001 and β=−0.37, p<0.001, respectively) and with FEV1% (β=0.19, p=0.001 and β=0.25, p<0.001, respectively) after adjusting for age, female sex, and the presence of asthma. On the other hand, multiple linear
regression analysis in patients with asthma revealed that negative mood score and disease severity score were significant
predictors for overall score of AQLQ after adjusting for other patient and disease characteristics (β=−0.17, p=0.008 and β=−0.64, p<0.001, respectively). The level of negative mood and disease severity in asthmatics significantly impair QoL. Thus, considering
that one of the main objectives of health care should be preserving a satisfactory QoL in asthmatics, the presence and seriousness
of negative mood and their effects on QoL should be taken into account as part of the clinical evaluation in asthmatics. 相似文献
3.
Amjad I. Hussain Andrew M. Garratt Jan Otto Beitnes Lars Gullestad Kjell I. Pettersen 《Quality of life research》2016,25(7):1703-1712
Purpose
Standard gamble (SG) is the preferred method of assessing preferences in situations with uncertainty and risk, which makes it relevant to patients considered for aortic valve replacement (AVR). The present study assesses SG preferences in patients with severe aortic stenosis (AS).Methods
All patients >18 years old with severe AS referred for AVR to our institution were invited to enroll in the study. The SG was administered by a clinical research nurse. The SF-36, EQ-5D 3L, Hospital Anxiety and Depression Scale (HADS), and AS symptoms were administered by self-completed questionnaire. We hypothesized that SG utilities would have low-to-moderate correlations with physical and mental aspects of health based on our pathophysiological understanding of severe AS. No correlations were expected with echocardiographic measures of the aortic valve.Results
The response rate for SG was 98 %. SG moderately correlated with physical aspects of SF-36 (PCS, role-physical, vitality), health transition, AS symptoms, and EQ-VAS (ρ S = 0.31–0.39, p < 0.001) and had low correlation with mental aspects of SF-36 and EQ-5D (ρ S = 0.17–0.28, p < 0.001). No correlation was found between SG and HADS, echocardiographic measures, age, gender, or education level (ρ S = 0.01–0.06).Conclusions
SG is an acceptable and feasible method of assessing preferences in patients with severe AS that has evidence for validity. The inclusion of uncertainty lends the SG face validity in this population as a direct approach to assessing preferences and basis for QALY calculations.4.
Background: This is a clinical randomized trail (RCT) to investigate the effects of a three-week training program on work readiness designed for musculoskeletal injured workers with long-term sick leave who had difficulties resuming their work role. The program was planned to help injured workers overcome the psychological and psychosocial problems and to facilitate their Work Readiness on Return to Work (RTW) based on the Employment readiness model. Methodology: A total of 64 injured workers were recruited and randomly assigned into the training (T) and control (C) groups. Observations were blinded between service providers and evaluators. A three-week intensive training on work readiness program was given to the T group while subjects in the C group were given advice on job placement by social workers in a community work health center. The training program was comprised of individual vocational counseling and group therapy using cognitive behavioral approach to alleviate symptoms of stress, pain and anxiety. The Chinese Lam Assessment of Stages of Employment Readiness (C-LASER), the Chinese State Trait and Anxiety Inventory (C-STAI) and the Short form of Health Survey (SF-36) were used to evaluate all subjects’ psychological health status and behavioral changes on job readiness before and after the intervention. Results: Subjects in the T group showed significant improvement in their work readiness (p < 0.05), level of anxiety (p < 0.05) and their self perception of health status measured by SF-36 (p < 0.02) when compared with subjects in the C group. Control of chronic pain, negative motivation, and anxiety level were some of the key behavioral changes found from the study. Conclusion: The TWR program appeared to improve injured workers’ motivation and employment readiness. Further study on the employment outcomes of subjects is recommended. 相似文献
5.
Jennifer O. McArthur Peter Petocz Ian D. Caterson 《Journal of the American College of Nutrition》2013,32(3):175-184
Objectives: Limited information is available on the role of pork meat in influencing iron status. The aim of this study was to determine the effect of consuming pork meat as compared to iron supplementation on nutritional status and feeling of well-being.Methods: Young women were randomly assigned to a control diet (CG), a pork-containing diet (PG), or a control diet with iron supplementation (SG) for 12 weeks. Sixty-five women aged 24.6 ± 4.4 years (mean ± SD) completed the trial.Results: Serum ferritin concentrations were increased significantly (p = 0.001) in participants assigned to the SG as compared with the other groups, as assessed by repeated-measures analysis of variance. At week 12, hemoglobin concentrations were significantly higher in PG and SG as compared with CG. Plasma zinc concentrations at the end of the intervention were similar to baseline concentrations for individuals in the CG and PG but were decreased significantly (p < 0.05) in SG. Plasma-, erythrocyte-folate, and serum vitamin B6 and B12 concentrations were not significantly affected by the intervention, although the concentrations of vitamins B6 and B12 tended to increase in PG. Well-being, as measured using the Health Survey Short Form (SF-36) and its 8 multi-item scales, showed significant improvement in vitality in SG (p < 0.05) and bodily pain in PG (p < 0.05). No significant relationships were observed between these health concept scores and biomarkers of nutritional status.Conclusions: Consumption of pork meat by young women maintains hemoglobin levels to the same extent as low-dose iron supplementation and enhances the components of well-being, mainly their perception of bodily pain. 相似文献
6.
Farideh Shishehbor Elham Rajaei Mohammad Hosein Haghighizadeh 《Journal of the American College of Nutrition》2013,32(8):685-690
ABSTRACTObjective: This study evaluated the effect of cinnamon on disease activity, serum levels of some inflammatory markers, and cardiovascular risk factors in women with rheumatoid arthritis (RA).Methods: In this randomized double-blind clinical trial, 36 women with RA were randomly divided to 2 groups, receiving 4 capsules of either 500 mg cinnamon powder or placebo daily for 8 weeks. Fasting blood sugar (FBS), lipid profile, liver enzymes, serum levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), erythrocyte sedimentation rate (ESR), blood pressure, and clinical symptoms were determined at baseline and end of the week 8.Results: At the end of the study, there was a significant decrease of serum levels of CRP (p < 0.001) and TNF-α (p < 0.001) in the cinnamon group as compared to the placebo group. Diastolic blood pressure was also significantly lower in the intervention group compared with the control group (p = 0.017). Compared with placebo, cinnamon intake significantly reduced the Disease Activity Score (DAS-28) (p < 0.001), Visual Analogue Scale (VAS) (p < 0.001), and tender (TJC) (p < 0.001) and swollen joints (SJC) (p < 0.001) counts. No significant changes were observed for FBS, lipid profile, liver enzymes, or ESR.Conclusion: Cinnamon supplementation can be a safe and potential adjunct treatment to improve inflammation and clinical symptoms in patients with RA. 相似文献
7.
This study investigated the validity of the Canadian Occupational Performance Measure (COPM) when included as one of the scales used by therapists with older adults on an inpatient sub-acute rehabilitation setting. Quantitative data from 36 participants in a sub-acute rehabilitation setting was obtained via the COPM, the Functional Independence Measure (FIM) and the Short Form 36 Health Survey (SF-36) using a pre-post methodology. Pearson's r correlations and linear regression analyses were computed. The COPM Performance admission score was significantly correlated with the FIM Total and FIM Physical admission scores (p <.05) while the COPM Satisfaction admission score was significantly correlated with the FIM Total and FIM Physical admission scores (p <.05). The COPM Performance discharge score was significantly associated with the FIM Total, FIM Physical, and SF-36 Physical Health discharge scores (p <.01) while the COPM Satisfaction discharge scores was significantly associated with the FIM Total, FIM Physical, and SF-36 Physical Health discharge scores (p <.01) respectively. Linear regression analyses determined that the COPM's Performance admission score uniquely explained 8.4% of the SF-36 Physical Health discharge score's total variance (p <.05). The results contribute to the COPM's evidence base, supporting its convergent validity and predictive validity. 相似文献
8.
Psychometric evaluation of the fatigue severity scale for use in chronic hepatitis C 总被引:5,自引:0,他引:5
L. Kleinman M.W. Zodet Z. Hakim J. Aledort C. Barker K. Chan L. Krupp D. Revicki 《Quality of life research》2000,9(5):499-508
Evidence exists demonstrating that infection with hepatitis C virus impairs health-related quality of life, but less is known
about the effect of fatigue, a common symptom, on everyday life. The psychometric properties of the fatigue severity scale
(FSS) were explored to determine suitability as an outcome measure in clinical trials. The FSS includes nine items developed
to measure disabling fatigue and a visual analog scale (VAS) to measure overall fatigue. Using baseline data from three clinical
trials (n = 1225) involving chronic hepatitis C patients, scaling and psychometric characteristics of the FSS were assessed.
The SF-36 was also used in the trials. Item response theory analysis demonstrated that the FSS items can be placed along a
single homogenous domain, fatigue. Internal consistency reliability was 0.94. Test–retest reliability was 0.82 for the total
score and 0.80 for the VAS. The total score and the VAS were significantly correlated with the SF-36 vitality subscale (r = −0.76 and r = −0.76 respectively). Correlations with other SF-36 subscales were moderate (r = −0.46 to r = −0.67, all p < 0.0001). In summary, the FSS possesses good psychometric properties.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
9.
Rondanelli M Opizzi A Antoniello N Boschi F Iadarola P Pasini E Aquilani R Dioguardi FS 《Clinical nutrition (Edinburgh, Scotland)》2011,30(5):571-577
Background & aims
This study assessed the efficacy of supplemented essential amino acids on depressive symptoms, nutrition, muscle function, daily physical activity, and health-related quality of life (HRQoL) of institutionalized elderly patients.Methods
Forty-one patients (58.5% women; mean age 79.8 yrs) with sequelae of coronary artery disease (73%), femoral fracture (34%), were randomly assigned to receive oral essential amino acids 4 gr 2 times a day for 8 weeks or isocaloric placebo. Before randomization and 8 weeks after the protocol started, the following variables were measured: depressive symptoms (Geriatric Depression Scale, GDS), nutritional panel (Mini Nutritional Assessment, MNA; serum albumin and prealbumin levels), muscle strength (Hand Grip, HG), Activity Daily Life (ADL), Quality of Life (SF-36, HRQoL) and amino acid profile.Results
Compared with the placebo group, EAA patients improved nutrition (MNA score 22.6 ± 1.5 post vs 21.8 ± 1.6 pre; p < 0. 04, albumin g/dl 4.04 ± 0.35 post vs 3.88 ± 0.3 pre; p < 0.01), GDS(score 10.3 ± 1.75 post vs 13.85 ± 3.37 pre; p < 0.001), HG (Kg 19.75 ± 1.7 post vs 18.68 ± 1.36 pre; p = 0.001), ADL (p < 0.04) and both physical and mental components of SF-36 (p < 0.002).Conclusions
Oral supplementation with essential amino acids improved several determinants of quality of life in institutionalized elderly patients, including depressive symptoms, nutrition, muscle function and daily life activity. 相似文献10.
Objective: Describe the development and evaluation of a new self-report instrument, the patient assessment of upper gastrointestinal disorders-symptom severity index (PAGI-SYM) in subjects with gastroesophageal reflux disease (GERD), dyspepsia, or gastroparesis. Methods: Recruited subjects with GERD (n=810), dyspepsia (n=767), or gastroparesis (n=169) from the US, France, Germany, Italy, the Netherlands, and Poland. Subjects completed the PAGI-SYM, SF-36, a disease-specific HRQL measure (PAGI-QOL), and disability day questions. Two-week reproducibility was evaluated in 277 stable subjects. We evaluated construct validity by correlating subscale scores with SF-36, PAGI-QOL, disability days, and global symptom severity scores. Results: The final 20-item PAGI-SYM has six subscales: heartburn/regurgitation, fullness/early satiety, nausea/vomiting, bloating, upper abdominal pain, and lower abdominal pain. Internal consistency reliability was good ( =0.79 0.91); test–retest reliability was acceptable (Intraclass correlation coefficients =0.60 0.82). PAGI-SYM subscale scores correlated significantly with SF-36 scores (all p < 0.0001), PAGI-QOL scores (all p < 0.0001), disability days (p< 0.0001), and global symptom severity (p < 0.0001). Mean PAGI-SYM scores varied significantly in groups defined by disability days (all p < 0.0001), where greater symptom severity was associated with more disability days. Conclusions: Results suggest the PAGI-SYM, a brief symptom severity instrument, has good reliability and evidence supporting construct validity in subjects with GERD, dyspepsia, or gastroparesis. 相似文献
11.
Health-related quality of life (HRQOL) measures predict cause-specific mortality, but few studies have explored whether generic
self-reported HRQOL measures are independently associated with mortality in community-dwelling older persons. We postulated
that a general measure of HRQOL, the short form 36-item questionnaire (SF-36), would be independently predictive of mortality
among community-dwelling older persons. To evaluate this hypothesis, we followed a fixed cohort of 4,424 community-dwelling
older persons recruited from a 2000 population-based survey in Taiwan until 2003 and investigated whether HRQOL was predictive
of 3-year mortality, even after adjusting for traditional clinical risk variables. The data were collected via a door-to-door
survey, and interviewers collected information on the subjects’ demographics, medical history, utilization of health services,
functional ability, falls, and self-reported physical and mental symptoms. Of the 6053 eligible subjects, 4,424 residents
agreed to participate in the baseline survey and were contacted in 2003. During the 3-year period, the 3-year cumulative mortality
rate for the study population was 5%. Mortality was significantly higher among males (5.57% vs. 4.27%, p = 0.049), and cumulative mortality increased with age (χ
2-test for trend; χ
2 = 7.734, p = 0.001). For all scales except bodily pain, there was a significant relationship between a 10-point lower baseline score
and mortality. Our primary multivariate risk model, which included two summary measures of HRQOL and significant clinical
variables, demonstrated that a 10-point decrease in either the baseline Physical Component Summary (PCS) score or the baseline
Mental Component Summary (MCS) score was associated with higher mortality (PCS: RR: 1.60, 95% CI: 1.39–1.83; p < 0.001; MCS: RR: 1.16, 95% CI: 1.01–1.34; p = 0.036). The findings suggested that low baseline PCS and MCS scores were important independent risk factors for 3-year
mortality among community-dwelling older persons, even after adjusting for other risk factors. 相似文献
12.
Lis Ribu Berit Rokne Hanestad Torbjorn Moum Kåre Birkeland Tone Rustoen 《Quality of life research》2007,16(2):179-189
Objective: The aim of this study was to describe health-related quality-of-life (HRQL) in patients with diabetic foot ulcers by comparing
their HRQL with that of a sample from the general population without diabetes (general population) and a subgroup with diabetes
(diabetes population), and to examine the differences between groups by sociodemographic characteristics and lifestyle factors.
Design and methods: A cross-sectional study was made of 127 adults with current diabetic foot ulcer, recruited from six hospital outpatient clinics,
a control sample categorized as a diabetes population (n = 221) from the Norwegian Survey of Level of Living, and a sample from the general population (n = 5903). Data on sociodemographic characteristics (sex, age, cohabitation, education and employment) and lifestyle (body
mass index [BMI] and smoking status) and HRQL (SF-36) were obtained.
Results: In all the SF-36 subscales and in the two SF-36 summary scales, the patients with diabetic foot ulcer reported significantly
poorer HRQL than the diabetes population. The most striking differences were for role limitation-physical (32.1 vs. 62.2,
p < 0.001), physical functioning (57.5 vs. 77.3, p < 0.001) and role limitation-emotional (57.4 vs. 72.0, p < 0.001). The patients with foot ulcer had significantly lower HRQL than the general population on all scales, and in particular
on role limitation-physical (32.1 vs. 74.3, p < 0.001), physical functioning (57.5 vs. 85.2, p < 0.001) and general health (50.1 vs. 74.3, p < 0.001). The most important sociodemographic characteristic that differed between the diabetic foot ulcer patients and the
diabetes population was that significantly more of the foot ulcer patients were men living alone. The largest differences
between the foot ulcer patients and the general population were that more of the foot ulcer patients were men, older, living
alone, less well educated, and not working. The diabetic foot ulcer patients, the diabetes population and the general population
differed in BMI: 28 kg/m2 in the foot ulcer patients, 27 kg/m2 in the diabetes population and 25 kg/m2 in the general population.
Conclusion: Diabetic foot ulcer patients had much worse HRQL compared with the diabetes population and the general population, especially
in physical health. Foot ulcer patients were more often men living alone, and obesity was a problem in both the foot ulcer
patients and the diabetes population. 相似文献
13.
The health-related quality of life (HRQL) impact of depression for low-income young African-American women has not been quantified.
Baseline scores on a generic HRQL measure, the SF-36, from a randomized controlled trial of depression treatments were used
as a basis for describing the HRQL of depressed (n = 124) and non-depressed (n = 44) low-income African-American young women.
Results were compared to U.S. normative values for well adults and for depressed adults. Relationship between SF-36 scores
and demographic variables were examined, and SF-36 scores were compared for those with depression only and those with comorbid
anxiety. SF-36 scores were lower for all eight subscales relative to the U.S. norms (p < 0.05) and lower on two subscales relative to a general U.S. depressed sample (p < 0.05). Higher age and higher number of children was associated with poorer scores. Comorbid anxiety was present in 66%
of the depressed sample; all SF-36 scores for the sample with comorbid anxiety were significantly lower than scores for subjects
with depression alone. Results indicate the substantial HRQL impact of depression among low-income young African-American
women with depression. 相似文献
14.
Anne M. Suskind Sandra H. Berry Marika J. Suttorp Marc N. Elliott Ron D. Hays Brett A. Ewing J. Quentin Clemens 《Quality of life research》2013,22(7):1537-1541
Purpose
To estimate the association of chronic non-urologic conditions [i.e., fibromyalgia (FM), chronic fatigue syndrome (CFS), and irritable bowel syndrome (IBS)] with health-related quality of life (HRQOL) in patients with interstitial cystitis/bladder pain syndrome (IC/BPS).Methods
A total of 276 women with established diagnoses of IC/BPS completed a telephone interview which included demographics, self-reported medical conditions, the SF-36 health survey, and the interstitial cystitis symptom index (ICSI). Multivariate linear regression analysis was used to identify correlates of SF-36 physical and mental component summary scores.Results
Mean patient age was 45.1 (SD 15.9) years, and 83 % of the subjects were white. Mean values for the SF-36 Physical Component Score (PCS) and Mental Component Score (MCS) means were 39 (SD 14) and 45 (SD 12), respectively, indicating significant HRQOL reductions. Mean ICSI score was 11.27 (SD = 4.86). FM and IBS were significantly associated with worse SF-36 scores: ?8 points on the PCS (p < 0.001) and ?6 points on the MCS (p < 0.001). CFS and the presence of other pelvic conditions (overactive bladder, vulvodynia, endometriosis) were not significantly associated with SF-36 PCS and MCS scores.Conclusions
In patients with IC/BPS, the presence of FM, CFS, and IBS has a significant association with HRQOL, equivalent in impact to the bladder symptoms themselves. These results emphasize the importance of a multidisciplinary approach to treating patients with IC/BPS and other conditions. 相似文献15.
Stuart R. Willes Thomas K. Fitzgerald Rebecca Bascom M.D. M.P.H. 《Archives of environmental & occupational health》2013,68(3):223-230
Environmental tobacco smoke (ETS) exposure is associated with rhinitis symptoms (i.e., runny nose and congestion) in some people. In an effort to better understand these symptoms, we recruited 18 historically ETS-sensitive subjects from the community and exposed them for 15 min to clean air and for 15 min to sidestream tobacco smoke (STS, 45 ppm carbon monoxide). Symptoms were recorded (0 = absent, 5 = severe), and posterior rhinomanometry was performed. There were significant changes in rhinitis symptoms (1.3 ± 0.4 pre- versus 6.1 ± 0.5 post-STS, p < .05); nasal airway resistance (2.86 ± 0.2 pre- versus 4.49 ± 0.6 post-STS, p < .05), and maximum inspiratory flow (2.74 ± 0.3 pre- versus 2.14 ± 0.3 post-STS, p < .05). A spectrum of individual responsiveness to ETS was observed, and nasal resistance increased from 0% to 265%. Increased nasal resistance occurred primarily at the upstream or flow-limiting segment of the nasal airway. 相似文献
16.
Nan Luo Boon-Kheng Seng Julian Thumboo David Feeny Shu-Chuen Li 《Quality of life research》2006,15(5):889-898
This study assessed the construct validity of the Health Utilities Index Mark 3 (HUI3) in patients with schizophrenia. Patients
with schizophrenia recruited from a tertiary mental hospital in Singapore completed the HUI3, the Short-Form 36 Health Survey
(SF-36) and the Schizophrenia Quality of Life Scale (SQLS). Patients were assessed for presence and absence of 22 common psychiatric
symptoms. Construct validity was assessed using 6 a priori hypotheses. Two hundred and two patients (mean age: 37.8 years, female: 52%) completed the survey. As hypothesized, overall
HUI3 utility scores were correlated with SF-36 measures (Spearman’s rho: 0.19 to 0.51), SQLS scales (Spearman’s rho: −0.56
to −0.36), and the number of psychiatric symptoms (Spearman’s rho: −0.49). The HUI3 emotion attribute was moderately correlated
with SF-36 mental health (Spearman’s rho: 0.45) and SQLS psychosocial scales (Spearman’s rho: −0.43), and HUI3 pain attribute
was strongly correlated with SF-36 bodily pain scale (Spearman’s rho: 0.58). The mean HUI3 overall, emotion, cognition, and
speech scores for patients with schizophrenia were 0.07, 0.09, 0.04 and 0.04 points lower than respective age-, sex- and ethnicity-adjusted
population norms (p<0.001 for all, ANCOVA). This study provides evidence for the construct validity of the HUI3 in patients with schizophrenia. 相似文献
17.
Objectives: The aim of this study was to determine whether a generic health outcome instrument would be helpful for evaluating women
with stress urinary incontinence (UI) combined with or without urge UI. Methods: A total of 109 women with UI and 80 controls participated in the study. Health-related quality of life (QOL) was measured
using the Medical Outcomes Study 36-Item Short-Form General Health Survey (SF-36) and the Incontinence Quality of Life (I-QoL)
questionnaire. Results: Among eight domains of the SF-36 questionnaire, only four domains, namely, ‘role-physical functioning’ (p<0.05), ‘vitality’ (p<0.05), ‘mental health’ (p<0.05) and ‘bodily pain’ (p<0.05) were significantly different between the groups. Comparing the I-QoL sores in the two groups, patients with UI had
significantly poorer subscale scores of I-QoL than the controls (p<0.05 for all domains). When women with UI were subdivided into groups of stress and mixed UI, only 2 domains of the SF-36
questionnaire, ‘role-physical functioning’ (p<0.05) and ‘bodily pain’ (p<0.05), were significantly different. The mixed UI group had higher scores only on these two domains compared to the stress
UI group. In the ‘role-physical functioning’ domain, there was no significant difference between the mixed UI group and the
controls. In ‘bodily pain’ domain, there was no significant difference between the stress UI group and the controls. The mixed
group had the highest scores observed. Patients with mixed UI had significantly lower total scores compared to those with
stress UI, including the subscale score of ‘avoidance behavior’ of the I-QoL. Among eight domains of the SF-36, only ‘physical
functioning’ (r = 0.281, p<0.01) and ‘social functioning’ (r = 0.239, p<0.05) were weakly correlated with ‘psychological impact’ of the I-QoL.
Conclusion: Our findings show that the generic QOL instrument is not sensitive measure of QOL in women with UI. 相似文献
18.
Emily Newfield Stacey Hart Suzanne Dibble Lori Kohler 《Quality of life research》2006,15(9):1447-1457
Objectives: We evaluated health-related quality of life in female-to-male (FTM) transgender individuals, using the Short-Form 36-Question Health Survey version 2 (SF-36v2).Methods: Using email, Internet bulletin boards, and postcards, we recruited individuals to an Internet site (), which contained a demographic survey and the SF36v2. We enrolled 446 FTM transgender and FTM transsexual participants, of which 384 were from the US.Results: Analysis of quality of life health concepts demonstrated statistically significant (p<0.01) diminished quality of life among the FTM transgender participants as compared to the US male and female population, particularly in regard to mental health. FTM transgender participants who received testosterone (67%) reported statistically significant higher quality of life scores (p<0.01) than those who had not received hormone therapy.Conclusions: FTM transgender participants reported significantly reduced mental health-related quality of life and require additional focus to determine the cause of this distress. Providing this community with the hormonal care they request is associated with improved quality of life. 相似文献
19.
INTRODUCTION: Algorithms have been developed that estimate preferences from the Short Form 36 (SF-36). The objective of this study was to compare SF-36-derived preferences to directly elicited preferences. METHODS: The authors used data from a clinical trial of adult asthmatics to derive preferences from the SF36 and compare those to visual analog scale (VAS) values and the Asthma Quality-of-Life Questionnaire (AQLQ). RESULTS: The differences between VAS and derived preferences ranged from -0.066 to 0.024 at baseline and 0.006 to 0.107 at the end of follow-up. All measures improved from baseline (P < 0.001); however, derived preferences underestimated change (0.066 to 0.131) compared to the VAS (0.173) (P < 0.001), which could affect economic evaluations. Correlations between preferences and the AQLQ ranged from 0.56 to 0.70 at baseline (P < 0.001) and 0.53 to 0.70 for changes from baseline (P < 0.001). CONCLUSIONS: The derivation methods produce valid and responsive measures of patient preference. However, derived preferences differ from one another and directly elicited VAS preferences. 相似文献
20.
Background and objectives: Previous studies suggested that the Chinese version of the Short-Form 36 Health Survey (SF-36) had smaller variability in the physical functioning (PF) and physical component summary (PCS) scores than the English SF-36. This may translate into differences in discriminative ability and sample size requirement. Materials and methods: Data were drawn from a community-based survey and a randomised crossover study of Singaporeans bilingual in the Chinese and English languages. The abilities of the two PF and PCS versions in discriminating subjects who reported chronic illness and acute disease symptoms versus those who did not were compared. Results: In all four comparisons (i.e. two health criteria in two studies) the Chinese version of PF showed a larger effect size than the English version. In three out of four comparisons the Chinese version of PCS showed a larger effect size than the English version. Conclusions: The Chinese version appeared more efficient in detecting a statistically significant difference between groups. Other factors being the same, the Chinese SF-36 may require a smaller sample size than the English SF-36 for the studies of physical aspects of health-related quality of life. 相似文献