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木瓜苷的镇痛作用(英文)
引用本文:汪倪萍,戴敏,王华,张玲玲,魏伟.木瓜苷的镇痛作用(英文)[J].中国药理学与毒理学杂志,2005,19(3):169-174.
作者姓名:汪倪萍  戴敏  王华  张玲玲  魏伟
作者单位:安徽医科大学临床药理研究所,安徽,合肥,230032
基金项目:安徽省自然科学基金,安徽省科研项目
摘    要:目的 观察木瓜苷的镇痛作用并研究其相关机制。方法 通过小鼠乙酸扭体反应,甲醛实验及佐剂性关节炎大鼠屈伸关节实验等疼痛模型,观察木瓜苷的镇痛作用并检测佐剂性关节炎大鼠滑膜细胞分泌的前列腺素E2 (PGE2 )及肿瘤坏死因子 α(TNF α)的含量。结果 不同剂量的木瓜苷(小鼠6 0 ,12 0和2 4 0mg·kg- 1,ig ,大鼠30 ,6 0和12 0mg·kg- 1,ig)可以抑制小鼠的乙酸扭体反应和甲醛第二相反应。木瓜苷(6 0 ,12 0mg·kg- 1)可使佐剂性关节炎大鼠致炎d 2 8关节滑膜细胞升高的PGE2 和TNF α水平显著降低。结论 木瓜苷具有镇痛作用,其可能机制与其抑制外周炎症介质有关。

关 键 词:镇痛试验  木瓜苷  地诺前列酮  肿瘤坏死因子
收稿时间:2004-10-31

Antinociceptive effect of glucosides of Chaenomeles speciosa
WANG Ni-Ping,DAI Min,WANG Hua,ZHANG Ling-ling,WEI Wei.Antinociceptive effect of glucosides of Chaenomeles speciosa[J].Chinese Journal of Pharmacology and Toxicology,2005,19(3):169-174.
Authors:WANG Ni-Ping  DAI Min  WANG Hua  ZHANG Ling-ling  WEI Wei
Affiliation:(Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032,China)
Abstract:AIM To observe the antinociceptive effects of glucosides of Chaenomeles speciosa(GCS) and to study their relative mechanism. METHODS The effects of GCS on normal and inflammatory animals were observed in mouse acetic acid writhing test, mouse formalin test and arthritic flexion test of adjuvant arthritis(AA) rats; the concentration of prostaglandin E2 (PGE2) and tumor necrosis factor-α(TNF-α) secreted by the synovial cells of AA rats were measured by radioimmunoassay. RESULTSDifferent doses of GCS (60, 120, 240 mg·kg-1 for mice and 30, 60, 120 mg·kg-1 for rats, ig) inhibited mice′s writhing response and second phase of formalin response. It also suppressed the increased arthritic flexion scores in AA rats. On 28 d after inflammation induction, GCS (60, 120 mg·kg-1) decreased the concentration of PGE2 and TNF-α of synovial cells in the AA rats. CONCLUSIONGCS have antinociceptive effects, which related to its inhibitory effects on peripheral inflammatory mediators.
Keywords:analgesia test  Chaenomeles speciosa  glucoside  dinoprostone  tumor necrosis factor
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