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| 科学评价含雄黄、朱砂中成药的安全性 | |
| 引用本文： | 陆远富,时京珍,石京山,刘杰.科学评价含雄黄、朱砂中成药的安全性[J].中国中药杂志,2011,36(24):3402-3405. |
| 作者姓名： | 陆远富 时京珍 石京山 刘杰 |
| 作者单位： | 1. 上海中医药大学,上海200071;遵义医学院药理学教研室贵州省基础药理重点实验室,贵州遵义563001 2. 贵阳中医学院实验中心基础医学实验室,贵州贵阳,550002 3. 遵义医学院药理学教研室贵州省基础药理重点实验室,贵州遵义563001;University of Kansas Medical Center, Kansas City, KS 66160, USA |
| 基金项目： | 贵州省科技厅项目(TZJF2009-41,2010-5);贵州省中医药管理局项目(D-330,D-331) |
| 摘 要： | 雄黄和朱砂与其他中药配伍应用于临床已有上千年历史,但由于雄黄含砷,朱砂含汞,其安全性近年来引起了越来越多的关注,加之现有对含雄黄和朱砂中药的金属含量仍以总砷和总汞为标准进行评价,所以含雄黄和朱砂的中成药因砷、汞超标引起了民众的广泛忧虑,不但治疗作用受质疑,毒性作用被夸大,而且使其出口受限制,声誉受影响.因此,含雄黄、朱砂中成药安全性评价就尤为重要,本文就含雄黄和朱砂中成药的毒理研究进展作一综述. |
| 关 键 词： | 雄黄 朱砂 中成药 安全性评价 |
| 收稿时间： | 2011/1/23 0:00:00 |
Safety evaluation of realgar-and cinnabar-containing traditional Chinese medicine |
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| LU Yuanfu,SHI Jingzhen,SHI Jingshan and LIU Jie.Safety evaluation of realgar-and cinnabar-containing traditional Chinese medicine[J].China Journal of Chinese Materia Medica,2011,36(24):3402-3405. | |
| Authors: | LU Yuanfu SHI Jingzhen SHI Jingshan and LIU Jie |
| Affiliation: | LU Yuanfu1,2,SHI Jingzhen3,SHI Jingshan1,LIU Jie2,4 (1.Shanghai University of Traditional Chinese Medicine,Shanghai 20071,China,2.Department of Pharmacology and Key Laboratory of Basic Pharmacology of Guizhou,Zunyi Medical College,Zunyi 563003,3.Guiyan Traditional Medical College,Guiyang 550002,4.University of Kansas Medical Center,Kansas City,KS 66160,USA) |
| Abstract: | Realgar (90% of As4S4) and cinnabar (96% of HgS) have been used in traditional Chinese medicines for thousands of years. Both arsenic and mercury are well-known for toxic effects and the safety of realgar-and cinnabar-containing traditional Chinese medicines is of concern. It is considered that any intentional use of known toxic metals in medicine is an unacceptable risk, while an opposing opinion presumes that realgar and cinnabar have clear pharmacological action with tolerable side effects. This review summarized the progress of toxicological study on realgar-and cinnbar-containing traditional Chinese medicines. |
| Keywords: | realgar cinnabar traditional Chinese medicine pharmacology and toxicology |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |
