| 小檗碱对急性缺血性脑卒中患者颈动脉粥样硬化斑块及血清炎症因子的作用 |
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| 引用本文： | 李迎,王佩,柴美静,杨凡,李红闪,赵婧,王欢,卢丹丹.小檗碱对急性缺血性脑卒中患者颈动脉粥样硬化斑块及血清炎症因子的作用[J].中国中药杂志,2016,41(21):4066-4071. |
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| 作者姓名： | 李迎 王佩 柴美静 杨凡 李红闪 赵婧 王欢 卢丹丹 |
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| 作者单位： | 承德医学院, 河北 承德 067000,保定市第一中心医院, 河北 保定 071000,保定市第一中心医院, 河北 保定 071000,保定市第一中心医院, 河北 保定 071000,保定市第一中心医院, 河北 保定 071000,保定市第一中心医院, 河北 保定 071000,保定市第一中心医院, 河北 保定 071000,保定市第一中心医院, 河北 保定 071000 |
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| 基金项目： | 保定市科技局技术支撑项目（zf15015） |
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| 摘 要： | 该研究旨在了解小檗碱对急性缺血性脑卒中(acute cerebral ischemic stroke,AIS)患者颈动脉粥样硬化斑块及血清炎症因子的作用。将120例AIS患者按照随机数字表分为小檗碱组(n=60)和常规组(n=60)。常规组按照最新AIS诊治指南给予常规治疗,小檗碱组在常规组治疗基础上加用盐酸小檗碱片(300 mg/次,每日3次)。测定所有患者治疗前后炎症因子浓度、神经功能缺损评分及颈动脉粥样硬化斑块指标包括颈动脉粥样硬化斑块总面积(total plaque area,TPA)、内膜中层厚度(intima-media thickness,IMT)及不稳定性斑块数目]的变化并进行比较。研究结果发现,第1天,2组患者炎症因子浓度,NIHSS(national institute of health stroke scale)评分及颈动脉粥样硬化斑块指标的比较无明显统计学差异且炎症因子水平与NIHSS评分呈正相关(P0.05)。第14天较第1天,2组患者炎症因子浓度及NIHSS评分显著下降(P0.05)。第14天,小檗碱组较常规组炎症因子浓度及NIHSS评分下降明显(P0.05)。第90天较第1天,2组患者TPA及不稳定性斑块数目显著减低,差异有统计学意义(P0.05),而IMT有下降趋势,差异无统计学意义。第90天,小檗碱组较常规组TPA及不稳定性斑块数目减少明显(P0.05),mRS(modified rankin scale)评分显著偏低且短期预后良好率显著偏高(P0.05)。2组不良反应发生率无明显差异。该研究结果表明在常规治疗基础上加用小檗碱可显著降低AIS患者急性期血清炎症因子水平,并在一定程度上减轻AIS患者的颈动脉粥样硬化程度,促进神经功能的恢复,改善缺血性卒中病人的短期预后。
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| 关 键 词： | 小檗碱 急性缺血性脑卒中(AIS) 巨噬细胞移动抑制因子(MIF) 白介素-6(IL-6) 颈动脉粥样硬化斑块 |
| 收稿时间： | 2016/7/26 0:00:00 |
Effects of berberine on serum inflammatory factors and carotid atherosclerotic plaques in patients with acute cerebral ischemic stroke |
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| LI Ying,WANG Pei,CHAI Mei-jing,YANG Fan,LI Hong-shan,ZHAO Jing,WANG and LU Dan-dan.Effects of berberine on serum inflammatory factors and carotid atherosclerotic plaques in patients with acute cerebral ischemic stroke[J].China Journal of Chinese Materia Medica,2016,41(21):4066-4071. |
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| Authors: | LI Ying WANG Pei CHAI Mei-jing YANG Fan LI Hong-shan ZHAO Jing WANG and LU Dan-dan |
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| Affiliation: | Chengde Medical University, Chengde 067000, China,Baoding No.1 Central Hospital, Baoding 071000, China,Baoding No.1 Central Hospital, Baoding 071000, China,Baoding No.1 Central Hospital, Baoding 071000, China,Baoding No.1 Central Hospital, Baoding 071000, China,Baoding No.1 Central Hospital, Baoding 071000, China,Baoding No.1 Central Hospital, Baoding 071000, China and Baoding No.1 Central Hospital, Baoding 071000, China |
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| Abstract: | This study aims to analyze the effect of berberine on serum inflammatory factors and carotid atherosclerotic plaques in ppatients with acute cerebral ischemic stroke(AIS). In the study, 120 patients with AIS were randomly divided into berberine group(n=60) and general group(n=60). The 60 cases in the general group were provided with general therapy according to the latest guidelines of diagnosis and treatment of AIS. The berberine group received berberine 300 mg(tid) in addition to the therapy of the general group. The levels of serum inflammatory factors, the nerve function defect grades and the indexes of carotid atherosclerosis plaquesincluding the total plaque area(TPA), intima-media thickness(IMT) and the number of unstable carotid atherosclerotic plaques] were measured and compared. The results indicated that the levels of serum inflammatory factors, the NIHSS(national institute of health stroke scales) cores and the indexes of carotid atherosclerosis plaques were not significantly different between the berberine groups of general group, with positive correlation between serum inflammatory factors and NIHSS scores(P<0.05). The levels of serum inflammatory factors and NIHSS scores of the berberine groups on 14 d were significantly lower than those on 1 d(P<0.05). The levels of serum inflammatory factors and NIHSS scores of the berberine group on 14 d were significantly lower than those of the general group(P<0.05). The TPA and the number of unstable carotid atherosclerotic plaques of the berberine groups on 90 d were significantly lower than those of general group, with significant differences(P<0.05). The IMT showed a downward trend, but with significant difference.The mRS(modified rankin scale) scores of the berberine group on 90 d were significantly lower, with a higher rate of short-term favorable prognosis(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups. This study showed that berberine in addition to the general therapy can significantly lower the levels of serum MIF and IL-6, reduce the degree of carotid atherosclerosis to some extent and improve neurological impairment and the prognosis of patients with AIS. |
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| Keywords: | berberine acute cerebral ischemic stroke(AIS) macrophage migration inhibitory factor(MIF) interleukin-6(IL-6) carotid atherosclerotic plaques |
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