| 糖尿病肾病发病机制研究进展 |
| |
| 引用本文： | 李敏州,高彦彬,马鸣飞,朱智耀,邹大威,李勤.糖尿病肾病发病机制研究进展[J].中国实验方剂学杂志,2012,18(22):344-349. |
| |
| 作者姓名： | 李敏州 高彦彬 马鸣飞 朱智耀 邹大威 李勤 |
| |
| 作者单位： | 1. 北京中医药大学东方医院内分泌科,北京,100078
2. 首都医科大学中医药学院,北京,100069 |
| |
| 基金项目： | 国家自然科学基金项目(81173238);北京市教育委员会科技计划重点项目(KZ201110025025);国家重点基础研究发展计划(973计划)项目(2012CB518602) |
| |
| 摘 要： | 对糖尿病肾病发病机制的研究进展进行文献整理和分析。通过检索PubMed数据库查阅有关糖尿病肾病作用机制的文献,对近年来国外有关糖尿病肾病发病机制的研究进行了整理和分析。糖尿病肾病的发病机制与多种因素密切相关,包括糖代谢紊乱:糖基化终末产物(AGEs)的生成、多元醇通络的活化、蛋白激酶C的激活、糖基化终末产物的积聚]、血流动力学异常、氧化应激、细胞因子(转化生长因子、血管内皮生长因子、肿瘤坏死因子α)参与及遗传因素等。近年来诸多学者对糖尿病肾病的发病机制进行的研究已取得了一定的进展,进一步研究本病的发病机制对于寻找有效的防治方法具有重要意义。
|
| 关 键 词： | 糖尿病肾病 发病机制 文献分类 |
Overview of Current Researches on Pathogenetic Mechanisms of Diabetic Nephropathy |
| |
| LI Min-zhou,GAO Yan-bin,MA Ming-fei,ZHU Zhi-yao,ZOU Da-wei and LI Qin.Overview of Current Researches on Pathogenetic Mechanisms of Diabetic Nephropathy[J].China Journal of Experimental Traditional Medical Formulae,2012,18(22):344-349. |
| |
| Authors: | LI Min-zhou GAO Yan-bin MA Ming-fei ZHU Zhi-yao ZOU Da-wei and LI Qin |
| |
| Affiliation: | Department of Endocrinology,Beijing University of Traditional Chinese Medicine Subsidiary Dongfang Hospital, Beijing 100078, China;School of Traditional Chinese Medicine,Capital Medical University, Beijing 100069, China;Department of Endocrinology,Beijing University of Traditional Chinese Medicine Subsidiary Dongfang Hospital, Beijing 100078, China;Department of Endocrinology,Beijing University of Traditional Chinese Medicine Subsidiary Dongfang Hospital, Beijing 100078, China;Department of Endocrinology,Beijing University of Traditional Chinese Medicine Subsidiary Dongfang Hospital, Beijing 100078, China;Department of Endocrinology,Beijing University of Traditional Chinese Medicine Subsidiary Dongfang Hospital, Beijing 100078, China |
| |
| Abstract: | Diabetic nephropathies(DN) is the most common chronic complications of diabetes mellitus(DM),and is the leading cause of end-stage renal disease(ESRD) either.There are a lot of pathogentic mechanisms can contribute to the development of the diaease,such as sugar metabolism disorders,hemodynamic dysfunctions,lipid metabolism disorders,cytokines,oxidatives stress mechanisms and genetic susceptibility etc.These pathogentic mechanisms will be overviewed as follows. |
| |
| Keywords: | diabetic nephropathy pathogenic mechanism literature sorting |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中国实验方剂学杂志》浏览原始摘要信息 |
|
点击此处可从《中国实验方剂学杂志》下载全文 |
|
