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蟾酥及其活性成分抗肿瘤作用研究进展
引用本文:刘俊珊,张冬梅,栗原博,叶文才.蟾酥及其活性成分抗肿瘤作用研究进展[J].国际药学研究杂志,2009,36(2):115-120.
作者姓名:刘俊珊  张冬梅  栗原博  叶文才
作者单位:暨南大学药学院,广东,广州,510632
摘    要:蟾酥作为一种传统中药,具有镇痛、消炎、麻醉等作用。近年来研究表明,蟾酥具有确切的抗肿瘤活性,能够诱导肿瘤细胞的凋亡、抑制肿瘤细胞增殖、促进肿瘤细胞的分化,还有逆转耐药性、抑制肿瘤血管形成及增强免疫的作用。本文主要就蟾酥及其活性成分抗肿瘤作用的研究进展作一综述。

关 键 词:蟾酥    华蟾酥毒基    抗肿瘤药    中药药理学
收稿时间:2008-11-6

Antitumor effects of venenum bufonis and its active components
LIU Jun-shan,ZHANG Dong-mei,KURIHARA Hiroshi,YE Wen-cai.Antitumor effects of venenum bufonis and its active components[J].Foreign Medical Sciences(Section of Pharmarcy),2009,36(2):115-120.
Authors:LIU Jun-shan  ZHANG Dong-mei  KURIHARA Hiroshi  YE Wen-cai
Affiliation:(College of Pharmacy, Jinan University, Guangzhou 510632, China)
Abstract:Venenum bufonis, as one of the traditional Chinese materia medica, has functions in analgesia, eliminating inflammation a,d narcosis et al. Recent studies indicated that venenum bufonis has the distinguished anticancer activity. It could induce apoptosis, inhibit the cell proliferation, promote the cell differentiation, reverse the drug resistance, restrain neovacularization and enhance the immunity system. This review mainly summarizes the antitumor effects of venenum bufonis and its active components in recent years.
Keywords:venenum bufonis  cinobufagin  antineoplastic drugs  pharmacology
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