| 红花黄色素抗氧化作用的研究 |
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| 引用本文： | 金鸣李金荣,吴伟.红花黄色素抗氧化作用的研究[J].中国中药杂志,2004,29(5):447-449. |
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| 作者姓名： | 金鸣李金荣 吴伟 |
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| 作者单位： | 北京市心肺血管疾病研究所,首都医科大学,附属北京安贞医院,药理研究室,北京,100029 |
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| 摘 要： | 目的 :观察红花黄色素 (SY)的抗氧化作用。方法 :以邻二氮菲-Fe2+ 氧化法检测SY清除H2O2 /Fe2+ 体系产生的羟自由基 ;硫代巴比妥酸比色法观察小鼠肝匀浆的脂质过氧化 ;比色法观察H2O2 /Fe2+ 体系产生的羟自由基致红细胞膜的破裂。结果 :1.39～ 3.4 2g·L-1SY的羟自由基清除率为 27.2 %～ 100 % ,呈明显量效关系 ;77.8～776 .1mg·L-1SY缓解小鼠肝匀浆脂质过氧化的抑制率为 10 .5 %～ 92 .8% ,呈明显的量效关系 ;37.1～ 2 97.1mg·L-1SY抑制羟自由基引发的红细胞破裂呈明显的量效关系。结论 :SY为红花水溶性抗氧化有效部位。
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| 关 键 词： | 红花黄色素 羟自由基 脂质过氧化 红细胞 |
| 文章编号： | 1001-5302(2004)05-0447-03 |
| 收稿时间： | 2003/11/10 0:00:00 |
Study on the antioxidative effect of Safflor Yellow |
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| JIN Ming;LI Jin-rong;WU Wei.Study on the antioxidative effect of Safflor Yellow[J].China Journal of Chinese Materia Medica,2004,29(5):447-449. |
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| Authors: | JIN Ming;LI Jin-rong;WU Wei |
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| Affiliation: | Department of Pharmacology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing 100029, China. jinzang@public3.bta.net.cn |
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| Abstract: | Objective: To observe the antioxidative effect of Safflor Yellow (SY). Method: Hydroxyl radical scavenge effect of SY was tested with 1,10-phenanthroline-Fe2+ oxidative assay.Lipid peroxidation of mouse liver suspension was measured with thiobarbituric acid colorimetry technique. Hemocytocatheresis was determined with colorimetry. Result: Hydroxyl radical could be scavenged by 1.39 to 3.42 g·L-1 SY dose dependently. Mouse liver suspension peroxidation was inhibited by 77.8 to 776.1 mg·L-1 SY dosage dependently. Hemocytocatheresis was attenuated by 37.1 to 297.1 mg·L -1 SY dose dependently. Conclusion: SY is an antioxidative part of Carthamus tinctorius . |
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| Keywords: | safflor yellow hydroxyl radical lipid peroxidation hemocytocatheresis |
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