| 妊娠晚期女性B族链球菌携带情况及对母婴妊娠结局的影响 |
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| 引用本文： | 叶知昀,梁辉标,许群,吴天霞.妊娠晚期女性B族链球菌携带情况及对母婴妊娠结局的影响[J].中华全科医学,2019,17(8):1344-1346,1359. |
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| 作者姓名： | 叶知昀 梁辉标 许群 吴天霞 |
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| 作者单位： | 1. 浙江中医药大学附属温州中西医结合医院产科, 浙江 温州 325000; |
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| 基金项目： | 浙江省医药卫生科技计划项目(2017KY425) |
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| 摘 要： | 目的观察妊娠晚期女性B族链球菌携带情况及对母体和胎儿妊娠结局的影响。方法以温州中西医结合医院2016年12月-2018年12月就诊的966例妊娠晚期女性为研究对象,均进行阴道及直肠分泌物B族链球菌检测,观察B族链球菌携带情况,跟踪妊娠结局,统计不同组研究对象母体和胎儿妊娠结局水平差异。结果本研究全部966例受试者GBS感染率为9.52%,不同年龄、流产史和生育史受试者GBS感染率差异均无统计学意义(均P>0.05);GBS阳性未干预组胎膜早破、羊膜炎、宫内感染、产褥感染、新生儿感染、胎儿窘迫和新生儿窒息发生率均显著高于GBS阴性组水平(均P<0.05),而GBS阳性干预组羊膜炎、宫内感染、产褥感染、新生儿感染、胎儿窘迫和新生儿窒息发生率均显著低于GBS阳性未干预组水平(均P<0.05),且GBS阳性干预组在羊膜炎、宫内感染和新生儿感染发生率均显著高于GBS阴性组水平(均P<0.05);3组受试者新生儿Apgar评分、早产、剖宫产和产后出血发生率差异不具有统计学意义(均P>0.05)。结论妊娠晚期孕妇GBS感染可导致胎膜早破、羊膜炎、宫内感染、产褥感染、新生儿感染、胎儿窘迫和新生儿窒息等母体和胎儿不良妊娠结局发生率增加,实施抗菌药物预防性治疗可在一定程上降低母婴不良妊娠结局发生率,妊娠晚期孕妇进行产前GBS筛查,具有较高的临床价值。
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| 关 键 词： | 妊娠晚期 B族链球菌 妊娠结局 预防性干预 影响 |
| 收稿时间： | 2019-02-18 |
Effect of group B streptococci on pregnancy and pregnancy outcome in late pregnancy women |
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| Affiliation: | Department of Obstetrics, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine, Wenzhou, Zhejiang 325000, China |
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| Abstract: | Objective To observe the carriage of group B streptococcus (GBS) in pregnant women and its effect on the pregnancy outcome of the mother and fetus. Methods A total of 966 cases of late pregnancy women were as research subjects. Vaginal and rectal secretion of GBS were detected in all subjects. The carrying status of GBS were observed. The pregnancy outcomes of different groups were traced. The difference of pregnancy outcome between the maternal and fetal groups was analyzed statistically. Results The GBS infection rate of all 966 subjects in this study was 9.52%, and there was no significant difference in the rate of GBS infection among the subjects of different ages, abortion history and reproductive history (all P>0.05). The incidence of premature rupture of membranes, amnionitis, intrauterine infection, puerperium infection, neonatal infection, fetal distress and neonatal asphyxia were significantly higher in GBS positive group than in the GBS negative group (all P<0.05). The incidence of amnionitis, intrauterine infection, puerperium infection, neonatal infection, fetal distress and neonatal asphyxia in GBS positive intervention group were significantly lower than that of GBS positive group (all P<0.05). The incidence of amniotic inflammation, intrauterine infection and neonatal infection in GBS positive intervention group was significantly higher than that in GBS negative group (all P<0.05). There was no significant difference in the Apgar score, preterm delivery, cesarean section and postpartum hemorrhage between the three groups (all P>0.05). Conclusion GBS infection in pregnant women in late pregnancy can lead to premature rupture of membranes, amnionitis, intrauterine infection, puerperal infection, neonatal infection, fetal distress and neonatal asphyxia. The incidence of maternal and fetal adverse pregnancy outcomes is increased. The incidence of maternal and infant undesirable pregnancy outcomes can be reduced on a certain course and late pregnancy in the late pregnancy by the implementation of antibiotic prophylactic treatment. Prenatal GBS screening for pregnant women is of high clinical value. |
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| Keywords: | Late pregnancy Group B streptococcal infection Pregnancy outcome Preventive intervention Influence |
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