| 丹参酮合成生物学研究进展 |
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| 引用本文： | 高伟,胡添源,郭娟,吕冬梅,戴住波,周雍进,黄璐琦.丹参酮合成生物学研究进展[J].中国中药杂志,2015,40(13):2486-2491. |
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| 作者姓名： | 高伟 胡添源 郭娟 吕冬梅 戴住波 周雍进 黄璐琦 |
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| 作者单位： | 首都医科大学 中医药学院, 北京 100069,首都医科大学 中医药学院, 北京 100069,中国中医科学院 中药资源中心, 北京 100700,中国中医科学院 中药资源中心, 北京 100700,中国科学院 天津工业生物技术研究所, 天津 300308,Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivögen 10, SE-41296 Göteborg, Sweden,中国中医科学院 中药资源中心, 北京 100700 |
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| 基金项目： | 国家自然科学优秀青年科学基金项目(81422053);国家杰出青年科学基金项目(81325023) |
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| 摘 要： | 通过阐明并模拟中药活性成分生物合成的基本规律,人工设计并构建新的、具有特定生理功能的生物系统(药用植物或微生物系统),这种中药合成生物学研究策略,将是一种极具潜力的中药活性成分资源获取方法。丹参酮是丹参中一类具有显著药理活性的二萜,该文系统介绍了丹参酮合成生物学研究进展,旨在为其他中药萜类活性成分研究提供借鉴,为中药资源可持续利用研究提供新的研究策略。
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| 关 键 词： | 丹参酮 生物合成途径 合成生物学 中药合成生物学 |
| 收稿时间： | 2015/6/20 0:00:00 |
Research progress of synthetic biology for tanshinones |
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| GAO Wei,HU Tian-yuan,GUO Juan,LV Dong-mei,DAI Zhu-bo,ZHOU Yong-jin and HUANG Lu-qi.Research progress of synthetic biology for tanshinones[J].China Journal of Chinese Materia Medica,2015,40(13):2486-2491. |
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| Authors: | GAO Wei HU Tian-yuan GUO Juan LV Dong-mei DAI Zhu-bo ZHOU Yong-jin and HUANG Lu-qi |
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| Affiliation: | School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China,School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China,National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China,Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivögen; 10, SE-41296 Göteborg, Sweden and National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | Synthetic biology research methods which design and build a new artificial biological systems (medicinal plants or microorganisms system) with specific physiological functions through clarifying and simulating the basic law of the biosynthesis of active components of traditional Chinese medicine, is considered to be a potential method to produce an abundant resources of bioactive components. Tanshinones is a kind of diterpene quinone compounds with important pharmacological activities from traditional Chinese medicine Salvia miltiorrhiza. This article systematically introduced the research progress of the synthetic biology of S. miltiorrhiza, in order to provide references for studies on other terpenoid bioactive components of traditional Chinese medicines, and give new research strategies for the sustainable development of traditional Chinese medicine resources. |
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| Keywords: | tanshinones biosynthetic pathway synthetic biology Chinese herbal medicine synthetic biology |
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