| 孕妇血维生素D水平与妊娠期糖尿病相关性研究 |
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| 引用本文： | 叶瑛瑛,王金辉,王丽君,龚爱敏.孕妇血维生素D水平与妊娠期糖尿病相关性研究[J].中华全科医学,2021,19(1):77. |
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| 作者姓名： | 叶瑛瑛 王金辉 王丽君 龚爱敏 |
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| 作者单位： | 玉环市人民医院妇科，浙江 玉环 317600 |
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| 基金项目： | 浙江省医药卫生科技计划项目(2018KY922)。 |
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| 摘 要： | 目的 探讨孕妇血清25-羟维生素D25-(OH)D]水平与妊娠期糖尿病(gestational diabetes mellitus，GDM)的关系，分析孕妇血清25-(OH)D水平的影响因素。 方法 采用随机数字表法选取2017年9月—2018年12月在玉环市人民医院产检的300例孕妇，在孕早期、中期、晚期分别检测25-(OH)D水平，根据血清25-(OH)D水平分为缺乏组和不缺乏组，比较2组孕妇妊娠期糖尿病发生率的差别；根据孕晚期血清25-(OH)D水平，分析孕妇血清25-(OH)D水平的影响因素。 结果 孕早期缺乏组、不缺乏组孕妇妊娠期糖尿病发生率分别为26.32%、12.50%，比较差异无统计学意义(P＞0.05)；孕中期缺乏组、不缺乏组孕妇妊娠期糖尿病发生率分别为28.65%、9.80%，比较差异有统计学意义(P < 0.05)；孕晚期缺乏组、不缺乏组孕妇妊娠期糖尿病发生率分别为27.47%、10.00%，比较差异有统计学意义(P < 0.05)；在单因素分析的基础上经多因素logistic回归分析显示每日户外活动时间少、孕晚期在冬春季、未正规补充维生素D、未及时补充维生素D为孕妇血清25-(OH)D缺乏的独立危险因素(均P < 0.05)。 结论 孕妇血清25-(OH)D水平下降可能增加妊娠期糖尿病发生的风险，孕早期合理补充维生素D可有效预防孕妇维生素D缺乏，有助于降低妊娠期糖尿病的发生风险。
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| 关 键 词： | 孕妇 25-羟维生素D 妊娠期糖尿病 维生素 |
| 收稿时间： | 2019-10-21 |
Study on the relationship between serum vitamin D level and gestational diabetes mellitus in pregnant women |
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| Authors: | YE Ying-ying WANG Jin-hui WANG Li-jun GONG Ai-min |
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| Affiliation: | Gynaecology, Yuhuan People's Hospital of Zhejiang Province, Yuhuan, Zhejiang 317600, China |
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| Abstract: | Objective To investigate the relationship between serum 25-hydroxyvitamin D25-(OH)D]level and gestational diabetes mellitus(GDM)in pregnant women,and to analyze the influencing factors of serum 25-hydroxyvitamin D level in pregnant women.Methods A random number table was used to select 300 pregnant women who were examined in Yuhuan People’s Hospital from September 2017 to December 2018.The levels of 25-(OH)D were detected in the early,middle and late stages of pregnancy.According to the serum levels of 25-(OH)D,the pregnant women were divided into two groups:lack group and no lack group,and the incidence of gestational diabetes was compared between the two groups.According to the serum 25-(OH)D level in the third trimester,the influencing factors of serum 25-(OH)D level in pregnant women were analyzed.Results The incidence of gestational diabetes was 26.32%in the lack group and 12.50%in the no lack group,with no statistically significant difference(P>0.05).The incidence of gestational diabetes in the second trimester deficiency group and the no deficiency group were 28.65%and 9.80%,respectively,with statistically significant differences(P<0.05).The incidence of gestational diabetes was 27.47%and 10.00%in the lack group and no lack group,respectively,with statistically significant differences(P<0.05).On the basis of univariate analysis,multivariate logistic regression analysis showed that the independent risk factors of serum 25-(OH)D deficiency in pregnant women were less time spent in outdoor activities,winter and spring,no regular vitamin D supplementation,and no timely vitamin D supplementation(all P<0.05).Conclusion Decreased serum 25-(OH)D level in pregnant women may increase the risk of gestational diabetes.Reasonable vitamin D supplementation in early pregnancy can effectively prevent vitamin D deficiency in pregnant women and help reduce the risk of gestational diabetes. |
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| Keywords: | Pregnant women 25-hydroxyvitamin D Gestational diabetes mellitus Vitamin |
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