| 灌注液中庆大霉素对白内障患者结膜囊细菌的作用 |
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| 引用本文： | 马文江,王俊妨,侯光华,孙鹏,李春艳.灌注液中庆大霉素对白内障患者结膜囊细菌的作用[J].天津医科大学学报,2020,0(2):175-177,187. |
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| 作者姓名： | 马文江 王俊妨 侯光华 孙鹏 李春艳 |
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| 作者单位： | （天津医科大学眼科医院检验科，天津300384） |
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| 摘 要： | 目的:分析白内障手术灌注液中庆大霉素对白内障患者结膜囊细菌的作用，为制定围手术期眼内炎预防措施提供依据。方法:采集200例白内障患者结膜囊拭子标本，进行细菌培养鉴定和药物敏感试验，观察检出细菌对20 μg/mL、40 μg/mL、80 μg/mL庆大霉素和2 μg/mL左氧氟沙星敏感率。结果:结膜囊细菌培养阳性检出率为62%，其中以表皮葡萄球菌为主，耐甲氧西林金黄色葡萄球菌（MRSA）检出率为3.22%，耐甲氧西林表皮葡萄球菌（MRSE）检出率为28.2%；全部检出细菌对20 μg/mL、40 μg/mL、80 μg/mL庆大霉素和2 μg/mL左氧氟沙星敏感率分别为79.84%、95.16%、97.58%、78.23%，中高浓度庆大霉素和左氧氟沙星比较，差异有统计学意义（均P<0.05）；MRSA和MRSE对20 μg/mL、40 μg/mL、80 μg/mL庆大霉素和2 μg/mL左氧氟沙星敏感率分别为69.23%、94.87%、100%、41.03%，各浓度庆大霉素和左氧氟沙星比较，差异有统计学意义（均P<0.05）。结论:白内障患者结膜囊细菌对灌注液中庆大霉素具有较高的敏感度，灌注液中加入适宜浓度庆大霉素，作为白内障围手术期眼内炎预防的措施应继续加以推广。
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| 关 键 词： | 灌注液 庆大霉素 白内障 眼内炎 左氧氟沙星 |
Effect of gentamicin in irrigating solutions on bacteria in conjunctival sac of cataract patient |
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| MA Wen-jiang,WANG Jun-fang,HOU Guang-hua,SUN Peng,LI Chun-yan.Effect of gentamicin in irrigating solutions on bacteria in conjunctival sac of cataract patient[J].Journal of Tianjin Medical University,2020,0(2):175-177,187. |
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| Authors: | MA Wen-jiang WANG Jun-fang HOU Guang-hua SUN Peng LI Chun-yan |
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| Affiliation: | （Clinical Laboratory of Tianjin Medical University Eye Hospital，Tianjin 300384, China） |
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| Abstract: | Objective: To analyze the effect of gentamicin in cataract irrigating solutions on bacteria in conjunctival sac of cataract patient and to provide the evidence for endophthalmitis precaution in cataract perioperative period. Methods: Bacterial culture and drug sensitive test were performed for 200 samples from cataract patients’ conjunctival sac. Susceptibility rates of detected pathogens against 20 μg/mL, 40 μg/mL, 80 μg/mL gentamicin and 2 μg/mL levofloxacin were observed. Results: Cultural positive rate of conjunctival sac was 62% (mainly Staphylococcus epidermidis, among them MRSA 3.22%, MRSE 28.2%). The sensitivity rates of all detected bacteria to 20 μg/mL, 40 μg/mL, 80 μg/mL gentamicin and 2 μg/mL levofloxacin were 79.84%, 95.16%, 97.58%, 78.23%, respectively. The difference between high and medium concentrations of gentamicin and levofloxacin was statistically significant(all P<0.05). The sensitivity rates of MRSA and MRSE to 20 μg/mL, 40 μg/mL, 80 μg/mL gentamicin and 2 μg/mL levofloxacin were 69.23%, 94.87%, 100%, 41.03%, respectively. The difference between gentamicin in each concentration and levofloxacin was statistically significant(all P<0.05). Conclusion: The bacteria in the conjunctival sac of patients with cataract have a high sensitivity to gentamicin in irrigating solutions. Gentamycin at appropriate concentration in irrigating solutions is a good measure for perioperative endophthalmitis prevention during cataract surgery. |
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| Keywords: | irrigating solutions gentamicin cataract endophthalmitis levofloxacin |
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