自体疣包埋治疗尖锐湿疣疗效的Meta分析

目的：评价自体疣包埋对尖锐湿疣的治疗效果。方法：在Pubmed、《中国学术期刊网络出版总库》、《万方数据库》、《中文科技期刊数据库》中检索符合标准的关于自体疣包埋治疗尖锐湿疣的随机对照试验,应用Review Manager 5.3.5软件进行Meta分析。结果：共纳入10篇文献,入选文献发表偏倚较小,无明显异质性（P=0.25）。Meta分析结果显示,自体疣包埋联合CO2激光治疗对尖锐湿疣的治愈率显著高于单用CO2激光治疗,差异有统计学意义[Z=9.54,P<0.00001, RR=1.50,95%CI (1.38-1.63)]。结论：自体疣包埋联合CO2激光治疗治疗尖锐湿疣疗效优于单用CO2激光治疗。     

微波治疗尖锐湿疣21例疗效观察

微波治疗尖锐湿疣２１例疗效观察符惠来黎雯（海南省皮肤性病防治研究所５７０２０３）尖锐湿疣治疗方法较多，我们采用微波治疗２１例，取得较好的效果、现报告如下：一、临床资料本组２１例患者均为女性，年龄１８－５２岁，２０岁以下３例，２０－２９岁１０例，３０－...     

中西医结合治疗复发性尖锐湿疣32例

目的：探讨中西医治疗复发性尖锐湿疣的临床疗效。方法：对32例复发性尖锐湿疣的患进行中西医治疗，观察临床效果。结果：30例痊愈，治愈率93％，2例复发，复发率7％。结论：采用中西医结合治疗复发性尖锐湿疣有一定的疗效。     

男性尖锐湿疣患者的异性性伴侣HPV感染监测及早期干预

目的：调查男性尖锐湿疣患者的异性性伴侣HPV感染率，并通过早期干预以期阻断女性尖锐湿疣发生和HPV持续感染状态。方法：采用前瞻性方法研究男性尖锐湿疣患者的异性性伴侣发生尖锐湿疣、HPV亚临床感染及潜伏感染的情况，通过性行为干预和早期局部治疗尖锐湿疣和HPV亚临床感染，并观察干预效果。结果：入选的120对病例，男性尖锐湿疣的异性性伴侣尖锐湿疣的发生率为35．8％，HPV亚临床感染率18．3％，子宫颈HPV潜伏感染发生率为25．0％；通过早期治疗和性行为干预，干预组受试者接受干预后尖锐湿疣／HPV感染发生率比对照组低，其差异有统计学意义（P〈0．01）。结论：对男性尖锐湿疣患者的性伴侣进行早期治疗和干预，能有效预防尖锐湿疣的传播，对控制性传播疾病的蔓延具有重要意义。     

抗疣洁尔与激光对比治疗尖锐湿疣疗效分析

抗疣洁尔与激光对比治疗尖锐湿疣疗效分析徐向东，陈美珍（浙江丽水市医院皮肤科３２３０００）我们于１９９１年５月至１９９２年８月对门诊确诊的７５例尖锐湿疣（ＣＡ）患者进行了抗疣洁尔与ＣＯ＿２激光对比治疗效果观察，现将结果报告如下。（－）临床资料：年龄１７...     

冷冻联合干扰素局部注射治疗尖锐湿疣疗效观察

为探讨尖锐湿疣(CA)的有效治疗方法，对冷冻治疗的CA患同时给予干扰素(IFN)局部注射治疗，并以单纯冷冻治疗的CA患作为对照，现将结果报告如下。     

不同方法治疗尖锐湿疣时合并干扰素的疗效观察

传统的方法治疗尖锐湿疣(CA)都有一定的复发率,为了降低复发率,许多学者都在使用干扰素(IFN),但疗效不一.为了评价IFN对治疗和预防CA复发所起的作用,我们将单独使用激光治疗的患者与单用或并用IFN治疗的患者,以及IFN不同给药途径治疗者的治愈率及复发率进行了比较观察,现报道如下.     

激光联合红光治疗尖锐湿疣98例

评估激光联合红光治疗尖锐湿疣的临床疗效。方法：采用强激光，大范围气化病灶，然后连续使用红光照射创面９８例，结果：激光与红光治疗的创面５－２０天愈合，９８例均获治愈，随访１－２．５年无复发。结论：此方法不仅能根尖锐湿疣，且红光还有促进创面愈合，增强局部皮肤功能，预防尖锐湿疣复发的功能。     

尖锐湿疣药物及外科治疗的研究进展

尖锐湿疣治疗方法很多，但复发率极高。治疗方法包括药物、外科等。现分析国内外文献中关于尖锐湿疣的治疗方法及疗效评价。     

YAG激光加白介素-2局部注射治疗尖锐湿疣疗效观察

尖锐湿疣（ＣＡ）是由人类乳头瘤病毒（ＨＰＶ）感染所引起的一种常见的性传播疾病目前治疗方法很多，但治疗效果不甚理想。我们采用ＹＡＧ激光加白介素－２局部注射治疗尖锐湿疣取得较好疗效，现报告如下：临床资料我们对７２例ＣＡ患者随机分为ＹＡＧ激光加白介素－２局部组（Ａ）和ＹＡＧ激光和干拢素局部治疗组（Ｂ）两组，患者的性别比较、年龄分布均无显著性差异。方法Ａ组：患者女性取膀胱截石位，男性取平卧位。按常规消毒，用２％盐酸利多卡因加白介素－２１０万Ｕ（上海华新高技术有限公司产注射用重组人白介素－２），从疣体根部…     

New fillers for the new man

ABSTRACT:  Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes.     

Outcomes and adverse effects of ablative vs nonablative lasers for skin resurfacing: A systematic review of 1093 patients

It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin.     

Genetic alterations in RAS‐regulated pathway in acral lentiginous melanoma

Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas.     

Occupational allergic contact dermatitis caused by decorative plants

12 cases of occupational allergic contact dermatitis caused by decorative plants were diagnosed in a 14-year period. The patients were middle-aged, and their average exposure time was 13 years. The plant families and plants causing occupational contact dermatitis were Compositae (5 patients: chrysanthemum, elecampane, gerbera, feverfew), Alstroemeriaceae (5 patients, Alstroemeria ), Liliaceae (4 patients; tulip, hyacinth). Amaryllidaceae (2 patients: narcissus) and Caryophyllaceae (2 patients; carnation, cauzeflower). The known chemical allergens causing dermatitis were tuliposide-A and sesquiterepene lactones, such as alantolactones and parthenolide, in the Liliaceae and Compositae families. 7 of the 12 patients were able to continue their work; 5 were not because of severe relapses of skin symptoms. The plant allergen and extract series currently available are of great help in the diagnosis.     

Deutliche Einschränkung der Lebensqualität bei Patienten mit Pemphigus vulgaris: Ergebnisse der deutschen Bullous Skin Disease (BSD)‐Studiengruppe

Background: Pemphigus vulgaris is a potentially life‐threatening autoimmune disorder of the skin and mucous membranes characterized by antibodies against epidermal adhesion molecules. Clinically characteristic are painful chronic blisters or erosions of mucous membranes and skin. There are no published studies on the impact o this disease on quality of life. Patients and methods: This registration was performed within the scope of the German BSD (Bullous Skin Disease) study group, from November 1997 until January 2002. A total of 36 patients with the first diagnosis of pemphigus vulgaris were registered at the university hospitals of Dresden, Erlangen, Kiel, Mannheim, München and Würzburg. Thirty of the 36 (83 %) patients participated in the quality of life questionnaire utilizing the German version of ‘Dermatology Life Quality Index’ (DLQI) provided by A. Y. Finlay. The DLQI varies from 0 to 30 with an increased DLQI score indicating a decrease in quality of quality. Results: The overall DLQI total score of 10 ± 6,7 in the investigated pemphigus patients was significantly increased in comparison to other skin diseases. Conclusions: These results suggest that the DLQI can be a very useful additional outcome criteria for clinical studies with pemphigus vulgaris and in the treatment of these patients.