| 晚发性抑郁症病人同型半胱氨酸水平和认知功能的研究 |
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| 引用本文： | 陈黎明,王小泉,王祖森.晚发性抑郁症病人同型半胱氨酸水平和认知功能的研究[J].蚌埠医学院学报,2020,45(6):815-817. |
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| 作者姓名： | 陈黎明 王小泉 王祖森 |
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| 作者单位： | 1.皖南医学院 研究生学院, 安徽 芜湖 2410022.安徽省芜湖市第四人民医院精神科, 2410023.安徽省芜湖市第四人民医院检验科, 241002 |
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| 基金项目： | 安徽省神经精神疾病与心理健康协同创新中心开放性课题NDMHCI-16-08 |
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| 摘 要： | 目的探讨晚发性抑郁症病人同型半胱氨酸（Hcy）水平与认知功能的关系。方法采用病例对照研究方法，对98例晚发性抑郁症病人（观察组）及88名正常老年人（对照组）进行认知功能评定，所有受试者采用酶法进行血液Hcy水平测定。结果观察组Hcy水平高于对照组（P < 0.05），各项认知功能评分均低于对照组（P < 0.01）。相关性分析显示，Hcy水平与HAMD评分无相关性（P>0.05），Hcy水平与简易智力状态检查量表总分呈负相关（P < 0.05）。结论晚发性抑郁症病人存在Hcy水平的增高。与正常老年群体相比，晚发性抑郁症病人存在明显的注意、短时记忆、言语及执行功能等方面的认知功能缺陷。
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| 关 键 词： | 晚发性抑郁 同型半胱氨酸 认知功能 |
| 收稿时间： | 2019-06-10 |
Study on the homocysteine level and cognitive function in late-onset depression |
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| Affiliation: | 1.Graduate School, Wannan Medical College, Wuhu Anhui 2410022.Deaprtment of Phychiatry, The Fourth People's Hospital of Wuhu, Wuhu Anhui 241002, China3.Department of Laboratory, The Fourth People's Hospital of Wuhu, Wuhu Anhui 241002, China |
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| Abstract: | ObjectiveTo study the relationship between homocysteine(Hcy) level and cognitive function in late-onset depression.MethodsThe cognitive function in 98 patients with late-onset depression(observation group) and 88 healthy olders(control group) was detected using case-control study method, and the serum levels of Hcy in two groups were enzymatically tested.ResultsThe Hcy level in observation group was higher than that in control group(P < 0.05).The cognitive function scores in observation group were lower than that in control group(P < 0.01).The results of correlation analysis showed that the Hcy level was not correlated with HAMD score(P>0.05), and the Hcy level was negatively correlated with the total score of MMSE(P < 0.05).ConclusionsThe levels of Hcy in patients with late-onset depression increase.Compared with the normal elderly population, the cognitive deficits in attention, short-term memory, speech, and executive function in patients with late-onset depression are obvious. |
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