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苓桂术甘汤配伍机制研究
引用本文:宋宗华,戴舒佳,黎辉琴,毕开顺,冯东.苓桂术甘汤配伍机制研究[J].中国中药杂志,2002,27(10):760-762.
作者姓名:宋宗华  戴舒佳  黎辉琴  毕开顺  冯东
作者单位:1. 沈阳药科大学,药学院,辽宁,沈阳,110016
2. 北京中顺制药厂,北京,101300
摘    要:目的 :研究《伤寒论》名方苓桂术甘汤的配伍机制 ,确定方中各药味的君臣佐使关系。方法 :采用正交试验设计对方中组成药味进行药味与药量同时加减拆方 ,选择小鼠常压耐缺氧、对抗氯仿所致小鼠心律失常和利尿 3项药理指标 ,对所得 16个处方进行药理实验 ;采用方差分析、逐步回归分析 (SREG)与典型相关分析 (CCOR)将所得药理数据和组方药味及药量相关联 ,探讨复方苓桂术甘汤的配伍机制。结果 :确定了方中以茯苓为君 ,以桂枝为臣 ,佐以白术 ,使以甘草的配伍关系 ,与对该复方中药的传统诠释相一致。结论 :本研究为探讨复方中药的配伍机制提供了有意义的尝试。

关 键 词:苓桂术甘汤  配伍机制  正交试验设计
文章编号:1001-5302(2002)10-0760-03
收稿时间:2001/11/30 0:00:00
修稿时间:2001年11月30

Study on the Compatibility of Composite Herbal Medicinesof the LingGuiZhuGan Decoction
SONG Zong-hua;DAI Shu-jia;LI Hui-qin;BI Kai-shun;FENG Dong.Study on the Compatibility of Composite Herbal Medicinesof the LingGuiZhuGan Decoction[J].China Journal of Chinese Materia Medica,2002,27(10):760-762.
Authors:SONG Zong-hua;DAI Shu-jia;LI Hui-qin;BI Kai-shun;FENG Dong
Affiliation:Shenyang Pharmaceutical University, Shenyang 110015, Liaoning, China.
Abstract:Objective: To study the compatibility of composite herbal medicines of the Ling Gui Zhu Gan Decoction. Method:Ethanol extract test solutions of the different combinations were prepared according to the orthogonal layout L16(45). Pharmacologic experiments, such as the time of surviving of mice in shortage of oxygen in regular air pressure, the antagonizing effect on arrhythmia induced by chloroform and diuresis were carried out with the solutions. Variance analysis, canonical correlation and stepwise regression analysis were applied to interrelate the amount of each drug and the pharmacologic data. Result:The results confirmed that Fuling and Guizhi are the basis, while Baizhuand Gancao are the adjuvans, which is conformed to the theory of TCM. Conclusion:This study provides a significant try for studying the compatibility of composite herbal medicines.
Keywords:Ling Gui Zhu Gan decoction  compatibility  orthogonal design
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