| Effect of valsartan-eluting stents on the expression of angiotensin Ⅱ type 2 receptor |
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| 作者姓名： | Wang L Li GH Chen H Li HW Zhao L Yao DK Ding RJ Jia SQ |
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| 作者单位： | Cardiovascular Center of Beijing Friendship Hospital, Capital University of Medicine Sciences, Beijing 100050, China |
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| 基金项目： | The study was supported by a grant from Beijing Municipal Nature Science Fund （No. 7042021）. |
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| 摘 要： | Percutaneous coronary intervention （PCI） with drug-eluting stent implantation has been provedefficient to reduce complications and restenosis in type B2/C lesions compared with bare stent, since the major drawback of the latter technique is intimal hyperplasia from the vessel media, which significantly cause in-stent restonosis. Despite the beneficial effects on the renin-angiotensin-aldosterone （RAAS） system, the role of angiotensin-converting enzyme （ACE） inhibitors after PCI is still unclear. However, first results of angiotensin receptor antagonist （valsartan） after stent implantation in the VaI-PREST1 and VALVACE2 trials have indicated the systemic pharmacological effect in the prevention of in-stent-restenosis. Up to our knowledge, whether local treatment of valsartan by implanting drug-eluting stent can generally prevent restenosis by inhibiting intimal hyperplasia has not been explored.
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| 关 键 词： | 血管紧张素Ⅱ 血管狭窄 药物洗脱支架 治疗 |
| 收稿时间： | 2006-03-01 |
Effect of valsartan-eluting stents on the expression of angiotensin II type 2 receptor |
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| Wang L,Li GH,Chen H,Li HW,Zhao L,Yao DK,Ding RJ,Jia SQ.Effect of valsartan-eluting stents on the expression of angiotensin II type 2 receptor[J].Chinese Medical Journal,2006,119(7):601-604. |
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| Authors: | Wang Lei Li Gui-hua Chen Hui Li Hong-wei Zhao Lin Yao Dao-kuo Ding Rong-jing Jia San-qing |
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| Affiliation: | Cardiovascular Center of Beijing Friendship Hospital, Capital University of Medicine Sciences, Beijing 100050, China |
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| Abstract: | |
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| Keywords: | eluting stent valsartan angiotensin II neointima restenosis |
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