| S100A12/RAGE/NF-κB炎性信号通路与急性脑梗死严重程度的相关性 |
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| 引用本文： | 解渊,苑瑞敏,张晗,袁超,储佺兵.S100A12/RAGE/NF-κB炎性信号通路与急性脑梗死严重程度的相关性[J].蚌埠医学院学报,2022,47(1):41-43, 46. |
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| 作者姓名： | 解渊 苑瑞敏 张晗 袁超 储佺兵 |
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| 作者单位： | 马鞍山十七冶医院 神经内科, 安徽 马鞍山 243000 |
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| 基金项目： | 安徽省马鞍山市科技局项目马科[2017]69号 |
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| 摘 要： | 目的观察急性脑梗死病人血清中S100钙结合蛋白A12（S100A12）、晚期糖基化终产物受体（RAGE）及核转录因子-κB（NF-κB）的动态变化，并分析其与脑梗死严重程度的相关性。方法纳入82例急性脑梗死病人为观察组，于入院后1、3、7 d进行美国国立卫生研究院卒中量表（NIHSS）评分，ELISA检测相应时间点血清S100 A12、RAGE及NF-κB水平变化，并与NIHSS评分进行相关性分析；另纳入85例因非脑血管病住院病人为对照组，于入院后1 d检测S100 A12、RAGE及NF-κB水平。结果观察组1、3、7 d血清S100 A12、RAGE及NF-κB水平均明显高于对照组（P < 0.01）；1 d血清S100 A12、RAGE以及NF-κB水平均最高（P < 0.05~P < 0.01）；3 d与7 d水平差异均无统计学意义（P>0.05）。相关性分析显示，各时间点血清S100 A12、RAGE及NF-κB水平与相应NIHSS评分均呈正相关关系（P < 0.05~P < 0.01）。结论脑梗死急性期S100 A12、RAGE及NF-κB水平升高，且与急性脑梗死后神经功能缺损严重程度相关。
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| 关 键 词： | 脑梗死 S100钙结合蛋白A12 晚期糖基化终产物受体 核转录因子-κB |
| 收稿时间： | 2020-03-30 |
Correlation between S100 A12/RAGE/NF-kB inflammatory signal pathway and severity of acute cerebral infarction |
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| XIE Yuan,YUAN Rui-min,ZHANG Han,YUAN Chao,CHU Quan-bing.Correlation between S100 A12/RAGE/NF-kB inflammatory signal pathway and severity of acute cerebral infarction[J].Journal of Bengbu Medical College,2022,47(1):41-43, 46. |
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| Authors: | XIE Yuan YUAN Rui-min ZHANG Han YUAN Chao CHU Quan-bing |
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| Affiliation: | Department of Neurology, Ma'anshan Shiqiye Hospital, Ma'anshan Anhui 243000, China |
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| Abstract: | ObjectiveTo observe the dynamic changes of S100 calcium binding protein A12(S100A12), receptor for advanced glycation end products(RAGE) and nuclear factor κB(NF-κB) in patients with acute cerebral infarction, and analyze the correlation between them and severity of cerebral infarction.MethodsEighty-two patients with acute cerebral infarction were set as the observation group.On the 1 d, 3 d and 7 d after admission, the NIHSS scores in the observation group were evaluated, the serum levels of S100A12, RAGE and NF-κB were detected using ELISA, and the correlation between the above indexes and NIHSS score was analyzed.Eighty-five patients without cerebrovascular disease were set as the control group, and the serum levels of S100A12, RAGE, NF-κB were detected on the first day after admission.ResultsThe serum levels of S100A12, RAGE and NF-κB in observation group on the 1 d, 3 d and 7 d were significantly higher than those in control group(P < 0.01).The levels of S100A12, RAGE and NF-κB was highest on the 1 d(P < 0.05 to P < 0.01), and tbe differences of which between 3 d and 7 d were not statistically significant(P>0.05).The results of correlation analysis indicated that the serum levels of S100A12, RAGE and NF-κB were positively correlated with NIHSS score at each time point(P < 0.05 to P < 0.01).ConclusionsThe levels of S100A12, RAGE and NF-κB increase, which are related to the severity degree of neurological deficit in patients with acute cerebral infarction. |
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