| 老年慢性阻塞性肺疾病伴鼾症临床表型病人血清Caspase-3及Caspase-9水平相关性 |
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| 引用本文： | 戈艳蕾,刘聪辉,付爱双,崔紫阳,张婉,解宝泉,王袁,王红阳,张嘉宾.老年慢性阻塞性肺疾病伴鼾症临床表型病人血清Caspase-3及Caspase-9水平相关性[J].蚌埠医学院学报,2021,46(2):176-178. |
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| 作者姓名： | 戈艳蕾 刘聪辉 付爱双 崔紫阳 张婉 解宝泉 王袁 王红阳 张嘉宾 |
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| 作者单位： | 1.华北理工大学附属医院 呼吸科, 河北 唐山 0630002.华北理工大学附属医院 内分泌科, 河北 唐山 0630003.华北理工大学附属医院 质量管理办公室, 河北 唐山 063000 |
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| 摘 要： | 目的探讨老年慢性阻塞性肺疾病（COPD）伴鼾症临床表型病人血清Caspase-3及Caspase-9水平相关性。方法选取老年COPD病人312例，根据病人是否存在鼾症，分为鼾症组及单纯组, 比较2组病人血清Caspase-3及Caspase-9水平变化，分析老年COPD伴鼾症临床表型病人血清Caspase-3及Caspase-9水平及其与睡眠监测指标相关性。结果鼾症组血清Caspase-3及Caspase-9水平明显高于单纯组（P < 0.01）。鼾症组睡眠呼吸暂停低通气指数、氧减指数与血清Caspase-3及Caspase-9水平呈明显正相关关系（P < 0.01），夜间最低血氧饱和度、夜间平均血氧饱和度与血清Caspase-3及Caspase-9水平呈明显负相关关系（P < 0.01）。结论在老年COPD伴鼾症临床表型病人，血清Caspase-3及Caspase-9水平增高与病人睡眠障碍低通气程度相关，睡眠障碍低通气程度越严重，血清Caspase-3及Caspase-9水平越高。
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| 关 键 词： | 慢性阻塞性肺疾病 鼾症 半胱氨酸天冬酶 |
| 收稿时间： | 2016-11-26 |
Relationship between serum levels of Caspase-3 and Caspase-9 and clinical phenotypes in COPD elderly patients complicated with snoring syndrome |
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| GE Yan-lei,LIU Cong-hui,FU Ai-shuang,CUI Zi-yang,ZHANG Wan,XIE Bao-quan,WANG Yuan,WANG Hong-yang,ZHANG Jia-bin.Relationship between serum levels of Caspase-3 and Caspase-9 and clinical phenotypes in COPD elderly patients complicated with snoring syndrome[J].Journal of Bengbu Medical College,2021,46(2):176-178. |
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| Authors: | GE Yan-lei LIU Cong-hui FU Ai-shuang CUI Zi-yang ZHANG Wan XIE Bao-quan WANG Yuan WANG Hong-yang ZHANG Jia-bin |
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| Affiliation: | 1.Department of Respiratory, North China University of Science and Technology, Tangshan Hebei 063000, China2.Department of Endocrinology, North China University of Science and Technology, Tangshan Hebei 063000, China3.Office of Quality Management, North China University of Science and Technology, Tangshan Hebei 063000, China |
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| Abstract: | ObjectiveTo investigate the correlations of the serum levels of Caspase-3 and Caspase-9 with clinical phenotypes in chronic obstructive pulmonary disease(COPD)elderly patients complicated with snoring syndrome.MethodsThree hundred and twelve elderly patients with COPD were divided into the snoring group and simple group according to the presence or absence of snoring syndrome.The serum levels of Caspase-3 and Caspase-9 were compared between two groups, and the relationships between serum levels of Caspase-3, Caspase-9 and sleep index in COPD elderly patients complicated with snoring syndrome were analyzed.ResultsThe serum levels of Caspase-3 and Caspase-9 in snoring group were significantly higher than those in simple group(P < 0.01).The AHI and ODI in snoring group were significantly positively correlated with the serum levels of Caspase-3 and Caspase-9, and the LSaO2 and MSaO2 were negatively correlated with the serum levels of Caspase-3 and Caspase-9(P < 0.01).ConclusionsThe high serum levels of Caspase-3 and Caspase-9 are correlated with the low degree of APNEA in elderly COPD patients complicated with snoring syndrome.The higher the serum levels of Caspase-3 and Caspase-9 are, the more severe of sleep disturbance is. |
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