| 肝炎相关性再生障碍性贫血 |
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| 引用本文： | 王红,常红.肝炎相关性再生障碍性贫血[J].现代临床医学,2014,40(2):147-149. |
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| 作者姓名： | 王红 常红 |
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| 作者单位： | 四川大学华西医院,四川大学华西医院 |
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| 摘 要： | 肝炎相关性再生障碍性贫血(hepatitis associated aplastic anemia,HAAA)简称肝炎相关性再障,是指急性肝炎2~3个月后出现全血细胞减少的再生障碍性贫血(aplastic anemia,AA,简称再障),是罕见的血液病。HAAA最常见于青年男性,如未及时治疗可威胁生命。由于绝大多数病例的甲至庚型肝炎病毒以及其他非肝炎病毒的血清检测均为阴性,因此确切的病原体至今未知。临床特征和实验室检查说明免疫异常在
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| 关 键 词： | 再生障碍性贫血 anemia aplastic 全血细胞减少 庚型肝炎病毒 再障 免疫抑制治疗 病毒感染 免疫异常 血清检测 |
| 收稿时间： | 2013/7/31 0:00:00 |
| 修稿时间： | 2014/3/29 0:00:00 |
Hepatitis-associated Aplastic Anemia |
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| WANG Hong and CHANG Hong.Hepatitis-associated Aplastic Anemia[J].Journal of Modern Clinical Medicine,2014,40(2):147-149. |
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| Authors: | WANG Hong and CHANG Hong |
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| Abstract: | Hepatitis-associated aplastic anemia (HAAA) is an uncommon but distinct variant of aplastic anemia in which pancytopenia appears two to three months after an acute attack of hepatitis. The frequency of HAAA was reported in 2-5% of aplastic patients in Europe and North America series and 4-10% in the Far East. HAAA occurs most frequently in young males and is lethal if leave untreated. The presumed cause of hepatitis is still unknown, since the vast majority of cases are seronegative for hepatitis A,B,C,D,E,G and other non hepatitis viruses. Clinical features and experimental results strongly suggest a central role for an immune-mediated pathogenesis. Treatment protocols include allogeneic bone marrow transplantation (BMT) and combined immunosuppressive therapy (IS) when a suitable donor is lacking. |
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