| 重性抑郁障碍患者药物治疗反应相关自发性神经活动改变的Meta分析 |
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| 引用本文： | 龙拥军,卓丽华,唐春耕,黄国平,周明.重性抑郁障碍患者药物治疗反应相关自发性神经活动改变的Meta分析[J].四川精神卫生,2020,33(2):150-155. |
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| 作者姓名： | 龙拥军 卓丽华 唐春耕 黄国平 周明 |
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| 作者单位： | 四川省精神卫生中心·绵阳市第三人民医院,四川 绵阳 621000;四川省精神卫生中心·绵阳市第三人民医院,四川 绵阳 621000;四川省精神卫生中心·绵阳市第三人民医院,四川 绵阳 621000;四川省精神卫生中心·绵阳市第三人民医院,四川 绵阳 621000;四川省精神卫生中心·绵阳市第三人民医院,四川 绵阳 621000 |
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| 基金项目： | 绵阳市卫生健康委员会科研项目（项目名称：利用Meta分析研究缓解期和发作期重型抑郁症患者静息态脑功能影像改变） |
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| 摘 要： | 目的探索重性抑郁障碍(MDD)患者与药物治疗反应相关的自发性神经活动改变,寻找与治疗反应相关的影像学指标。方法计算机检索中国知网数据库、万方数据库、维普数据库、PubMed、Embase和Web of Science数据库,收集与MDD患者治疗反应相关的静息态脑功能影像研究,使用AES-SDM进行Meta分析。结果共8篇文章纳入Meta分析,包括288例患者和304例健康对照组。Meta分析结果显示,与健康对照组相比,治疗有效的MDD患者左侧小脑(峰值坐标:X=-22,Y=-78,Z=-18,SDM-Z=1.458)、左侧颞叶(峰值坐标:X=-50,Y=-30,Z=-8,SDM-Z=1.539)及右侧角回(峰值坐标:X=48,Y=-66,Z=36,SDM-Z=1.536)的脑功能活动增加,左侧辅助运动区(峰值坐标:X=-10,Y=-2,Z=72,SDM-Z=-1.107)脑功能活动降低;治疗无效的MDD患者双侧额上回、前扣带回(峰值坐标:X=12,Y=42,Z=-4,SDM-Z=1.526)脑功能活动增加,左侧额下回(峰值坐标:X=-48,Y=16,Z=6,SDM-Z=-1.912)脑功能活动降低。结论小脑半球自发性神经活动的改变可能成为预测MDD患者治疗反应的影像学指标。
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| 关 键 词： | 重性抑郁障碍 Meta分析 治疗反应 脑功能影像 |
| 收稿时间： | 2019/7/10 0:00:00 |
Spontaneous neural activity differences associated with antidepressant response in patients with major depressive disorder: a Meta-analysis |
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| Long Yongjun,Zhuo Lihu,Tang Chungeng,Huang Guoping,Zhou Ming.Spontaneous neural activity differences associated with antidepressant response in patients with major depressive disorder: a Meta-analysis[J].Sichuan Mental Health,2020,33(2):150-155. |
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| Authors: | Long Yongjun Zhuo Lihu Tang Chungeng Huang Guoping Zhou Ming |
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| Affiliation: | (Sichuan Mental Health Center·The Third Hospital of Mianyang,Mianyang 621000,China) |
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| Abstract: | Objective To explore the spontaneous neural activity differences associated with antidepressant response in patients with major depressive disorder (MDD), and to search for imaging indicators related to the treatment response of MDD.Methods Researches related to the resting-state fMRI of MDD published in Chinese databases (CNKI, Wanfang, VIP) and English databases (PubMed, Embase and Web of Science) were retrieved, and Meta-analysis was performed using AES-SDM.Results A total of 288 patients and 304 healthy controls in 8 literatures were enrolled in this study. Meta-analysis showed that functional activity in the left cerebellum (peak coordinates: X=-22, Y=-78, Z=-18, SDM-Z=1.458), left temporal lobe (peak coordinates: X=-50, Y=-30, Z=-8, SDM-Z=1.539) and right angular gyrus (peak coordinates: X=48, Y=-66, Z=36, SDM-Z=1.536) of MDD patients with effective treatment was increased, while functional activity in the left auxiliary motor area (peak coordinates: X=-10, Y=-2, Z=72, SDM-Z=-1.107) was decreased. In MDD patients with no response to treatment, bilateral superior frontal gyrus and anterior cingulate gyrus (peak coordinates: X=12, Y=42, Z=-4, SDM-Z=1.526) showed increased brain functional activity, while the left inferior frontal gyrus (peak coordinates: X=-48, Y=16, Z=6, SDM-Z=-1.912) showed decreased brain functional activity.Conclusion The change of spontaneous neural activity in cerebellum can be used to predict the treatment response of MDD patients. |
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| Keywords: | Major depressive disorder Meta-analysis Treatment response Brain functional image |
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