| 特殊生境真菌来源的新结构活性物质研究 |
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| 引用本文： | 车永胜.特殊生境真菌来源的新结构活性物质研究[J].国际药学研究杂志,2011,38(1):12-27. |
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| 作者姓名： | 车永胜 |
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| 作者单位： | 中国科学院微生物研究所真菌地衣系统学重点实验室,北京,100190 |
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| 基金项目： | 国家自然科学基金项目，杰出青年基金项目，国家重大基础研究发展计划资助项目，国家高技术研究发展计划重点项目，国家科技重大专项，中国科学院"百人计划"、知识创新工程重要方向性项目 |
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| 摘 要： | 真菌的物种与生态多样性导致了其次生代谢产物结构与活性的多样性,是药物先导化合物的重要来源之一.常规真菌来源活性物质的研究多是针对普通资源的盲筛,尽管通过高通量筛选能提高效率.但发现新活性物质的几率较低,成为制约先导化合物发现的瓶颈.由于特殊生境真菌资源的收集、整理以及培养的难度较大,制约了相关的研究,因而挖掘其代谢潜力...
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| 关 键 词： | 植物内生真菌 地衣内生真菌 冬虫夏草定殖真菌 新结构 次生代谢产物 抗菌活性 抗肿瘤活性 |
| 收稿时间： | 2010-11-22 |
| 修稿时间： | 2010-12-23 |
Discovery of new bioactive natural products from fungi of unique ecological niches |
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| CHE Yong-sheng.Discovery of new bioactive natural products from fungi of unique ecological niches[J].Foreign Medical Sciences(Section of Pharmarcy),2011,38(1):12-27. |
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| Authors: | CHE Yong-sheng |
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| Affiliation: | （Key Laboratory of Systematic Mycology &; Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China） |
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| Abstract: | The biodiversity of fungi in taxonomy and the biotopes in which they inhabit leads to the production of a variety of secondary metabolites that display a broad range of bioactivities, from which some very important medicines have been discovered. Even though the fungal secondary metabolites are an important source of drug leads, it has become increasingly difficult to discover new natural product scaffolds due to extensive screening of common soil fungi. Those special types of fungi have been largely neglected, presumably due to the difficulty in collecting and culturing of the organisms. Therefore, fungi of significantly underexplored taxonomic and ecological groups provide limitless metabolic potential for the production of new bioactive natural products, and systematic investigations of these fungal species will definitely play a key role in the discovery of new drug leads and understanding the chemical and biological bases for their living strategies. During the past four years, our research group has mainly focused on special types of fungi as sources of new bioactive metabolites, such as the endophytic fungi and the Cordyceps-colonizing fungi. Some results from this work are summarized herein. |
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| Keywords: | plant endophytic fungi lichenolic fungi Cordyceps-colonizing fungi new structures secondary metabolites antimicrobial activity antitumor activity |
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