| Abstract: | Cerebral ischemia seriously affects the quality of life and health of human worldwide. W026B is a newly synthesized lignan derivative that has a protective effect on the focal cerebral ischemia/reperfusion model, while it is unclear whether W026B has a cerebral protective effect on the model of global cerebral ischemia/reperfusion (GCI/R). In this study, we investigated the protective effect of W026B on the four-vessel occlusion GCI/R model. The results showed that W026B obviously increased the survival rate of rats during 7 d after GCI/R and significantly improved neurological deficits within 7 d after GCI/R. It evidently enhanced the number of survival neurons in the hippocampus of GCI/R rats. Furthermore, W026B notably lowered the level of ROS, and increased the activity of SOD in the hippocampus of GCI/R rats. Moreover, it also decreased the expression of NF-κB p65 and the level of IL-6 apparently. In addition, W026B evidently lowered the activity of caspase-3. In conclusion, this study firstly proves that W026B has the protective effect on GCI/R rats. Its cerebral protective effect maybe related to the inhibition of oxidative stress, inflammatory response, and cell apoptosis during GCI/R. These results provide new evidence with the protective effect of W026B on cerebral ischemia/reperfusion injury. |
