| 牙周基础治疗对2型糖尿病伴慢性牙周炎患者血清生化指标及炎性细胞因子的影响 |
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| 引用本文： | 武玮,郝树立,周玉森,梅艳洁,刘振飞.牙周基础治疗对2型糖尿病伴慢性牙周炎患者血清生化指标及炎性细胞因子的影响[J].中华全科医学,2020,18(2):249. |
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| 作者姓名： | 武玮 郝树立 周玉森 梅艳洁 刘振飞 |
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| 作者单位： | 1. 亳州市人民医院内分泌科, 安徽 亳州 236800; |
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| 基金项目： | 安徽省2017公益性技术应用研究联动计划项目(1704f0804037) |
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| 摘 要： | 目的 通过对2型糖尿病伴慢性牙周炎患者进行牙周基础治疗和常规治疗,分析牙周基础治疗对患者血清中生化指标及炎性细胞因子的影响。 方法 选择2017年8月—2019年2月亳州市人民医院内分泌及口腔科2型糖尿病伴轻中度慢性牙周炎住院患者共120例,男性58例,女性62例,年龄(56.63±10.96)岁。利用随机数字表法随机分为牙周基础治疗组和常规治疗组,各60例,牙周基础治疗组进行糖尿病常规治疗(包括糖尿病宣教、牙周健康教育、饮食指导、血糖控制)和牙周基础治疗包括菌斑控制、洁治术和龈下刮治术(根面平整术)、术后洗必泰含漱(3次/d)],常规治疗只进行糖尿病常规治疗。比较治疗前和治疗3个月后2组的血清生化指标(血糖、血脂、糖化血红蛋白比值、血钙、血磷、C-反应蛋白)及炎性细胞因子(TNF-α、IL-1β、IL-6、IL-10)水平。 结果 治疗前牙周基础治疗组与常规治疗组年龄、性别、BMI、腰围、空腹C肽、牙周炎情况、生化指标及炎症因子水平差异均无统计学意义(均P>0.05);治疗3个月后牙周基础治疗组的血糖、糖化血红蛋白比值、甘油三酯明显低于常规治疗组(均P<0.05);牙周基础治疗组TNF-α、IL-1β水平较常规治疗组明显下降,IL-10水平较常规治疗组明显升高,差异均有统计学意义(均P<0.05)。 结论 牙周基础治疗可以通过降低血糖、血脂及调节炎性细胞因子水平来改善2型糖尿病合并慢性牙周炎患者的糖脂代谢及炎症状态。
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| 关 键 词： | 2型糖尿病 牙周基础治疗 牙周炎 生化指标 炎性细胞因子 |
| 收稿时间： | 2019-08-31 |
Effect of non-surgical periodontal treatment on serum biochemical indexes and inflammatory cytokines in patients with type 2 diabetes mellitus and chronic periodontitis |
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| Affiliation: | 1. Department of Endocrinology,Bozhou People's Hospital,Bozhou,Anhui 236800,China |
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| Abstract: | Objective To analyze the effect of non-surgical periodontal treatment on biochemical indexes and inflammatory cytokines in serum of patients with type 2 diabetes mellitus and chronic periodontitis through carrying out non-surgical periodontal treatment and routine treatment in patients with type 2 diabetes mellitus and chronic periodontitis. Methods A total of 120 cases of type 2 diabetes mellitus with mild to moderate chronic periodontitis in Bozhou People's Hospital from August 2017 to February 2019,58 males and 62 females,aged(56.63 ± 10.96) years were collected. According to random number table,patients were divided into the non-surgical periodontal treatment group and the routine treatment group,60 cases each group. The non-surgical periodontal treatment group were received the routine treatment of diabetes,including diabetes education,periodontal health education,diet guidance,blood glucose control,and the non-surgical periodontal treatment,including plaque control,scaling and subgingival scaling(root planning),postoperative chlorhexidine gargle(3 times/d). The routine treatment group were only received the routine treatment of diabetes. The serum biochemical indexes(blood glucose,blood lipid,ratio of glycosylated hemoglobin,blood calcium,blood phosphorus,Creactive protein and inflammatory cytokines(TNF-α,IL-1β,IL-6,IL-10) before and after 3 months of treatment were compared. Results There was no significant difference in age,gender,BMI,waist circumference,fasting C-peptide,periodontitis condition,biochemical indexes and inflammatory factors between the two groups before treatment(all P>0.05). After 3 months of treatment,the blood glucose,glycosylated hemoglobin ratio,triglyceride,the levels of TNF-αand IL-1β in the non-surgical periodontal treatment group were significantly lower than those in the routine treatment group(all P<0.05). The levels of IL-10 in the non-surgical periodontal treatment group were significantly increased compared with those in the routine treatment group(all P<0.05). Conclusion Non-surgical periodontal treatment can improve the glucose and lipid metabolism and inflammatory state of patients with type 2 diabetes mellitus and chronic periodontitis by reducing the patients' level of blood glucose,blood lipid and adjust inflammatory cytokines. |
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