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| 大青叶的化学成分研究 | |
| 引用本文： | 柳继锋,张雪梅,薛多清,江志勇,顾琼,陈纪军.大青叶的化学成分研究[J].中国中药杂志,2006,31(23):1961-1964. |
| 作者姓名： | 柳继锋 张雪梅 薛多清 江志勇 顾琼 陈纪军 |
| 作者单位： | 1. 中国科学院,昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,云南,昆明,650204 2. 中国药科大学,中药分析教研室,江苏,南京,210038 3. 中国科学院,昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,云南,昆明,650204;中国科学院,西南基地,抗病毒天然药物联合实验室,云南,昆明,650204 |
| 摘 要： | 目的：对十字花科植物菘蓝Isatis indigotica Fort.叶的化学成分进行研究。方法：大青叶的干燥叶用80%乙醇提取,依次用石油醚,醋酸乙酯,正丁醇萃取,对醋酸乙酯部分采用硅胶、Sephadex LH-20, Rp-8, Rp-18柱色谱进行分离纯化,通过波谱数据分析(MS,1H-NMR,13C-NMR)进行结构鉴定。结论：从醋酸乙酯部分分离鉴定了11个化合物,其中5个生物碱,2个芳香酸,2个木脂素,2个黄酮。分别鉴定为：10H-indolo［3,2-b］quinoline(1),靛玉红(2),4(3H)-喹唑酮(3),(E)-3-(3′,5′-dimethoxy-4′-hydroxybenzylidene)-2-indolinone(4),deoxyvascinone(5),苯甲酸(6),邻羟基苯甲酸(7),(-)-落叶松脂素(8),(+)-异落叶松树脂醇(9),异牡荆素(10),6-β-D-glucopyranosyldiosmetin(11)。其中化合物1,4,5,8,9,11为首次从大青叶中分离得到。 |
| 关 键 词： | 大青叶 生物碱 芳香酸 木脂素 黄酮 |
| 文章编号： | 1001-5302（2006）23-1961-05 |
| 收稿时间： | 1/9/2006 12:00:00 AM |
| 修稿时间： | 2006-01-09 |
Studies on chemical constituents from leaves of Isatis indigotica |
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| LIU Ji-feng ;ZHANG Xue-mei ;XUE Duo-qing ;JIANG Zhi-yong ;GU Qiong ;CHEN Ji-jun ;.Studies on chemical constituents from leaves of Isatis indigotica[J].China Journal of Chinese Materia Medica,2006,31(23):1961-1964. | |
| Authors: | LIU Ji-feng ;ZHANG Xue-mei ;XUE Duo-qing ;JIANG Zhi-yong ;GU Qiong ;CHEN Ji-jun ; |
| Affiliation: | 1. State Key Labortatory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming 650204, China ; 2. Department of Chinese Medicinal Analysis, China Pharmaceutical University, Nanjing 210038, China; 3. Joint-Laboratory of Anti- Virus Natural Medicines, Kunming Branch, the Chinese Academy of Sciences, Kunming 650204, China |
| Abstract: | OBJECTIVE: To study the chemical constituents of the leaves of Isatis indigotica. METHOD: The leaves of I. indigotica were extracted with 80% ethanol. The EtOH extract was dispersed in H20 and extracted with petroleum, EtOAc and BuOH successively. The EtOAc fraction was isolated and purified by column chromatography on silica gel, Sephadex LH -20 and Rp-8, Rp-18. All the compounds were identified on the basis of spectral analyses (including MS, 1H-NMR, 13 C-NMR) , RESULT: Eleven compounds were isolated from the leaves of I. indigotica, and structures were characterized as 10H-indolo 3, 2-b] quinoline (1), indirubin (2), 4 (3H)-quinazo-linone (3), (E)-3-(3', 5'-dimethoxy-4'-hydroxybenzylidene) -2-indolinone (4), 2, 3-dihydropyrrolo 2, 1-b] quinazolin-9(1H) -one (5) , benzoic acid (6) , o-droxy-benzoic acid (7), ( - ) -lariciresinol (8) , ( + ) -isolariciresinol (9), isovitexin (10), 6-f-D-glucopyranosyldiosmetin (11). CONCLUSION: 1, 4, 5, 8, 9, 11 were obtained from the leaves of I. indigotica for the first time. |
| Keywords: | Isatis indigotica alkaloids organic acids lignans flavones |
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