| 知柏地黄丸治疗卵巢储备功能低下不孕疗效研究 |
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| 引用本文： | 顾雨婷,梁程程,沈 聪,高晓晴.知柏地黄丸治疗卵巢储备功能低下不孕疗效研究[J].陕西中医,2022,0(10):1376-1379. |
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| 作者姓名： | 顾雨婷 梁程程 沈 聪 高晓晴 |
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| 作者单位： | (上海中医药大学附属曙光医院妇科,上海 201203) |
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| 摘 要： | 目的:观察知柏地黄丸治疗卵巢储备功能低下不孕患者疗效及作用机制。方法:将90例卵巢储备功能低下的受试对象用随机数字表法平均分为对照组和观察组,每组45例。对照组予常规治疗,观察组在对照组基础上加用知柏地黄丸,比较两组患者治疗前后中医证候评分、临床疗效、卵巢形态、抗缪勒管激素(AMH)、性激素水平促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E2)]、辅助T细胞1(Th1)、辅助T细胞2(Th2)细胞水平。结果:治疗后,两组患者中医证候评分结果均下降,观察组的中医证候评分低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组临床总有效率(91.11%)高于对照组(71.11%),且差异有统计学意义(P<0.05)。治疗后,两组患者基础窦卵泡数、卵泡数增多,平均卵巢体积增大,子宫内膜厚度、卵巢动脉血舒张期及收缩期最高血流速度均增加,观察组各指标总体改善程度优于对照组,且差异有统计学意义(均P<0.05)。治疗后,两组患者的AMH、E2升高,FSH、LH降低(均P<0.05); 与对照组比较,观察组的AMH、E2水平较高,FSH、LH水平较低(均P<0.05)。治疗后,Th1较前下降,Th2较前升高,差异有统计学意义(均P<0.05); 与对照组比较,观察组Th1下降,Th2上升(均P<0.05)。与对照组比较,观察组妊娠率、月经恢复率均较高,流产率较低(均P<0.05)。结论:知柏地黄丸治疗卵巢储备功能低下不孕患者疗效较好,可改善AMH及性激素水平,其作用机制可能与调节Th1/Th2平衡有关。
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| 关 键 词： | 卵巢储备功能低下 不孕症 知柏地黄丸 中医证候评分 卵巢形态 性激素 |
Study on the effect and mechanism of Zhibai Dihuang pill on infertility with low ovarian reserve function |
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| GU Yuting,LIANG Chengcheng,SHEN Cong,GAO Xiaoqing.Study on the effect and mechanism of Zhibai Dihuang pill on infertility with low ovarian reserve function[J].Shaanxi Journal of Traditional Chinese Medicine,2022,0(10):1376-1379. |
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| Authors: | GU Yuting LIANG Chengcheng SHEN Cong GAO Xiaoqing |
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| Affiliation: | (Department of Gynecology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China) |
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| Abstract: | Objective:To observe the efficacy and mechanism of Zhibai Dihuang pill in the treatment of infertile patients with low ovarian reserve.Methods:Ninety subjects with low ovarian reserve were equally divided into control group and observation group by random number table method,45 cases in each group.The control group was given routine treatment,and the observation group was given Zhibai Dihuang pill on the basis of the control group.The TCM symptom scores,clinical efficacy,ovarian morphology,anti-Mullerian hormone(AMH),and sex hormone levels follicle-stimulating hormones(FSH),luteinizing hormone(LH),estradiol(E2)] were compared between the two groups before and after treatment,T helper 1(Th1),T helper 2(Th2)cell levels.Results:After treatment,the scores of TCM syndromes of the two groups of subjects decreased,and the TCM syndrome scores of the observation group were lower than those in the control group(P<0.05).After treatment,the total clinical effective rate(91.11%)of the subjects in the observation group was higher than that in the control group(71.11%)(P<0.05).After treatment,the basal number of antral follicles and follicles in the two groups increased,the average ovarian volume increased,the endometrial thickness,and the maximum blood flow velocity of ovarian artery blood in diastole and systole all increased.The overall improvement of the observation group was better than that in the control group(all P<0.05).After treatment,the levels of AMH and E2 in the two groups were increased,and the levels of FSH and LH were decreased(all P<0.05).Compared with the control group,the levels of AMH and E2 in the observation group were higher,and the levels of FSH and LH were lower(all P<0.05).After treatment,Th1 decreased and Th2 increased,and the difference was statistically significant(all P<0.05); compared with the control group,Th1 decreased and Th2 increased in the observation group(all P<0.05).Compared with the control group,the pregnancy rate and menstrual recovery rate of the observation group were higher,and the miscarriage rate was lower(all P<0.05).Conclusion:Zhibai Dihuang pill has good curative effect in the treatment of infertility patients with low ovarian reserve,and can improve the levels of AMH and sex hormones.Its mechanism of action may be related to the regulation of Th1/Th2 balance. |
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| Keywords: | Low ovarian reserve function Infertility Zhibai Dihuang pill TCM symptom score Ovarian morphology Sex hormone |
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