| 穿心莲内酯及其衍生物抗感染研究近10年进展 |
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| 引用本文： | 严园园,施高翔,邵菁,汪天明,汪长中.穿心莲内酯及其衍生物抗感染研究近10年进展[J].中国中药杂志,2013,38(22):3819-3824. |
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| 作者姓名： | 严园园 施高翔 邵菁 汪天明 汪长中 |
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| 作者单位： | 安徽中医学院 中西医结合临床学院, 安徽 合肥 230038;安徽中医学院 中西医结合临床学院, 安徽 合肥 230038;安徽中医学院 中西医结合临床学院, 安徽 合肥 230038;安徽中医学院 中西医结合临床学院, 安徽 合肥 230038;安徽中医学院 中西医结合临床学院, 安徽 合肥 230038 |
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| 基金项目： | 国家自然科学基金项目(81073127) |
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| 摘 要： | 穿心莲内酯是穿心莲的主要有效成分,穿心莲内酯及其衍生物具有抗感染、抗肿瘤和免疫调节等作用,尤其是其突出的抗细菌、抗真菌、抗病毒、抗原虫等活性对日益增多的机会性感染具有重要作用。该文结合本课题组多年来对穿心莲内酯的研究,对其及衍生物抗感染的基础与临床研究近10年进展作一综述。
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| 关 键 词： | 穿心莲内酯 衍生物 抗感染 |
| 收稿时间： | 2013/4/25 0:00:00 |
Advance in studies on anti-infection of andrographolide and its derivatives in past 10 years |
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| YAN Yuan-yuan,SHI Gao-xiang,SHAO Jing,WANG Tian-ming and WANG Chang-zhong.Advance in studies on anti-infection of andrographolide and its derivatives in past 10 years[J].China Journal of Chinese Materia Medica,2013,38(22):3819-3824. |
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| Authors: | YAN Yuan-yuan SHI Gao-xiang SHAO Jing WANG Tian-ming and WANG Chang-zhong |
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| Affiliation: | School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China;School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China;School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China;School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China;School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China |
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| Abstract: | Andrographolide (AG) is a main effective ingredient in leaves of Andrographis paniculata. AG and its derivatives have such effects in anti-infection, anti-tumor and immuno-regulation. Particularly, its antibacterial, antiviral and anti-protozoal activities play an increasingly important role in resisting opportunistic infections. On the basis of our studies on AG over the years, we made a summary for the basis and clinical studies on AG and its derivatives over the past 10 years. |
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| Keywords: | andrographolide derivative anti-infection |
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