| 新疆维吾尔族、汉族同型半胱氨酸与原发性高血压患者早期肾功能损害的相关性研究 |
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| 引用本文： | 陈红丽,李瑜,王红,时庆平,欧阳菊艳,路艳霞,陈诚.新疆维吾尔族、汉族同型半胱氨酸与原发性高血压患者早期肾功能损害的相关性研究[J].中华全科医学,2017,15(11):1897-1900. |
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| 作者姓名： | 陈红丽 李瑜 王红 时庆平 欧阳菊艳 路艳霞 陈诚 |
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| 作者单位： | 新疆医科大学第一附属医院老年病科, 新疆 乌鲁木齐 830054 |
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| 基金项目： | 新疆维吾尔自治区心血管病研究室开放课题 (XJDX0903-2013-05) |
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| 摘 要： | 目的 探讨维吾尔族和汉族原发性高血压(essential hypertension，EH)患者同型半胱氨酸(homocysteine，Hcy)与早期肾功能损害的相关性及民族差异性。 方法 收集2012年9月—2016年7月住院的EH患者812例。根据Hcy≥10 μmol/L分为H型高血压组(维吾尔族254例，汉族294例)，Hcy<10 μmol/L为单纯高血压组(维吾尔族149例，汉族115例)。检测Hcy、肌酐等指标，分析Hcy与肾功能的关系并比较民族差异。 结果 维吾尔族、汉族同民族间H型高血压组与单纯高血压组比较，肌酐、胱抑素C水平及早期肾损害率均明显升高(P<0.05)，eGFR明显下降(P<0.05)。H型高血压组和单纯高血压组中维吾尔族、汉族比较，eGFR和早期肾损害率差异无统计学意义(P>0.05)。Logistic回归分析显示，LnHcy (OR=2.201，95%CI:1.066～4.543，P=0.033)、胱抑素C (OR=1.475，95%CI:1.303～1.699，P<0.001)、低高密度脂蛋白胆固醇(OR=2.475，95%CI:1.436～4.268，P=0.001)、血尿素氮(OR=1.277，95%CI:1.054～1.547，P=0.013)是维吾尔族EH患者早期肾功能损害的独立危险因素；LnHcy (OR=3.804，95%CI:1.855～7.798，P<0.001)、胱抑素C (OR=1.655，95%CI:1.433～1.911，P<0.001)、低高密度脂蛋白胆固醇(OR=2.059，95%CI:1.208～3.509，P=0.008)、血尿素氮(OR=1.222，95%CI:1.018～1.468，P=0.032)、吸烟(OR=1.993，95%CI:1.082～3.671，P=0.027)是汉族EH患者早期肾功能损害的独立危险因素。 结论 Hcy是维吾尔族和汉族原发性高血压患者早期肾功能损害的共同危险因素，原发性高血压患者早期肾损害率在两民族间无差异。
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| 关 键 词： | 同型半胱氨酸 早期肾功能损害 原发性高血压 民族 |
| 收稿时间： | 2016-11-17 |
Association of Homocysteine with Early Renal Damage in Essential Hypertension in Ethnic Uyghurs and Hans from Xinjiang |
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| Affiliation: | Department of Geriatric Ward, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China |
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| Abstract: | Objective To investigate plasma homocysteine(Hcy) levels and early renal damage in essential hypertension in ethnic Uyghurs and Hans patients,and to explore the difference of early renal damage in the two ethnics. Methods Eight hundred and twelve cases with essential hypertension were included and divided into two groups:H-type hypertension group(Hcy ≥ 10 μmol/L,254 cases were Uyghurs and 294 cases were Hans) and non H-type hypertension group(Hcy<10 μmol/L,149 cases were Uyghur and 115 cases were Hans).The plasma levels of Hcy and creatinine were measured.The correlation between Hcy and early renal damage and the difference of early renal damage in the two ethnics were analysed. Results Compared with the non H-type hypertension group,the levels of creatinine,cystatin C,and the early renal damage prevalence were statistically higher in H-type hypertension group in both ethnic Uyghurs and Hans(P<0.05),while eGFR was significantly lower(P<0.05).There were no difference of early renal damage prevalence in the two ethnics in both H-type hypertension group and non H-type hypertension group(P>0.05).Logistic regression analysis indicated that LnHcy(OR=2.201,95% CI:1.066-4.543,P=0.033),cystatin C(OR=1.475,95% CI:1.303-1.699,P<0.001),low HDL-C(OR=2.475,95% CI:1.436-4.268,P=0.001),BUN(OR=1.277,95% CI:1.054-1.547,P=0.013) were independent risk factors for early renal damage in essential hypertension among ethnic Uyghurs.While LnHcy(OR=3.804,95% CI:1.855-7.798,P<0.001),cystatin C(OR=1.655,95% CI:1.433-1.911,P<0.001),low HDL-C(OR=2.059,95% CI:1.208-3.509,P=0.008),BUN(OR=1.222,95% CI:1.018-1.468,P=0.032),cigarette(OR=1.993,95% CI:1.082-3.671,P=0.027) were independent risk factors for early renal damage in essential hypertension among ethnic Hans. Conclusion Plasma levels of Hcy is associated with early renal damage in essential hypertension in both ethnic Uyghurs and Hans patients,there were no difference of early renal damage prevalence in the two ethnics. |
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