| 食管癌放疗过程中如何选择中药注射剂的网状Meta分析 |
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| 引用本文： | 葛龙,毛蕾,田金徽,石芳毓,娄丽丽,邱霞,李金龙,杨克虎.食管癌放疗过程中如何选择中药注射剂的网状Meta分析[J].中国中药杂志,2015,40(18):3674-3681. |
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| 作者姓名： | 葛龙 毛蕾 田金徽 石芳毓 娄丽丽 邱霞 李金龙 杨克虎 |
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| 作者单位： | 兰州大学 第一临床医学院, 甘肃 兰州 730000;兰州大学 循证医学中心, 甘肃 兰州 730000,兰州大学 循证医学中心, 甘肃 兰州 730000;兰州大学 第二临床医学院, 甘肃 兰州 730000,兰州大学 循证医学中心, 甘肃 兰州 730000;甘肃省循证医学与临床转化重点实验室, 甘肃 兰州 730000,兰州大学 第一临床医学院, 甘肃 兰州 730000;兰州大学 循证医学中心, 甘肃 兰州 730000,兰州大学 循证医学中心, 甘肃 兰州 730000,兰州大学 循证医学中心, 甘肃 兰州 730000;兰州大学 第二临床医学院, 甘肃 兰州 730000,兰州大学 第一临床医学院, 甘肃 兰州 730000;兰州大学 循证医学中心, 甘肃 兰州 730000,兰州大学 循证医学中心, 甘肃 兰州 730000;甘肃省循证医学与临床转化重点实验室, 甘肃 兰州 730000 |
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| 摘 要： | 采用网状Meta分析的方法间接比较中药注射剂联合放疗治疗食管癌的疗效和安全性。计算机检索PubMed,the Cochrane Library,EMBASE,CBM,CNKI,万方和维普数据库,检索时间截止2014年9月,纳入中药注射剂联合放疗对比单纯放疗治疗食管癌的随机对照研究(RCT),2名研究者独立进行数据提取和质量评价,采用GeMTC 0.14.3软件和Stata 12.0软件进行统计分析。最终纳入43个RCT,包含3 289例患者。纳入的各比较组构成星型网络,网状Meta分析结果提示7种中药注射剂在提高食管癌放疗患者的有效率和生活质量、降低呕心呕吐和白细胞减少发生率方面均显示出其优越性,然而7种中药注射剂之间比较差异并不显著。根据概率排序结果,参芪扶正和黄芪多糖注射剂在提高食管癌放疗患者有效率和生活质量上成为最有效注射剂的可能性最大,其次为华蟾素和康艾注射剂,然而由于参芪扶正和黄芪多糖受限于纳入研究数量和样本量,目前证据推荐在提高食管癌放疗患者有效率和生活质量上优先考虑华蟾素或康艾注射剂,而在降低放疗患者呕心呕吐(III-IV)和白细胞减少(III-IV)方面艾迪或复方苦参注射剂更具优势。今后研究重点关注参芪扶正和黄芪多糖等注射剂联合放疗治疗食管癌的疗效;并规范报告研究结果,尤其针对食管癌放疗相关的毒副作用。
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| 关 键 词： | 网状Meta分析 食管癌 中药注射剂 放疗 |
| 收稿时间： | 2015/3/11 0:00:00 |
Network meta-analysis on selecting Chinese medical injections in radiotherapy for esophageal cancer |
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| GE Long,MAO Lei,TIAN Jin-hui,SHI Fang-yu,LOU Li-li,QIU Xi,LI Jin-long and YANG Ke-hu.Network meta-analysis on selecting Chinese medical injections in radiotherapy for esophageal cancer[J].China Journal of Chinese Materia Medica,2015,40(18):3674-3681. |
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| Authors: | GE Long MAO Lei TIAN Jin-hui SHI Fang-yu LOU Li-li QIU Xi LI Jin-long and YANG Ke-hu |
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| Affiliation: | The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China;Evidence-Based Medical Center, Lanzhou University, Lanzhou 730000, China,Evidence-Based Medical Center, Lanzhou University, Lanzhou 730000, China;The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China,Evidence-Based Medical Center, Lanzhou University, Lanzhou 730000, China;Key Laboratory of Evidence-based Medicine and Clinical Translational Research of Gansu Province, Lanzhou 730000, China,The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China;Evidence-Based Medical Center, Lanzhou University, Lanzhou 730000, China,Evidence-Based Medical Center, Lanzhou University, Lanzhou 730000, China,Evidence-Based Medical Center, Lanzhou University, Lanzhou 730000, China;The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China,The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China;Evidence-Based Medical Center, Lanzhou University, Lanzhou 730000, China and Evidence-Based Medical Center, Lanzhou University, Lanzhou 730000, China;Key Laboratory of Evidence-based Medicine and Clinical Translational Research of Gansu Province, Lanzhou 730000, China |
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| Abstract: | To assess the clinical effect and safety of Chinese traditional medicine injection combined with radiotherapy for esophageal cancer. The relative randomized controlled trials (RCTs) of Chinese medical injections (CMI) combined with radiotherapy as well as simple radiotherapy for esophageal cancer were searched from PubMed, Cochrane Library, EMBASE, Chinese Biomedical Literature Database(CBM), China National Knowledge Infrastructure (CNKI), Wanfang Database and VIP Database as at September 2014. Two researchers completed the data extraction and quality evaluation independently. The data were analyzed by GeMTC 0.14.3 and Stata 12.0 software. Finally, 43 RCTs involving 3 289 patients were finally included. The star network was constructed by different comparison groups. The results of network meta-analysis showed that the seven CMIs combined with radiotherapy was superior to simple radiotherapy in the treatment of esophageal cancer in efficacy, quality of life, and reduction in the incidence of nausea and leucopenia, but with no significant difference among the seven CMIs. Probability ranking result showed a great possibility for Shenqi Fuzheng and astragalus polysaccharide injections in improving the overall response rate and quality of life, which were followed by cinobufagin and kangai injections. However, only one study was included for Shenqi Fuzheng and astragalus polysaccharide injections. Therefore, cinobufagin or kangai injections were preferred in improving the overall response rate and quality of life. Aidi or compound sophora injections were better than other CMIs in reducing?the incidences of nausea (III-IV) and leukopenia. More RCTs of Shenqi Fuzheng and astragalus polysaccharide injections combined with radiotherapy for patients with esophageal cancer were expected in the future to confirm our results. Moreover, study findings will be reported, particularly for the adverse events in radiotherapy for esophageal cancer. |
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| Keywords: | network meta-analyses esophageal cancer Chinese traditional medicine injection radiotherapy |
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