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Biological investigation of phenyl benzoate,benzophenone, and xanthone compounds
Authors:Beidou Zhou  Chun Lei  Xuemei Liao  Hang Zhu  Zhipeng Ruan  Yuanyuan Fang  Guifen Xu  Yuli Chen
Abstract:In the present study, we evaluated the antitumor, anti-tyrosinase, anti-pancreatic lipase, antibacterial, antifungal, and anti-α‐glycosidase activities for all or a subset of 20 known compounds. They included 8 phenyl benzoates, 10 benzophenones, and 2 xanthones. Phenyl benzoate compounds 18 did not exhibit evident antitumor activity, which was consistent with existing theories. Compounds 16, 17, and 18 exhibited moderate anti-tyrosinase activity. In addition, compounds 11 and 18 exhibited moderate inhibitory activity against Candida albicans, and compound 20 exhibited stronger anti-α-glycosidase activity than quercetin, with an IC50 of approximately 2.45 μM. These results demonstrated that compounds 11, 1618, and 20 were promising leads for further structural modification.
Keywords:Phenyl benzoate  Benzophenone  Xanthone  Antibacterial  Antifungal  α-Glycosidase  
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