| 多靶区协同增强神经环路调控:思考与创新 |
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| 引用本文： | 郑娅,许东升.多靶区协同增强神经环路调控:思考与创新[J].四川大学学报(医学版),2020,51(5):587-591. |
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| 作者姓名： | 郑娅 许东升 |
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| 作者单位： | 1.同济大学附属同济医院 康复医学中心 （上海 200065） |
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| 摘 要： | 运动功能损伤大多阻断或干扰运动神经传导通路。本团队创新设计的多靶区磁刺激（magnetic stimulation, MS）技术通过刺激皮层和神经根，激活人体中枢和外周神经系统，目前已在科研和临床探索中取得初步疗效。机制研究涉及神经元的激活、神经传导、损伤区微环境的调节和基因调控等。然而，如何使MS技术在临床康复中实现更精准有效的神经修复，是神经调控目前面临的瓶颈问题，可能需要从神经环路重建和任务导向训练去突破。本专题聚焦“神经再生调控与康复”，旨在将神经再生与神经调控的理念运用于临床的康复治疗中，并为探索康复效果的神经生物学机制提供有力依据。本述评将通过多靶区协同增强神经环路调控技术在神经环路重建中发挥的重要作用展开思考，建立更精准有效的MS创新技术与临床路径，以期推动神经调控的基础和临床应用研究。
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| 关 键 词： | 经颅磁刺激 神经调控 神经环路 临床试验 突触可塑性 |
| 收稿时间： | 2020-03-05 |
Multi-target Synergistic Enhanced Neural Circuit Modulation: Thinking and Innovation |
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| ZHENG Ya,XU Dong-sheng.Multi-target Synergistic Enhanced Neural Circuit Modulation: Thinking and Innovation[J].Journal of West China University of Medical Sciences,2020,51(5):587-591. |
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| Authors: | ZHENG Ya XU Dong-sheng |
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| Affiliation: | 1.Rehabilitation Medical Center, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai 200065, China |
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| Abstract: | Motor function injuries mostly block or interfere with motor nerve conduction pathways. Theinnovative multi-target magnetic stimulation (MS) technology stimulates the cortex and nerve roots to activate the human central and peripheral nervous system, and has achieved preliminary results in scientificand clinical exploration. The mechanismsof these researches involve the activation of neurons, nerve conduction, the regulation of the microenvironment of the injured area, and gene regulation. However, how to make the multi-target MS technology achieve more accurate and effective nerve repair in rehabilitation is a bottleneck problem, which may need to break through neural circuit reconstruction and task-oriented training. This topic focuses on Nerve Regeneration Modulation and Rehabilitation, aiming to apply the concepts of nerve regeneration and neuromodulation totreatment of rehabilitation, and to supportfor exploring the neurobiological mechanism of rehabilitation. This review will explore the important role of multi-target synergistic enhanced neural circuit modulation technology in neural circuit reconstruction, and establish more accurate and effective multi-target innovative technologies and clinical pathways, so as to promote the basic and clinical research of neuromodulation. |
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