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| 芍药甘草复方效应组分谱效关系研究 | |
| 引用本文： | 沈岚,张梁,冯怡,徐德生,林晓.芍药甘草复方效应组分谱效关系研究[J].中国中药杂志,2008,33(22):2658-2658. |
| 作者姓名： | 沈岚 张梁 冯怡 徐德生 林晓 |
| 作者单位： | 1. 上海中医药大学中药学院,上海,201203 2. 上海中医药大学科技中心,上海,201203 3. 上海中医药大学附属曙光医院,上海,200021 |
| 基金项目： | 国家自然科学基金杰出青年科学基金，上海市青年科技启明星计划A类，上海市教委重点学科建设项目，高等学校博士学科点专项科研基金 |
| 摘 要： | 目的：研究芍药甘草复方大鼠给药后的解痉活性成分。方法：在建立芍药甘草体内成分指纹图谱分析方法的基础上，通过对芍药甘草各效应组分8组不同配比给药后大鼠血清的胃底肌条解痉实验，获得各组抑制率，将药效学信息与各组血清HPLC指纹图谱化学信息进行相关性研究。并采用HPLCESIMS/MS分析芍药甘草效应组分给药后血清样品。结果：谱效相关性研究发现，芍药甘草效应组分给药后体内4个色谱峰与药效相关性较大，与药效呈正相关，且相关系数大于04，分别为0774，0678，0566，0472，其保留时间分别为803，517，5459，7243 min；经质谱分析，主要为效应组分代谢成分。结论：通过谱效研究直接获得体内活性物质，建立了体内活性物质谱效研究的一种新方法，是复方中药的药效物质基础确定的有效手段。 |
| 关 键 词： | 芍药甘草 谱效 物质基础 |
| 收稿时间： | 1/1/1900 12:00:00 AM |
| 修稿时间： | 1/1/1900 12:00:00 AM |
Study on fingerprints correlated with pharmacodynamic of Paeonia lacliflora and Glycyrrhiza uralensis effective compounds |
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| SHEN Lan; ZHANG Liang; FENG Yi; XU De sheng; LIN Xiao.Study on fingerprints correlated with pharmacodynamic of Paeonia lacliflora and Glycyrrhiza uralensis effective compounds [J].China Journal of Chinese Materia Medica,2008,33(22):2658-2658. |
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| Authors: | SHEN Lan; ZHANG Liang; FENG Yi; XU De sheng; LIN Xiao |
| Affiliation: | SHEN Lan,ZHANG Liang,FENG Yi,XU De-sheng,LIN Xiao(1.School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China,2.Technology Center,3.Shuguang Hospital,Shanghai 200021,China) |
| Abstract: | Objective: To study the spasmolysisy activity constituents of the Radix Paeoniae alba and Radix et Rhizoma compound.Method: The three effective compounds of Radix Paeoniae and Radix et Rhizoma were arrayed to eight groups by orthogonal design rat,serum samples were collected after administered in these groups,and these serum samples were used to carry out the experiments of serum pharmacology of spasmolysis.The inhibition ratios were assigned as pharmacodynamic variable X,the areas of characteristic peaks o... |
| Keywords: | Paeonia lacliflora and Glycyrrhiza uralensis fingerprints-pharmacology material foundation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
