| 瑞香狼毒细胞培养物的化学成分研究 |
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| 引用本文： | 乔立瑞,杨林,张德武,邹建华,戴均贵.瑞香狼毒细胞培养物的化学成分研究[J].中国中药杂志,2011,36(24):3457-3462. |
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| 作者姓名： | 乔立瑞 杨林 张德武 邹建华 戴均贵 |
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| 作者单位： | 中国医学科学院北京协和医学院药物研究所,天然药物活性物质与功能国家重点实验室,北京100050 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09301-003-4-1) |
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| 摘 要： | 采用常压与减压硅胶柱色谱、半制备HPLC、Sephadex LH-20等方法,从瑞香狼毒Stellera chamaejasme细胞培养物85％乙醇提取物的乙酸乙酯部分分离纯化得到了17个化合物,依据理化性质和各种波谱技术分别鉴定为:丁香脂素(1),杜仲树脂酚(2),松脂素(3),(1R,2S,5R,6S) -2-(4-hydroxyphenyl) -6-( 3-methoxy-4- hydroxyphenyl)-3,7-dioxabicyclo3,3,0]octane(4),表松脂酚(5),caruilignan D(6),3-羰基愈创木烷-4-烯-11,12-二醇(7),落叶松脂素(8),tetrahydro-2-( 4-hydroxy-3-methoxyphenyl) -4- (4-hydroxyphenyl) methyl] -3-furanmethanol(9),5′-甲氧基落叶松脂醇(10),vladinol D( 11),环(L-脯氨酸-L-缬氨酸)(12),7′-羰基马台树脂醇(13),(+) -guayarol( 14),acutissimalignanB(15),异落叶松脂素(16)以及β-谷甾醇(17).其中化合物12为环二肽类化合物,7为倍半萜类化合物.除化合物7,12与17外,其余均为木脂素类化合物.17个化合物均首次从该植物组织培养物中获得.
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| 关 键 词： | 瑞香狼毒 细胞培养物 木脂素类 |
| 收稿时间： | 2011/4/20 0:00:00 |
Studies on chemical constitutes from callus cultures of Stellera chamaejasme |
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| QIAO Lirui,YANG Lin,ZHANG Dewu,ZOU Jianhua and DAI Jungui.Studies on chemical constitutes from callus cultures of Stellera chamaejasme[J].China Journal of Chinese Materia Medica,2011,36(24):3457-3462. |
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| Authors: | QIAO Lirui YANG Lin ZHANG Dewu ZOU Jianhua and DAI Jungui |
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| Affiliation: | QIAO Lirui,YANG Lin,ZHANG Dewu,ZOU Jianhua,DAI Jungui (State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China) |
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| Abstract: | From callus cultures of Stellera chamaejasme, 17 compounds were isolated. Based on their physical and chemical data and spectroscopic analysis, they were identified as syringaresinol (1), medioresinol (2), pinoresinol (3), (1R, 2S, 5R, 6S)- 2-(4- hydroxyphenyl)-6-(3-methoxy-4-hydroxyphenyl)-3, 7-dioxabicyclo 3, 3, 0] octane (4), epipinoresinol (5), caruilignan D (6), 3-oxo-guai-4-ene-11, 12-diol (7), (-) -lariciresinol (8), tetrahydro-2-(4-hydroxy-3-methoxyphenyl)-4-(4-hydroxyphenyl) methyl]-3-furanmethanol (9), 5'-methoxylariciresinol (10), vladinol D (11), cyclo (L-Pro-L-Val) (12), oxomatairesinol (13), (+) -guayarol (14); acutissimalignan B (15), isolariciresinol (16), and beta-sitosterol (17), respectively. Among these compounds, 12 was a cyclodipeptide, 7 was a sesquiterpene, and the others except 17 were lignans. All compounds were first isolated from callus cultures of S. chamaejasme. |
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| Keywords: | Stellera chamaejasme callus cultures lignans |
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