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| 中药巴布剂的研究现状 | |
| 引用本文： | 贾伟,高文远,王涛,刘云斌,薛京,肖培根.中药巴布剂的研究现状[J].中国中药杂志,2003,28(1):7-7. |
| 作者姓名： | 贾伟 高文远 王涛 刘云斌 薛京 肖培根 |
| 作者单位： | 1. 天津大学,药物科学与技术学院,天津,300072 2. 上海云南白药透皮技术有限公司,上海,201203 3. 中国医学科学院,中国协和医科大学,药用植物研究所,北京,100094 |
| 摘 要： | 中药巴布剂已成为一种用于治疗关节炎、软组织损伤、腱鞘炎、腰椎突出、神经痛、骨质增生、腹腔疾病、癌症等各种疾病引起的疼痛 ,并具备优良的柔韧性和黏着性的新型贴剂。我国于 2 0世纪 80年代开展了中药巴布剂的研究 ,并在治疗各种骨疾病引起的疼痛方面取得了另人满意的疗效。 90年代初中药巴布剂开始规模生产 ,至今已有多个产品在全国上市。在临床治疗多种疼痛性疾病的报道中 ,作为外用中药贴剂的巴布剂较受患者的欢迎。尽管化学药物在治疗骨疾病以及癌症引起的疼痛方面依然占主导地位 ,实践证明在此基础上采用口服和中药巴布剂的中西结合方法 ,能较好地缓解疾病的症状、有效改善病人的生活质量。和传统的中药贴膏剂相比 ,巴布剂中的高分子基质材料能更好地吸收和承载包括多种水溶性和脂溶性成分的中药提取物并予以“凝胶化”成型。由于药物基质含有高达 40 %～ 70 %的水分 ,这样的结构犹如一个“药库” ,能快速、持久地透皮释放基质中所包含的有效成分。本文分 3个部分对中药巴布剂制备工艺研究、中药巴布剂开发的优点和国内开发现状以及中药巴布剂的应用前景作了综述。 |
| 关 键 词： | 药巴布剂 制剂工艺 中药制剂 |
| 文章编号： | 1001-5302(2003)01-0007-05 |
| 收稿时间： | 9/4/2002 12:00:00 AM |
Cataplasma of Traditional Chinese Medicine |
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| JIA Wei ;GAO Wen-yuan ;WANG Tao ;LIU Yun-bin ;XUE Jing ;XIAO Pei-gen.Cataplasma of Traditional Chinese Medicine[J].China Journal of Chinese Materia Medica,2003,28(1):7-7. | |
| Authors: | JIA Wei ;GAO Wen-yuan ;WANG Tao ;LIU Yun-bin ;XUE Jing ;XIAO Pei-gen |
| Affiliation: | College of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. |
| Abstract: | The TCM (traditional Chinese medicine) transdermal plaster (also known as "cataplasma") are flexible adhesive patches used for treatment of pain, resulted from arthritis, sprain and bruise, tendovaginitis, lumbar spine protrude, neuralgia, hyperosteogeny ache, abdominal discomfort and metastatic cancer, etc. Since the 1980's, investigators in China have used this modern patch delivery system for herbal drugs and obtained satisfactory results especially from the treatment of various types of pain associated with bone diseases, abdominal discomfort, and tumors, etc. The production of TCM cataplasma was successfully scaled up in early 90's and the commercial product line for an antirheumatic agent was first established in Shanghai by Leiyunshang Group. Thus far, a number of products in the form of TCM cataplasma became commercially available in the market, and clinical investigations with these products indicated that topically applicable herbal preparations, especially in the form of cataplasma, are preferred formulations with respect to the treatment comfort of the patient. Compared to the traditional preparations which utilize rubber and rosin as adhesives, cataplasma is advantageous in that the lipophilic and hydrophilic ingredients of the herbal extracts are solubilized and then "gellified" with the organic polymers, and that the drug matrix containing up to 40%- 70% of water serves as a "drug reservoir" that will sustain the quick and continuous release of herbal ingredients over several days across the skin. While there are conventional remedies for palliation of pain and discomfort associated with bone diseases or cancers, administration of oral medicinal herbs combined with topical agents such as TCM cataplasma may significantly alleviate the symptoms and improve their quality of life. This article provides a review on three aspects, which include the process development, characteristics and developmental status of TCM cataplasma,and future development of such a technology. |
| Keywords: | cataplasma dosage forms TCM products |
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