| 长链非编码RNA-FENDRR在膀胱癌组织中的表达及临床意义 |
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| 引用本文： | 王玉杰,沈冲,高深,达拉,胡海龙.长链非编码RNA-FENDRR在膀胱癌组织中的表达及临床意义[J].天津医科大学学报,2020,0(5):445-449，465. |
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| 作者姓名： | 王玉杰 沈冲 高深 达拉 胡海龙 |
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| 作者单位： | （天津医科大学第二医院泌尿外科，天津市泌尿外科研究所，天津300211） |
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| 摘 要： | 目的:探究长链非编码RNA-FENDRR在膀胱癌组织中的表达情况及其与膀胱癌患者临床预后的关系。方法:收集50例（对）膀胱癌组织，用qRT-PCR检测FENDRR的表达量；同样在T24、5637、EJ和 253J-BV 等4种膀胱癌细胞系中验证其表达水平。用χ2检验分析FENDRR和患者临床特征的相关性，用Kaplan-Meier生存曲线分析不同表达组患者的生存状况，用Log-rank检验两组患者的肿瘤特异性生存 率差异。结果:LncRNA-FENDRR在膀胱癌组织中明显下调（t=7.222，P＜0.000 1），细胞系中验证结果一致，其中膀胱癌细胞系5637中表达量最低（P＜0.000 1）。相关性分析发现FENDRR表达水平与患 者浸润深度有关（χ2=4.612，P＜0.05）。生存分析发现，lncRNA-FENDRR低表达组患者的肿瘤特异性生存率显著低于高表达组（HR=3.17，95%CI:1.37～7.32，P<0.05）。结论:LncRNA-FENDRR在膀胱 癌组织中显著下调，其低表达与膀胱癌患者的不良预后有关。
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| 关 键 词： | 膀胱癌 长链非编码RNA FENDRR |
Expression of long non-coding RNA FENDRR in human bladder cancer tissues and Clinical significance |
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| WANG Yu-jie,SHEN Chong,GAO Shen,DA La,HU Hai-long.Expression of long non-coding RNA FENDRR in human bladder cancer tissues and Clinical significance[J].Journal of Tianjin Medical University,2020,0(5):445-449，465. |
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| Authors: | WANG Yu-jie SHEN Chong GAO Shen DA La HU Hai-long |
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| Affiliation: | （Department of Urology，The Second Hospital，Tianjin Medical University，Tianjin Institute of Urology，Tianjin 300211，China） |
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| Abstract: | Objective: To investigate the expression of long non-coding RNA-FENDRR(FOXF1 adjacent non-coding developmental regulatory RNA) in bladder cancer(BCa) tissues and its relationship with prognosis of patients with BCa. Methods: A total of 50 bladder cancer tissues were collected and qRT-PCR assay was performed to detected the expression of lncRNA-FENDRR, and its expression levels were also verified in four bladder cancer cell lines including T24, 5637, EJ and 253J-BV. Chi-square test was performed to evaluate the correlation between FENDRR expression and clinicopathological features of patients with BCa. Kaplan-Meier method and Log-rank test were performed to determine the correlation between FENDRR expression and prognosis of BCa patients. Results: LncRNA-FENDRR was significantly down-regulated in bladder cancer tissues(t=7.222，P＜0.000 1).The results were consistent in bladder cancer cell lines, among which the expression of lncRNA-FENDRR in cell line 5637 was the lowest(P＜0.000 1). Correlation analysis showed that expression levels of lncRNA-FENDRR were associated with the depth of invasion in patients（χ2=4.612, P＜0.05）. Survival analysis revealed that the tumor-specific survival rate of patients with low expression of lncRNA-FENDRR was significantly lower than that with high expression of lncRNA-FENDRR(HR=3.17,95% CI:1.37-7.32, P<0.05). Conclusion: LncRNA- FENDRR is significantly down-regulated in bladder cancer tissues and is associated with poor prognosis of bladder cancer patients. |
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| Keywords: | bladder cancer long noncoding RNA FENDRR |
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