| 意向性运动干预影响局部脑缺血大鼠GLUA2和N-cadherin表达的影响 |
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| 作者姓名： | 蒋雯 梅松 李海江 蒋国梁 黄丹 |
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| 作者单位： | 1.昆明医科大学第一附属医院神经内科，云南 昆明 650032 |
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| 基金项目： | 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202001AY07001-186）；云南省神经系统疾病临床医学研究中心应用研究基金资助项目（ 202002AA100204）；云南省神经系统疾病诊疗中心应用基础研究基金资助项目（ZX2019-03-05） |
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| 摘 要： | 目的 研究意向性运动干预治疗对大脑局部缺血大鼠行为学及梗死灶周围组织中GluA2和N-cadherin表达的影响.方法 利用鱼线栓堵法将大鼠制成大脑中动脉栓塞(middle cerebral artery occlusion,MCAO)模型共144只,随机分成模型(MCAO)组、生活环境变化(environment m...
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| 关 键 词： | 局灶性脑缺血 意向性运动 突触可塑性 GLUA2 N-cadherin |
| 收稿时间： | 2022-01-22 |
Effects of Willed Movement on the Expression of GLUA2 and N-cadherin in Rats with Focal Cerebral Ischemia |
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| Affiliation: | 1.Dept. of Neurology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 6500322.Dept. of Renal Endocrinology，Kunming Tongren Hospital， Kunming Yunnan 650228，China |
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| Abstract: | Objective To explore effect of the Willed movement on behaviours of rats with focal cerebral ischemia and the expression of GluA2 and N-cadherin in the brain tissue around ischemia. Methods We selected clean-level healthy male SD rats, and prepared 144 middle cerebral artery occlusion （MCAO） models by thread occlusion method, and randomly divided them into model （MCAO） group, environment modification （EM） group, control rehabilitstion （CR） group and Willed movement （WM） group, each group was divided into four subgroups of 7, 15, and 30 days according to the postoperative time. The behavioral changes of rats in each group were dynamically observed, and the expression changes of GluA2 and N-cadherin protein in the brain tissue around the ischemic area were observed by immunohistochemical staining. Results On 7, 15, and 30 days after reperfusion, the climbing frequency of rats which were treated by willed movement was obviously higher than EM and CR group （P < 0.01）. After 30 days of reperfusion, the neurological deficits score of the intentional exercise intervention group was lower than MCAO rats （P < 0.05）. Compare with MCAO rats, the expression levels of GLUA2 and N-cadherin were higher in ischemic penumbra （P < 0.05）. Conclusions Willed movement can promote the recovery of damaged nerve function after focal cerebral ischemia, which may be related to up-regulating the expression of GLUA2 and N-cadherin in the brain tissue around the ischemic focus and enhancing synaptic plasticity. |
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