| 人参皂苷Rg_1通过作用于炎性因子和糖皮质激素受体减少金葡菌对肺上皮细胞的损伤(英文) |
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| 引用本文： | 袁梽漪,孟甄,柴玉爽,兰嘉琦,雷帆,李慧颖,邢东明,李慧玉,杜力军.人参皂苷Rg_1通过作用于炎性因子和糖皮质激素受体减少金葡菌对肺上皮细胞的损伤(英文)[J].中国药学,2011,20(3):266. |
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| 作者姓名： | 袁梽漪 孟甄 柴玉爽 兰嘉琦 雷帆 李慧颖 邢东明 李慧玉 杜力军 |
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| 作者单位： | 清华大学教育部蛋白质科学重点实验室;清华大学医学院生命科学学院药物药理研究室; |
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| 基金项目： | National Natural Science Foundation of China (Grant No.30973896,30801523 and 81073092); the National S＆T Major Special Project for New Drug R＆D of China(Grant No. 2009ZX09103 -301,2009ZX09502 and 2011ZX09101-002-11 ) |
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| 摘 要： | 本文旨在探讨人参皂苷Rg_1体外对金葡菌感染肺上皮细胞所致病变的作用及其可能的机制。实验采用体外大鼠原代肺上皮细胞感染模型。RT-PCR和Western blot方法观察肺细胞中integrinβ1,NF-κB和糖皮质激素受体(GR)等相关因子的表达。结果表明人参皂苷Rg_1可以明显抑制金葡菌感染后肺上皮细胞整合素integrinβ1的表达,下调炎性因子NF-κB,ICAM-1,TNF-α,IL-2和IL-6,上调GR的表达。人参皂苷Rg_1可以明显抑制金葡菌感染肺上皮细胞后的炎性因子,从而对肺脏起到一定的保护作用。
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| 关 键 词： | 金黄色葡萄球菌 人参皂苷Rg_1 肺上皮细胞 |
Ginsenoside Rg_1 reduced the invasion of S.aureus into respiratory epithelial cells involving pro-inflammatory cytokines and glucocorticoid receptor |
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| Zhi-Yi Yuan,Zhen Meng,Yu-Shuang Chai,Jia-Qi Lan,Fan Lei,Hui-Ying Li,Dong-Ming Xing,Hui-Yu Li,Li-Jun Du Protein Science Laboratory of the Ministry of Education,Laboratory of Pharmaceutical Sciences,School of Medicine , School of Life Science,Tsinghua University,Beijing ,China.Ginsenoside Rg_1 reduced the invasion of S.aureus into respiratory epithelial cells involving pro-inflammatory cytokines and glucocorticoid receptor[J].Journal of Chinese Pharmaceutical Sciences,2011,20(3):266. |
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| Authors: | Zhi-Yi Yuan Zhen Meng Yu-Shuang Chai Jia-Qi Lan Fan Lei Hui-Ying Li Dong-Ming Xing Hui-Yu Li Li-Jun Du Protein Science Laboratory of the Ministry of Education Laboratory of Pharmaceutical Sciences School of Medicine School of Life Science Tsinghua University Beijing China |
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| Affiliation: | Zhi-Yi Yuan,Zhen Meng,Yu-Shuang Chai,Jia-Qi Lan,Fan Lei,Hui-Ying Li,Dong-Ming Xing,Hui-Yu Li,Li-Jun Du~* Protein Science Laboratory of the Ministry of Education,Laboratory of Pharmaceutical Sciences,School of Medicine and School of Life Science,Tsinghua University,Beijing 100084,China |
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| Abstract: | |
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| Keywords: | Staphylococcus aureus Ginsenoside Rg_1 Pulmonary epithelial cell |
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