| 一种新型抗体替代品——亲和体的研究进展 |
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| 引用本文： | 杨佳,周璐琪,张丽芳,朱珊丽.一种新型抗体替代品——亲和体的研究进展[J].国际生物制品学杂志,2022,45(5):272-276. |
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| 作者姓名： | 杨佳 周璐琪 张丽芳 朱珊丽 |
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| 作者单位： | 温州医科大学基础医学院微生物学与免疫学教研室，温州 325000 |
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| 摘 要： | 作为抗体的一种新型替代品，亲和体不仅以高亲和力与靶蛋白特异性结合，同时又具备相对分子质量小（~6 500）、穿透性强、免疫原性弱和制备过程简单等诸多特性。因此，亲和体在肿瘤靶向治疗、体内成像诊断和生物技术应用等方面具更突出的优势和可行性。此文对其特性和应用研究进展做一综述。
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| 关 键 词： | 亲和体 靶向治疗 成像诊断 生物技术 |
Research progress of affibody—— anovel substitute for antibody |
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| Affiliation: | Department of Microbiology and Immunology, School of Basic Medicine, Wenzhou Medical University, Wenzhou 325000, China |
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| Abstract: | As a new substitute for antibodies, affibody not only binds to target protein specifically with high affinity, but also has many characteristics such as relatively small molecular mass (approximately 6 500), strong penetration, weak immunogenicity and simple preparation process. Therefore, affibody has more prominent advantages and feasibility in tumor targeting therapy, in vivo imaging diagnosis and biotechnology application. The characteristics of affibody and research progress of application are reviewed in this paper. |
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| Keywords: | Affibody Targeting therapy Imaging diagnosis Biotechnology |
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